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Q05876

- FYN_CHICK

UniProt

Q05876 - FYN_CHICK

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Protein

Tyrosine-protein kinase Fyn

Gene
FYN
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactori

Manganese.

Enzyme regulationi

Inhibited by phosphorylation of Tyr-528 by leukocyte common antigen and activated by dephosphorylation of this site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ATP By similarity
Active sitei387 – 3871Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2829ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein kinase activity Source: AgBase
  5. protein tyrosine kinase activity Source: AgBase
  6. tubulin binding Source: AgBase

GO - Biological processi

  1. forebrain development Source: AgBase
  2. neuron migration Source: AgBase
  3. peptidyl-tyrosine phosphorylation Source: AgBase
  4. regulation of cell shape Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Fyn (EC:2.7.10.2)
Alternative name(s):
Proto-oncogene c-Fyn
p59-Fyn
Gene namesi
Name:FYN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 534533Tyrosine-protein kinase FynPRO_0000088098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi3 – 31S-palmitoyl cysteine By similarity
Lipidationi6 – 61S-palmitoyl cysteine By similarity
Modified residuei12 – 121Phosphothreonine; by PKC By similarity
Modified residuei417 – 4171Phosphotyrosine; by autocatalysis By similarity
Modified residuei528 – 5281Phosphotyrosine By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ05876.
PRIDEiQ05876.

Expressioni

Tissue specificityi

Thymus and spleen.1 Publication

Interactioni

Subunit structurei

Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.

Protein-protein interaction databases

DIPiDIP-738N.
MINTiMINT-7222020.
STRINGi9031.ENSGALP00000036526.

Structurei

Secondary structure

1
534
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi87 – 915
Beta strandi96 – 1005
Beta strandi108 – 1136
Beta strandi117 – 1248
Turni125 – 1273
Beta strandi130 – 1345
Helixi135 – 1373
Beta strandi138 – 1403

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2PNMR-A85-142[»]
2LP5NMR-A85-142[»]
3CQTX-ray1.60A85-142[»]
ProteinModelPortaliQ05876.
SMRiQ05876. Positions 84-534.

Miscellaneous databases

EvolutionaryTraceiQ05876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 14362SH3Add
BLAST
Domaini149 – 24698SH2Add
BLAST
Domaini268 – 521254Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
KOiK05703.
PhylomeDBiQ05876.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05876-1 [UniParc]FASTAAdd to Basket

« Hide

MGCVQCKDKE ATKLTDERDG SLTQSSGYRY GTDPTPQHYP SFGVTSIPNY    50
NNFHATGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFEAL YDYEARTEDD 100
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 150
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 200
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF NLTVIATNNT 250
PQTVGLAKDA WEVARDSLFL EQKLGQGCFA EVWRGTWNGN TKVAIKTLKP 300
GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SRRPIYIVTE YMSKGSLLIF 350
LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI 400
CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG 450
ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMPCPQDCPI SLHELMIHCW 500
KKDPEERPTF EYLQGFLEDY FTATEPQYQP GDNL 534
Length:534
Mass (Da):60,265
Last modified:January 23, 2007 - v2
Checksum:i00A170357C5374F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52841 mRNA. Translation: CAA37025.1.
PIRiS33568.
RefSeqiNP_990680.1. NM_205349.1.
UniGeneiGga.48382.

Genome annotation databases

GeneIDi396294.
KEGGigga:396294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52841 mRNA. Translation: CAA37025.1 .
PIRi S33568.
RefSeqi NP_990680.1. NM_205349.1.
UniGenei Gga.48382.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L2P NMR - A 85-142 [» ]
2LP5 NMR - A 85-142 [» ]
3CQT X-ray 1.60 A 85-142 [» ]
ProteinModelPortali Q05876.
SMRi Q05876. Positions 84-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-738N.
MINTi MINT-7222020.
STRINGi 9031.ENSGALP00000036526.

Proteomic databases

PaxDbi Q05876.
PRIDEi Q05876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396294.
KEGGi gga:396294.

Organism-specific databases

CTDi 2534.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
KOi K05703.
PhylomeDBi Q05876.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1306.

Miscellaneous databases

EvolutionaryTracei Q05876.
NextBioi 20816344.
PROi Q05876.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
    Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
    Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: White leghorn.
    Tissue: Muscle.
  2. "The glypiated neuronal cell adhesion molecule contactin/F11 complexes with src-family protein tyrosine kinase Fyn."
    Zisch A.H., D'Alessandri L., Amrein K., Ranscht B., Winterhalter K.H., Vaughan L.
    Mol. Cell. Neurosci. 6:263-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFYN_CHICK
AccessioniPrimary (citable) accession number: Q05876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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