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Protein

High mobility group protein D

Gene

HmgD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi5 – 7167HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • AT DNA binding Source: FlyBase
  • DNA binding Source: FlyBase
  • DNA binding, bending Source: FlyBase

GO - Biological processi

  • chromatin organization Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • muscle organ development Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DME-112382. Formation of RNA Pol II elongation complex.
R-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-DME-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein D
Short name:
HMG-D
Gene namesi
Name:HmgD
ORF Names:CG17950
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004362. HmgD.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112High mobility group protein DPRO_0000048552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei12 – 121Phosphotyrosine1 Publication
Modified residuei103 – 1031Phosphoserine2 Publications
Modified residuei111 – 1111Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05783.
PRIDEiQ05783.

PTM databases

iPTMnetiQ05783.

Expressioni

Developmental stagei

Present in all stages of development.1 Publication

Gene expression databases

BgeeiFBgn0004362.
ExpressionAtlasiQ05783. differential.
GenevisibleiQ05783. DM.

Interactioni

Protein-protein interaction databases

BioGridi63106. 19 interactions.
DIPiDIP-22805N.
IntActiQ05783. 1 interaction.
MINTiMINT-843935.
STRINGi7227.FBpp0071625.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2515Combined sources
Beta strandi27 – 293Combined sources
Helixi32 – 4514Combined sources
Helixi50 – 7021Combined sources
Turni71 – 733Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783.
SMRiQ05783. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05783.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 11212Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
InParanoidiQ05783.
OMAiDSIKREN.
OrthoDBiEOG091G12RL.
PhylomeDBiQ05783.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPKRPLS AYMLWLNSAR ESIKRENPGI KVTEVAKRGG ELWRAMKDKS
60 70 80 90 100
EWEAKAAKAK DDYDRAVKEF EANGGSSAAN GGGAKKRAKP AKKVAKKSKK
110
EESDEDDDDE SE
Length:112
Mass (Da):12,416
Last modified:February 1, 1995 - v1
Checksum:i3F537CCFD62FEC9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA. Translation: AAA28609.1.
X71138 mRNA. Translation: CAA50468.1.
AM294353 Genomic DNA. Translation: CAL26283.1.
AM294354 Genomic DNA. Translation: CAL26284.1.
AM294355 Genomic DNA. Translation: CAL26285.1.
AM294356 Genomic DNA. Translation: CAL26286.1.
AM294357 Genomic DNA. Translation: CAL26287.1.
AM294358 Genomic DNA. Translation: CAL26288.1.
AM294359 Genomic DNA. Translation: CAL26289.1.
AM294360 Genomic DNA. Translation: CAL26290.1.
AM294361 Genomic DNA. Translation: CAL26291.1.
AM294362 Genomic DNA. Translation: CAL26292.1.
AM294363 Genomic DNA. Translation: CAL26293.1.
AE013599 Genomic DNA. Translation: AAF46759.1.
AY118333 mRNA. Translation: AAM48362.1.
PIRiA44382.
RefSeqiNP_001163244.1. NM_001169773.2.
NP_001286696.1. NM_001299767.1.
NP_726109.1. NM_166479.2.
NP_726110.1. NM_166480.2.
UniGeneiDm.7318.

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362.
FBtr0071709; FBpp0071626; FBgn0004362.
FBtr0301410; FBpp0290624; FBgn0004362.
FBtr0345487; FBpp0311598; FBgn0004362.
GeneIDi37481.
KEGGidme:Dmel_CG17950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77023 mRNA. Translation: AAA28609.1.
X71138 mRNA. Translation: CAA50468.1.
AM294353 Genomic DNA. Translation: CAL26283.1.
AM294354 Genomic DNA. Translation: CAL26284.1.
AM294355 Genomic DNA. Translation: CAL26285.1.
AM294356 Genomic DNA. Translation: CAL26286.1.
AM294357 Genomic DNA. Translation: CAL26287.1.
AM294358 Genomic DNA. Translation: CAL26288.1.
AM294359 Genomic DNA. Translation: CAL26289.1.
AM294360 Genomic DNA. Translation: CAL26290.1.
AM294361 Genomic DNA. Translation: CAL26291.1.
AM294362 Genomic DNA. Translation: CAL26292.1.
AM294363 Genomic DNA. Translation: CAL26293.1.
AE013599 Genomic DNA. Translation: AAF46759.1.
AY118333 mRNA. Translation: AAM48362.1.
PIRiA44382.
RefSeqiNP_001163244.1. NM_001169773.2.
NP_001286696.1. NM_001299767.1.
NP_726109.1. NM_166479.2.
NP_726110.1. NM_166480.2.
UniGeneiDm.7318.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E7JNMR-A1-74[»]
1HMANMR-A2-74[»]
1QRVX-ray2.20A/B2-74[»]
3NM9X-ray2.85A/D/G/J/M/P2-74[»]
ProteinModelPortaliQ05783.
SMRiQ05783. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63106. 19 interactions.
DIPiDIP-22805N.
IntActiQ05783. 1 interaction.
MINTiMINT-843935.
STRINGi7227.FBpp0071625.

PTM databases

iPTMnetiQ05783.

Proteomic databases

PaxDbiQ05783.
PRIDEiQ05783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071708; FBpp0071625; FBgn0004362.
FBtr0071709; FBpp0071626; FBgn0004362.
FBtr0301410; FBpp0290624; FBgn0004362.
FBtr0345487; FBpp0311598; FBgn0004362.
GeneIDi37481.
KEGGidme:Dmel_CG17950.

Organism-specific databases

CTDi37481.
FlyBaseiFBgn0004362. HmgD.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
InParanoidiQ05783.
OMAiDSIKREN.
OrthoDBiEOG091G12RL.
PhylomeDBiQ05783.

Enzyme and pathway databases

ReactomeiR-DME-112382. Formation of RNA Pol II elongation complex.
R-DME-674695. RNA Polymerase II Pre-transcription Events.
R-DME-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-DME-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

ChiTaRSiHmgD. fly.
EvolutionaryTraceiQ05783.
GenomeRNAii37481.
PROiQ05783.

Gene expression databases

BgeeiFBgn0004362.
ExpressionAtlasiQ05783. differential.
GenevisibleiQ05783. DM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGD_DROME
AccessioniPrimary (citable) accession number: Q05783
Secondary accession number(s): Q540Z0, Q9W2D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.