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Protein

78 kDa glucose-regulated protein homolog

Gene
N/A
Organism
Plasmodium falciparum (isolate NF54)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
OrganismiPlasmodium falciparum (isolate NF54)
Taxonomic identifieri5843 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 65563178 kDa glucose-regulated protein homologPRO_0000013575Add
BLAST

Proteomic databases

PRIDEiQ05866.

Structurei

3D structure databases

ProteinModelPortaliQ05866.
SMRiQ05866. Positions 27-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi652 – 6554Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQIRPYILL LIVSLLKFIS AVDSNIEGPV IGIDLGTTYS CVGVFKNGRV
60 70 80 90 100
EILNNELGNR ITPSYVSFVD GERKVGEAAK LEATVHPTQT VFDVKRLIGR
110 120 130 140 150
KFDDQEVVKD RSLLPYEIVN NQGKPNIKVQ IKDKDTTFAP EQISAMVLEK
160 170 180 190 200
MKEIAQSFLG KPVKNAVVTV PAYFNDAQRQ ATKDAGTIAG LNIVRIIINQ
210 220 230 240 250
PTAAALAYAL DKKEETSILV YDLGGGTFDV SILVIDNGVF EVYATAGNTH
260 270 280 290 300
LGGEDFDQRV MDYFIKMFKK KNNIDLRTDK RAIQKLRKEV EIAKRNLSVV
310 320 330 340 350
HSTQIEIEDI VEGHNFSETL TRAKFEELND DLFRETLEPV KKVLDDAKYE
360 370 380 390 400
KSKIDEIVLV GGSTRIPKIQ QIIKEFEFFN GKEPNRGINP DEAVAYGAAI
410 420 430 440 450
QAGIILGEEL QDVVLLDVTP LTLGIETVGG IMTQLIKRNT VIPTKKSQTF
460 470 480 490 500
STYQDNQPAV LIQVFEGERA LTKDNHLLGK FELSGIPPAQ RGVPKIEVTF
510 520 530 540 550
TVDKNGILHV EAEDKGTGKS RGITITNDKG RLSKEQIEKM INDAEKFADE
560 570 580 590 600
DKNLREKVEA KNKLDNYIQS MKATVEDKDK LADKIEKEDK NTILSAVKDA
610 620 630 640 650
EDWLNNNSNA DSEALKQKLK DLEAVCQPII VKLYGQPGGP SPQPSGDEDV

DSDEL
Length:655
Mass (Da):72,776
Last modified:November 1, 1995 - v1
Checksum:i4957A9CE9D725996
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02822 Genomic DNA. Translation: AAA29623.1.
PIRiA48468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02822 Genomic DNA. Translation: AAA29623.1.
PIRiA48468.

3D structure databases

ProteinModelPortaliQ05866.
SMRiQ05866. Positions 27-576.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ05866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein."
    Kumar N., Zheng H.
    Mol. Biochem. Parasitol. 56:353-356(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGRP78_PLAFO
AccessioniPrimary (citable) accession number: Q05866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.