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Q05876

- FYN_CHICK

UniProt

Q05876 - FYN_CHICK

Protein

Tyrosine-protein kinase Fyn

Gene

FYN

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Cofactori

    Manganese.

    Enzyme regulationi

    Inhibited by phosphorylation of Tyr-528 by leukocyte common antigen and activated by dephosphorylation of this site.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei296 – 2961ATPPROSITE-ProRule annotation
    Active sitei387 – 3871Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2829ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    4. protein kinase activity Source: AgBase
    5. protein tyrosine kinase activity Source: AgBase
    6. tubulin binding Source: AgBase

    GO - Biological processi

    1. forebrain development Source: AgBase
    2. neuron migration Source: AgBase
    3. peptidyl-tyrosine phosphorylation Source: AgBase
    4. regulation of cell shape Source: AgBase

    Keywords - Molecular functioni

    Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Fyn (EC:2.7.10.2)
    Alternative name(s):
    Proto-oncogene c-Fyn
    p59-Fyn
    Gene namesi
    Name:FYN
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 534533Tyrosine-protein kinase FynPRO_0000088098Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Lipidationi6 – 61S-palmitoyl cysteineBy similarity
    Modified residuei12 – 121Phosphothreonine; by PKCBy similarity
    Modified residuei417 – 4171Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei528 – 5281PhosphotyrosineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiQ05876.
    PRIDEiQ05876.

    Expressioni

    Tissue specificityi

    Thymus and spleen.1 Publication

    Interactioni

    Subunit structurei

    Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.

    Protein-protein interaction databases

    DIPiDIP-738N.
    MINTiMINT-7222020.
    STRINGi9031.ENSGALP00000036526.

    Structurei

    Secondary structure

    1
    534
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi87 – 915
    Beta strandi96 – 1005
    Beta strandi108 – 1136
    Beta strandi117 – 1248
    Turni125 – 1273
    Beta strandi130 – 1345
    Helixi135 – 1373
    Beta strandi138 – 1403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L2PNMR-A85-142[»]
    2LP5NMR-A85-142[»]
    3CQTX-ray1.60A85-142[»]
    ProteinModelPortaliQ05876.
    SMRiQ05876. Positions 84-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ05876.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14362SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 24698SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 521254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233858.
    HOVERGENiHBG008761.
    KOiK05703.
    PhylomeDBiQ05876.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05876-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCVQCKDKE ATKLTDERDG SLTQSSGYRY GTDPTPQHYP SFGVTSIPNY    50
    NNFHATGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFEAL YDYEARTEDD 100
    LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 150
    FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 200
    KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF NLTVIATNNT 250
    PQTVGLAKDA WEVARDSLFL EQKLGQGCFA EVWRGTWNGN TKVAIKTLKP 300
    GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SRRPIYIVTE YMSKGSLLIF 350
    LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI 400
    CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG 450
    ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMPCPQDCPI SLHELMIHCW 500
    KKDPEERPTF EYLQGFLEDY FTATEPQYQP GDNL 534
    Length:534
    Mass (Da):60,265
    Last modified:January 23, 2007 - v2
    Checksum:i00A170357C5374F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52841 mRNA. Translation: CAA37025.1.
    PIRiS33568.
    RefSeqiNP_990680.1. NM_205349.1.
    UniGeneiGga.48382.

    Genome annotation databases

    GeneIDi396294.
    KEGGigga:396294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52841 mRNA. Translation: CAA37025.1 .
    PIRi S33568.
    RefSeqi NP_990680.1. NM_205349.1.
    UniGenei Gga.48382.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L2P NMR - A 85-142 [» ]
    2LP5 NMR - A 85-142 [» ]
    3CQT X-ray 1.60 A 85-142 [» ]
    ProteinModelPortali Q05876.
    SMRi Q05876. Positions 84-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-738N.
    MINTi MINT-7222020.
    STRINGi 9031.ENSGALP00000036526.

    Proteomic databases

    PaxDbi Q05876.
    PRIDEi Q05876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396294.
    KEGGi gga:396294.

    Organism-specific databases

    CTDi 2534.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233858.
    HOVERGENi HBG008761.
    KOi K05703.
    PhylomeDBi Q05876.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1306.

    Miscellaneous databases

    EvolutionaryTracei Q05876.
    NextBioi 20816344.
    PROi Q05876.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
      Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
      Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: White leghorn.
      Tissue: Muscle.
    2. "The glypiated neuronal cell adhesion molecule contactin/F11 complexes with src-family protein tyrosine kinase Fyn."
      Zisch A.H., D'Alessandri L., Amrein K., Ranscht B., Winterhalter K.H., Vaughan L.
      Mol. Cell. Neurosci. 6:263-279(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiFYN_CHICK
    AccessioniPrimary (citable) accession number: Q05876
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3