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Q05876

- FYN_CHICK

UniProt

Q05876 - FYN_CHICK

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Protein

Tyrosine-protein kinase Fyn

Gene

FYN

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Enzyme regulationi

Inhibited by phosphorylation of Tyr-528 by leukocyte common antigen and activated by dephosphorylation of this site.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ATPPROSITE-ProRule annotation
Active sitei387 – 3871Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2829ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein kinase activity Source: AgBase
  5. protein tyrosine kinase activity Source: AgBase
  6. tubulin binding Source: AgBase

GO - Biological processi

  1. forebrain development Source: AgBase
  2. neuron migration Source: AgBase
  3. peptidyl-tyrosine phosphorylation Source: AgBase
  4. regulation of cell shape Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.
ReactomeiREACT_248632. EPH-Ephrin signaling.
REACT_253932. EPHA-mediated growth cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Fyn (EC:2.7.10.2)
Alternative name(s):
Proto-oncogene c-Fyn
p59-Fyn
Gene namesi
Name:FYN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 534533Tyrosine-protein kinase FynPRO_0000088098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Lipidationi6 – 61S-palmitoyl cysteineBy similarity
Modified residuei12 – 121Phosphothreonine; by PKCBy similarity
Modified residuei417 – 4171Phosphotyrosine; by autocatalysisBy similarity
Modified residuei528 – 5281PhosphotyrosineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ05876.
PRIDEiQ05876.

Expressioni

Tissue specificityi

Thymus and spleen.1 Publication

Interactioni

Subunit structurei

Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.

Protein-protein interaction databases

DIPiDIP-738N.
MINTiMINT-7222020.
STRINGi9031.ENSGALP00000036526.

Structurei

Secondary structure

1
534
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi87 – 915Combined sources
Beta strandi96 – 1005Combined sources
Beta strandi108 – 1136Combined sources
Beta strandi117 – 1248Combined sources
Turni125 – 1273Combined sources
Beta strandi130 – 1345Combined sources
Helixi135 – 1373Combined sources
Beta strandi138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L2PNMR-A85-142[»]
2LP5NMR-A85-142[»]
3CQTX-ray1.60A85-142[»]
ProteinModelPortaliQ05876.
SMRiQ05876. Positions 84-534.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 14362SH3PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 24698SH2PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 521254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ05876.
KOiK05703.
PhylomeDBiQ05876.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05876-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCVQCKDKE ATKLTDERDG SLTQSSGYRY GTDPTPQHYP SFGVTSIPNY
60 70 80 90 100
NNFHATGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFEAL YDYEARTEDD
110 120 130 140 150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY
160 170 180 190 200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV
210 220 230 240 250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF NLTVIATNNT
260 270 280 290 300
PQTVGLAKDA WEVARDSLFL EQKLGQGCFA EVWRGTWNGN TKVAIKTLKP
310 320 330 340 350
GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SRRPIYIVTE YMSKGSLLIF
360 370 380 390 400
LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI
410 420 430 440 450
CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG
460 470 480 490 500
ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMPCPQDCPI SLHELMIHCW
510 520 530
KKDPEERPTF EYLQGFLEDY FTATEPQYQP GDNL
Length:534
Mass (Da):60,265
Last modified:January 23, 2007 - v2
Checksum:i00A170357C5374F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52841 mRNA. Translation: CAA37025.1.
PIRiS33568.
RefSeqiNP_990680.1. NM_205349.1.
UniGeneiGga.48382.

Genome annotation databases

GeneIDi396294.
KEGGigga:396294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52841 mRNA. Translation: CAA37025.1 .
PIRi S33568.
RefSeqi NP_990680.1. NM_205349.1.
UniGenei Gga.48382.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L2P NMR - A 85-142 [» ]
2LP5 NMR - A 85-142 [» ]
3CQT X-ray 1.60 A 85-142 [» ]
ProteinModelPortali Q05876.
SMRi Q05876. Positions 84-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-738N.
MINTi MINT-7222020.
STRINGi 9031.ENSGALP00000036526.

Proteomic databases

PaxDbi Q05876.
PRIDEi Q05876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396294.
KEGGi gga:396294.

Organism-specific databases

CTDi 2534.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi Q05876.
KOi K05703.
PhylomeDBi Q05876.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1306.
Reactomei REACT_248632. EPH-Ephrin signaling.
REACT_253932. EPHA-mediated growth cone collapse.

Miscellaneous databases

EvolutionaryTracei Q05876.
NextBioi 20816344.
PROi Q05876.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
    Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
    Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: White leghorn.
    Tissue: Muscle.
  2. "The glypiated neuronal cell adhesion molecule contactin/F11 complexes with src-family protein tyrosine kinase Fyn."
    Zisch A.H., D'Alessandri L., Amrein K., Ranscht B., Winterhalter K.H., Vaughan L.
    Mol. Cell. Neurosci. 6:263-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFYN_CHICK
AccessioniPrimary (citable) accession number: Q05876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3