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Q05767

- Q05767_BRANA

UniProt

Q05767 - Q05767_BRANA

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Protein

Acetolactate synthase

Gene

ALS2

Organism
Brassica napus (Rape)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 pyruvate = 2-acetolactate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.
Binds 1 thiamine pyrophosphate per subunit.

Pathwayi

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00047; UER00055.
UPA00049; UER00059.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
Gene namesi
Name:ALS2Imported
OrganismiBrassica napus (Rape)Imported
Taxonomic identifieri3708 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Structurei

3D structure databases

ProteinModelPortaliQ05767.
SMRiQ05767. Positions 22-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05767-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLLPLKKP TRTRLSSPAT LPDEPRKGAD ILVEALERQG VETVFAYPGG
60 70 80 90 100
ASMEIHQALT RSSTIRNVLP RHEQGGVFAA EGYARSSGKP GICIATSGPG
110 120 130 140 150
ATNLVSGLAD AMLDSVPLVA ITGQVPRRMI GTDAFQETPI VEVTRSITKH
160 170 180 190 200
NYLVMDVDDI PRIVQEAFFL ATSGRPGPVL VDVPKDIQQQ LAIPNWDQPM
210 220 230 240 250
RLPGYMSRLP QPPEVSQLGQ IVRLISESKR PVLYVGGGSL NSSEELGRFV
260 270 280 290 300
ELTGIPVAST LMGLGSYPCN DELSLQMLGM HGTVYANYAV EHSDLLLAFG
310 320 330 340 350
VRFDDRVTGK LEAFASRAKI VHIDIDSAEI GKNKTPHVSV CGDVKLALQG
360 370 380 390 400
MNKVLENRAE ELKLDFGVWR SELSEQKQKF PLSFKTFGEA IPPQYAIQIL
410 420 430 440 450
DELTEGKAII STGVGQHQMW AAQFYKYRKP RQWLSSSGLG AMGFGLPAAI
460 470 480 490 500
GASVANPDAI VVDIDGDGSF IMNVQELATI RVENLPVKIL LLNNQHLGMV
510 520 530 540 550
MQWEDRFYKA NRAHTYLGDP ARENEIFPNM LQFAGACGIP AARVTKKEEL
560 570 580 590
REAIQTMLDT PGPYLLDVIC PHQEHVLPMI PSGGTFKDVI TEGDGRTKY
Length:599
Mass (Da):65,458
Last modified:November 1, 1996 - v1
Checksum:i00CD148858DFD91A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60068 mRNA. Translation: AAA62705.1.
PIRiS15004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60068 mRNA. Translation: AAA62705.1 .
PIRi S15004.

3D structure databases

ProteinModelPortali Q05767.
SMRi Q05767. Positions 22-596.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00055 .
UPA00049 ; UER00059 .

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR012846. Acetolactate_synth_lsu.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view ]
Pfami PF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00118. acolac_lg. 1 hit.
PROSITEi PS00187. TPP_ENZYMES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, structure and expression of a cDNA for acetolactate synthase from Brassica napus."
    Bekkaoui F., Condie J.A., Neustaedter D.A., Moloney M.M., Crosby W.L.
    Plant Mol. Biol. 16:741-744(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WestarImported.

Entry informationi

Entry nameiQ05767_BRANA
AccessioniPrimary (citable) accession number: Q05767
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)