Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q05909 (PTPRG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase gamma

Short name=Protein-tyrosine phosphatase gamma
Short name=R-PTP-gamma
EC=3.1.3.48
Gene names
Name:Ptprg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possesses tyrosine phosphatase activity By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Monomer; active form. Homodimer; inactive form By similarity. Interacts with CNTN3, CNTN4, CNTN5 and CNTN6. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Detected in brain, lung, kidney, heart, liver, skeletal muscle, spleen and testes. It is developmentally regulated in the brain.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.

Contains 1 alpha-carbonic anhydrase domain.

Contains 1 fibronectin type-III domain.

Contains 2 tyrosine-protein phosphatase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 14421423Receptor-type tyrosine-protein phosphatase gamma
PRO_0000025442

Regions

Topological domain20 – 733714Extracellular Potential
Transmembrane734 – 75926Helical; Potential
Topological domain760 – 1442683Cytoplasmic Potential
Domain58 – 321264Alpha-carbonic anhydrase
Domain349 – 448100Fibronectin type-III
Domain845 – 1116272Tyrosine-protein phosphatase 1
Domain1147 – 1407261Tyrosine-protein phosphatase 2
Region1057 – 10637Substrate binding By similarity

Sites

Active site10571Phosphocysteine intermediate By similarity
Binding site10251Substrate By similarity
Binding site11011Substrate By similarity
Site13481Ancestral active site

Amino acid modifications

Modified residue11791Phosphoserine By similarity
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3591N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 261 Ref.2

Secondary structure

................................................. 1442
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q05909 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5887715568FBECD8

FASTA1,442161,243
        10         20         30         40         50         60 
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGTLQE SRQDSSVQIR RRKASGDPYW 

        70         80         90        100        110        120 
AYSGAYGPEH WVTSSVSCGG SHQSPIDILD HHARVGDEYQ ELQLDGFDNE SSNKTWMKNT 

       130        140        150        160        170        180 
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSVNGRRF PVEMQIFFYN 

       190        200        210        220        230        240 
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFILRD 

       250        260        270        280        290        300 
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE 

       310        320        330        340        350        360 
YLRNNFRPQQ ALNDRVVSKS AVRDAWNHDL ADFLDNPLGT EASKVCSSPP IHMKVQPLNQ 

       370        380        390        400        410        420 
TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL 

       430        440        450        460        470        480 
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW 

       490        500        510        520        530        540 
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT 

       550        560        570        580        590        600 
ASAASKQAGR TVLATTEALA SPGPDVHSAP SKDSEGTEEG EKEEKSESED GEREHEEEEK 

       610        620        630        640        650        660 
DSEKKEKSEA THTAAESDRT APAPTPSSPH RTAAEGGHQT IPGRRQDHSA PATDQPGHVA 

       670        680        690        700        710        720 
PDLDPLVDTA TQVPPTATEE HYSGSDPRRP EMPSKKPMSR GDRFSEDSKF ITVNPAEKNT 

       730        740        750        760        770        780 
SGMLSRPSPG RMEWIIPLIV VSALTFVCLV LLIAVLVYWR GCNKIKSKGF PRRSREVPSS 

       790        800        810        820        830        840 
GERGEKGSRK CFQTAHFYVE DSSSPRVVPN ESVPIIPIPD DMEAIPVKQF GKHIGELYSN 

       850        860        870        880        890        900 
SQHGFSEDFE EVQRCTADMN ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH 

       910        920        930        940        950        960 
SDYINANYVD GYNKAKAYIA TQGPLKSTFE DFWRMIWEQN TGIIIMITNL VEKGRRKCDQ 

       970        980        990       1000       1010       1020 
YWPTENTEEY GNIIVTLKST KVHACYTVRR LSVRNTKVKK GQKGNPKGRQ NERTVIQYHY 

      1030       1040       1050       1060       1070       1080 
TQWPDMGVPE YALPVLTFVR RSSAARMPDM GPVLVHCSAG VGRTGTYIVI DSMLQQIKDK 

      1090       1100       1110       1120       1130       1140 
STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK ETAVSSSQLH SYVNSILIPG 

      1150       1160       1170       1180       1190       1200 
VGGKTRLEKQ FKLITQCNAK YVECFSAQKE CNKEKNRNSS VVPAERARVG LAPLPGMKGT 

      1210       1220       1230       1240       1250       1260 
DYINASYIMG YYRSNEFIIT QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW 

      1270       1280       1290       1300       1310       1320 
PSREESMNCE AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD 

      1330       1340       1350       1360       1370       1380 
APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGMLCA LTTLSQQLEN ENAVDVFQVA 

      1390       1400       1410       1420       1430       1440 
KMINLMRPGV FTDIEQYQFV YKAMLSLIST KENGNGPMTG DKNGAVLTAE ESDPAESMES 


LV 

« Hide

References

[1]"Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases."
Barnea G., Silvennoinen O., Shaanan B., Honegger A.M., Canoll P.D., D'Eustachio P., Morse B., Levy J.B., Laforgia S., Huebner K., Musacchio J.M., Sap J., Schlessinger J.
Mol. Cell. Biol. 13:1497-1506(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
Bouyain S., Watkins D.J.
Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 55-320 IN COMPLEX WITH CNTN4, INTERACTION WITH CNTN3; CNTN4; CNTN5 AND CNTN6, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09562 mRNA. Translation: AAA40022.1.
CCDSCCDS26816.1.
PIRB48148.
RefSeqNP_033007.2. NM_008981.3.
UniGeneMm.431266.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3JXGX-ray1.70A/B/C/D55-320[»]
3KLDX-ray2.00B55-320[»]
ProteinModelPortalQ05909.
SMRQ05909. Positions 57-320, 348-443, 822-1409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ05909. 1 interaction.
MINTMINT-4109151.
STRING10090.ENSMUSP00000022264.

PTM databases

PhosphoSiteQ05909.

Proteomic databases

PaxDbQ05909.
PRIDEQ05909.

Protocols and materials databases

DNASU19270.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19270.
KEGGmmu:19270.

Organism-specific databases

CTD5793.
MGIMGI:97814. Ptprg.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000060222.
HOVERGENHBG053760.
InParanoidQ05909.
KOK16667.
PhylomeDBQ05909.

Gene expression databases

CleanExMM_PTPRG.
GenevestigatorQ05909.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProIPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ05909.
NextBio296154.
PROQ05909.
SOURCESearch...

Entry information

Entry namePTPRG_MOUSE
AccessionPrimary (citable) accession number: Q05909
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot