Reviewed, UniProtKB/Swiss-Prot Q057N6 (AROA_BUCCC)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BCc_191

Organism

Buchnera aphidicola subsp. Cinara cedri [Complete proteome] [HAMAP]

Taxonomic identifier

372461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012415

Sequences

	Sequence		Length	Mass (Da)
	Q057N6-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 177B4635E3E836D4	FASTA	435	48,962
	10 20 30 40 50 60 MQDSLTLKPV DYIQGKINIP GSKSISNRVL LLSALSNGKT ILKNLLYSDD IKYMLKALLK 70 80 90 100 110 120 LGIFYKLDKK KSKCTIYGIS DAFSVKNKIK LFLGNAGTAM RPLLAILSLK KNKIILTGEK 130 140 150 160 170 180 RMKERPIHHL VDSLRQGGAN ITYKNKKKFP PLYIKGGFKG GKIFIDGSIS SQFLSSLLMA 190 200 210 220 230 240 APLAELDTEI IVKNQLVSKP YINLTINLME KFGISVSILN DYKHFYIKGN QKYISPKKYY 250 260 270 280 290 300 IESDLSSATY FLAAAAIKGG SIQINGIQKK SIQGDINFIK ILKQMGVSIQ WKKNSVICKK 310 320 330 340 350 360 NKLLGITVDC NHIPDAAMTI AILGVFSKKK VYIKNIYNWR VKETDRIYAM STELKKIGAR 370 380 390 400 410 420 VITGKDYIKV YPVKNFIHAK INTYNDHRIA MCFSLISLSG TSVTLLNPKC VNKTFPSFFK 430 NFYSICHYSN INKNI

References

[1]	"A small microbial genome: the end of a long symbiotic relationship?" Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A. Science 314:312-313(2006) [PubMed: 17038625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000263 Genomic DNA. Translation: ABJ90663.1.
RefSeq	YP_802756.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q057N6.
Genome annotation databases
GeneID	4440685.
GenomeReviews	Gene locus BCc_191 in contig CP000263_GR.
KEGG	bcc:BCc_191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIDTYND.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BUCCC

Accession

Primary (citable) accession number: Q057N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)