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Protein

Thymidine kinase

Gene

TK

Organism
Choristoneura biennis entomopoxvirus (CbEPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorSequence Analysis
Binding sitei118 – 1181Substrate; via amide nitrogenBy similarity
Metal bindingi143 – 1431ZincBy similarity
Metal bindingi146 – 1461ZincBy similarity
Metal bindingi175 – 1751ZincBy similarity
Metal bindingi178 – 1781ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiChoristoneura biennis entomopoxvirus (CbEPV)
Taxonomic identifieri10288 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) [TaxID: 7141]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Thymidine kinasePRO_0000174943Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ05879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni162 – 1665Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRCEEDDNIL
60 70 80 90 100
INHDGFKISH DDFIKTNILI NKIKIFDKYE IIGIDECQFF DSNDLMIFCD
110 120 130 140 150
TLANNGKKII VAGLNSDFNK NPFKSIIKLI PISEKITKLQ SICNFCYNDA
160 170 180
TFTMKKFNKD IIIEIGGSDL YIPVCRICYN ENNTIN
Length:186
Mass (Da):21,426
Last modified:February 1, 1994 - v1
Checksum:iC6F63B2F4DAAB9C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10680 Genomic DNA. Translation: BAA01526.1.
PIRiJQ1922.
RefSeqiYP_008004114.1. NC_021248.1.

Genome annotation databases

GeneIDi15613034.
KEGGivg:15613034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10680 Genomic DNA. Translation: BAA01526.1.
PIRiJQ1922.
RefSeqiYP_008004114.1. NC_021248.1.

3D structure databases

ProteinModelPortaliQ05879.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15613034.
KEGGivg:15613034.

Phylogenomic databases

KOiK00857.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the thymidine kinase genes from three entomopoxviruses."
    Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
    J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_CBEPV
AccessioniPrimary (citable) accession number: Q05879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.