ID   KHSE_BUCCC              Reviewed;         315 AA.
AC   Q057U7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Homoserine kinase;
DE            Short=HSK;
DE            Short=HK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=BCc_126;
OS   Buchnera aphidicola subsp. Cinara cedri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=372461;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17038625; DOI=10.1126/science.1130441;
RA   Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M.,
RA   Michelena J.M., Silva F.J., Moya A., Latorre A.;
RT   "A small microbial genome: the end of a long symbiotic relationship?";
RL   Science 314:312-313(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; CP000263; ABJ90602.1; -; Genomic_DNA.
DR   RefSeq; YP_802695.1; -.
DR   GeneID; 4440836; -.
DR   GenomeReviews; CP000263_GR; BCc_126.
DR   KEGG; bcc:BCc_126; -.
DR   OMA; Q057U7; CGSAHAD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00384; -; 1.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR000870; Homoserine_kin.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   PRINTS; PR00958; HOMSERKINASE.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    315       Homoserine kinase.
FT                                /FTId=PRO_1000049111.
FT   NP_BIND      91    101       ATP (Potential).
SQ   SEQUENCE   315 AA;  35319 MW;  1DFC48C19B1CBAB2 CRC64;
     MIKIYAPASI GNVGVGFDIL GIAIKPIDKT LLGDCISIKP SKKFQLKNHG NFSKQLPVNI
     KENIIWKAWK YFNKKAKKKK TVKIVLEKNM PIGSGLGSSA SSIVACVIAL NKFYKTKLSK
     TKLLKIMGKL EGIISGEVHY DNVAPCYLGG LQLITNDQKN ITQKLPIFTD WLWVIAWPGV
     TLSTSQARNI LPLKYKKKTC IHNSRNLATF IHALYTKQSE LAIRYMKDII AEPYRIPLIP
     KFLISKKKII ELGALTCNIS GSGPTLFSVC PNISIAKKVK IWLKKNYMEN QTGFVHICKI
     DQSGARKMEK KNEII
//