Reviewed,
UniProtKB/Swiss-Prot Q05865 (FOLC_BACSU)
Last modified
June 16, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Folylpolyglutamate synthase EC=6.3.2.17 Alternative name(s): Folylpoly-gamma-glutamate synthetase Short name=FPGS Tetrahydrofolate synthase Tetrahydrofolylpolyglutamate synthase | ||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 430 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10-formyltetrahydrofolate as folate substrate. |
| Catalytic activity | ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
| Pathway | Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. |
| Sequence similarities | Belongs to the folylpolyglutamate synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon compound metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolylpolyglutamate synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sporulation gene spoIIB from Bacillus subtilis." Margolis P.S., Driks A., Losick R. J. Bacteriol. 175:528-540(1993) [PubMed: 8419299] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / PY79. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Molecular cloning and characterization of comC, a late competence gene of Bacillus subtilis." Mohan S., Aghion J., Guillen N., Dubnau D.A. J. Bacteriol. 171:6043-6051(1989) [PubMed: 2553669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 294-429. |
Cross-references
Sequence databases | |
|---|---|
| L04520 Genomic DNA. Translation: AAB59021.1. AL009126 Genomic DNA. Translation: CAB14768.1. M30805 Genomic DNA. Translation: AAA83364.1. Different initiation. | |
| PIR | B40646. |
| RefSeq | NP_390686.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FGS based on UniProtKB P15925. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 936327. |
| GenomeReviews | Gene locus BSU28080 in contig AL009126_GR. |
| KEGG | bsu:BSU28080. |
| NMPDR | fig|224308.1.peg.2811. |
Organism-specific databases | |
| SubtiList | BG10322. folC. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q05865. |
| OMA | Q05865. QRWPETK. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU2804-MON. |
| BRENDA | 6.3.2.17. 150. |
Family and domain databases | |
| InterPro | IPR018109. Folylpolyglutamate_synth_CS. IPR001645. Fpolygl_synthtse. IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| PANTHER | PTHR11136. Fpolygl_synthtse. 1 hit. |
| Pfam | PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01499. folC. 1 hit. |
| PROSITE | PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit. PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FOLC_BACSU | ||||||||
| Accession | Primary (citable) accession number: Q05865 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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