Reviewed, UniProtKB/Swiss-Prot Q057U7 (KHSE_BUCCC)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BCc_126

Organism

Buchnera aphidicola subsp. Cinara cedri [Complete proteome] [HAMAP]

Taxonomic identifier

372461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Homoserine kinase HAMAP MF_00384		PRO_1000049111
Regions
	Nucleotide binding	91 – 101	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q057U7-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 1DFC48C19B1CBAB2	FASTA	315	35,319
	10 20 30 40 50 60 MIKIYAPASI GNVGVGFDIL GIAIKPIDKT LLGDCISIKP SKKFQLKNHG NFSKQLPVNI 70 80 90 100 110 120 KENIIWKAWK YFNKKAKKKK TVKIVLEKNM PIGSGLGSSA SSIVACVIAL NKFYKTKLSK 130 140 150 160 170 180 TKLLKIMGKL EGIISGEVHY DNVAPCYLGG LQLITNDQKN ITQKLPIFTD WLWVIAWPGV 190 200 210 220 230 240 TLSTSQARNI LPLKYKKKTC IHNSRNLATF IHALYTKQSE LAIRYMKDII AEPYRIPLIP 250 260 270 280 290 300 KFLISKKKII ELGALTCNIS GSGPTLFSVC PNISIAKKVK IWLKKNYMEN QTGFVHICKI 310 DQSGARKMEK KNEII

References

[1]	"A small microbial genome: the end of a long symbiotic relationship?" Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A. Science 314:312-313(2006) [PubMed: 17038625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000263 Genomic DNA. Translation: ABJ90602.1.
RefSeq	YP_802695.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4440836.
GenomeReviews	Gene locus BCc_126 in contig CP000263_GR.
KEGG	bcc:BCc_126.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q057U7. CGSAHAD.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_BUCCC

Accession

Primary (citable) accession number: Q057U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)