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Protein

Major capsid protein

Gene

MCP

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Major capsid protein that self assembles to form an icosahedral capsid with a T=147 symmetry. Represents around 50% of the total virion protein mass.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Short name:
MCP
Alternative name(s):
P50
Gene namesi
Name:MCP
ORF Names:IIV-6 274L
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Major capsid proteinPRO_0000222381Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ05815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NCLDV major capsid protein family.Curated

Family and domain databases

Gene3Di2.70.9.10. 1 hit.
2.70.9.20. 1 hit.
InterProiIPR016114. ASFV_p72.
IPR016111. Hexon_subdom4.
IPR007542. Virus_major_coat_C.
IPR016112. VP_dsDNA_II.
[Graphical view]
PfamiPF04451. Capsid_NCLDV. 1 hit.
[Graphical view]
SUPFAMiSSF49749. SSF49749. 2 hits.

Sequencei

Sequence statusi: Complete.

Q05815-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSISSSNVTS GFIDIATKDE IEKYMYGGKT STAYFVRETR KATWFTQVPV
60 70 80 90 100
SLTRANGSAN FGSEWSASIS RAGDYLLYTW LRVRIPSVTL LSTNQFGANG
110 120 130 140 150
RIRWCRNFMH NLIRECSITF NDLVAARFDH YHLDFWAAFT TPASKAVGYD
160 170 180 190 200
NMIGNVSALI QPQPVPVAPA TVSLPEADLN LPLPFFFSRD SGVALPTAAL
210 220 230 240 250
PYNEMRINFQ FHDWQRLLIL DNIAAVASQT VVPVVGATSD IATAPVLHHG
260 270 280 290 300
TVWGNYAIVS NEERRRMGCS VRDILVEQVQ TAPRHVWNPT TNDAPNYDIR
310 320 330 340 350
FSHAIKALFF AVRNTTFSNQ PSNYTTASPV ITSTTVILEP STGAFDPIHH
360 370 380 390 400
TTLIYENTNR LNHMGSDYFS LVNPWYHAPT IPGLTGFHEY SYSLAFNEID
410 420 430 440 450
PMGSTNYGKL TNISIVPTAS PAAKVGAAGT GPAGSGQNFP QTFEFIVTAL
460
NNNIIRISGG ALGFPVL
Length:467
Mass (Da):51,322
Last modified:January 23, 2002 - v2
Checksum:i5A81E1E79D3B41A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281S → Y(PubMed:8492091)Curated
Sequence conflicti331 – 3311I → L(PubMed:8492091)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAK82135.1.
PIRiJQ2215.
RefSeqiNP_149737.1. NC_003038.1.

Genome annotation databases

GeneIDi1733341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAK82135.1.
PIRiJQ2215.
RefSeqiNP_149737.1. NC_003038.1.

3D structure databases

ProteinModelPortaliQ05815.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1733341.

Family and domain databases

Gene3Di2.70.9.10. 1 hit.
2.70.9.20. 1 hit.
InterProiIPR016114. ASFV_p72.
IPR016111. Hexon_subdom4.
IPR007542. Virus_major_coat_C.
IPR016112. VP_dsDNA_II.
[Graphical view]
PfamiPF04451. Capsid_NCLDV. 1 hit.
[Graphical view]
SUPFAMiSSF49749. SSF49749. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the gene encoding the major capsid protein of insect iridescent virus type 6 by polymerase chain reaction."
    Stohwasser R., Raab K., Schnitzler P., Janssen W., Darai G.
    J. Gen. Virol. 74:873-879(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  4. Cited for: STRUCTURE BY CRYO-ELECTRON MICROSCOPY OF THE CAPSID.

Entry informationi

Entry nameiMCP_IIV6
AccessioniPrimary (citable) accession number: Q05815
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2002
Last modified: January 7, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.