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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH372461:G1GK7-43-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BCc_042
OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
Taxonomic identifieri372461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000669 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000018771 – 474Glutamate--tRNA ligaseAdd BLAST474

Proteomic databases

PRIDEiQ058C8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi372461.BCc_042

Structurei

3D structure databases

ProteinModelPortaliQ058C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.3501 hit
3.40.50.6201 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q058C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTRFSPS PTGLLHMGGV RTALYSWLFA RKNNGSFILR IEDTDKNRVK
60 70 80 90 100
NNSVQDILYG LRYLQLNWDE GPFFQSNRIN IYKNIILFML KKGIAYKCYC
110 120 130 140 150
SKNRLDKLRK NQILNKKKPK YDNKCRNKNF FLKKSNIPYV IRFKNPTKGL
160 170 180 190 200
VEFRDMIRGK ISISNKELDD LVIQRSNGMP TYNFCVVVDD WQMNITHIIR
210 220 230 240 250
GEDHIHNTPR QINLLSSLNA YIPQYAHTSM ILDKKRKKLS KRCSSYSIIN
260 270 280 290 300
YINNGFIPEA ILNYALQLGW SYKNQEIFSI NEMKNIFNIK YINKSPSIID
310 320 330 340 350
KKKFLWFNHY YLNNISFNLK YKYFFSYCKK NNIFFDKDVN ISGVIKDFLG
360 370 380 390 400
RHSTFKDFIQ TYDYFYKEIN ISNIKNIYLY NKLINITILK FLYKKFNLLN
410 420 430 440 450
NWDLKNILLI IKESILYFKI SFKEIAILIR IVITGKKQTP SISSIIFYIG
460 470
KKKFLLRIKN FLKYLQLNNS NFSK
Length:474
Mass (Da):56,540
Last modified:November 14, 2006 - v1
Checksum:i4A62292F1D55B43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000263 Genomic DNA Translation: ABJ90521.1
RefSeqiWP_011672440.1, NC_008513.1

Genome annotation databases

EnsemblBacteriaiABJ90521; ABJ90521; BCc_042
KEGGibcc:BCc_042

Similar proteinsi

Entry informationi

Entry nameiSYE_BUCCC
AccessioniPrimary (citable) accession number: Q058C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome