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Protein

Eukaryotic translation initiation factor 3 subunit J

Gene

HCR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation1 Publication

Miscellaneous

Present with 17900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • translation initiation factor activity Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32314-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit JUniRule annotation
Short name:
eIF3jUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 30 kDa subunit
Short name:
eIF-3 30 kDa
Gene namesi
Name:HCR1UniRule annotation
Ordered Locus Names:YLR192C
ORF Names:L8167.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR192C
SGDiS000004182 HCR1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Marked reduction in binding of the eIF-3 core complex to 40S ribosomes.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi215R → I: Increased association of the eIF-3 complex and 40S ribosomes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001235091 – 265Eukaryotic translation initiation factor 3 subunit JAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphothreonineCombined sources1
Modified residuei92PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05775
PaxDbiQ05775
PRIDEiQ05775

PTM databases

iPTMnetiQ05775

Interactioni

Subunit structurei

Probable component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Is not part of the eIF-3 core complex, with which it is associated in substochiometric amounts.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31462348 interactors.
DIPiDIP-4532N
IntActiQ05775 30 interactors.
MINTiQ05775
STRINGi4932.YLR192C

Structurei

3D structure databases

ProteinModelPortaliQ05775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-3 subunit J family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246847
InParanoidiQ05775
KOiK03245
OMAiNAHPRER
OrthoDBiEOG092C4T6B

Family and domain databases

Gene3Di1.10.246.601 hit
HAMAPiMF_03009 eIF3j, 1 hit
InterProiView protein in InterPro
IPR023194 eIF3-like_dom_sf
IPR013906 eIF3j
PANTHERiPTHR21681 PTHR21681, 1 hit
PfamiView protein in Pfam
PF08597 eIF3_subunit, 1 hit

Sequencei

Sequence statusi: Complete.

Q05775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWDDEAING SMGNDDAVLM DSWDAEIGDD EPVMQSWDAE EEEKKPAPKP
60 70 80 90 100
KKEQPKKVKK GKESSADRAL LDIDTLDEKT RKELIKKAEM ESDLNNAADL
110 120 130 140 150
FAGLGVAEEH PRARALQKEQ EEQALKRPAF TKDTPIETHP LFNAETKREY
160 170 180 190 200
QDLRKALTAA ITPMNKKSPL NYSSSLAIDL IRDVAKPMSI ESIRQTVATL
210 220 230 240 250
NVLIKDKERE ERQARLARVR GGTATGGAGK KKVKGKTNLG GAFKKDQDFD
260
LDGPDDFEFG DDDFM
Length:265
Mass (Da):29,564
Last modified:November 1, 1996 - v1
Checksum:iBDDBC5943DD7F9BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14913 Genomic DNA Translation: AAB67433.1
AY557943 Genomic DNA Translation: AAS56269.1
BK006945 Genomic DNA Translation: DAA09511.1
PIRiS48545
RefSeqiNP_013293.1, NM_001182079.1

Genome annotation databases

EnsemblFungiiYLR192C; YLR192C; YLR192C
GeneIDi850889
KEGGisce:YLR192C

Similar proteinsi

Entry informationi

Entry nameiEIF3J_YEAST
AccessioniPrimary (citable) accession number: Q05775
Secondary accession number(s): D6VYJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome