Q05866 (GRP78_PLAFO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 78 kDa glucose-regulated protein homolog Short name=GRP-78
Organism	Plasmodium falciparum (isolate NF54)
Taxonomic identifier	5843 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Protein attributes

Sequence length	655 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 655	631	78 kDa glucose-regulated protein homolog		PRO_0000013575
Regions
	Motif	652 – 655	4	Prevents secretion from ER Potential

Sequences

	Sequence		Length	Mass (Da)
	Q05866 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4957A9CE9D725996	FASTA	655	72,776
	10 20 30 40 50 60 MNQIRPYILL LIVSLLKFIS AVDSNIEGPV IGIDLGTTYS CVGVFKNGRV EILNNELGNR 70 80 90 100 110 120 ITPSYVSFVD GERKVGEAAK LEATVHPTQT VFDVKRLIGR KFDDQEVVKD RSLLPYEIVN 130 140 150 160 170 180 NQGKPNIKVQ IKDKDTTFAP EQISAMVLEK MKEIAQSFLG KPVKNAVVTV PAYFNDAQRQ 190 200 210 220 230 240 ATKDAGTIAG LNIVRIIINQ PTAAALAYAL DKKEETSILV YDLGGGTFDV SILVIDNGVF 250 260 270 280 290 300 EVYATAGNTH LGGEDFDQRV MDYFIKMFKK KNNIDLRTDK RAIQKLRKEV EIAKRNLSVV 310 320 330 340 350 360 HSTQIEIEDI VEGHNFSETL TRAKFEELND DLFRETLEPV KKVLDDAKYE KSKIDEIVLV 370 380 390 400 410 420 GGSTRIPKIQ QIIKEFEFFN GKEPNRGINP DEAVAYGAAI QAGIILGEEL QDVVLLDVTP 430 440 450 460 470 480 LTLGIETVGG IMTQLIKRNT VIPTKKSQTF STYQDNQPAV LIQVFEGERA LTKDNHLLGK 490 500 510 520 530 540 FELSGIPPAQ RGVPKIEVTF TVDKNGILHV EAEDKGTGKS RGITITNDKG RLSKEQIEKM 550 560 570 580 590 600 INDAEKFADE DKNLREKVEA KNKLDNYIQS MKATVEDKDK LADKIEKEDK NTILSAVKDA 610 620 630 640 650 EDWLNNNSNA DSEALKQKLK DLEAVCQPII VKLYGQPGGP SPQPSGDEDV DSDEL

References

[1]	"Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein." Kumar N., Zheng H. Mol. Biochem. Parasitol. 56:353-356(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L02822 Genomic DNA. Translation: AAA29623.1.
PIR	A48468.
3D structure databases
ProteinModelPortal	Q05866.
SMR	Q05866. Positions 27-576.
ModBase	Search...
Proteomic databases
PRIDE	Q05866.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRP78_PLAFO

Accession

Primary (citable) accession number: Q05866

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)