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Q057G3

- SYL_BUCCC

UniProt

Q057G3 - SYL_BUCCC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei610 – 6101ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH372461:GHAJ-275-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BCc_274
    OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
    Taxonomic identifieri372461 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000669: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 847847Leucine--tRNA ligasePRO_0000334735Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi372461.BCc_274.

    Structurei

    3D structure databases

    ProteinModelPortaliQ057G3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi607 – 6115"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q057G3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNNNYNPKK IEKYVQKYWV KKKIFFTKID KEKKKFYCLP MLPYPSGKLH    50
    MGHVRNYTIS DVISRFHRML GKNVLQPIGW DSFGLPAEET AIKNNISPKK 100
    WTFKNIKTMK KQLQSLGFSY DWNKEITTCN PEYYRWEQLF FIKLFKKKLI 150
    YKKKSIVNWC EKDKTVLANE QVQKGVCWRC GTKIKLRKIS QWFIKIKKYA 200
    DKFLKDLKLL KKWPKEVISM QKNWIGKSKG LKIKCKIYKK KYFLKIFTTK 250
    PETIMGISFF AISMYHPLIN LFLRKNIEIQ KFLKKNKYSI NTEFQKSNIL 300
    FGINTHLYVI HPINKKKIPL WISNYVKYNY ATGAIMSVPC SNKIDYNFSK 350
    LYNIPFIKIF SKKNKKLLIN SDNFNNLNIK KARNKISNFL INKKIAKKYI 400
    YYKIQDWCIS RQRYWGTPIP IVIDNKKNII TVPKKKLPVI LPKYIYKKKS 450
    LQSLSLYSLW LKTKISGKKV TRETDTLDTF MESSWYYARY TNPKYEKDII 500
    DPKASEYWLP VDQYIGGIEH AVMHLIYFRF YHKLLYDFGY VQSKEPVKKL 550
    ICQGMVIIDS FYKYNKDGSK KWLSISKIEI NRDSKGKIIS AIEKSSQKKI 600
    IYAGKIKMSK SKNNGIDPVN IIKQYGADSL RLFIMFAAPI NISLEWNSKN 650
    IIGMHRFLKK IWNFVFIIIK KKKEKIKKID LNKNKKTYIY KLNTIIKKVT 700
    YNIQERNSFN TAIAEIIKFF NYLVKLYKIY NIKKKNLIFC ISTIIKMLYP 750
    FTPHICFILW KKIYGKKSCI EKETWPKFNK KFFLKEKNNI IIQINGKKKD 800
    IMKIHAIISK KEIIKLILKN EKIKKHLYKK IIKKTIYIPN KVINFVL 847
    Length:847
    Mass (Da):101,253
    Last modified:November 14, 2006 - v1
    Checksum:iA1330936B233079C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000263 Genomic DNA. Translation: ABJ90736.1.
    RefSeqiYP_802829.1. NC_008513.1.

    Genome annotation databases

    EnsemblBacteriaiABJ90736; ABJ90736; BCc_274.
    GeneIDi4440936.
    KEGGibcc:BCc_274.
    PATRICi21246493. VBIBucAph7855_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000263 Genomic DNA. Translation: ABJ90736.1 .
    RefSeqi YP_802829.1. NC_008513.1.

    3D structure databases

    ProteinModelPortali Q057G3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 372461.BCc_274.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ90736 ; ABJ90736 ; BCc_274 .
    GeneIDi 4440936.
    KEGGi bcc:BCc_274.
    PATRICi 21246493. VBIBucAph7855_0258.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BAPH372461:GHAJ-275-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A small microbial genome: the end of a long symbiotic relationship?"
      Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A.
      Science 314:312-313(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Cc.

    Entry informationi

    Entry nameiSYL_BUCCC
    AccessioniPrimary (citable) accession number: Q057G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3