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Q05907

- GLNA_PYRFU

UniProt

Q05907 - GLNA_PYRFU

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Protein

Glutamine synthetase

Gene
glnA, PF0450
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:PF0450
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Glutamine synthetasePRO_0000153209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei358 – 3581O-AMP-tyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ05907.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0450.

Structurei

3D structure databases

ProteinModelPortaliQ05907.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005156.
KOiK01915.
OMAiGSERIEY.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05907-1 [UniParc]FASTAAdd to Basket

« Hide

MNISVSMNKF DSKIKFVQLV FVDINGMPKG MEIPASRLEE AVTDGISFDG    50
SSVPGFQGIE DSDLVFKADP DTYVEVPWDN VARVYGFIYK DNKPYGADPR 100
GILKRALEEL EKEGYKAYIG PEPEFYLFKK NGTWELEIPD VGGYFDILTL 150
DKARDIRREI AEYMPSFGLI PEVLHHEVGK AQHEIDFRYD EALKTADNIV 200
SFKYITKAVA EMHGLYATFM PKPLFGFPGN GMHLHISLWK DGENVFMGEE 250
GLSEIALHFI GGILKHAKAL TAVTNPTVNS YKRLVPSYEA PVYISWGYRN 300
RSALIRVPAF WGKGARIEYR CPDPSANPYF AFAAVLKAGL DGIKHKIDPF 350
AYVEENVYEM SEEKRKELGI ETLPGSLGEA LEELEKDKVV KEALGDAYKN 400
FINYKWKEWE SYLEYLEEKH MPKDTKKVTE WELERYFFL 439
Length:439
Mass (Da):50,183
Last modified:April 3, 2002 - v2
Checksum:i96563A8E9A0E0892
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031K → G in AAA71968. 1 Publication
Sequence conflicti232 – 2321M → L in AAA71968. 1 Publication
Sequence conflicti351 – 3511A → S in AAA71968. 1 Publication
Sequence conflicti370 – 3701I → L in AAA71968. 1 Publication
Sequence conflicti376 – 3761S → N in AAA71968. 1 Publication
Sequence conflicti382 – 3821E → G in AAA71968. 1 Publication
Sequence conflicti397 – 3971A → S in AAA71968. 1 Publication
Sequence conflicti421 – 4266MPKDTK → IPPDTE in AAA71968. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12410 Genomic DNA. Translation: AAA71968.1.
AE009950 Genomic DNA. Translation: AAL80574.1.
RefSeqiNP_578179.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80574; AAL80574; PF0450.
GeneIDi1468291.
KEGGipfu:PF0450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12410 Genomic DNA. Translation: AAA71968.1 .
AE009950 Genomic DNA. Translation: AAL80574.1 .
RefSeqi NP_578179.1. NC_003413.1.

3D structure databases

ProteinModelPortali Q05907.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF0450.

Proteomic databases

PRIDEi Q05907.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL80574 ; AAL80574 ; PF0450 .
GeneIDi 1468291.
KEGGi pfu:PF0450.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005156.
KOi K01915.
OMAi GSERIEY.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary relationships of bacterial and archaeal glutamine synthetase genes."
    Brown J.R., Masuchi Y., Robb F.T., Doolittle W.F.
    J. Mol. Evol. 38:566-576(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiGLNA_PYRFU
AccessioniPrimary (citable) accession number: Q05907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 3, 2002
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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