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Q05823

- RN5A_HUMAN

UniProt

Q05823 - RN5A_HUMAN

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Protein

2-5A-dependent ribonuclease

Gene

RNASEL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.1 Publication

Catalytic activityi

Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.

Cofactori

Manganese or magnesium. Required for optimal RNA cleavage rates.

Enzyme regulationi

After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 44450C6-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. endoribonuclease activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. protein kinase activity Source: InterPro
  5. RNA binding Source: UniProtKB
  6. rRNA binding Source: Ensembl

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. defense response to virus Source: UniProtKB
  3. mRNA processing Source: InterPro
  4. negative regulation of viral genome replication Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. protein phosphorylation Source: UniProtKB
  7. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  8. rRNA processing Source: Ensembl
  9. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS06069-MONOMER.
ReactomeiREACT_25162. Interferon alpha/beta signaling.
SignaLinkiQ05823.

Names & Taxonomyi

Protein namesi
Recommended name:
2-5A-dependent ribonuclease (EC:3.1.26.-)
Short name:
2-5A-dependent RNase
Alternative name(s):
Ribonuclease 4
Ribonuclease L
Short name:
RNase L
Gene namesi
Name:RNASEL
Synonyms:RNS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10050. RNASEL.

Subcellular locationi

Cytoplasm 1 Publication. Mitochondrion 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrion Source: UniProtKB-KW
  3. nuclear matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi240 – 2401K → N: Reduced 2-5A binding activity; almost complete loss of 2-5A binding activity; when associated with N-274. 1 Publication
Mutagenesisi274 – 2741K → N: Reduced 2-5A binding activity; almost complete loss of 2-5A binding activity; when associated with N-240. 1 Publication
Mutagenesisi392 – 3921K → R: Complete loss of enzymatic activity and enzyme dimerization. No change in binding to 2-5A and RNA. 1 Publication
Mutagenesisi583 – 5831H → A: No change in enzymatic activity. 1 Publication
Mutagenesisi584 – 5841P → A: No change in enzymatic activity. 1 Publication
Mutagenesisi632 – 6321W → A: No change in enzymatic activity. 1 Publication
Mutagenesisi661 – 6611D → A: Complete loss of enzymatic activity. 1 Publication
Mutagenesisi667 – 6671R → A: Complete loss of enzymatic activity. No change in 2-5A binding and enzyme dimerization. 1 Publication
Mutagenesisi672 – 6721H → A: Complete loss of enzymatic activity. No change in 2-5A binding activity and enzyme dimerization. 1 Publication

Organism-specific databases

MIMi176807. phenotype.
601518. phenotype.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA34418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7417412-5A-dependent ribonucleasePRO_0000067051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei684 – 6841N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ05823.
PaxDbiQ05823.
PeptideAtlasiQ05823.
PRIDEiQ05823.

PTM databases

PhosphoSiteiQ05823.

Miscellaneous databases

PMAP-CutDBQ05823.

Expressioni

Tissue specificityi

Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Inductioni

By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RNASEL.

Gene expression databases

BgeeiQ05823.
CleanExiHS_RNASEL.
ExpressionAtlasiQ05823. baseline and differential.
GenevestigatoriQ05823.

Organism-specific databases

HPAiCAB010906.
HPA002633.

Interactioni

Subunit structurei

Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IQGAP1P469402EBI-8390477,EBI-297509

Protein-protein interaction databases

BioGridi111969. 2 interactions.
IntActiQ05823. 2 interactions.
MINTiMINT-7990548.
STRINGi9606.ENSP00000356530.

Structurei

Secondary structure

1
741
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3413
Helixi38 – 469
Turni56 – 583
Helixi62 – 687
Helixi72 – 809
Helixi95 – 1028
Helixi105 – 1139
Helixi128 – 1347
Helixi138 – 1469
Helixi159 – 1635
Helixi171 – 1788
Helixi181 – 1899
Helixi205 – 2117
Turni215 – 2173
Helixi218 – 22710
Helixi237 – 2393
Helixi242 – 2487
Helixi252 – 2609
Beta strandi261 – 2633
Helixi276 – 2827
Helixi286 – 29510
Beta strandi301 – 3033
Helixi304 – 3107
Helixi314 – 3229
Beta strandi341 – 3444
Helixi345 – 3528
Beta strandi361 – 3633
Helixi367 – 3693
Beta strandi370 – 3745
Beta strandi377 – 39519
Helixi399 – 40911
Beta strandi420 – 4256
Beta strandi427 – 4359
Beta strandi438 – 4403
Helixi441 – 4455
Helixi459 – 47719
Helixi488 – 4903
Beta strandi491 – 4933
Beta strandi495 – 4973
Beta strandi499 – 5013
Helixi514 – 53219
Turni533 – 5353
Helixi539 – 5446
Helixi547 – 5515
Helixi557 – 56711
Helixi576 – 5805
Helixi584 – 5863
Helixi589 – 60012
Helixi603 – 6064
Helixi613 – 6186
Turni628 – 6314
Helixi632 – 6343
Helixi638 – 6458
Helixi646 – 6483
Turni649 – 6524
Helixi659 – 67214
Helixi681 – 6855
Helixi688 – 6958
Helixi699 – 7079
Helixi711 – 7155

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WDYX-ray1.80A21-305[»]
4G8KX-ray2.40A/B1-337[»]
4G8LX-ray2.80A/B/C/D1-337[»]
4OAUX-ray2.60C21-719[»]
4OAVX-ray2.10B/D21-719[»]
ProteinModelPortaliQ05823.
SMRiQ05823. Positions 21-719.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05823.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 5330ANK 1Add
BLAST
Repeati58 – 8730ANK 2Add
BLAST
Repeati91 – 12030ANK 3Add
BLAST
Repeati124 – 15330ANK 4Add
BLAST
Repeati167 – 19731ANK 5Add
BLAST
Repeati201 – 23434ANK 6Add
BLAST
Repeati238 – 26831ANK 7Add
BLAST
Repeati272 – 30130ANK 8Add
BLAST
Repeati303 – 32927ANK 9Add
BLAST
Domaini365 – 586222Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini589 – 723135KENPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 242142-5A binding (P-loop) 1Add
BLAST
Regioni253 – 275232-5A binding (P-loop) 2Add
BLAST

Domaini

The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.
The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 1 KEN domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 44450C6-type; atypicalAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118867.
HOGENOMiHOG000276879.
HOVERGENiHBG012673.
InParanoidiQ05823.
KOiK01165.
OMAiDCGDLVM.
OrthoDBiEOG7VDXNN.
PhylomeDBiQ05823.
TreeFamiTF344032.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010513. KEN_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR006567. PUG-dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
PF06479. Ribonuc_2-5A. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
SM00580. PUG. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS51392. KEN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q05823-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRDHNNPQ EGPTSSSGRR AAVEDNHLLI KAVQNEDVDL VQQLLEGGAN
60 70 80 90 100
VNFQEEEGGW TPLHNAVQMS REDIVELLLR HGADPVLRKK NGATPFILAA
110 120 130 140 150
IAGSVKLLKL FLSKGADVNE CDFYGFTAFM EAAVYGKVKA LKFLYKRGAN
160 170 180 190 200
VNLRRKTKED QERLRKGGAT ALMDAAEKGH VEVLKILLDE MGADVNACDN
210 220 230 240 250
MGRNALIHAL LSSDDSDVEA ITHLLLDHGA DVNVRGERGK TPLILAVEKK
260 270 280 290 300
HLGLVQRLLE QEHIEINDTD SDGKTALLLA VELKLKKIAE LLCKRGASTD
310 320 330 340 350
CGDLVMTARR NYDHSLVKVL LSHGAKEDFH PPAEDWKPQS SHWGAALKDL
360 370 380 390 400
HRIYRPMIGK LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR
410 420 430 440 450
AQREVSCLQS SRENSHLVTF YGSESHRGHL FVCVTLCEQT LEACLDVHRG
460 470 480 490 500
EDVENEEDEF ARNVLSSIFK AVQELHLSCG YTHQDLQPQN ILIDSKKAAH
510 520 530 540 550
LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE DLKAQSNEEV
560 570 580 590 600
VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG
610 620 630 640 650
NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK
660 670 680 690 700
RGNFYQNTVG DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV
710 720 730 740
IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA GGASGLASPG C
Length:741
Mass (Da):83,533
Last modified:February 1, 1996 - v2
Checksum:i91385EA307E3CE1D
GO
Isoform 2 (identifier: Q05823-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-652: INECVMKKMNKFYEKRG → MSKLRHRQIIFPTTQNQ
     653-741: Missing.

Show »
Length:652
Mass (Da):73,416
Checksum:i4F39B25B82F07216
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591G → S.2 Publications
Corresponds to variant rs151296858 [ dbSNP | Ensembl ].
VAR_013509
Natural varianti97 – 971I → L.1 Publication
Corresponds to variant rs56250729 [ dbSNP | Ensembl ].
VAR_042358
Natural varianti289 – 2891A → T.1 Publication
Corresponds to variant rs35553278 [ dbSNP | Ensembl ].
VAR_042359
Natural varianti406 – 4061S → F.1 Publication
Corresponds to variant rs145787003 [ dbSNP | Ensembl ].
VAR_013510
Natural varianti462 – 4621R → Q Risk factor for prostate cancer; reduced enzymatic activity. 3 Publications
Corresponds to variant rs486907 [ dbSNP | Ensembl ].
VAR_012056
Natural varianti541 – 5411D → E No change in enzymatic activity. 3 Publications
Corresponds to variant rs627928 [ dbSNP | Ensembl ].
VAR_012057
Natural varianti592 – 5921R → H.1 Publication
Corresponds to variant rs35896902 [ dbSNP | Ensembl ].
VAR_042360

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei636 – 65217INECV…YEKRG → MSKLRHRQIIFPTTQNQ in isoform 2. 2 PublicationsVSP_056272Add
BLAST
Alternative sequencei653 – 74189Missing in isoform 2. 2 PublicationsVSP_056273Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10381 Genomic DNA. Translation: AAA18032.1.
CR627369 mRNA. Translation: CAH10468.1.
AL138776 Genomic DNA. Translation: CAH71322.1.
CH471067 Genomic DNA. Translation: EAW91128.1.
BC090934 mRNA. Translation: AAH90934.1.
BC114433 mRNA. Translation: AAI14434.1.
CCDSiCCDS1347.1. [Q05823-1]
PIRiA45771.
RefSeqiNP_066956.1. NM_021133.3.
XP_005245468.1. XM_005245411.1.
UniGeneiHs.518545.

Genome annotation databases

EnsembliENST00000367559; ENSP00000356530; ENSG00000135828. [Q05823-1]
ENST00000539397; ENSP00000440844; ENSG00000135828. [Q05823-2]
GeneIDi6041.
KEGGihsa:6041.
UCSCiuc009wxz.2. human. [Q05823-1]

Polymorphism databases

DMDMi1350802.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10381 Genomic DNA. Translation: AAA18032.1 .
CR627369 mRNA. Translation: CAH10468.1 .
AL138776 Genomic DNA. Translation: CAH71322.1 .
CH471067 Genomic DNA. Translation: EAW91128.1 .
BC090934 mRNA. Translation: AAH90934.1 .
BC114433 mRNA. Translation: AAI14434.1 .
CCDSi CCDS1347.1. [Q05823-1 ]
PIRi A45771.
RefSeqi NP_066956.1. NM_021133.3.
XP_005245468.1. XM_005245411.1.
UniGenei Hs.518545.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WDY X-ray 1.80 A 21-305 [» ]
4G8K X-ray 2.40 A/B 1-337 [» ]
4G8L X-ray 2.80 A/B/C/D 1-337 [» ]
4OAU X-ray 2.60 C 21-719 [» ]
4OAV X-ray 2.10 B/D 21-719 [» ]
ProteinModelPortali Q05823.
SMRi Q05823. Positions 21-719.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111969. 2 interactions.
IntActi Q05823. 2 interactions.
MINTi MINT-7990548.
STRINGi 9606.ENSP00000356530.

Chemistry

BindingDBi Q05823.
ChEMBLi CHEMBL3575.

PTM databases

PhosphoSitei Q05823.

Polymorphism databases

DMDMi 1350802.

Proteomic databases

MaxQBi Q05823.
PaxDbi Q05823.
PeptideAtlasi Q05823.
PRIDEi Q05823.

Protocols and materials databases

DNASUi 6041.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367559 ; ENSP00000356530 ; ENSG00000135828 . [Q05823-1 ]
ENST00000539397 ; ENSP00000440844 ; ENSG00000135828 . [Q05823-2 ]
GeneIDi 6041.
KEGGi hsa:6041.
UCSCi uc009wxz.2. human. [Q05823-1 ]

Organism-specific databases

CTDi 6041.
GeneCardsi GC01M182542.
HGNCi HGNC:10050. RNASEL.
HPAi CAB010906.
HPA002633.
MIMi 176807. phenotype.
180435. gene.
601518. phenotype.
neXtProti NX_Q05823.
Orphaneti 1331. Familial prostate cancer.
PharmGKBi PA34418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00760000118867.
HOGENOMi HOG000276879.
HOVERGENi HBG012673.
InParanoidi Q05823.
KOi K01165.
OMAi DCGDLVM.
OrthoDBi EOG7VDXNN.
PhylomeDBi Q05823.
TreeFami TF344032.

Enzyme and pathway databases

BioCyci MetaCyc:HS06069-MONOMER.
Reactomei REACT_25162. Interferon alpha/beta signaling.
SignaLinki Q05823.

Miscellaneous databases

EvolutionaryTracei Q05823.
GeneWikii Ribonuclease_L.
RNASEL.
GenomeRNAii 6041.
NextBioi 23543.
PMAP-CutDB Q05823.
PROi Q05823.
SOURCEi Search...

Gene expression databases

Bgeei Q05823.
CleanExi HS_RNASEL.
ExpressionAtlasi Q05823. baseline and differential.
Genevestigatori Q05823.

Family and domain databases

Gene3Di 1.25.40.20. 3 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010513. KEN_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR006567. PUG-dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
PF06479. Ribonuc_2-5A. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 8 hits.
SM00580. PUG. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS51392. KEN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action."
    Zhou A., Hassel B.A., Silverman R.H.
    Cell 72:753-765(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF LYS-240 AND LYS-274.
    Tissue: Kidney.
  2. "Analysis and origins of the human and mouse RNase L genes: mediators of interferon action."
    Zhou A., Nie H., Silverman R.H.
    Mamm. Genome 11:989-992(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon carcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lymph.
  7. "Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase."
    Dong B., Xu L., Zhou A., Hassel B.A., Lee X., Torrence P.F., Silverman R.H.
    J. Biol. Chem. 269:14153-14158(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF RNASEL ACTIVITY.
  8. "Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway."
    Bisbal C., Martinand C., Silhol M., Lebleu B., Salehzada T.
    J. Biol. Chem. 270:13308-13317(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ABCE1.
  9. "The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells."
    Le Roy F., Bisbal C., Silhol M., Martinand C., Lebleu B., Salehzada T.
    J. Biol. Chem. 276:48473-48482(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Erratum
    Le Roy F., Bisbal C., Silhol M., Martinand C., Lebleu B., Salehzada T.
    J. Biol. Chem. 277:13354-13354(2002)
  11. "The 2-5A system in viral infection and apoptosis."
    Castelli J., Wood K.A., Youle R.J.
    Biomed. Pharmacother. 52:386-390(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L."
    Dong B., Silverman R.H.
    Nucleic Acids Res. 27:439-445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LYS-392.
  13. "Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p."
    Dong B., Niwa M., Walter P., Silverman R.H.
    RNA 7:361-373(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF HIS-583; PRO-584; TRP-632; ASP-661; ARG-667 AND HIS-672.
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L."
    Tanaka N., Nakanishi M., Kusakabe Y., Goto Y., Kitade Y., Nakamura K.T.
    EMBO J. 23:3929-3938(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-305 IN COMPLEX WITH THE ACTIVATOR 2-5A.
  16. "Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer."
    Roekman A., Ikonen T., Seppaelae E.H., Nupponen N., Autio V., Mononen N., Bailey-Wilson J., Trent J., Carpten J., Matikainen M.P., Koivisto P.A., Tammela T.L.J., Kallioniemi O.-P., Schleutker J.
    Am. J. Hum. Genet. 70:1299-1304(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SER-59; PHE-406; GLN-462 AND GLU-541.
  17. Cited for: VARIANTS SER-59; GLN-462 AND GLU-541.
  18. Cited for: CHARACTERIZATION OF VARIANTS GLN-462 AND GLU-541.
  19. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-97; THR-289; GLN-462; GLU-541 AND HIS-592.

Entry informationi

Entry nameiRN5A_HUMAN
AccessioniPrimary (citable) accession number: Q05823
Secondary accession number(s): Q5W0L2, Q6AI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3