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Q058A0 (Q058A0_BUCCC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnsD EMBL ABJ90549.1
Ordered Locus Names:BCc_071
OrganismBuchnera aphidicola subsp. Cinara cedri (strain Cc) [Complete proteome] [HAMAP]
Taxonomic identifier372461 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region185 – 1862Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1821Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1891Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1901Substrate By similarity PIRSR PIRSR000109-2
Binding site2591Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2861Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q058A0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 88A57B310D7BFA19

FASTA47053,285
        10         20         30         40         50         60 
MKNKDIGIIG MGVMGKNLAV NIANHGYKVS VFNRSYNFTF KKLVNEPIKN IFPYRSVKDF 

        70         80         90        100        110        120 
ISSLCIPRCI LLMIQSGTPI DDMIKKILPY LNKNDVIIDG GNSFYIDSIR RYNVLKEKSI 

       130        140        150        160        170        180 
HFLGVGISGG EEGALKGPSI MPGGNKEAYK IVSPIFKKIA AKYKDTACVK YIGSDGSGHY 

       190        200        210        220        230        240 
VKMVHNGIEY SDMQLISESY TLLKYLIGMD NLEISDTFKK WNSGELSSYL IEITSNIFCK 

       250        260        270        280        290        300 
KDDKNHFIID NILDVASNKG TGKWTAQNSL ELQIPCSILT ESVFCRYLSS LKANRMIAST 

       310        320        330        340        350        360 
ILSGPKLFIV KDSKKEEIIE DIRRALYLGK IISYAQGFSL MKKASEYYNW KLKFFDIAKI 

       370        380        390        400        410        420 
FRSGCIIRAK LLNEIVFSYS ENNDLVDLLF TSNFKKIINL YTSSLRNIVI LSIKNGISIP 

       430        440        450        460        470 
IFTNVLSYYD AYRTVNSSAN LIQAQRDYFG SHTYERIDQI GSFHTNWLDK

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References

[1]"A small microbial genome: the end of a long symbiotic relationship?"
Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A.
Science 314:312-313(2006) [PubMed: 17038625] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Cc.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000263 Genomic DNA. Translation: ABJ90549.1.
RefSeqYP_802642.1. NC_008513.1.

3D structure databases

ProteinModelPortalQ058A0.
SMRQ058A0. Positions 1-468.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ058A0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000001524; EBBUCP00000001434; EBBUCG00000001524.
GeneID4440775.
GenomeReviewsGene locus BCc_071 in contig CP000263_GR.
KEGGbcc:BCc_071.
PATRIC21246083. VBIBucAph7855_0067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
GeneTreeEBGT00050000007968.
HOGENOMHBG286913.
OMAAVNIANH.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ058A0_BUCCC
AccessionPrimary (citable) accession number: Q058A0
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info