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Q05766

- CYAA_PASMU

UniProt

Q05766 - CYAA_PASMU

Protein

Adenylate cyclase

Gene

cya

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMUL272843:GC8W-1886-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cya
    Ordered Locus Names:PM1811
    OrganismiPasteurella multocida (strain Pm70)
    Taxonomic identifieri272843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
    ProteomesiUP000000809: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 838838Adenylate cyclasePRO_0000195677Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272843.PM1811.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 541541CatalyticSequence AnalysisAdd
    BLAST
    Regioni547 – 838292RegulatorySequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-1 family.Curated

    Phylogenomic databases

    eggNOGiCOG3072.
    HOGENOMiHOG000270910.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05766-1 [UniParc]FASTAAdd to Basket

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    MNYDLFSAQK KVEYLDKLRI ERALSGSSGE FQHVFQLLTL LLHINHPNLP    50
    GYVADAPVGI ADFVISPYQK QYLLTTVPSL EANQSLLPSF SYRSTNAILG 100
    VYVMGSIASI SQTPKSDLDT WVCHRDDLST KEKEALQRKT HLLKNWAKQF 150
    NIEINFYLMD QKRFRCFRYA EPLTAENCGS AQYMLLLDEF YRSAIRLAGK 200
    PLLWLHLLIE QEENYESEVE RLVRTQQICL DDWVDFGGLG QLSANEYFGA 250
    SLWQLYKGID APYKSVIKIL LLETYSSEYP NTYLIARQFK EELLTGKLNP 300
    SHHFDPYLAM LQRATRYLTK HNELKRLGFV RRSVYLKATE GMCWQDPNAT 350
    NNWRLQHLQK LIQEWDWSDA LIEELNQRAN WKIKQVKKAH NSLIKFLMLS 400
    YRNLVAFARK HKVNSSIMPQ DISVLTRKLY TAFEELPGKI TLLNPQISLN 450
    LSEKNLLFFE VKGSKTFKDG WYVVNQTPSV AGFVQKRYTE YSESLNKLVA 500
    WAYFNRILTA NTDLHIISPN VSLTTLRHFV TDLRLSFPVT VSSVTNEDLT 550
    HACEIRSLIV AVNLTVDPTK KITQVKSRIQ ASDLFSFGPK EESLVGSIDI 600
    TYRNLWNEIR TLHFEGPNAI LLALKVLSNK IHRGAPSPKL IQVFSYSHRY 650
    RRTLSNIVTA LINRCISIQI GDALPPQNNL LRVAGKNWQF FFEERGISLQ 700
    EIHSNEELEA TGFDTALQTE VEEKESALPD TSRTYPPEID HFASEGFLQF 750
    FFEDNSDGSF NVYILDEANR IEIYRNCDGQ KEKKILEINH IYQSSGLDEN 800
    NNPYKIVQRD FNYPQFYQLL LQENGVKIVP FHSRLAMS 838
    Length:838
    Mass (Da):96,799
    Last modified:April 27, 2001 - v2
    Checksum:i08D64CA7B0A30E62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti469 – 4691D → A in AAA25532. (PubMed:1917858)Curated
    Sequence conflicti659 – 6602TA → PH in AAA25532. (PubMed:1917858)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68901 Genomic DNA. Translation: AAA25532.1.
    AE004439 Genomic DNA. Translation: AAK03895.1.
    PIRiA38172.
    RefSeqiNP_246750.1. NC_002663.1.

    Genome annotation databases

    EnsemblBacteriaiAAK03895; AAK03895; PM1811.
    GeneIDi1245158.
    KEGGipmu:PM1811.
    PATRICi22872949. VBIPasMul88067_1835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68901 Genomic DNA. Translation: AAA25532.1 .
    AE004439 Genomic DNA. Translation: AAK03895.1 .
    PIRi A38172.
    RefSeqi NP_246750.1. NC_002663.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272843.PM1811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK03895 ; AAK03895 ; PM1811 .
    GeneIDi 1245158.
    KEGGi pmu:PM1811.
    PATRICi 22872949. VBIPasMul88067_1835.

    Phylogenomic databases

    eggNOGi COG3072.
    HOGENOMi HOG000270910.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.

    Enzyme and pathway databases

    BioCyci PMUL272843:GC8W-1886-MONOMER.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional relationships between Pasteurella multocida and enterobacterial adenylate cyclases."
      Mock M., Crasnier M., Duflot E., Dumay V., Danchin A.
      J. Bacteriol. 173:6265-6269(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43137 / LMG 2851 / NCTC 10322 / W-9217.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pm70.
    3. "Phylogeny of adenylyl cyclases."
      Danchin A.
      Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCYAA_PASMU
    AccessioniPrimary (citable) accession number: Q05766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3