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Q05866 (GRP78_PLAFO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
OrganismPlasmodium falciparum (isolate NF54)
Taxonomic identifier5843 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 65563178 kDa glucose-regulated protein homolog
PRO_0000013575

Regions

Motif652 – 6554Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q05866 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4957A9CE9D725996

FASTA65572,776
        10         20         30         40         50         60 
MNQIRPYILL LIVSLLKFIS AVDSNIEGPV IGIDLGTTYS CVGVFKNGRV EILNNELGNR 

        70         80         90        100        110        120 
ITPSYVSFVD GERKVGEAAK LEATVHPTQT VFDVKRLIGR KFDDQEVVKD RSLLPYEIVN 

       130        140        150        160        170        180 
NQGKPNIKVQ IKDKDTTFAP EQISAMVLEK MKEIAQSFLG KPVKNAVVTV PAYFNDAQRQ 

       190        200        210        220        230        240 
ATKDAGTIAG LNIVRIIINQ PTAAALAYAL DKKEETSILV YDLGGGTFDV SILVIDNGVF 

       250        260        270        280        290        300 
EVYATAGNTH LGGEDFDQRV MDYFIKMFKK KNNIDLRTDK RAIQKLRKEV EIAKRNLSVV 

       310        320        330        340        350        360 
HSTQIEIEDI VEGHNFSETL TRAKFEELND DLFRETLEPV KKVLDDAKYE KSKIDEIVLV 

       370        380        390        400        410        420 
GGSTRIPKIQ QIIKEFEFFN GKEPNRGINP DEAVAYGAAI QAGIILGEEL QDVVLLDVTP 

       430        440        450        460        470        480 
LTLGIETVGG IMTQLIKRNT VIPTKKSQTF STYQDNQPAV LIQVFEGERA LTKDNHLLGK 

       490        500        510        520        530        540 
FELSGIPPAQ RGVPKIEVTF TVDKNGILHV EAEDKGTGKS RGITITNDKG RLSKEQIEKM 

       550        560        570        580        590        600 
INDAEKFADE DKNLREKVEA KNKLDNYIQS MKATVEDKDK LADKIEKEDK NTILSAVKDA 

       610        620        630        640        650 
EDWLNNNSNA DSEALKQKLK DLEAVCQPII VKLYGQPGGP SPQPSGDEDV DSDEL 

« Hide

References

[1]"Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein."
Kumar N., Zheng H.
Mol. Biochem. Parasitol. 56:353-356(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L02822 Genomic DNA. Translation: AAA29623.1.
PIRA48468.

3D structure databases

ProteinModelPortalQ05866.
SMRQ05866. Positions 27-576.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ05866.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_PLAFO
AccessionPrimary (citable) accession number: Q05866
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families