Reviewed, UniProtKB/Swiss-Prot Q058D5 (ARLY_BUCCC)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BCc_033

Organism

Buchnera aphidicola subsp. Cinara cedri [Complete proteome] [HAMAP]

Taxonomic identifier

372461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000455

Sequences

	Sequence		Length	Mass (Da)
	Q058D5-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 3EF523898B223280	FASTA	460	52,510
	10 20 30 40 50 60 MSLWGGRFTK ISNTEFDSFN NSLRIDHRLI KDDIKSSIAW SKILLDVQVL TKKEQKIIEN 70 80 90 100 110 120 TLLSILKKNK NNFTKILSSN SEDIHSWLET TVINTIGDLG KKLYTGRSRN DQIATDLKLW 130 140 150 160 170 180 CKRKSKKICR RIIQLQNDFL DNAYLHINTI IPGYTHLQRA QPITFSYWCL AYIEMLERDR 190 200 210 220 230 240 LRILNLTQFL NSSPLGSGAI SGTSWEIDRK KLAFFMGFSE ITKNALDSVS DRDFILDILS 250 260 270 280 290 300 AAAISMMHLS RFSEDLIFYN SGEANFIELS DSITSGSSLM PQKKNPDILE LIRAKCSSVY 310 320 330 340 350 360 GSLFSMFSLL KGLPLSYNKD FQEDKNHLFS GLDIWEDCLK ISSLVLKNIK LKKSNCKKSA 370 380 390 400 410 420 QLGYSNATEL AEYLVKKGIS FRDSHHITGK IVIASIKKNK CLEELDLLFL KKYCSKIESD 430 440 450 460 VYQHLSLESC LNKKNSIGGV SNKQIKISLD QVKKRLSTFK

References

[1]	"A small microbial genome: the end of a long symbiotic relationship?" Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A. Science 314:312-313(2006) [PubMed: 17038625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000263 Genomic DNA. Translation: ABJ90514.1.
RefSeq	YP_802607.1.
3D structure databases
SMR	Q058D5. Positions 3-456.
ModBase	Search...
Protein-protein interaction databases
STRING	Q058D5.
Genome annotation databases
GeneID	4440708.
GenomeReviews	Gene locus BCc_033 in contig CP000263_GR.
KEGG	bcc:BCc_033.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BUCCC

Accession

Primary (citable) accession number: Q058D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)