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Protein

ATP synthase subunit beta, mitochondrial

Gene

ATPsynbeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 190ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1268020 Mitochondrial protein import
R-DME-163210 Formation of ATP by chemiosmotic coupling
R-DME-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit beta, mitochondrial (EC:3.6.3.14)
Gene namesi
Name:ATPsynbetaImported
Synonyms:ATPsyn-betaImported
ORF Names:CG11154Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0010217 ATPsynbeta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000000244832 – 505ATP synthase subunit beta, mitochondrialAdd BLAST474

Proteomic databases

PaxDbiQ05825
PRIDEiQ05825

Expressioni

Gene expression databases

BgeeiFBgn0010217
ExpressionAtlasiQ05825 baseline and differential
GenevisibleiQ05825 DM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Binary interactionsi

WithEntry#Exp.IntActNotes
anon-EST:fe2A5Q9VES83EBI-86574,EBI-173806

Protein-protein interaction databases

BioGridi68655, 68 interactors
IntActiQ05825, 31 interactors
MINTiQ05825
STRINGi7227.FBpp0305828

Structurei

3D structure databases

ProteinModelPortaliQ05825
SMRiQ05825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1350 Eukaryota
COG0055 LUCA
InParanoidiQ05825
KOiK02133
OMAiFNMIMDG
OrthoDBiEOG091G0KVV
PhylomeDBiQ05825

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
HAMAPiMF_01347 ATP_synth_beta_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR005722 ATP_synth_F1_bsu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034 ATPase_F1/V1_b/a_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01039 atpD, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFALRAASKA DKNLLPFLGQ LSRSHAAKAA KAAAAANGKI VAVIGAVVDV
60 70 80 90 100
QFDDNLPPIL NALEVDNRSP RLVLEVAQHL GENTVRTIAM DGTEGLVRGQ
110 120 130 140 150
KVLDTGYPIR IPVGAETLGR IINVIGEPID ERGPIDTDKT AAIHAEAPEF
160 170 180 190 200
VQMSVEQEIL VTGIKVVDLL APYAKGGKIG LFGGAGVGKT VLIMELINNV
210 220 230 240 250
AKAHGGYSVF AGVGERTREG NDLYNEMIEG GVISLKDKTS KVALVYGQMN
260 270 280 290 300
EPPGARARVA LTGLTVAEYF RDQEGQDVLL FIDNIFRFTQ AGSEVSALLG
310 320 330 340 350
RIPSAVGYQP TLATDMGSMQ ERITTTKKGS ITSVQAIYVP ADDLTDPAPA
360 370 380 390 400
TTFAHLDATT VLSRAIAELG IYPAVDPLDS TSRIMDPNII GQEHYNVARG
410 420 430 440 450
VQKILQDYKS LQDIIAILGM DELSEEDKLT VARARKIQRF LSQPFQVAEV
460 470 480 490 500
FTGHAGKLVP LEQTIKGFSA ILAGDYDHLP EVAFYMVGPI EEVVEKADRL

AKEAA
Length:505
Mass (Da):54,108
Last modified:May 24, 2004 - v3
Checksum:i92FA2CE1F0F919A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494 – 495VE → CR in CAA50332 (PubMed:8373413).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71013 mRNA Translation: CAA50332.1
AE014135 Genomic DNA Translation: AAF59391.1
AY118367 mRNA Translation: AAM48396.1
PIRiJN0760
RefSeqiNP_001284719.1, NM_001297790.1
NP_726631.1, NM_166808.3
UniGeneiDm.1407

Genome annotation databases

EnsemblMetazoaiFBtr0089186; FBpp0088250; FBgn0010217
FBtr0344754; FBpp0311086; FBgn0010217
GeneIDi43829
KEGGidme:Dmel_CG11154

Similar proteinsi

Entry informationi

Entry nameiATPB_DROME
AccessioniPrimary (citable) accession number: Q05825
Secondary accession number(s): Q9V494
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 24, 2004
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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