Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q05909

- PTPRG_MOUSE

UniProt

Q05909 - PTPRG_MOUSE

Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

Ptprg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Possesses tyrosine phosphatase activity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1025 – 10251SubstrateBy similarity
    Active sitei1057 – 10571Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1101 – 11011SubstrateBy similarity
    Sitei1348 – 13481Ancestral active site

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase gamma
    Short name:
    R-PTP-gamma
    Gene namesi
    Name:Ptprg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97814. Ptprg.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 14421423Receptor-type tyrosine-protein phosphatase gammaPRO_0000025442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 2611 Publication
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1179 – 11791PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ05909.
    PRIDEiQ05909.

    PTM databases

    PhosphoSiteiQ05909.

    Expressioni

    Tissue specificityi

    Detected in brain, lung, kidney, heart, liver, skeletal muscle, spleen and testes. It is developmentally regulated in the brain.

    Gene expression databases

    CleanExiMM_PTPRG.
    GenevestigatoriQ05909.

    Interactioni

    Subunit structurei

    Monomer; active form. Homodimer; inactive form By similarity. Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ05909. 1 interaction.
    MINTiMINT-4109151.
    STRINGi10090.ENSMUSP00000022264.

    Structurei

    Secondary structure

    1
    1442
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi64 – 663
    Helixi68 – 736
    Helixi76 – 794
    Helixi90 – 923
    Beta strandi93 – 953
    Beta strandi103 – 1064
    Beta strandi116 – 1194
    Beta strandi124 – 1274
    Beta strandi133 – 1353
    Beta strandi143 – 15210
    Beta strandi162 – 1654
    Beta strandi171 – 1799
    Turni181 – 1833
    Helixi187 – 1926
    Beta strandi197 – 20610
    Helixi212 – 2143
    Helixi215 – 2228
    Beta strandi230 – 2323
    Helixi238 – 2414
    Beta strandi249 – 2546
    Beta strandi265 – 2728
    Beta strandi274 – 2763
    Helixi278 – 2858
    Beta strandi288 – 2903
    Beta strandi299 – 3013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3JXGX-ray1.70A/B/C/D55-320[»]
    3KLDX-ray2.00B55-320[»]
    ProteinModelPortaliQ05909.
    SMRiQ05909. Positions 57-320, 348-443, 822-1409.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ05909.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 733714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini760 – 1442683CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei734 – 75926HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 321264Alpha-carbonic anhydraseAdd
    BLAST
    Domaini349 – 448100Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST
    Domaini845 – 1116272Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1147 – 1407261Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1057 – 10637Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000060222.
    HOVERGENiHBG053760.
    InParanoidiQ05909.
    KOiK16667.
    PhylomeDBiQ05909.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.200.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00194. Carb_anhydrase. 1 hit.
    PF00041. fn3. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    SM00060. FN3. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF51069. SSF51069. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS51144. ALPHA_CA_2. 1 hit.
    PS50853. FN3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGTLQE SRQDSSVQIR     50
    RRKASGDPYW AYSGAYGPEH WVTSSVSCGG SHQSPIDILD HHARVGDEYQ 100
    ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF 150
    HWGHSNGSAG SEHSVNGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM 200
    AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFILRD LLPASLGSYY 250
    RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 300
    YLRNNFRPQQ ALNDRVVSKS AVRDAWNHDL ADFLDNPLGT EASKVCSSPP 350
    IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK 400
    DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ 450
    GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS 500
    SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT ASAASKQAGR 550
    TVLATTEALA SPGPDVHSAP SKDSEGTEEG EKEEKSESED GEREHEEEEK 600
    DSEKKEKSEA THTAAESDRT APAPTPSSPH RTAAEGGHQT IPGRRQDHSA 650
    PATDQPGHVA PDLDPLVDTA TQVPPTATEE HYSGSDPRRP EMPSKKPMSR 700
    GDRFSEDSKF ITVNPAEKNT SGMLSRPSPG RMEWIIPLIV VSALTFVCLV 750
    LLIAVLVYWR GCNKIKSKGF PRRSREVPSS GERGEKGSRK CFQTAHFYVE 800
    DSSSPRVVPN ESVPIIPIPD DMEAIPVKQF GKHIGELYSN SQHGFSEDFE 850
    EVQRCTADMN ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH 900
    SDYINANYVD GYNKAKAYIA TQGPLKSTFE DFWRMIWEQN TGIIIMITNL 950
    VEKGRRKCDQ YWPTENTEEY GNIIVTLKST KVHACYTVRR LSVRNTKVKK 1000
    GQKGNPKGRQ NERTVIQYHY TQWPDMGVPE YALPVLTFVR RSSAARMPDM 1050
    GPVLVHCSAG VGRTGTYIVI DSMLQQIKDK STVNVLGFLK HIRTQRNYLV 1100
    QTEEQYIFIH DALLEAILGK ETAVSSSQLH SYVNSILIPG VGGKTRLEKQ 1150
    FKLITQCNAK YVECFSAQKE CNKEKNRNSS VVPAERARVG LAPLPGMKGT 1200
    DYINASYIMG YYRSNEFIIT QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ 1250
    SLAEDEFVYW PSREESMNCE AFTVTLISKD RLCLSNEEQI IIHDFILEAT 1300
    QDDYVLEVRH FQCPKWPNPD APISSTFELI NVIKEEALTR DGPTIVHDEY 1350
    GAVSAGMLCA LTTLSQQLEN ENAVDVFQVA KMINLMRPGV FTDIEQYQFV 1400
    YKAMLSLIST KENGNGPMTG DKNGAVLTAE ESDPAESMES LV 1442
    Length:1,442
    Mass (Da):161,243
    Last modified:February 1, 1994 - v1
    Checksum:i5887715568FBECD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09562 mRNA. Translation: AAA40022.1.
    CCDSiCCDS26816.1.
    PIRiB48148.
    RefSeqiNP_033007.2. NM_008981.3.
    UniGeneiMm.431266.

    Genome annotation databases

    GeneIDi19270.
    KEGGimmu:19270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09562 mRNA. Translation: AAA40022.1 .
    CCDSi CCDS26816.1.
    PIRi B48148.
    RefSeqi NP_033007.2. NM_008981.3.
    UniGenei Mm.431266.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3JXG X-ray 1.70 A/B/C/D 55-320 [» ]
    3KLD X-ray 2.00 B 55-320 [» ]
    ProteinModelPortali Q05909.
    SMRi Q05909. Positions 57-320, 348-443, 822-1409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q05909. 1 interaction.
    MINTi MINT-4109151.
    STRINGi 10090.ENSMUSP00000022264.

    PTM databases

    PhosphoSitei Q05909.

    Proteomic databases

    PaxDbi Q05909.
    PRIDEi Q05909.

    Protocols and materials databases

    DNASUi 19270.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19270.
    KEGGi mmu:19270.

    Organism-specific databases

    CTDi 5793.
    MGIi MGI:97814. Ptprg.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000060222.
    HOVERGENi HBG053760.
    InParanoidi Q05909.
    KOi K16667.
    PhylomeDBi Q05909.

    Miscellaneous databases

    EvolutionaryTracei Q05909.
    NextBioi 296154.
    PROi Q05909.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PTPRG.
    Genevestigatori Q05909.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.200.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00194. Carb_anhydrase. 1 hit.
    PF00041. fn3. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    SM00060. FN3. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF51069. SSF51069. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS51144. ALPHA_CA_2. 1 hit.
    PS50853. FN3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases."
      Barnea G., Silvennoinen O., Shaanan B., Honegger A.M., Canoll P.D., D'Eustachio P., Morse B., Levy J.B., Laforgia S., Huebner K., Musacchio J.M., Sap J., Schlessinger J.
      Mol. Cell. Biol. 13:1497-1506(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
      Bouyain S., Watkins D.J.
      Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 55-320 IN COMPLEX WITH CNTN4, INTERACTION WITH CNTN3; CNTN4; CNTN5 AND CNTN6, DISULFIDE BOND.

    Entry informationi

    Entry nameiPTPRG_MOUSE
    AccessioniPrimary (citable) accession number: Q05909
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3