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Q05879

- KITH_CBEPV

UniProt

Q05879 - KITH_CBEPV

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Protein
Thymidine kinase
Gene
TK
Organism
Choristoneura biennis entomopoxvirus (CbEPV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor Reviewed prediction
Binding sitei118 – 1181Substrate; via amide nitrogen By similarity
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity
Metal bindingi175 – 1751Zinc By similarity
Metal bindingi178 – 1781Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiChoristoneura biennis entomopoxvirus (CbEPV)
Taxonomic identifieri10288 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Thymidine kinase
PRO_0000174943Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ05879.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni162 – 1665Substrate binding By similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05879-1 [UniParc]FASTAAdd to Basket

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MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRCEEDDNIL    50
INHDGFKISH DDFIKTNILI NKIKIFDKYE IIGIDECQFF DSNDLMIFCD 100
TLANNGKKII VAGLNSDFNK NPFKSIIKLI PISEKITKLQ SICNFCYNDA 150
TFTMKKFNKD IIIEIGGSDL YIPVCRICYN ENNTIN 186
Length:186
Mass (Da):21,426
Last modified:February 1, 1994 - v1
Checksum:iC6F63B2F4DAAB9C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10680 Genomic DNA. Translation: BAA01526.1.
PIRiJQ1922.
RefSeqiYP_008004114.1. NC_021248.1.

Genome annotation databases

GeneIDi15613034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10680 Genomic DNA. Translation: BAA01526.1 .
PIRi JQ1922.
RefSeqi YP_008004114.1. NC_021248.1.

3D structure databases

ProteinModelPortali Q05879.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15613034.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the thymidine kinase genes from three entomopoxviruses."
    Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
    J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_CBEPV
AccessioniPrimary (citable) accession number: Q05879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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