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Protein

Thymidine kinase

Gene

TK

Organism
Choristoneura fumiferana entomopoxvirus (CfEPV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Proton acceptorSequence analysis1
Binding sitei117Substrate; via amide nitrogenBy similarity1
Metal bindingi142ZincBy similarity1
Metal bindingi145ZincBy similarity1
Metal bindingi174ZincBy similarity1
Metal bindingi177ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiChoristoneura fumiferana entomopoxvirus (CfEPV)
Taxonomic identifieri28322 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749441 – 185Thymidine kinaseAdd BLAST185

Structurei

3D structure databases

ProteinModelPortaliQ05880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRHDDDNILI
60 70 80 90 100
NHDGFKISHD DFIKTNILIN KIKIFDKYEI IGIDECQFFD SNDLIIFCDT
110 120 130 140 150
LANNGKKIIV AGLNSDFNKN PFKSIIKLIP ISEKITKLQS ICNFCYNDAT
160 170 180
FTMKKFNKDI IIEIGGSDLY IPVCRICYNE NNTIN
Length:185
Mass (Da):21,299
Last modified:February 1, 1994 - v1
Checksum:i33AD4B3A93F5F5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10681 Genomic DNA. Translation: BAA01527.1.
PIRiJQ1923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10681 Genomic DNA. Translation: BAA01527.1.
PIRiJQ1923.

3D structure databases

ProteinModelPortaliQ05880.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_CFEPV
AccessioniPrimary (citable) accession number: Q05880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.