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Protein

MIOREX complex component 2

Gene

COQ11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707). Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis (PubMed:25631044).2 Publications

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • ubiquinone-6 biosynthetic process Source: SGD

Keywordsi

Biological processUbiquinone biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32385-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
MIOREX complex component 21 Publication
Alternative name(s):
Mitochondrial organization of gene expression protein 21 Publication
Gene namesi
Name:COQ111 Publication
Synonyms:MRX21 Publication
Ordered Locus Names:YLR290CImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR290C.
SGDiS000004281. COQ11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Shows impaired de novo coenzyme Q biosynthesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686261 – 277MIOREX complex component 2Add BLAST277

Proteomic databases

MaxQBiQ05892.
PRIDEiQ05892.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome (PubMed:25683707). Component of a multi-subunit COQ enzyme complex (PubMed:25631044).2 Publications

Protein-protein interaction databases

BioGridi31556. 196 interactors.
DIPiDIP-4742N.
IntActiQ05892. 5 interactors.
MINTiMINT-547040.
STRINGi4932.YLR290C.

Structurei

3D structure databases

ProteinModelPortaliQ05892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000216854.
InParanoidiQ05892.
OMAiGSRICKY.
OrthoDBiEOG092C3200.

Family and domain databases

InterProiView protein in InterPro
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF01370. Epimerase. 1 hit.
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

Q05892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPKLIVFGG NGFLGKRICQ EAVTSGYQVV SVSRSGKAPH SNELNDKQWM
60 70 80 90 100
QEVQWTAADI FKPDSYHELL NNATNVVHSL GILLENENYK QTLSKSPTYD
110 120 130 140 150
SKSRLLSFGA GPNPLKKSSP YFTYEMMNKQ SAIILADTFK QKILKKSKKE
160 170 180 190 200
QEKANQRSFT YISADKGFPL IPSGYINSKR EAEIELEKMQ RYFRPIIVRP
210 220 230 240 250
GFMFDEHRNA IGPRSFIHTA LELLYCGNKF LLRNKLQLLN DLIRPTVSTQ
260 270
QVSKSVLKNI ENPDFKGVVT LEEILKA
Length:277
Mass (Da):31,524
Last modified:November 1, 1996 - v1
Checksum:i1C7970D1DCAD1049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17243 Genomic DNA. Translation: AAB67336.1.
BK006945 Genomic DNA. Translation: DAA09602.1.
PIRiS50375.
RefSeqiNP_013393.1. NM_001182178.1.

Genome annotation databases

EnsemblFungiiYLR290C; YLR290C; YLR290C.
GeneIDi850997.
KEGGisce:YLR290C.

Similar proteinsi

Entry informationi

Entry nameiCOQ11_YEAST
AccessioniPrimary (citable) accession number: Q05892
Secondary accession number(s): D6VYT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names