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Protein

Neuronal acetylcholine receptor subunit beta-3

Gene

CHRNB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine binding Source: Ensembl
  • acetylcholine-gated cation-selective channel activity Source: ProtInc
  • channel activity Source: ProtInc
  • drug binding Source: Ensembl
  • ligand-gated ion channel activity Source: Reactome

GO - Biological processi

  • cation transmembrane transport Source: GO_Central
  • neuromuscular synaptic transmission Source: GO_Central
  • protein heterooligomerization Source: Ensembl
  • response to nicotine Source: GO_Central
  • signal transduction Source: ProtInc
  • synaptic transmission, cholinergic Source: ProtInc
  • transport Source: ProtInc

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-HSA-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit beta-3
Gene namesi
Name:CHRNB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147432.6.
HGNCiHGNC:1963. CHRNB3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 232ExtracellularSequence analysisAdd BLAST208
Transmembranei233 – 257HelicalSequence analysisAdd BLAST25
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Transmembranei299 – 320HelicalSequence analysisAdd BLAST22
Topological domaini321 – 428CytoplasmicSequence analysisAdd BLAST108
Transmembranei429 – 447HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi1142.
OpenTargetsiENSG00000147432.
PharmGKBiPA26495.

Chemistry databases

ChEMBLiCHEMBL2109233.
DrugBankiDB00898. Ethanol.
DB00674. Galantamine.
DB00184. Nicotine.

Polymorphism and mutation databases

BioMutaiCHRNB3.
DMDMi2506128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000038325 – 458Neuronal acetylcholine receptor subunit beta-3Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 167By similarity
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ05901.
PaxDbiQ05901.
PRIDEiQ05901.

PTM databases

PhosphoSitePlusiQ05901.

Expressioni

Gene expression databases

BgeeiENSG00000147432.
CleanExiHS_CHRNB3.
ExpressionAtlasiQ05901. baseline and differential.
GenevisibleiQ05901. HS.

Organism-specific databases

HPAiHPA045555.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

Protein-protein interaction databases

BioGridi107564. 3 interactors.
STRINGi9606.ENSP00000289957.

Chemistry databases

BindingDBiQ05901.

Structurei

3D structure databases

ProteinModelPortaliQ05901.
SMRiQ05901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ05901.
KOiK04814.
OMAiLLCMKGH.
OrthoDBiEOG091G0R20.
PhylomeDBiQ05901.
TreeFamiTF315605.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS
60 70 80 90 100
NDTIKVYFGL KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI
110 120 130 140 150
HSIKVPSESL WLPDIVLFEN ADGRFEGSLM TKVIVKSNGT VVWTPPASYK
160 170 180 190 200
SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM VDLILINENV DRKDFFDNGE
210 220 230 240 250
WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL IIPCLGLSFL
260 270 280 290 300
TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL
310 320 330 340 350
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK
360 370 380 390 400
DHVDRYSSPE KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR
410 420 430 440 450
YISRHVKKEH FISQVVQDWK FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL

KMWLHSYH
Length:458
Mass (Da):52,729
Last modified:November 1, 1997 - v2
Checksum:iD6E919E53CBD21F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 38LFQ → EWK in CAA47851 (PubMed:7690916).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048173451K → E. Corresponds to variant dbSNP:rs35327613Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62438 mRNA. Translation: AAB40116.1.
Y08417 mRNA. Translation: CAA69694.1.
AF140765
, AF140760, AF140761, AF140762, AF140763, AF140764 Genomic DNA. Translation: AAD33063.1.
BC069681 mRNA. Translation: AAH69681.1.
BC069703 mRNA. Translation: AAH69703.1.
BC069788 mRNA. Translation: AAH69788.1.
X67513 mRNA. Translation: CAA47851.1.
CCDSiCCDS6134.1.
PIRiI38056.
RefSeqiNP_000740.1. NM_000749.4.
UniGeneiHs.654576.

Genome annotation databases

EnsembliENST00000289957; ENSP00000289957; ENSG00000147432.
GeneIDi1142.
KEGGihsa:1142.
UCSCiuc003xpi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACHB3_HUMAN
AccessioniPrimary (citable) accession number: Q05901
Secondary accession number(s): Q15827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families