Q05879 (KITH_CBEPV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Choristoneura biennis entomopoxvirus (CbEPV)

Taxonomic identifier

10288 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Entomopoxvirinae › Betaentomopoxvirus

Virus host

Choristoneura fumiferana (Spruce budworm) [TaxID: 7141]

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Thymidine kinase		PRO_0000174943
Regions
	Nucleotide binding	8 – 15	8	ATP By similarity
	Region	162 – 166	5	Substrate binding By similarity
Sites
	Active site	86	1	Proton acceptor Potential
	Metal binding	143	1	Zinc By similarity
	Metal binding	146	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Binding site	118	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q05879 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: C6F63B2F4DAAB9C7	FASTA	186	21,426
	10 20 30 40 50 60 MSIEIITGPM YSGKTTELIR RITRYKLCKK NCVIISHSID NRCEEDDNIL INHDGFKISH 70 80 90 100 110 120 DDFIKTNILI NKIKIFDKYE IIGIDECQFF DSNDLMIFCD TLANNGKKII VAGLNSDFNK 130 140 150 160 170 180 NPFKSIIKLI PISEKITKLQ SICNFCYNDA TFTMKKFNKD IIIEIGGSDL YIPVCRICYN ENNTIN

References

[1]	"Comparison of the thymidine kinase genes from three entomopoxviruses." Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C. J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10680 Genomic DNA. Translation: BAA01526.1.
PIR	JQ1922.
3D structure databases
ProteinModelPortal	Q05879.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_CBEPV

Accession

Primary (citable) accession number: Q05879

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program