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Q05766 (CYAA_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cya
Ordered Locus Names:PM1811
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 838838Adenylate cyclase
PRO_0000195677

Regions

Region1 – 541541Catalytic Potential
Region547 – 838292Regulatory Potential

Experimental info

Sequence conflict4691D → A in AAA25532. Ref.1
Sequence conflict659 – 6602TA → PH in AAA25532. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q05766 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 08D64CA7B0A30E62

FASTA83896,799
        10         20         30         40         50         60 
MNYDLFSAQK KVEYLDKLRI ERALSGSSGE FQHVFQLLTL LLHINHPNLP GYVADAPVGI 

        70         80         90        100        110        120 
ADFVISPYQK QYLLTTVPSL EANQSLLPSF SYRSTNAILG VYVMGSIASI SQTPKSDLDT 

       130        140        150        160        170        180 
WVCHRDDLST KEKEALQRKT HLLKNWAKQF NIEINFYLMD QKRFRCFRYA EPLTAENCGS 

       190        200        210        220        230        240 
AQYMLLLDEF YRSAIRLAGK PLLWLHLLIE QEENYESEVE RLVRTQQICL DDWVDFGGLG 

       250        260        270        280        290        300 
QLSANEYFGA SLWQLYKGID APYKSVIKIL LLETYSSEYP NTYLIARQFK EELLTGKLNP 

       310        320        330        340        350        360 
SHHFDPYLAM LQRATRYLTK HNELKRLGFV RRSVYLKATE GMCWQDPNAT NNWRLQHLQK 

       370        380        390        400        410        420 
LIQEWDWSDA LIEELNQRAN WKIKQVKKAH NSLIKFLMLS YRNLVAFARK HKVNSSIMPQ 

       430        440        450        460        470        480 
DISVLTRKLY TAFEELPGKI TLLNPQISLN LSEKNLLFFE VKGSKTFKDG WYVVNQTPSV 

       490        500        510        520        530        540 
AGFVQKRYTE YSESLNKLVA WAYFNRILTA NTDLHIISPN VSLTTLRHFV TDLRLSFPVT 

       550        560        570        580        590        600 
VSSVTNEDLT HACEIRSLIV AVNLTVDPTK KITQVKSRIQ ASDLFSFGPK EESLVGSIDI 

       610        620        630        640        650        660 
TYRNLWNEIR TLHFEGPNAI LLALKVLSNK IHRGAPSPKL IQVFSYSHRY RRTLSNIVTA 

       670        680        690        700        710        720 
LINRCISIQI GDALPPQNNL LRVAGKNWQF FFEERGISLQ EIHSNEELEA TGFDTALQTE 

       730        740        750        760        770        780 
VEEKESALPD TSRTYPPEID HFASEGFLQF FFEDNSDGSF NVYILDEANR IEIYRNCDGQ 

       790        800        810        820        830 
KEKKILEINH IYQSSGLDEN NNPYKIVQRD FNYPQFYQLL LQENGVKIVP FHSRLAMS 

« Hide

References

« Hide 'large scale' references
[1]"Structural and functional relationships between Pasteurella multocida and enterobacterial adenylate cyclases."
Mock M., Crasnier M., Duflot E., Dumay V., Danchin A.
J. Bacteriol. 173:6265-6269(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 43137 / LMG 2851 / NCTC 10322 / W-9217.
[2]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.
[3]"Phylogeny of adenylyl cyclases."
Danchin A.
Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68901 Genomic DNA. Translation: AAA25532.1.
AE004439 Genomic DNA. Translation: AAK03895.1.
PIRA38172.
RefSeqNP_246750.1. NC_002663.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272843.PM1811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK03895; AAK03895; PM1811.
GeneID1245158.
KEGGpmu:PM1811.
PATRIC22872949. VBIPasMul88067_1835.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3072.
HOGENOMHOG000270910.
KOK05851.
OMASEGFLQF.
OrthoDBEOG63JR9H.

Enzyme and pathway databases

BioCycPMUL272843:GC8W-1886-MONOMER.

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_PASMU
AccessionPrimary (citable) accession number: Q05766
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families