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Protein

ATP synthase subunit beta, mitochondrial

Gene

ATPsynbeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1908ATPBy similarity

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP synthesis coupled proton transport Source: FlyBase
  • lateral inhibition Source: FlyBase
  • proton transport Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-2151201. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit beta, mitochondrial (EC:3.6.3.14)
Gene namesi
Name:ATPsynbetaImported
Synonyms:ATPsyn-betaImported
ORF Names:CG11154Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0010217. ATPsynbeta.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionSequence analysisAdd
BLAST
Chaini32 – 505474ATP synthase subunit beta, mitochondrialPRO_0000002448Add
BLAST

Proteomic databases

PaxDbiQ05825.
PRIDEiQ05825.

Expressioni

Gene expression databases

BgeeiFBgn0010217.
ExpressionAtlasiQ05825. differential.
GenevisibleiQ05825. DM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Binary interactionsi

WithEntry#Exp.IntActNotes
CG10340Q9VES83EBI-86574,EBI-173806

Protein-protein interaction databases

BioGridi68655. 49 interactions.
IntActiQ05825. 31 interactions.
MINTiMINT-908620.
STRINGi7227.FBpp0305828.

Structurei

3D structure databases

ProteinModelPortaliQ05825.
SMRiQ05825. Positions 38-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1350. Eukaryota.
COG0055. LUCA.
InParanoidiQ05825.
KOiK02133.
OrthoDBiEOG091G0KVV.
PhylomeDBiQ05825.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFALRAASKA DKNLLPFLGQ LSRSHAAKAA KAAAAANGKI VAVIGAVVDV
60 70 80 90 100
QFDDNLPPIL NALEVDNRSP RLVLEVAQHL GENTVRTIAM DGTEGLVRGQ
110 120 130 140 150
KVLDTGYPIR IPVGAETLGR IINVIGEPID ERGPIDTDKT AAIHAEAPEF
160 170 180 190 200
VQMSVEQEIL VTGIKVVDLL APYAKGGKIG LFGGAGVGKT VLIMELINNV
210 220 230 240 250
AKAHGGYSVF AGVGERTREG NDLYNEMIEG GVISLKDKTS KVALVYGQMN
260 270 280 290 300
EPPGARARVA LTGLTVAEYF RDQEGQDVLL FIDNIFRFTQ AGSEVSALLG
310 320 330 340 350
RIPSAVGYQP TLATDMGSMQ ERITTTKKGS ITSVQAIYVP ADDLTDPAPA
360 370 380 390 400
TTFAHLDATT VLSRAIAELG IYPAVDPLDS TSRIMDPNII GQEHYNVARG
410 420 430 440 450
VQKILQDYKS LQDIIAILGM DELSEEDKLT VARARKIQRF LSQPFQVAEV
460 470 480 490 500
FTGHAGKLVP LEQTIKGFSA ILAGDYDHLP EVAFYMVGPI EEVVEKADRL

AKEAA
Length:505
Mass (Da):54,108
Last modified:May 24, 2004 - v3
Checksum:i92FA2CE1F0F919A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti494 – 4952VE → CR in CAA50332 (PubMed:8373413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71013 mRNA. Translation: CAA50332.1.
AE014135 Genomic DNA. Translation: AAF59391.1.
AY118367 mRNA. Translation: AAM48396.1.
PIRiJN0760.
RefSeqiNP_001284719.1. NM_001297790.1.
NP_726631.1. NM_166808.3.
UniGeneiDm.1407.

Genome annotation databases

EnsemblMetazoaiFBtr0089186; FBpp0088250; FBgn0010217.
FBtr0344754; FBpp0311086; FBgn0010217.
GeneIDi43829.
KEGGidme:Dmel_CG11154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71013 mRNA. Translation: CAA50332.1.
AE014135 Genomic DNA. Translation: AAF59391.1.
AY118367 mRNA. Translation: AAM48396.1.
PIRiJN0760.
RefSeqiNP_001284719.1. NM_001297790.1.
NP_726631.1. NM_166808.3.
UniGeneiDm.1407.

3D structure databases

ProteinModelPortaliQ05825.
SMRiQ05825. Positions 38-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68655. 49 interactions.
IntActiQ05825. 31 interactions.
MINTiMINT-908620.
STRINGi7227.FBpp0305828.

Proteomic databases

PaxDbiQ05825.
PRIDEiQ05825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089186; FBpp0088250; FBgn0010217.
FBtr0344754; FBpp0311086; FBgn0010217.
GeneIDi43829.
KEGGidme:Dmel_CG11154.

Organism-specific databases

CTDi43829.
FlyBaseiFBgn0010217. ATPsynbeta.

Phylogenomic databases

eggNOGiKOG1350. Eukaryota.
COG0055. LUCA.
InParanoidiQ05825.
KOiK02133.
OrthoDBiEOG091G0KVV.
PhylomeDBiQ05825.

Enzyme and pathway databases

ReactomeiR-DME-2151201. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSiATPsyn-beta. fly.
GenomeRNAii43829.
PROiQ05825.

Gene expression databases

BgeeiFBgn0010217.
ExpressionAtlasiQ05825. differential.
GenevisibleiQ05825. DM.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01347. ATP_synth_beta_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR005722. ATPase_F1-cplx_bsu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01039. atpD. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPB_DROME
AccessioniPrimary (citable) accession number: Q05825
Secondary accession number(s): Q9V494
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 24, 2004
Last modified: September 7, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.