SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q05866

- GRP78_PLAFO

UniProt

Q05866 - GRP78_PLAFO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

78 kDa glucose-regulated protein homolog

Gene
N/A
Organism
Plasmodium falciparum (isolate NF54)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
OrganismiPlasmodium falciparum (isolate NF54)
Taxonomic identifieri5843 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 65563178 kDa glucose-regulated protein homologPRO_0000013575Add
BLAST

Proteomic databases

PRIDEiQ05866.

Structurei

3D structure databases

ProteinModelPortaliQ05866.
SMRiQ05866. Positions 27-576.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi652 – 6554Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05866-1 [UniParc]FASTAAdd to Basket

« Hide

MNQIRPYILL LIVSLLKFIS AVDSNIEGPV IGIDLGTTYS CVGVFKNGRV    50
EILNNELGNR ITPSYVSFVD GERKVGEAAK LEATVHPTQT VFDVKRLIGR 100
KFDDQEVVKD RSLLPYEIVN NQGKPNIKVQ IKDKDTTFAP EQISAMVLEK 150
MKEIAQSFLG KPVKNAVVTV PAYFNDAQRQ ATKDAGTIAG LNIVRIIINQ 200
PTAAALAYAL DKKEETSILV YDLGGGTFDV SILVIDNGVF EVYATAGNTH 250
LGGEDFDQRV MDYFIKMFKK KNNIDLRTDK RAIQKLRKEV EIAKRNLSVV 300
HSTQIEIEDI VEGHNFSETL TRAKFEELND DLFRETLEPV KKVLDDAKYE 350
KSKIDEIVLV GGSTRIPKIQ QIIKEFEFFN GKEPNRGINP DEAVAYGAAI 400
QAGIILGEEL QDVVLLDVTP LTLGIETVGG IMTQLIKRNT VIPTKKSQTF 450
STYQDNQPAV LIQVFEGERA LTKDNHLLGK FELSGIPPAQ RGVPKIEVTF 500
TVDKNGILHV EAEDKGTGKS RGITITNDKG RLSKEQIEKM INDAEKFADE 550
DKNLREKVEA KNKLDNYIQS MKATVEDKDK LADKIEKEDK NTILSAVKDA 600
EDWLNNNSNA DSEALKQKLK DLEAVCQPII VKLYGQPGGP SPQPSGDEDV 650
DSDEL 655
Length:655
Mass (Da):72,776
Last modified:November 1, 1995 - v1
Checksum:i4957A9CE9D725996
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02822 Genomic DNA. Translation: AAA29623.1.
PIRiA48468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02822 Genomic DNA. Translation: AAA29623.1 .
PIRi A48468.

3D structure databases

ProteinModelPortali Q05866.
SMRi Q05866. Positions 27-576.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q05866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein."
    Kumar N., Zheng H.
    Mol. Biochem. Parasitol. 56:353-356(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGRP78_PLAFO
AccessioniPrimary (citable) accession number: Q05866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi