Q05766 (CYAA_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:	cya
Ordered Locus Names:	PM1811

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella › Pasteurella multocida › Pasteurella multocida subsp. multocida

Protein attributes

Sequence length	838 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 838	838	Adenylate cyclase		PRO_0000195677
Regions
	Region	1 – 541	541	Catalytic Potential
	Region	547 – 838	292	Regulatory Potential
Experimental info
	Sequence conflict	469	1	D → A in AAA25532. Ref.1
	Sequence conflict	659 – 660	2	TA → PH in AAA25532. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q05766 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 08D64CA7B0A30E62	FASTA	838	96,799
	10 20 30 40 50 60 MNYDLFSAQK KVEYLDKLRI ERALSGSSGE FQHVFQLLTL LLHINHPNLP GYVADAPVGI 70 80 90 100 110 120 ADFVISPYQK QYLLTTVPSL EANQSLLPSF SYRSTNAILG VYVMGSIASI SQTPKSDLDT 130 140 150 160 170 180 WVCHRDDLST KEKEALQRKT HLLKNWAKQF NIEINFYLMD QKRFRCFRYA EPLTAENCGS 190 200 210 220 230 240 AQYMLLLDEF YRSAIRLAGK PLLWLHLLIE QEENYESEVE RLVRTQQICL DDWVDFGGLG 250 260 270 280 290 300 QLSANEYFGA SLWQLYKGID APYKSVIKIL LLETYSSEYP NTYLIARQFK EELLTGKLNP 310 320 330 340 350 360 SHHFDPYLAM LQRATRYLTK HNELKRLGFV RRSVYLKATE GMCWQDPNAT NNWRLQHLQK 370 380 390 400 410 420 LIQEWDWSDA LIEELNQRAN WKIKQVKKAH NSLIKFLMLS YRNLVAFARK HKVNSSIMPQ 430 440 450 460 470 480 DISVLTRKLY TAFEELPGKI TLLNPQISLN LSEKNLLFFE VKGSKTFKDG WYVVNQTPSV 490 500 510 520 530 540 AGFVQKRYTE YSESLNKLVA WAYFNRILTA NTDLHIISPN VSLTTLRHFV TDLRLSFPVT 550 560 570 580 590 600 VSSVTNEDLT HACEIRSLIV AVNLTVDPTK KITQVKSRIQ ASDLFSFGPK EESLVGSIDI 610 620 630 640 650 660 TYRNLWNEIR TLHFEGPNAI LLALKVLSNK IHRGAPSPKL IQVFSYSHRY RRTLSNIVTA 670 680 690 700 710 720 LINRCISIQI GDALPPQNNL LRVAGKNWQF FFEERGISLQ EIHSNEELEA TGFDTALQTE 730 740 750 760 770 780 VEEKESALPD TSRTYPPEID HFASEGFLQF FFEDNSDGSF NVYILDEANR IEIYRNCDGQ 790 800 810 820 830 KEKKILEINH IYQSSGLDEN NNPYKIVQRD FNYPQFYQLL LQENGVKIVP FHSRLAMS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural and functional relationships between Pasteurella multocida and enterobacterial adenylate cyclases." Mock M., Crasnier M., Duflot E., Dumay V., Danchin A. J. Bacteriol. 173:6265-6269(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43137 / LMG 2851 / NCTC 10322 / W-9217.
[2]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
[3]	"Phylogeny of adenylyl cyclases." Danchin A. Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M68901 Genomic DNA. Translation: AAA25532.1. AE004439 Genomic DNA. Translation: AAK03895.1.
PIR	A38172.
RefSeq	NP_246750.1. NC_002663.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272843.PM1811.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK03895; AAK03895; PM1811.
GeneID	1245158.
KEGG	pmu:PM1811.
PATRIC	22872949. VBIPasMul88067_1835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3072.
HOGENOM	HOG000270910.
KO	K05851.
OMA	LWQLYKG.
ProtClustDB	PRK09450.
Family and domain databases
InterPro	IPR000274. Adenylate_cyclase_1. IPR024686. Adenylate_cyclase_1_CS. IPR024685. Adenylate_cyclase_1_N. [Graphical view]
Pfam	PF12633. Adenyl_cycl_N. 1 hit. PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_PASMU

Accession

Primary (citable) accession number: Q05766

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program