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Q058B1 (DAPA_BUCCC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:BCc_060
OrganismBuchnera aphidicola subsp. Cinara cedri (strain Cc) [Complete proteome] [HAMAP]
Taxonomic identifier372461 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Dihydrodipicolinate synthase HAMAP MF_00418
PRO_1000050169

Regions

Region48 – 492Pyruvate binding By similarity

Sites

Active site1611Schiff-base intermediate with substrate By similarity
Binding site1061Pyruvate By similarity
Site1331Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q058B1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 7047F4F1B03B9778

FASTA29732,906
        10         20         30         40         50         60 
MFKGSIVALI TPMDIKGNIC KKSLKKLVKY HIKNKTNAII SVGTTGESAT LNKNEHTNVI 

        70         80         90        100        110        120 
MHTLEYADEK IPIIAGTGSN ATSESILLTK KLELSGISGC LNITPYYNKP TQEGLYLHFK 

       130        140        150        160        170        180 
SISESTDLPQ ILYNVPHRTG CDLLPQTIAK LAKFKNIIGL KDASGDLSRV NQIKSLVNKN 

       190        200        210        220        230        240 
FILISGDDTT ALDFIQLGGN GVISVTANIA ARHISKICKL ALAGNFYKAR KINEKLKILH 

       250        260        270        280        290 
NLLFKETNPI PIKWAAKYIG LIETDKIRLP MTQLLDKNKK NLKKIINLLQ LNKNKFL

« Hide

References

[1]"A small microbial genome: the end of a long symbiotic relationship?"
Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A.
Science 314:312-313(2006) [PubMed: 17038625] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Cc.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000263 Genomic DNA. Translation: ABJ90538.1.
RefSeqYP_802631.1. NC_008513.1.

3D structure databases

ProteinModelPortalQ058B1.
SMRQ058B1. Positions 1-283.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ058B1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000001387; EBBUCP00000001297; EBBUCG00000001387.
GeneID4440764.
GenomeReviewsGene locus BCc_060 in contig CP000263_GR.
KEGGbcc:BCc_060.
PATRIC21246061. VBIBucAph7855_0056.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
GeneTreeEBGT00050000008107.
HOGENOMHBG358848.
OMAITRELCG.

Enzyme and pathway databases

BioCycBAPH372461:BCC_060-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_BUCCC
AccessionPrimary (citable) accession number: Q058B1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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