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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei610ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH372461:G1GK7-277-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BCc_274
OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
Taxonomic identifieri372461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000669 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347351 – 847Leucine--tRNA ligaseAdd BLAST847

Proteomic databases

PRIDEiQ057G3

Interactioni

Protein-protein interaction databases

STRINGi372461.BCc_274

Structurei

3D structure databases

ProteinModelPortaliQ057G3
SMRiQ057G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi607 – 611"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q057G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNNNYNPKK IEKYVQKYWV KKKIFFTKID KEKKKFYCLP MLPYPSGKLH
60 70 80 90 100
MGHVRNYTIS DVISRFHRML GKNVLQPIGW DSFGLPAEET AIKNNISPKK
110 120 130 140 150
WTFKNIKTMK KQLQSLGFSY DWNKEITTCN PEYYRWEQLF FIKLFKKKLI
160 170 180 190 200
YKKKSIVNWC EKDKTVLANE QVQKGVCWRC GTKIKLRKIS QWFIKIKKYA
210 220 230 240 250
DKFLKDLKLL KKWPKEVISM QKNWIGKSKG LKIKCKIYKK KYFLKIFTTK
260 270 280 290 300
PETIMGISFF AISMYHPLIN LFLRKNIEIQ KFLKKNKYSI NTEFQKSNIL
310 320 330 340 350
FGINTHLYVI HPINKKKIPL WISNYVKYNY ATGAIMSVPC SNKIDYNFSK
360 370 380 390 400
LYNIPFIKIF SKKNKKLLIN SDNFNNLNIK KARNKISNFL INKKIAKKYI
410 420 430 440 450
YYKIQDWCIS RQRYWGTPIP IVIDNKKNII TVPKKKLPVI LPKYIYKKKS
460 470 480 490 500
LQSLSLYSLW LKTKISGKKV TRETDTLDTF MESSWYYARY TNPKYEKDII
510 520 530 540 550
DPKASEYWLP VDQYIGGIEH AVMHLIYFRF YHKLLYDFGY VQSKEPVKKL
560 570 580 590 600
ICQGMVIIDS FYKYNKDGSK KWLSISKIEI NRDSKGKIIS AIEKSSQKKI
610 620 630 640 650
IYAGKIKMSK SKNNGIDPVN IIKQYGADSL RLFIMFAAPI NISLEWNSKN
660 670 680 690 700
IIGMHRFLKK IWNFVFIIIK KKKEKIKKID LNKNKKTYIY KLNTIIKKVT
710 720 730 740 750
YNIQERNSFN TAIAEIIKFF NYLVKLYKIY NIKKKNLIFC ISTIIKMLYP
760 770 780 790 800
FTPHICFILW KKIYGKKSCI EKETWPKFNK KFFLKEKNNI IIQINGKKKD
810 820 830 840
IMKIHAIISK KEIIKLILKN EKIKKHLYKK IIKKTIYIPN KVINFVL
Length:847
Mass (Da):101,253
Last modified:November 14, 2006 - v1
Checksum:iA1330936B233079C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000263 Genomic DNA Translation: ABJ90736.1
RefSeqiWP_011672655.1, NC_008513.1

Genome annotation databases

EnsemblBacteriaiABJ90736; ABJ90736; BCc_274
KEGGibcc:BCc_274

Similar proteinsi

Entry informationi

Entry nameiSYL_BUCCC
AccessioniPrimary (citable) accession number: Q057G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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