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Protein

High mobility group protein D

Gene

HmgD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 71HMG boxPROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

  • AT DNA binding Source: FlyBase
  • DNA binding Source: FlyBase
  • DNA binding, bending Source: FlyBase

GO - Biological processi

  • chromatin organization Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • muscle organ development Source: FlyBase

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein D
Short name:
HMG-D
Gene namesi
Name:HmgD
ORF Names:CG17950
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004362. HmgD.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485521 – 112High mobility group protein DAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine1 Publication1
Modified residuei12Phosphotyrosine1 Publication1
Modified residuei103Phosphoserine2 Publications1
Modified residuei111Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05783.
PRIDEiQ05783.

PTM databases

iPTMnetiQ05783.

Expressioni

Developmental stagei

Present in all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0004362.
ExpressionAtlasiQ05783. differential.
GenevisibleiQ05783. DM.

Interactioni

Protein-protein interaction databases

BioGridi63106. 23 interactors.
DIPiDIP-22805N.
IntActiQ05783. 1 interactor.
MINTiMINT-843935.
STRINGi7227.FBpp0071625.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 25Combined sources15
Beta strandi27 – 29Combined sources3
Helixi32 – 45Combined sources14
Helixi50 – 70Combined sources21
Turni71 – 73Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783.
SMRiQ05783.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05783.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 112Asp/Glu-rich (acidic)Add BLAST12

Sequence similaritiesi

Belongs to the HMGB family.Curated

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
InParanoidiQ05783.
OMAiDSIKREN.
OrthoDBiEOG091G12RL.
PhylomeDBiQ05783.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPKRPLS AYMLWLNSAR ESIKRENPGI KVTEVAKRGG ELWRAMKDKS
60 70 80 90 100
EWEAKAAKAK DDYDRAVKEF EANGGSSAAN GGGAKKRAKP AKKVAKKSKK
110
EESDEDDDDE SE
Length:112
Mass (Da):12,416
Last modified:February 1, 1995 - v1
Checksum:i3F537CCFD62FEC9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA. Translation: AAA28609.1.
X71138 mRNA. Translation: CAA50468.1.
AM294353 Genomic DNA. Translation: CAL26283.1.
AM294354 Genomic DNA. Translation: CAL26284.1.
AM294355 Genomic DNA. Translation: CAL26285.1.
AM294356 Genomic DNA. Translation: CAL26286.1.
AM294357 Genomic DNA. Translation: CAL26287.1.
AM294358 Genomic DNA. Translation: CAL26288.1.
AM294359 Genomic DNA. Translation: CAL26289.1.
AM294360 Genomic DNA. Translation: CAL26290.1.
AM294361 Genomic DNA. Translation: CAL26291.1.
AM294362 Genomic DNA. Translation: CAL26292.1.
AM294363 Genomic DNA. Translation: CAL26293.1.
AE013599 Genomic DNA. Translation: AAF46759.1.
AY118333 mRNA. Translation: AAM48362.1.
PIRiA44382.
RefSeqiNP_001163244.1. NM_001169773.2.
NP_001286696.1. NM_001299767.1.
NP_726109.1. NM_166479.2.
NP_726110.1. NM_166480.2.
UniGeneiDm.7318.

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362.
FBtr0071709; FBpp0071626; FBgn0004362.
FBtr0301410; FBpp0290624; FBgn0004362.
FBtr0345487; FBpp0311598; FBgn0004362.
GeneIDi37481.
KEGGidme:Dmel_CG17950.

Similar proteinsi

Entry informationi

Entry nameiHMGD_DROME
AccessioniPrimary (citable) accession number: Q05783
Secondary accession number(s): Q540Z0, Q9W2D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families