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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

Ptprg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1025SubstrateBy similarity1
Active sitei1057Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1101SubstrateBy similarity1
Sitei1348Ancestral active site1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of epithelial cell migration Source: MGI
  • toxin transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:Ptprg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97814. Ptprg.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 733ExtracellularSequence analysisAdd BLAST714
Transmembranei734 – 759HelicalSequence analysisAdd BLAST26
Topological domaini760 – 1442CytoplasmicSequence analysisAdd BLAST683

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002544220 – 1442Receptor-type tyrosine-protein phosphatase gammaAdd BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 2611 Publication
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1
Glycosylationi719N-linked (GlcNAc...)Sequence analysis1
Modified residuei1179PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ05909.
PaxDbiQ05909.
PRIDEiQ05909.

PTM databases

iPTMnetiQ05909.
PhosphoSitePlusiQ05909.
SwissPalmiQ05909.

Expressioni

Tissue specificityi

Detected in brain, lung, kidney, heart, liver, skeletal muscle, spleen and testes. It is developmentally regulated in the brain.

Gene expression databases

CleanExiMM_PTPRG.

Interactioni

Subunit structurei

Monomer; active form. Homodimer; inactive form (By similarity). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ05909. 2 interactors.
MINTiMINT-4109151.
STRINGi10090.ENSMUSP00000022264.

Structurei

Secondary structure

11442
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 66Combined sources3
Helixi68 – 73Combined sources6
Helixi76 – 79Combined sources4
Helixi90 – 92Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi103 – 106Combined sources4
Beta strandi116 – 119Combined sources4
Beta strandi124 – 127Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi143 – 152Combined sources10
Beta strandi162 – 165Combined sources4
Beta strandi171 – 179Combined sources9
Turni181 – 183Combined sources3
Helixi187 – 192Combined sources6
Beta strandi197 – 206Combined sources10
Helixi212 – 214Combined sources3
Helixi215 – 222Combined sources8
Beta strandi230 – 232Combined sources3
Helixi238 – 241Combined sources4
Beta strandi249 – 254Combined sources6
Beta strandi265 – 272Combined sources8
Beta strandi274 – 276Combined sources3
Helixi278 – 285Combined sources8
Beta strandi288 – 290Combined sources3
Beta strandi299 – 301Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXGX-ray1.70A/B/C/D55-320[»]
3KLDX-ray2.00B55-320[»]
5E5UX-ray2.00A/C57-320[»]
ProteinModelPortaliQ05909.
SMRiQ05909.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 321Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST264
Domaini349 – 448Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini845 – 1116Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST272
Domaini1147 – 1407Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1057 – 1063Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
KOG0789. Eukaryota.
COG3338. LUCA.
COG5599. LUCA.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ05909.
KOiK16667.
PhylomeDBiQ05909.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGTLQE SRQDSSVQIR
60 70 80 90 100
RRKASGDPYW AYSGAYGPEH WVTSSVSCGG SHQSPIDILD HHARVGDEYQ
110 120 130 140 150
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
160 170 180 190 200
HWGHSNGSAG SEHSVNGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM
210 220 230 240 250
AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFILRD LLPASLGSYY
260 270 280 290 300
RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE
310 320 330 340 350
YLRNNFRPQQ ALNDRVVSKS AVRDAWNHDL ADFLDNPLGT EASKVCSSPP
360 370 380 390 400
IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
410 420 430 440 450
DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ
460 470 480 490 500
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS
510 520 530 540 550
SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT ASAASKQAGR
560 570 580 590 600
TVLATTEALA SPGPDVHSAP SKDSEGTEEG EKEEKSESED GEREHEEEEK
610 620 630 640 650
DSEKKEKSEA THTAAESDRT APAPTPSSPH RTAAEGGHQT IPGRRQDHSA
660 670 680 690 700
PATDQPGHVA PDLDPLVDTA TQVPPTATEE HYSGSDPRRP EMPSKKPMSR
710 720 730 740 750
GDRFSEDSKF ITVNPAEKNT SGMLSRPSPG RMEWIIPLIV VSALTFVCLV
760 770 780 790 800
LLIAVLVYWR GCNKIKSKGF PRRSREVPSS GERGEKGSRK CFQTAHFYVE
810 820 830 840 850
DSSSPRVVPN ESVPIIPIPD DMEAIPVKQF GKHIGELYSN SQHGFSEDFE
860 870 880 890 900
EVQRCTADMN ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH
910 920 930 940 950
SDYINANYVD GYNKAKAYIA TQGPLKSTFE DFWRMIWEQN TGIIIMITNL
960 970 980 990 1000
VEKGRRKCDQ YWPTENTEEY GNIIVTLKST KVHACYTVRR LSVRNTKVKK
1010 1020 1030 1040 1050
GQKGNPKGRQ NERTVIQYHY TQWPDMGVPE YALPVLTFVR RSSAARMPDM
1060 1070 1080 1090 1100
GPVLVHCSAG VGRTGTYIVI DSMLQQIKDK STVNVLGFLK HIRTQRNYLV
1110 1120 1130 1140 1150
QTEEQYIFIH DALLEAILGK ETAVSSSQLH SYVNSILIPG VGGKTRLEKQ
1160 1170 1180 1190 1200
FKLITQCNAK YVECFSAQKE CNKEKNRNSS VVPAERARVG LAPLPGMKGT
1210 1220 1230 1240 1250
DYINASYIMG YYRSNEFIIT QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ
1260 1270 1280 1290 1300
SLAEDEFVYW PSREESMNCE AFTVTLISKD RLCLSNEEQI IIHDFILEAT
1310 1320 1330 1340 1350
QDDYVLEVRH FQCPKWPNPD APISSTFELI NVIKEEALTR DGPTIVHDEY
1360 1370 1380 1390 1400
GAVSAGMLCA LTTLSQQLEN ENAVDVFQVA KMINLMRPGV FTDIEQYQFV
1410 1420 1430 1440
YKAMLSLIST KENGNGPMTG DKNGAVLTAE ESDPAESMES LV
Length:1,442
Mass (Da):161,243
Last modified:February 1, 1994 - v1
Checksum:i5887715568FBECD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09562 mRNA. Translation: AAA40022.1.
CCDSiCCDS26816.1.
PIRiB48148.
RefSeqiNP_033007.2. NM_008981.3.
UniGeneiMm.431266.

Genome annotation databases

GeneIDi19270.
KEGGimmu:19270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09562 mRNA. Translation: AAA40022.1.
CCDSiCCDS26816.1.
PIRiB48148.
RefSeqiNP_033007.2. NM_008981.3.
UniGeneiMm.431266.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JXGX-ray1.70A/B/C/D55-320[»]
3KLDX-ray2.00B55-320[»]
5E5UX-ray2.00A/C57-320[»]
ProteinModelPortaliQ05909.
SMRiQ05909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ05909. 2 interactors.
MINTiMINT-4109151.
STRINGi10090.ENSMUSP00000022264.

PTM databases

iPTMnetiQ05909.
PhosphoSitePlusiQ05909.
SwissPalmiQ05909.

Proteomic databases

MaxQBiQ05909.
PaxDbiQ05909.
PRIDEiQ05909.

Protocols and materials databases

DNASUi19270.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19270.
KEGGimmu:19270.

Organism-specific databases

CTDi5793.
MGIiMGI:97814. Ptprg.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
KOG0789. Eukaryota.
COG3338. LUCA.
COG5599. LUCA.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ05909.
KOiK16667.
PhylomeDBiQ05909.

Miscellaneous databases

EvolutionaryTraceiQ05909.
PROiQ05909.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PTPRG.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRG_MOUSE
AccessioniPrimary (citable) accession number: Q05909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.