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Q05909

- PTPRG_MOUSE

UniProt

Q05909 - PTPRG_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

Ptprg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1025 – 10251SubstrateBy similarity
Active sitei1057 – 10571Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1101 – 11011SubstrateBy similarity
Sitei1348 – 13481Ancestral active site

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:Ptprg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97814. Ptprg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 733714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei734 – 75926HelicalSequence AnalysisAdd
BLAST
Topological domaini760 – 1442683CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 14421423Receptor-type tyrosine-protein phosphatase gammaPRO_0000025442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 2611 Publication
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
Modified residuei1179 – 11791PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ05909.
PaxDbiQ05909.
PRIDEiQ05909.

PTM databases

PhosphoSiteiQ05909.

Expressioni

Tissue specificityi

Detected in brain, lung, kidney, heart, liver, skeletal muscle, spleen and testes. It is developmentally regulated in the brain.

Gene expression databases

CleanExiMM_PTPRG.
GenevestigatoriQ05909.

Interactioni

Subunit structurei

Monomer; active form. Homodimer; inactive form (By similarity). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.By similarity1 Publication

Protein-protein interaction databases

IntActiQ05909. 1 interaction.
MINTiMINT-4109151.
STRINGi10090.ENSMUSP00000022264.

Structurei

Secondary structure

1
1442
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi64 – 663Combined sources
Helixi68 – 736Combined sources
Helixi76 – 794Combined sources
Helixi90 – 923Combined sources
Beta strandi93 – 953Combined sources
Beta strandi103 – 1064Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi124 – 1274Combined sources
Beta strandi133 – 1353Combined sources
Beta strandi143 – 15210Combined sources
Beta strandi162 – 1654Combined sources
Beta strandi171 – 1799Combined sources
Turni181 – 1833Combined sources
Helixi187 – 1926Combined sources
Beta strandi197 – 20610Combined sources
Helixi212 – 2143Combined sources
Helixi215 – 2228Combined sources
Beta strandi230 – 2323Combined sources
Helixi238 – 2414Combined sources
Beta strandi249 – 2546Combined sources
Beta strandi265 – 2728Combined sources
Beta strandi274 – 2763Combined sources
Helixi278 – 2858Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi299 – 3013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JXGX-ray1.70A/B/C/D55-320[»]
3KLDX-ray2.00B55-320[»]
ProteinModelPortaliQ05909.
SMRiQ05909. Positions 57-320, 348-443, 822-1409.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 321264Alpha-carbonic anhydraseAdd
BLAST
Domaini349 – 448100Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini845 – 1116272Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1147 – 1407261Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1057 – 10637Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000060222.
HOVERGENiHBG053760.
InParanoidiQ05909.
KOiK16667.
PhylomeDBiQ05909.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGTLQE SRQDSSVQIR
60 70 80 90 100
RRKASGDPYW AYSGAYGPEH WVTSSVSCGG SHQSPIDILD HHARVGDEYQ
110 120 130 140 150
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
160 170 180 190 200
HWGHSNGSAG SEHSVNGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM
210 220 230 240 250
AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFILRD LLPASLGSYY
260 270 280 290 300
RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE
310 320 330 340 350
YLRNNFRPQQ ALNDRVVSKS AVRDAWNHDL ADFLDNPLGT EASKVCSSPP
360 370 380 390 400
IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
410 420 430 440 450
DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ
460 470 480 490 500
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS
510 520 530 540 550
SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT ASAASKQAGR
560 570 580 590 600
TVLATTEALA SPGPDVHSAP SKDSEGTEEG EKEEKSESED GEREHEEEEK
610 620 630 640 650
DSEKKEKSEA THTAAESDRT APAPTPSSPH RTAAEGGHQT IPGRRQDHSA
660 670 680 690 700
PATDQPGHVA PDLDPLVDTA TQVPPTATEE HYSGSDPRRP EMPSKKPMSR
710 720 730 740 750
GDRFSEDSKF ITVNPAEKNT SGMLSRPSPG RMEWIIPLIV VSALTFVCLV
760 770 780 790 800
LLIAVLVYWR GCNKIKSKGF PRRSREVPSS GERGEKGSRK CFQTAHFYVE
810 820 830 840 850
DSSSPRVVPN ESVPIIPIPD DMEAIPVKQF GKHIGELYSN SQHGFSEDFE
860 870 880 890 900
EVQRCTADMN ITAEHSNHPD NKHKNRYINI LAYDHSRVKL RPLPGKDSKH
910 920 930 940 950
SDYINANYVD GYNKAKAYIA TQGPLKSTFE DFWRMIWEQN TGIIIMITNL
960 970 980 990 1000
VEKGRRKCDQ YWPTENTEEY GNIIVTLKST KVHACYTVRR LSVRNTKVKK
1010 1020 1030 1040 1050
GQKGNPKGRQ NERTVIQYHY TQWPDMGVPE YALPVLTFVR RSSAARMPDM
1060 1070 1080 1090 1100
GPVLVHCSAG VGRTGTYIVI DSMLQQIKDK STVNVLGFLK HIRTQRNYLV
1110 1120 1130 1140 1150
QTEEQYIFIH DALLEAILGK ETAVSSSQLH SYVNSILIPG VGGKTRLEKQ
1160 1170 1180 1190 1200
FKLITQCNAK YVECFSAQKE CNKEKNRNSS VVPAERARVG LAPLPGMKGT
1210 1220 1230 1240 1250
DYINASYIMG YYRSNEFIIT QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ
1260 1270 1280 1290 1300
SLAEDEFVYW PSREESMNCE AFTVTLISKD RLCLSNEEQI IIHDFILEAT
1310 1320 1330 1340 1350
QDDYVLEVRH FQCPKWPNPD APISSTFELI NVIKEEALTR DGPTIVHDEY
1360 1370 1380 1390 1400
GAVSAGMLCA LTTLSQQLEN ENAVDVFQVA KMINLMRPGV FTDIEQYQFV
1410 1420 1430 1440
YKAMLSLIST KENGNGPMTG DKNGAVLTAE ESDPAESMES LV
Length:1,442
Mass (Da):161,243
Last modified:February 1, 1994 - v1
Checksum:i5887715568FBECD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09562 mRNA. Translation: AAA40022.1.
CCDSiCCDS26816.1.
PIRiB48148.
RefSeqiNP_033007.2. NM_008981.3.
UniGeneiMm.431266.

Genome annotation databases

GeneIDi19270.
KEGGimmu:19270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09562 mRNA. Translation: AAA40022.1 .
CCDSi CCDS26816.1.
PIRi B48148.
RefSeqi NP_033007.2. NM_008981.3.
UniGenei Mm.431266.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3JXG X-ray 1.70 A/B/C/D 55-320 [» ]
3KLD X-ray 2.00 B 55-320 [» ]
ProteinModelPortali Q05909.
SMRi Q05909. Positions 57-320, 348-443, 822-1409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q05909. 1 interaction.
MINTi MINT-4109151.
STRINGi 10090.ENSMUSP00000022264.

PTM databases

PhosphoSitei Q05909.

Proteomic databases

MaxQBi Q05909.
PaxDbi Q05909.
PRIDEi Q05909.

Protocols and materials databases

DNASUi 19270.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 19270.
KEGGi mmu:19270.

Organism-specific databases

CTDi 5793.
MGIi MGI:97814. Ptprg.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000060222.
HOVERGENi HBG053760.
InParanoidi Q05909.
KOi K16667.
PhylomeDBi Q05909.

Miscellaneous databases

EvolutionaryTracei Q05909.
NextBioi 296154.
PROi Q05909.
SOURCEi Search...

Gene expression databases

CleanExi MM_PTPRG.
Genevestigatori Q05909.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.200.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00194. Carb_anhydrase. 1 hit.
PF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01057. Carb_anhydrase. 1 hit.
SM00060. FN3. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF51069. SSF51069. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS51144. ALPHA_CA_2. 1 hit.
PS50853. FN3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases."
    Barnea G., Silvennoinen O., Shaanan B., Honegger A.M., Canoll P.D., D'Eustachio P., Morse B., Levy J.B., Laforgia S., Huebner K., Musacchio J.M., Sap J., Schlessinger J.
    Mol. Cell. Biol. 13:1497-1506(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 55-320 IN COMPLEX WITH CNTN4, INTERACTION WITH CNTN3; CNTN4; CNTN5 AND CNTN6, DISULFIDE BOND.

Entry informationi

Entry nameiPTPRG_MOUSE
AccessioniPrimary (citable) accession number: Q05909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3