Q05880 (KITH_CFEPV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Choristoneura fumiferana entomopoxvirus (CfEPV)

Taxonomic identifier

28322 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Entomopoxvirinae › Betaentomopoxvirus

Virus host

Choristoneura fumiferana (Spruce budworm) [TaxID: 7141]

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Thymidine kinase		PRO_0000174944
Regions
	Nucleotide binding	8 – 15	8	ATP By similarity
	Region	161 – 165	5	Substrate binding By similarity
Sites
	Active site	85	1	Proton acceptor Potential
	Metal binding	142	1	Zinc By similarity
	Metal binding	145	1	Zinc By similarity
	Metal binding	174	1	Zinc By similarity
	Metal binding	177	1	Zinc By similarity
	Binding site	117	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q05880 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 33AD4B3A93F5F5AB	FASTA	185	21,299
	10 20 30 40 50 60 MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRHDDDNILI NHDGFKISHD 70 80 90 100 110 120 DFIKTNILIN KIKIFDKYEI IGIDECQFFD SNDLIIFCDT LANNGKKIIV AGLNSDFNKN 130 140 150 160 170 180 PFKSIIKLIP ISEKITKLQS ICNFCYNDAT FTMKKFNKDI IIEIGGSDLY IPVCRICYNE NNTIN

References

[1]	"Comparison of the thymidine kinase genes from three entomopoxviruses." Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C. J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10681 Genomic DNA. Translation: BAA01527.1.
PIR	JQ1923.
3D structure databases
ProteinModelPortal	Q05880.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_CFEPV

Accession

Primary (citable) accession number: Q05880

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program