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Protein

High mobility group protein D

Gene

HmgD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 71HMG boxPROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

  • AT DNA binding Source: FlyBase
  • DNA binding Source: FlyBase
  • DNA binding, bending Source: FlyBase

GO - Biological processi

  • chromatin organization Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • muscle organ development Source: FlyBase

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein D
Short name:
HMG-D
Gene namesi
Name:HmgD
ORF Names:CG17950
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004362. HmgD.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleus Source: FlyBase

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485521 – 112High mobility group protein DAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine1 Publication1
Modified residuei12Phosphotyrosine1 Publication1
Modified residuei103Phosphoserine2 Publications1
Modified residuei111Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05783.
PRIDEiQ05783.

PTM databases

iPTMnetiQ05783.

Expressioni

Developmental stagei

Present in all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0004362.
GenevisibleiQ05783. DM.

Interactioni

Protein-protein interaction databases

BioGridi63106. 19 interactors.
DIPiDIP-22805N.
IntActiQ05783. 1 interactor.
MINTiMINT-843935.
STRINGi7227.FBpp0071625.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 25Combined sources15
Beta strandi27 – 29Combined sources3
Helixi32 – 45Combined sources14
Helixi50 – 70Combined sources21
Turni71 – 73Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783.
SMRiQ05783.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05783.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 112Asp/Glu-rich (acidic)Add BLAST12

Sequence similaritiesi

Belongs to the HMGB family.Curated

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
InParanoidiQ05783.
OMAiDSIKREN.
OrthoDBiEOG091G12RL.
PhylomeDBiQ05783.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPKRPLS AYMLWLNSAR ESIKRENPGI KVTEVAKRGG ELWRAMKDKS
60 70 80 90 100
EWEAKAAKAK DDYDRAVKEF EANGGSSAAN GGGAKKRAKP AKKVAKKSKK
110
EESDEDDDDE SE
Length:112
Mass (Da):12,416
Last modified:February 1, 1995 - v1
Checksum:i3F537CCFD62FEC9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA. Translation: AAA28609.1.
X71138 mRNA. Translation: CAA50468.1.
AM294353 Genomic DNA. Translation: CAL26283.1.
AM294354 Genomic DNA. Translation: CAL26284.1.
AM294355 Genomic DNA. Translation: CAL26285.1.
AM294356 Genomic DNA. Translation: CAL26286.1.
AM294357 Genomic DNA. Translation: CAL26287.1.
AM294358 Genomic DNA. Translation: CAL26288.1.
AM294359 Genomic DNA. Translation: CAL26289.1.
AM294360 Genomic DNA. Translation: CAL26290.1.
AM294361 Genomic DNA. Translation: CAL26291.1.
AM294362 Genomic DNA. Translation: CAL26292.1.
AM294363 Genomic DNA. Translation: CAL26293.1.
AE013599 Genomic DNA. Translation: AAF46759.1.
AY118333 mRNA. Translation: AAM48362.1.
PIRiA44382.
RefSeqiNP_001163244.1. NM_001169773.2.
NP_001286696.1. NM_001299767.1.
NP_726109.1. NM_166479.2.
NP_726110.1. NM_166480.2.
UniGeneiDm.7318.

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362.
FBtr0071709; FBpp0071626; FBgn0004362.
FBtr0301410; FBpp0290624; FBgn0004362.
FBtr0345487; FBpp0311598; FBgn0004362.
GeneIDi37481.
KEGGidme:Dmel_CG17950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA. Translation: AAA28609.1.
X71138 mRNA. Translation: CAA50468.1.
AM294353 Genomic DNA. Translation: CAL26283.1.
AM294354 Genomic DNA. Translation: CAL26284.1.
AM294355 Genomic DNA. Translation: CAL26285.1.
AM294356 Genomic DNA. Translation: CAL26286.1.
AM294357 Genomic DNA. Translation: CAL26287.1.
AM294358 Genomic DNA. Translation: CAL26288.1.
AM294359 Genomic DNA. Translation: CAL26289.1.
AM294360 Genomic DNA. Translation: CAL26290.1.
AM294361 Genomic DNA. Translation: CAL26291.1.
AM294362 Genomic DNA. Translation: CAL26292.1.
AM294363 Genomic DNA. Translation: CAL26293.1.
AE013599 Genomic DNA. Translation: AAF46759.1.
AY118333 mRNA. Translation: AAM48362.1.
PIRiA44382.
RefSeqiNP_001163244.1. NM_001169773.2.
NP_001286696.1. NM_001299767.1.
NP_726109.1. NM_166479.2.
NP_726110.1. NM_166480.2.
UniGeneiDm.7318.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783.
SMRiQ05783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63106. 19 interactors.
DIPiDIP-22805N.
IntActiQ05783. 1 interactor.
MINTiMINT-843935.
STRINGi7227.FBpp0071625.

PTM databases

iPTMnetiQ05783.

Proteomic databases

PaxDbiQ05783.
PRIDEiQ05783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362.
FBtr0071709; FBpp0071626; FBgn0004362.
FBtr0301410; FBpp0290624; FBgn0004362.
FBtr0345487; FBpp0311598; FBgn0004362.
GeneIDi37481.
KEGGidme:Dmel_CG17950.

Organism-specific databases

CTDi37481.
FlyBaseiFBgn0004362. HmgD.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
InParanoidiQ05783.
OMAiDSIKREN.
OrthoDBiEOG091G12RL.
PhylomeDBiQ05783.

Miscellaneous databases

ChiTaRSiHmgD. fly.
EvolutionaryTraceiQ05783.
GenomeRNAii37481.
PROiQ05783.

Gene expression databases

BgeeiFBgn0004362.
GenevisibleiQ05783. DM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHMGD_DROME
AccessioniPrimary (citable) accession number: Q05783
Secondary accession number(s): Q540Z0, Q9W2D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 15, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.