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Protein

Acetate kinase

Gene

ackA

Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei92SubstrateUniRule annotation1
Active sitei151Proton donor/acceptorUniRule annotation1
Sitei183Transition state stabilizerUniRule annotation1
Sitei244Transition state stabilizerUniRule annotation1
Metal bindingi389MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 215ATPUniRule annotation5
Nucleotide bindingi286 – 288ATPUniRule annotation3
Nucleotide bindingi335 – 339ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH372461:G1GK7-119-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:BCc_114
OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
Taxonomic identifieri372461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000669 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000899631 – 406Acetate kinaseAdd BLAST406

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi372461.BCc_114.

Structurei

3D structure databases

ProteinModelPortaliQ057V8.
SMRiQ057V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q057V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKLILVLN CGSSSVKFSI IDVIEGVLYI SGIANTINNV SFLKIYDIKK
60 70 80 90 100
KIKIVKKNIS TDSYKKLILL ICDLLFIHFN KYLKLIIGIG HRIVHGGKDI
110 120 130 140 150
KKSMIINKKI LLKIKKSAIF APLHNPYHLI AIKIILNKFV KLKNRNVAVF
160 170 180 190 200
DTSFHQTMPK KSFLYGIPYS FYKKYSIRKY GAHGINHFYI THECSLFLKK
210 220 230 240 250
STNNLNIISC HLGSGSSITA IVNGKSIDTS MGLTPLEGLV MGTRCGDIDP
260 270 280 290 300
YIIIYMIKKL NFSITQIQKI LTKSSGVLGI SSITSDFREL EKKYYSHKKA
310 320 330 340 350
KLAIDIFCRR VSKYIAGYSS LMPKGKLDAI VFTGGIGENS SFIRKKIIKN
360 370 380 390 400
LSIIGFFLDI EKNLIKTGNN NRFIHTINSK PILVIPADEN KIIAKETYNI

LIKNNF
Length:406
Mass (Da):45,881
Last modified:November 14, 2006 - v1
Checksum:i6A37B5CDABD1F4DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000263 Genomic DNA. Translation: ABJ90591.1.
RefSeqiWP_011672510.1. NC_008513.1.

Genome annotation databases

EnsemblBacteriaiABJ90591; ABJ90591; BCc_114.
KEGGibcc:BCc_114.

Similar proteinsi

Entry informationi

Entry nameiACKA_BUCCC
AccessioniPrimary (citable) accession number: Q057V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 14, 2006
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome