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Q057G3 (SYL_BUCCC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BCc_274
OrganismBuchnera aphidicola subsp. Cinara cedri (strain Cc) [Complete proteome] [HAMAP]
Taxonomic identifier372461 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length847 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 847847Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334735

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif607 – 6115"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6101ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q057G3 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: A1330936B233079C

FASTA847101,253
        10         20         30         40         50         60 
MKNNNYNPKK IEKYVQKYWV KKKIFFTKID KEKKKFYCLP MLPYPSGKLH MGHVRNYTIS 

        70         80         90        100        110        120 
DVISRFHRML GKNVLQPIGW DSFGLPAEET AIKNNISPKK WTFKNIKTMK KQLQSLGFSY 

       130        140        150        160        170        180 
DWNKEITTCN PEYYRWEQLF FIKLFKKKLI YKKKSIVNWC EKDKTVLANE QVQKGVCWRC 

       190        200        210        220        230        240 
GTKIKLRKIS QWFIKIKKYA DKFLKDLKLL KKWPKEVISM QKNWIGKSKG LKIKCKIYKK 

       250        260        270        280        290        300 
KYFLKIFTTK PETIMGISFF AISMYHPLIN LFLRKNIEIQ KFLKKNKYSI NTEFQKSNIL 

       310        320        330        340        350        360 
FGINTHLYVI HPINKKKIPL WISNYVKYNY ATGAIMSVPC SNKIDYNFSK LYNIPFIKIF 

       370        380        390        400        410        420 
SKKNKKLLIN SDNFNNLNIK KARNKISNFL INKKIAKKYI YYKIQDWCIS RQRYWGTPIP 

       430        440        450        460        470        480 
IVIDNKKNII TVPKKKLPVI LPKYIYKKKS LQSLSLYSLW LKTKISGKKV TRETDTLDTF 

       490        500        510        520        530        540 
MESSWYYARY TNPKYEKDII DPKASEYWLP VDQYIGGIEH AVMHLIYFRF YHKLLYDFGY 

       550        560        570        580        590        600 
VQSKEPVKKL ICQGMVIIDS FYKYNKDGSK KWLSISKIEI NRDSKGKIIS AIEKSSQKKI 

       610        620        630        640        650        660 
IYAGKIKMSK SKNNGIDPVN IIKQYGADSL RLFIMFAAPI NISLEWNSKN IIGMHRFLKK 

       670        680        690        700        710        720 
IWNFVFIIIK KKKEKIKKID LNKNKKTYIY KLNTIIKKVT YNIQERNSFN TAIAEIIKFF 

       730        740        750        760        770        780 
NYLVKLYKIY NIKKKNLIFC ISTIIKMLYP FTPHICFILW KKIYGKKSCI EKETWPKFNK 

       790        800        810        820        830        840 
KFFLKEKNNI IIQINGKKKD IMKIHAIISK KEIIKLILKN EKIKKHLYKK IIKKTIYIPN 


KVINFVL 

« Hide

References

[1]"A small microbial genome: the end of a long symbiotic relationship?"
Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A.
Science 314:312-313(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Cc.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000263 Genomic DNA. Translation: ABJ90736.1.
RefSeqYP_802829.1. NC_008513.1.

3D structure databases

ProteinModelPortalQ057G3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING372461.BCc_274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ90736; ABJ90736; BCc_274.
GeneID4440936.
KEGGbcc:BCc_274.
PATRIC21246493. VBIBucAph7855_0258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycBAPH372461:GHAJ-275-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BUCCC
AccessionPrimary (citable) accession number: Q057G3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries