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Q05907

- GLNA_PYRFU

UniProt

Q05907 - GLNA_PYRFU

Protein

Glutamine synthetase

Gene

glnA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (03 Apr 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:PF0450
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Glutamine synthetasePRO_0000153209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei358 – 3581O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ05907.

    Interactioni

    Protein-protein interaction databases

    STRINGi186497.PF0450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05907.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005156.
    KOiK01915.
    OMAiGSERIEY.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05907-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNISVSMNKF DSKIKFVQLV FVDINGMPKG MEIPASRLEE AVTDGISFDG    50
    SSVPGFQGIE DSDLVFKADP DTYVEVPWDN VARVYGFIYK DNKPYGADPR 100
    GILKRALEEL EKEGYKAYIG PEPEFYLFKK NGTWELEIPD VGGYFDILTL 150
    DKARDIRREI AEYMPSFGLI PEVLHHEVGK AQHEIDFRYD EALKTADNIV 200
    SFKYITKAVA EMHGLYATFM PKPLFGFPGN GMHLHISLWK DGENVFMGEE 250
    GLSEIALHFI GGILKHAKAL TAVTNPTVNS YKRLVPSYEA PVYISWGYRN 300
    RSALIRVPAF WGKGARIEYR CPDPSANPYF AFAAVLKAGL DGIKHKIDPF 350
    AYVEENVYEM SEEKRKELGI ETLPGSLGEA LEELEKDKVV KEALGDAYKN 400
    FINYKWKEWE SYLEYLEEKH MPKDTKKVTE WELERYFFL 439
    Length:439
    Mass (Da):50,183
    Last modified:April 3, 2002 - v2
    Checksum:i96563A8E9A0E0892
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031K → G in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti232 – 2321M → L in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti351 – 3511A → S in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti370 – 3701I → L in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti376 – 3761S → N in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti382 – 3821E → G in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti397 – 3971A → S in AAA71968. (PubMed:7916055)Curated
    Sequence conflicti421 – 4266MPKDTK → IPPDTE in AAA71968. (PubMed:7916055)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12410 Genomic DNA. Translation: AAA71968.1.
    AE009950 Genomic DNA. Translation: AAL80574.1.
    RefSeqiNP_578179.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL80574; AAL80574; PF0450.
    GeneIDi1468291.
    KEGGipfu:PF0450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12410 Genomic DNA. Translation: AAA71968.1 .
    AE009950 Genomic DNA. Translation: AAL80574.1 .
    RefSeqi NP_578179.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali Q05907.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF0450.

    Proteomic databases

    PRIDEi Q05907.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL80574 ; AAL80574 ; PF0450 .
    GeneIDi 1468291.
    KEGGi pfu:PF0450.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005156.
    KOi K01915.
    OMAi GSERIEY.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relationships of bacterial and archaeal glutamine synthetase genes."
      Brown J.R., Masuchi Y., Robb F.T., Doolittle W.F.
      J. Mol. Evol. 38:566-576(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
    2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiGLNA_PYRFU
    AccessioniPrimary (citable) accession number: Q05907
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: April 3, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3