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Q05880

- KITH_CFEPV

UniProt

Q05880 - KITH_CFEPV

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Protein

Thymidine kinase

Gene

TK

Organism
Choristoneura fumiferana entomopoxvirus (CfEPV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Proton acceptorSequence Analysis
Binding sitei117 – 1171Substrate; via amide nitrogenBy similarity
Metal bindingi142 – 1421ZincBy similarity
Metal bindingi145 – 1451ZincBy similarity
Metal bindingi174 – 1741ZincBy similarity
Metal bindingi177 – 1771ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiChoristoneura fumiferana entomopoxvirus (CfEPV)
Taxonomic identifieri28322 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Thymidine kinasePRO_0000174944Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ05880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1655Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05880-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRHDDDNILI
60 70 80 90 100
NHDGFKISHD DFIKTNILIN KIKIFDKYEI IGIDECQFFD SNDLIIFCDT
110 120 130 140 150
LANNGKKIIV AGLNSDFNKN PFKSIIKLIP ISEKITKLQS ICNFCYNDAT
160 170 180
FTMKKFNKDI IIEIGGSDLY IPVCRICYNE NNTIN
Length:185
Mass (Da):21,299
Last modified:February 1, 1994 - v1
Checksum:i33AD4B3A93F5F5AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10681 Genomic DNA. Translation: BAA01527.1.
PIRiJQ1923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10681 Genomic DNA. Translation: BAA01527.1 .
PIRi JQ1923.

3D structure databases

ProteinModelPortali Q05880.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the thymidine kinase genes from three entomopoxviruses."
    Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
    J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_CFEPV
AccessioniPrimary (citable) accession number: Q05880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3