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Protein

High mobility group protein D

Gene

HmgD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 71HMG boxPROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

  • AT DNA binding Source: FlyBase
  • DNA binding Source: FlyBase
  • DNA binding, bending Source: FlyBase

GO - Biological processi

  • chromatin organization Source: FlyBase

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein D
Short name:
HMG-D
Gene namesi
Name:HmgD
ORF Names:CG17950
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0004362 HmgD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485521 – 112High mobility group protein DAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine1 Publication1
Modified residuei12Phosphotyrosine1 Publication1
Modified residuei103Phosphoserine2 Publications1
Modified residuei111Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05783
PRIDEiQ05783

PTM databases

iPTMnetiQ05783

Expressioni

Developmental stagei

Present in all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0004362
ExpressionAtlasiQ05783 baseline and differential
GenevisibleiQ05783 DM

Interactioni

Protein-protein interaction databases

BioGridi63106, 23 interactors
DIPiDIP-22805N
IntActiQ05783, 1 interactor
STRINGi7227.FBpp0071625

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 25Combined sources15
Beta strandi27 – 29Combined sources3
Helixi32 – 45Combined sources14
Helixi50 – 70Combined sources21
Turni71 – 73Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783
SMRiQ05783
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05783

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 112Asp/Glu-rich (acidic)Add BLAST12

Sequence similaritiesi

Belongs to the HMGB family.Curated

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
InParanoidiQ05783
OMAiDSIKREN
OrthoDBiEOG091G12RL
PhylomeDBiQ05783

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q05783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPKRPLS AYMLWLNSAR ESIKRENPGI KVTEVAKRGG ELWRAMKDKS
60 70 80 90 100
EWEAKAAKAK DDYDRAVKEF EANGGSSAAN GGGAKKRAKP AKKVAKKSKK
110
EESDEDDDDE SE
Length:112
Mass (Da):12,416
Last modified:February 1, 1995 - v1
Checksum:i3F537CCFD62FEC9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA Translation: AAA28609.1
X71138 mRNA Translation: CAA50468.1
AM294353 Genomic DNA Translation: CAL26283.1
AM294354 Genomic DNA Translation: CAL26284.1
AM294355 Genomic DNA Translation: CAL26285.1
AM294356 Genomic DNA Translation: CAL26286.1
AM294357 Genomic DNA Translation: CAL26287.1
AM294358 Genomic DNA Translation: CAL26288.1
AM294359 Genomic DNA Translation: CAL26289.1
AM294360 Genomic DNA Translation: CAL26290.1
AM294361 Genomic DNA Translation: CAL26291.1
AM294362 Genomic DNA Translation: CAL26292.1
AM294363 Genomic DNA Translation: CAL26293.1
AE013599 Genomic DNA Translation: AAF46759.1
AY118333 mRNA Translation: AAM48362.1
PIRiA44382
RefSeqiNP_001163244.1, NM_001169773.2
NP_001286696.1, NM_001299767.1
NP_726109.1, NM_166479.2
NP_726110.1, NM_166480.2
UniGeneiDm.7318

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362
FBtr0071709; FBpp0071626; FBgn0004362
FBtr0301410; FBpp0290624; FBgn0004362
FBtr0345487; FBpp0311598; FBgn0004362
GeneIDi37481
KEGGidme:Dmel_CG17950

Entry informationi

Entry nameiHMGD_DROME
AccessioniPrimary (citable) accession number: Q05783
Secondary accession number(s): Q540Z0, Q9W2D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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