ID   AROE_BUCCC              Reviewed;         280 AA.
AC   Q057D3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BCc_312;
OS   Buchnera aphidicola subsp. Cinara cedri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=372461;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17038625; DOI=10.1126/science.1130441;
RA   Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M.,
RA   Michelena J.M., Silva F.J., Moya A., Latorre A.;
RT   "A small microbial genome: the end of a long symbiotic relationship?";
RL   Science 314:312-313(2006).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000263; ABJ90766.1; -; Genomic_DNA.
DR   RefSeq; YP_802859.1; -.
DR   GeneID; 4440670; -.
DR   GenomeReviews; CP000263_GR; BCc_312.
DR   KEGG; bcc:BCc_312; -.
DR   OMA; Q057D3; YDMMYGR.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    280       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325110.
FT   NP_BIND     135    139       NADP (By similarity).
FT   ACT_SITE     74     74       Proton acceptor (Potential).
SQ   SEQUENCE   280 AA;  32079 MW;  F8E9EDC4A8A2A713 CRC64;
     MQNSKYCEKK IHIALFGNPI EHSLSPLIHK NFSKEIKINY NYNSFLCTKS NFFVIVKNFF
     QNGGFGCNIT VPFKKKSFQI SNKNTKYVKI SNSVNVLKKS SNNNIIGYNT DGIGLIYDLN
     RLKYITENSF ILILGSGGAV YSIVYHLLKK KCCIFILNRT ISKSCILVNK FKKFGKIFVF
     DKNLYTKKFD IIINATSCGL YNFSPKFPKN LIFPNTKCYD ISYSKNKKLT PFLSTCRDLG
     SRKYSDGLGM LVAQAAYSCY IWFNILPNIK KNINLLKSII
//