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Protein

MIOREX complex component 2

Gene

COQ11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis (PubMed:25631044).2 Publications

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • ubiquinone-6 biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubiquinone biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32385-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
MIOREX complex component 21 Publication
Alternative name(s):
Mitochondrial organization of gene expression protein 21 Publication
Gene namesi
Name:COQ111 Publication
Synonyms:MRX21 Publication
Ordered Locus Names:YLR290CImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR290C.
SGDiS000004281. COQ11.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Shows impaired de novo coenzyme Q biosynthesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277MIOREX complex component 2PRO_0000268626Add
BLAST

Proteomic databases

MaxQBiQ05892.
PeptideAtlasiQ05892.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome (PubMed:25683707). Component of a multi-subunit COQ enzyme complex (PubMed:25631044).2 Publications

Protein-protein interaction databases

BioGridi31556. 41 interactions.
DIPiDIP-4742N.
IntActiQ05892. 1 interaction.
MINTiMINT-547040.

Structurei

3D structure databases

ProteinModelPortaliQ05892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000216854.
InParanoidiQ05892.
OMAiRICKYAV.
OrthoDBiEOG73JM5T.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q05892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPKLIVFGG NGFLGKRICQ EAVTSGYQVV SVSRSGKAPH SNELNDKQWM
60 70 80 90 100
QEVQWTAADI FKPDSYHELL NNATNVVHSL GILLENENYK QTLSKSPTYD
110 120 130 140 150
SKSRLLSFGA GPNPLKKSSP YFTYEMMNKQ SAIILADTFK QKILKKSKKE
160 170 180 190 200
QEKANQRSFT YISADKGFPL IPSGYINSKR EAEIELEKMQ RYFRPIIVRP
210 220 230 240 250
GFMFDEHRNA IGPRSFIHTA LELLYCGNKF LLRNKLQLLN DLIRPTVSTQ
260 270
QVSKSVLKNI ENPDFKGVVT LEEILKA
Length:277
Mass (Da):31,524
Last modified:November 1, 1996 - v1
Checksum:i1C7970D1DCAD1049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17243 Genomic DNA. Translation: AAB67336.1.
BK006945 Genomic DNA. Translation: DAA09602.1.
PIRiS50375.
RefSeqiNP_013393.1. NM_001182178.1.

Genome annotation databases

EnsemblFungiiYLR290C; YLR290C; YLR290C.
GeneIDi850997.
KEGGisce:YLR290C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17243 Genomic DNA. Translation: AAB67336.1.
BK006945 Genomic DNA. Translation: DAA09602.1.
PIRiS50375.
RefSeqiNP_013393.1. NM_001182178.1.

3D structure databases

ProteinModelPortaliQ05892.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31556. 41 interactions.
DIPiDIP-4742N.
IntActiQ05892. 1 interaction.
MINTiMINT-547040.

Proteomic databases

MaxQBiQ05892.
PeptideAtlasiQ05892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR290C; YLR290C; YLR290C.
GeneIDi850997.
KEGGisce:YLR290C.

Organism-specific databases

EuPathDBiFungiDB:YLR290C.
SGDiS000004281. COQ11.

Phylogenomic databases

HOGENOMiHOG000216854.
InParanoidiQ05892.
OMAiRICKYAV.
OrthoDBiEOG73JM5T.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciYEAST:G3O-32385-MONOMER.

Miscellaneous databases

NextBioi967534.
PROiQ05892.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies."
    Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S., Lamkemeyer T., Langer T., Ott M.
    Cell Rep. 10:843-853(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  6. "Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae."
    Allan C.M., Awad A.M., Johnson J.S., Shirasaki D.I., Wang C., Blaby-Haas C.E., Merchant S.S., Loo J.A., Clarke C.F.
    J. Biol. Chem. 290:7517-7534(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCOQ11_YEAST
AccessioniPrimary (citable) accession number: Q05892
Secondary accession number(s): D6VYT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.