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Q05816

- FABP5_MOUSE

UniProt

Q05816 - FABP5_MOUSE

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Protein

Fatty acid-binding protein, epidermal

Gene

Fabp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High specificity for fatty acids. Highest affinity for C18 chain length (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Fatty acidBy similarity

GO - Molecular functioni

  1. fatty acid binding Source: Ensembl
  2. transporter activity Source: InterPro

GO - Biological processi

  1. glucose metabolic process Source: MGI
  2. glucose transport Source: MGI
  3. lipid metabolic process Source: MGI
  4. phosphatidylcholine biosynthetic process Source: MGI
  5. response to wounding Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, epidermal
Alternative name(s):
Epidermal-type fatty acid-binding protein
Short name:
E-FABP
Fatty acid-binding protein 5
Keratinocyte lipid-binding protein
Psoriasis-associated fatty acid-binding protein homolog
Short name:
PA-FABP
Gene namesi
Name:Fabp5
Synonyms:Fabpe, Klbp, Mal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:101790. Fabp5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 135134Fatty acid-binding protein, epidermalPRO_0000067378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Disulfide bondi120 ↔ 127By similarity
Modified residuei131 – 1311PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ05816.
PaxDbiQ05816.
PRIDEiQ05816.

2D gel databases

REPRODUCTION-2DPAGEQ05816.
UCD-2DPAGEQ05816.

PTM databases

PhosphoSiteiQ05816.

Expressioni

Tissue specificityi

Most abundant in keratinocytes and also in stratified epithelia of epidermis and tongue. Relatively high levels found in adipose and mammary tissues and small amounts found in heart, brain, liver, spleen, muscle and lung.

Gene expression databases

BgeeiQ05816.
CleanExiMM_FABP5.
ExpressionAtlasiQ05816. baseline and differential.
GenevestigatoriQ05816.

Interactioni

Protein-protein interaction databases

BioGridi200959. 1 interaction.
IntActiQ05816. 4 interactions.
MINTiMINT-1869678.

Structurei

Secondary structure

1
135
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 74
Beta strandi9 – 1810
Helixi19 – 268
Helixi30 – 378
Beta strandi42 – 487
Beta strandi51 – 577
Beta strandi62 – 687
Beta strandi73 – 764
Beta strandi82 – 909
Beta strandi93 – 1008
Beta strandi103 – 11210
Beta strandi115 – 1228
Beta strandi125 – 1339

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AZNX-ray2.51A/B1-135[»]
4AZOX-ray2.33A1-135[»]
4AZPX-ray2.10A1-135[»]
4AZQX-ray2.00A1-135[»]
ProteinModelPortaliQ05816.
SMRiQ05816. Positions 2-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG309791.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ05816.
KOiK08754.
OMAiVECDMNG.
OrthoDBiEOG7NW6BZ.
PhylomeDBiQ05816.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLKDLEGK WRLMESHGFE EYMKELGVGL ALRKMAAMAK PDCIITCDGN
60 70 80 90 100
NITVKTESTV KTTVFSCNLG EKFDETTADG RKTETVCTFQ DGALVQHQQW
110 120 130
DGKESTITRK LKDGKMIVEC VMNNATCTRV YEKVQ
Length:135
Mass (Da):15,137
Last modified:January 23, 2007 - v3
Checksum:i6A6C8DBEBB046185
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70100 mRNA. Translation: CAA49703.1.
AJ223066 Genomic DNA. Translation: CAA11069.1.
AF061015, AF061014 Genomic DNA. Translation: AAC82368.1.
AK008782 mRNA. Translation: BAB25890.1.
AK011551 mRNA. Translation: BAB27692.1.
BC002008 mRNA. Translation: AAH02008.1.
CCDSiCCDS38388.1.
PIRiA47497.
RefSeqiNP_034764.1. NM_010634.3.
UniGeneiMm.741.

Genome annotation databases

EnsembliENSMUST00000029046; ENSMUSP00000029046; ENSMUSG00000027533.
GeneIDi16592.
KEGGimmu:16592.
UCSCiuc008opg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70100 mRNA. Translation: CAA49703.1 .
AJ223066 Genomic DNA. Translation: CAA11069.1 .
AF061015 , AF061014 Genomic DNA. Translation: AAC82368.1 .
AK008782 mRNA. Translation: BAB25890.1 .
AK011551 mRNA. Translation: BAB27692.1 .
BC002008 mRNA. Translation: AAH02008.1 .
CCDSi CCDS38388.1.
PIRi A47497.
RefSeqi NP_034764.1. NM_010634.3.
UniGenei Mm.741.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AZN X-ray 2.51 A/B 1-135 [» ]
4AZO X-ray 2.33 A 1-135 [» ]
4AZP X-ray 2.10 A 1-135 [» ]
4AZQ X-ray 2.00 A 1-135 [» ]
ProteinModelPortali Q05816.
SMRi Q05816. Positions 2-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200959. 1 interaction.
IntActi Q05816. 4 interactions.
MINTi MINT-1869678.

PTM databases

PhosphoSitei Q05816.

2D gel databases

REPRODUCTION-2DPAGE Q05816.
UCD-2DPAGE Q05816.

Proteomic databases

MaxQBi Q05816.
PaxDbi Q05816.
PRIDEi Q05816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029046 ; ENSMUSP00000029046 ; ENSMUSG00000027533 .
GeneIDi 16592.
KEGGi mmu:16592.
UCSCi uc008opg.1. mouse.

Organism-specific databases

CTDi 2171.
MGIi MGI:101790. Fabp5.

Phylogenomic databases

eggNOGi NOG309791.
HOGENOMi HOG000004829.
HOVERGENi HBG005633.
InParanoidi Q05816.
KOi K08754.
OMAi VECDMNG.
OrthoDBi EOG7NW6BZ.
PhylomeDBi Q05816.
TreeFami TF316894.

Miscellaneous databases

NextBioi 290145.
PROi Q05816.
SOURCEi Search...

Gene expression databases

Bgeei Q05816.
CleanExi MM_FABP5.
ExpressionAtlasi Q05816. baseline and differential.
Genevestigatori Q05816.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin."
    Krieg P., Feil S., Fuerstenberger G., Bowden T.G.
    J. Biol. Chem. 268:17362-17369(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Keratinocyte.
  2. "Cloning and chromosomal localisation of the murine epidermal-type fatty acid binding protein gene (Fabpe)."
    Bleck B., Hohoff C., Binas B., Rustow B., Dixkens C., Hameister H., Boerchers T., Spener F.
    Gene 215:123-130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Cloning and chromosomal location of the murine Keratinocyte lipid-binding protein gene."
    Hertzel A.V., Bernlohr D.A.
    Gene 221:235-243(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  6. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 13-24, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiFABP5_MOUSE
AccessioniPrimary (citable) accession number: Q05816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3