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Q057G3

- SYL_BUCCC

UniProt

Q057G3 - SYL_BUCCC

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Protein

Leucine--tRNA ligase

Gene
leuS, BCc_274
Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei610 – 6101ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH372461:GHAJ-275-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BCc_274
OrganismiBuchnera aphidicola subsp. Cinara cedri (strain Cc)
Taxonomic identifieri372461 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000669: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Leucine--tRNA ligaseUniRule annotationPRO_0000334735Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi372461.BCc_274.

Structurei

3D structure databases

ProteinModelPortaliQ057G3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi607 – 6115"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q057G3-1 [UniParc]FASTAAdd to Basket

« Hide

MKNNNYNPKK IEKYVQKYWV KKKIFFTKID KEKKKFYCLP MLPYPSGKLH    50
MGHVRNYTIS DVISRFHRML GKNVLQPIGW DSFGLPAEET AIKNNISPKK 100
WTFKNIKTMK KQLQSLGFSY DWNKEITTCN PEYYRWEQLF FIKLFKKKLI 150
YKKKSIVNWC EKDKTVLANE QVQKGVCWRC GTKIKLRKIS QWFIKIKKYA 200
DKFLKDLKLL KKWPKEVISM QKNWIGKSKG LKIKCKIYKK KYFLKIFTTK 250
PETIMGISFF AISMYHPLIN LFLRKNIEIQ KFLKKNKYSI NTEFQKSNIL 300
FGINTHLYVI HPINKKKIPL WISNYVKYNY ATGAIMSVPC SNKIDYNFSK 350
LYNIPFIKIF SKKNKKLLIN SDNFNNLNIK KARNKISNFL INKKIAKKYI 400
YYKIQDWCIS RQRYWGTPIP IVIDNKKNII TVPKKKLPVI LPKYIYKKKS 450
LQSLSLYSLW LKTKISGKKV TRETDTLDTF MESSWYYARY TNPKYEKDII 500
DPKASEYWLP VDQYIGGIEH AVMHLIYFRF YHKLLYDFGY VQSKEPVKKL 550
ICQGMVIIDS FYKYNKDGSK KWLSISKIEI NRDSKGKIIS AIEKSSQKKI 600
IYAGKIKMSK SKNNGIDPVN IIKQYGADSL RLFIMFAAPI NISLEWNSKN 650
IIGMHRFLKK IWNFVFIIIK KKKEKIKKID LNKNKKTYIY KLNTIIKKVT 700
YNIQERNSFN TAIAEIIKFF NYLVKLYKIY NIKKKNLIFC ISTIIKMLYP 750
FTPHICFILW KKIYGKKSCI EKETWPKFNK KFFLKEKNNI IIQINGKKKD 800
IMKIHAIISK KEIIKLILKN EKIKKHLYKK IIKKTIYIPN KVINFVL 847
Length:847
Mass (Da):101,253
Last modified:November 14, 2006 - v1
Checksum:iA1330936B233079C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000263 Genomic DNA. Translation: ABJ90736.1.
RefSeqiYP_802829.1. NC_008513.1.

Genome annotation databases

EnsemblBacteriaiABJ90736; ABJ90736; BCc_274.
GeneIDi4440936.
KEGGibcc:BCc_274.
PATRICi21246493. VBIBucAph7855_0258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000263 Genomic DNA. Translation: ABJ90736.1 .
RefSeqi YP_802829.1. NC_008513.1.

3D structure databases

ProteinModelPortali Q057G3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 372461.BCc_274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ90736 ; ABJ90736 ; BCc_274 .
GeneIDi 4440936.
KEGGi bcc:BCc_274.
PATRICi 21246493. VBIBucAph7855_0258.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAPH372461:GHAJ-275-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A small microbial genome: the end of a long symbiotic relationship?"
    Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A.
    Science 314:312-313(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Cc.

Entry informationi

Entry nameiSYL_BUCCC
AccessioniPrimary (citable) accession number: Q057G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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