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Q05866

- GRP78_PLAFO

UniProt

Q05866 - GRP78_PLAFO

Protein

78 kDa glucose-regulated protein homolog

Gene
N/A
Organism
Plasmodium falciparum (isolate NF54)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    OrganismiPlasmodium falciparum (isolate NF54)
    Taxonomic identifieri5843 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 65563178 kDa glucose-regulated protein homologPRO_0000013575Add
    BLAST

    Proteomic databases

    PRIDEiQ05866.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05866.
    SMRiQ05866. Positions 27-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi652 – 6554Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05866-1 [UniParc]FASTAAdd to Basket

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    MNQIRPYILL LIVSLLKFIS AVDSNIEGPV IGIDLGTTYS CVGVFKNGRV    50
    EILNNELGNR ITPSYVSFVD GERKVGEAAK LEATVHPTQT VFDVKRLIGR 100
    KFDDQEVVKD RSLLPYEIVN NQGKPNIKVQ IKDKDTTFAP EQISAMVLEK 150
    MKEIAQSFLG KPVKNAVVTV PAYFNDAQRQ ATKDAGTIAG LNIVRIIINQ 200
    PTAAALAYAL DKKEETSILV YDLGGGTFDV SILVIDNGVF EVYATAGNTH 250
    LGGEDFDQRV MDYFIKMFKK KNNIDLRTDK RAIQKLRKEV EIAKRNLSVV 300
    HSTQIEIEDI VEGHNFSETL TRAKFEELND DLFRETLEPV KKVLDDAKYE 350
    KSKIDEIVLV GGSTRIPKIQ QIIKEFEFFN GKEPNRGINP DEAVAYGAAI 400
    QAGIILGEEL QDVVLLDVTP LTLGIETVGG IMTQLIKRNT VIPTKKSQTF 450
    STYQDNQPAV LIQVFEGERA LTKDNHLLGK FELSGIPPAQ RGVPKIEVTF 500
    TVDKNGILHV EAEDKGTGKS RGITITNDKG RLSKEQIEKM INDAEKFADE 550
    DKNLREKVEA KNKLDNYIQS MKATVEDKDK LADKIEKEDK NTILSAVKDA 600
    EDWLNNNSNA DSEALKQKLK DLEAVCQPII VKLYGQPGGP SPQPSGDEDV 650
    DSDEL 655
    Length:655
    Mass (Da):72,776
    Last modified:November 1, 1995 - v1
    Checksum:i4957A9CE9D725996
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02822 Genomic DNA. Translation: AAA29623.1.
    PIRiA48468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02822 Genomic DNA. Translation: AAA29623.1 .
    PIRi A48468.

    3D structure databases

    ProteinModelPortali Q05866.
    SMRi Q05866. Positions 27-576.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q05866.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein."
      Kumar N., Zheng H.
      Mol. Biochem. Parasitol. 56:353-356(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGRP78_PLAFO
    AccessioniPrimary (citable) accession number: Q05866
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3