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Q05880 (KITH_CFEPV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismChoristoneura fumiferana entomopoxvirus (CfEPV)
Taxonomic identifier28322 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Thymidine kinase
PRO_0000174944

Regions

Nucleotide binding8 – 158ATP By similarity
Region161 – 1655Substrate binding By similarity

Sites

Active site851Proton acceptor Potential
Metal binding1421Zinc By similarity
Metal binding1451Zinc By similarity
Metal binding1741Zinc By similarity
Metal binding1771Zinc By similarity
Binding site1171Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05880 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 33AD4B3A93F5F5AB

FASTA18521,299
        10         20         30         40         50         60 
MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRHDDDNILI NHDGFKISHD 

        70         80         90        100        110        120 
DFIKTNILIN KIKIFDKYEI IGIDECQFFD SNDLIIFCDT LANNGKKIIV AGLNSDFNKN 

       130        140        150        160        170        180 
PFKSIIKLIP ISEKITKLQS ICNFCYNDAT FTMKKFNKDI IIEIGGSDLY IPVCRICYNE 


NNTIN 

« Hide

References

[1]"Comparison of the thymidine kinase genes from three entomopoxviruses."
Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10681 Genomic DNA. Translation: BAA01527.1.
PIRJQ1923.

3D structure databases

ProteinModelPortalQ05880.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_CFEPV
AccessionPrimary (citable) accession number: Q05880
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families