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Protein

CCAAT/enhancer-binding protein beta

Gene

CEBPB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates the transcription of these genes.1 Publication
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8467792). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein beta
Short name:
C/EBP beta
Alternative name(s):
Transcription factor NF-M
Short name:
CCR protein
Gene namesi
Name:CEBPB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi3R → A: Not methylated. Increases interaction with SMARCA2 and MED23. 1 Publication1
Mutagenesisi3R → L: Decreases interaction with SMARCA2 and MED23. 1 Publication1
Mutagenesisi39K → A: Decreases methylation. Increases transactivation activity inhibition. 1 Publication1
Mutagenesisi220T → D: Decreases methylation by CARM1 and increases transactivation activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766201 – 328CCAAT/enhancer-binding protein betaAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3Omega-N-methylated arginine; by CARM11 Publication1
Modified residuei39N6-methylated lysine1 Publication1
Modified residuei220Phosphothreonine; by RPS6KA1, CDK2 and MAPK1 Publication1

Post-translational modificationi

Methylated. Methylation at Arg-3 by CARM1 and at Lys-39 by EHMT2, inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-220.By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ05826.

PTM databases

iPTMnetiQ05826.

Expressioni

Tissue specificityi

Specifically expressed in myelomoncytic cells.

Gene expression databases

BgeeiENSGALG00000008014.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CARM1Q86X553EBI-7774198,EBI-2339854From a different organism.

Protein-protein interaction databases

IntActiQ05826. 2 interactors.
MINTiMINT-7895061.
STRINGi9031.ENSGALP00000012991.

Structurei

3D structure databases

ProteinModelPortaliQ05826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 317bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 278Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni280 – 287Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ05826.
KOiK10048.
OMAiCKKPAEY.
OrthoDBiEOG091G11FC.
PhylomeDBiQ05826.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLVAWDAA CLPIQPPAFK SMEVANFYYE ADCLAALNKL HPRAAGGRSM
60 70 80 90 100
TELTVGDHER AIDFSPYLDP LAASQQPAQP PPPAAAAGGN FEPACSSGGQ
110 120 130 140 150
DFLSDLFAED YKGSGGGKKP DYTYISLTRH GHPCGSQSHK PGVLPGCFPP
160 170 180 190 200
QIVETKVEPV FETLDSCKGP RKEEGGAGPG PGGMSSPYGS TVRSYLGYQS
210 220 230 240 250
VPSGSSGNLS TSSSSSPPGT PNPSESSKSA AGAGGYSGPP AGKNKPKKCV
260 270 280 290 300
DKHSDEYKLR RERNNIAVRK SRDKAKMRNL ETQHKVLELT AENERLQKKV
310 320
EQLSRELSTL RNLFKQLPEP LLASSPRC
Length:328
Mass (Da):35,030
Last modified:February 1, 1995 - v1
Checksum:i5AAE257F8213671C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21646 mRNA. Translation: CAA79760.1.
X70813 mRNA. Translation: CAA50144.1.
AY212285 Genomic DNA. Translation: AAO39751.1.
PIRiS35336.
RefSeqiNP_990584.1. NM_205253.2.
UniGeneiGga.4285.

Genome annotation databases

EnsembliENSGALT00000013006; ENSGALP00000012991; ENSGALG00000008014.
GeneIDi396185.
KEGGigga:396185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21646 mRNA. Translation: CAA79760.1.
X70813 mRNA. Translation: CAA50144.1.
AY212285 Genomic DNA. Translation: AAO39751.1.
PIRiS35336.
RefSeqiNP_990584.1. NM_205253.2.
UniGeneiGga.4285.

3D structure databases

ProteinModelPortaliQ05826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ05826. 2 interactors.
MINTiMINT-7895061.
STRINGi9031.ENSGALP00000012991.

PTM databases

iPTMnetiQ05826.

Proteomic databases

PaxDbiQ05826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013006; ENSGALP00000012991; ENSGALG00000008014.
GeneIDi396185.
KEGGigga:396185.

Organism-specific databases

CTDi1051.

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ05826.
KOiK10048.
OMAiCKKPAEY.
OrthoDBiEOG091G11FC.
PhylomeDBiQ05826.
TreeFamiTF105008.

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

PROiQ05826.

Gene expression databases

BgeeiENSGALG00000008014.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPB_CHICK
AccessioniPrimary (citable) accession number: Q05826
Secondary accession number(s): Q540C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.