Reviewed, UniProtKB/Swiss-Prot Q057D3 (AROE_BUCCC)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BCc_312

Organism

Buchnera aphidicola subsp. Cinara cedri [Complete proteome] [HAMAP]

Taxonomic identifier

372461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325110
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	74	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q057D3-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: F8E9EDC4A8A2A713	FASTA	280	32,079
	10 20 30 40 50 60 MQNSKYCEKK IHIALFGNPI EHSLSPLIHK NFSKEIKINY NYNSFLCTKS NFFVIVKNFF 70 80 90 100 110 120 QNGGFGCNIT VPFKKKSFQI SNKNTKYVKI SNSVNVLKKS SNNNIIGYNT DGIGLIYDLN 130 140 150 160 170 180 RLKYITENSF ILILGSGGAV YSIVYHLLKK KCCIFILNRT ISKSCILVNK FKKFGKIFVF 190 200 210 220 230 240 DKNLYTKKFD IIINATSCGL YNFSPKFPKN LIFPNTKCYD ISYSKNKKLT PFLSTCRDLG 250 260 270 280 SRKYSDGLGM LVAQAAYSCY IWFNILPNIK KNINLLKSII

References

[1]	"A small microbial genome: the end of a long symbiotic relationship?" Perez-Brocal V., Gil R., Ramos S., Lamelas A., Postigo M., Michelena J.M., Silva F.J., Moya A., Latorre A. Science 314:312-313(2006) [PubMed: 17038625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000263 Genomic DNA. Translation: ABJ90766.1.
RefSeq	YP_802859.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4440670.
GenomeReviews	Gene locus BCc_312 in contig CP000263_GR.
KEGG	bcc:BCc_312.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q057D3. YDMMYGR.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BUCCC

Accession

Primary (citable) accession number: Q057D3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)