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Q05880

- KITH_CFEPV

UniProt

Q05880 - KITH_CFEPV

Protein

Thymidine kinase

Gene

TK

Organism
Choristoneura fumiferana entomopoxvirus (CfEPV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Proton acceptorSequence Analysis
    Binding sitei117 – 1171Substrate; via amide nitrogenBy similarity
    Metal bindingi142 – 1421ZincBy similarity
    Metal bindingi145 – 1451ZincBy similarity
    Metal bindingi174 – 1741ZincBy similarity
    Metal bindingi177 – 1771ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiChoristoneura fumiferana entomopoxvirus (CfEPV)
    Taxonomic identifieri28322 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
    Virus hostiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Thymidine kinasePRO_0000174944Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ05880.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1655Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05880-1 [UniParc]FASTAAdd to Basket

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    MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRHDDDNILI    50
    NHDGFKISHD DFIKTNILIN KIKIFDKYEI IGIDECQFFD SNDLIIFCDT 100
    LANNGKKIIV AGLNSDFNKN PFKSIIKLIP ISEKITKLQS ICNFCYNDAT 150
    FTMKKFNKDI IIEIGGSDLY IPVCRICYNE NNTIN 185
    Length:185
    Mass (Da):21,299
    Last modified:February 1, 1994 - v1
    Checksum:i33AD4B3A93F5F5AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10681 Genomic DNA. Translation: BAA01527.1.
    PIRiJQ1923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10681 Genomic DNA. Translation: BAA01527.1 .
    PIRi JQ1923.

    3D structure databases

    ProteinModelPortali Q05880.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the thymidine kinase genes from three entomopoxviruses."
      Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
      J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_CFEPV
    AccessioniPrimary (citable) accession number: Q05880
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3