Neuronal acetylcholine receptor subunit beta-3 precursor

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Q05901 (ACHB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 129. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Neuronal acetylcholine receptor subunit beta-3

Gene names

Name:

CHRNB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subunit structure	Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Traceable author statement Ref.5. Source: ProtInc synaptic transmission, cholinergic Traceable author statement Ref.5. Source: ProtInc
Cellular_component	acetylcholine-gated channel complex Traceable author statement Ref.5. Source: ProtInc cell junction Inferred from electronic annotation. Source: UniProtKB-KW neuron projection Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetylcholine binding Inferred from electronic annotation. Source: Compara acetylcholine-activated cation-selective channel activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 458

434

Neuronal acetylcholine receptor subunit beta-3

PRO_0000000383

Regions

Topological domain

25 – 232

208

Extracellular Potential

Transmembrane

233 – 257

Helical; Potential

Transmembrane

265 – 282

Helical; Potential

Transmembrane

299 – 320

Helical; Potential

Topological domain

321 – 428

108

Cytoplasmic Potential

Transmembrane

429 – 447

Helical; Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

138

N-linked (GlcNAc...) Potential

Glycosylation

166

N-linked (GlcNAc...) Potential

Disulfide bond

153 ↔ 167

By similarity

Natural variations

Natural variant

451

K → E.
Corresponds to variant rs35327613 [ dbSNP | Ensembl ].

VAR_048173

Experimental info

Sequence conflict

36 – 38

LFQ → EWK in CAA47851. Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

Q05901 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D6E919E53CBD21F8
Show »

FASTA

458

52,729

        10         20         30         40         50         60 
MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS NDTIKVYFGL 

        70         80         90        100        110        120 
KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI HSIKVPSESL WLPDIVLFEN 

       130        140        150        160        170        180 
ADGRFEGSLM TKVIVKSNGT VVWTPPASYK SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM 

       190        200        210        220        230        240 
VDLILINENV DRKDFFDNGE WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL 

       250        260        270        280        290        300 
IIPCLGLSFL TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL 

       310        320        330        340        350        360 
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK DHVDRYSSPE 

       370        380        390        400        410        420 
KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR YISRHVKKEH FISQVVQDWK 

       430        440        450 
FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL KMWLHSYH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits." Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M. J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Substantia nigra.
[2]	"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32." Groot Kormelink P.J., Luyten W.H.M.L. FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pons.
[3]	"Genomic structure and mutation analysis of the CHRNB3 gene." Keddache M., Durner M., Greenberg D.A. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit." Willoughby J.J., Ninkina N.N., Beech M.M., Latchman D.S., Wood J.N. Neurosci. Lett. 155:136-139(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-458. Tissue: Brain stem.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62438 mRNA. Translation: AAB40116.1. Y08417 mRNA. Translation: CAA69694.1. AF140765 AF140764 Genomic DNA. Translation: AAD33063.1. BC069681 mRNA. Translation: AAH69681.1. BC069703 mRNA. Translation: AAH69703.1. BC069788 mRNA. Translation: AAH69788.1. X67513 mRNA. Translation: CAA47851.1.
IPI	IPI00016662.
PIR	I38056.
RefSeq	NP_000740.1. NM_000749.3.
UniGene	Hs.654576.
3D structure databases
ProteinModelPortal	Q05901.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000289957.
PTM databases
PhosphoSite	Q05901.
Polymorphism databases
DMDM	2506128.
Proteomic databases
PaxDb	Q05901.
PRIDE	Q05901.
Protocols and materials databases
DNASU	1142.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000289957; ENSP00000289957; ENSG00000147432.
GeneID	1142.
KEGG	hsa:1142.
UCSC	uc003xpi.1. human.
Organism-specific databases
CTD	1142.
GeneCards	GC08P042552.
HGNC	HGNC:1963. CHRNB3.
HPA	HPA045555.
MIM	118508. gene.
neXtProt	NX_Q05901.
PharmGKB	PA26495.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252943.
HOGENOM	HOG000006756.
HOVERGEN	HBG003756.
InParanoid	Q05901.
KO	K04814.
OMA	INENVDR.
OrthoDB	EOG40VVPK.
PhylomeDB	Q05901.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q05901.
CleanEx	HS_CHRNB3.
Genevestigator	Q05901.
GermOnline	ENSG00000147432. Homo sapiens.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00254. NICOTINICR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q05901.
ChEMBL	CHEMBL2586.
GenomeRNAi	1142.
NextBio	4752.
SOURCE	Search...

Entry information

Entry name

ACHB3_HUMAN

Accession

Primary (citable) accession number: Q05901
Secondary accession number(s): Q15827

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents