Q05865 (FOLC_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 88.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Folylpolyglutamate synthase EC=6.3.2.17 Alternative name(s): Folylpoly-gamma-glutamate synthetase Short name=FPGS Tetrahydrofolate synthase Tetrahydrofolylpolyglutamate synthase | ||||
| Gene names |
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| Organism | Bacillus subtilis | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 430 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10-formyltetrahydrofolate as folate substrate. |
| Catalytic activity | ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
| Pathway | Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. |
| Sequence similarities | Belongs to the folylpolyglutamate synthase family. |
| Sequence caution | The sequence AAA83364.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolylpolyglutamate synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sporulation gene spoIIB from Bacillus subtilis." Margolis P.S., Driks A., Losick R. J. Bacteriol. 175:528-540(1993) [PubMed: 8419299] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / PY79. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Molecular cloning and characterization of comC, a late competence gene of Bacillus subtilis." Mohan S., Aghion J., Guillen N., Dubnau D.A. J. Bacteriol. 171:6043-6051(1989) [PubMed: 2553669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 294-429. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L04520 Genomic DNA. Translation: AAB59021.1. AL009126 Genomic DNA. Translation: CAB14768.1. M30805 Genomic DNA. Translation: AAA83364.1. Different initiation. |
| PIR | B40646. |
| RefSeq | NP_390686.1. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | Q05865. |
| SMR | Q05865. Positions 2-430. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000001837; EBBACP00000001837; EBBACG00000001834. |
| GeneID | 936327. |
| GenomeReviews | Gene locus BSU28080 in contig AL009126_GR. |
| KEGG | bsu:BSU28080. |
| NMPDR | fig|224308.1.peg.2811. |
| PATRIC | 18977490. VBIBacSub10457_2934. |
Organism-specific databases | |
| GenoList | BSU28080. [Micado] |
Phylogenomic databases | |
| GeneTree | EBGT00050000000631. |
| HOGENOM | HBG744947. |
| OMA | AVERISI. |
| PhylomeDB | Q05865. |
| ProtClustDB | CLSK2460946. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU28080-MONOMER. |
Family and domain databases | |
| InterPro | IPR001645. Folylpolyglutamate_synth. IPR018109. Folylpolyglutamate_synth_CS. IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| KO | K11754. |
| PANTHER | PTHR11136. Fpolygl_synthtse. 1 hit. |
| Pfam | PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| PIRSF | PIRSF001563. Folylpolyglu_synth. 1 hit. |
| SUPFAM | SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit. |
| TIGRFAMs | TIGR01499. FolC. 1 hit. |
| PROSITE | PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit. PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FOLC_BACSU | ||||||||
| Accession | Primary (citable) accession number: Q05865 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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