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Protein

Adenylate cyclase

Gene

cya

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cya
Ordered Locus Names:PM1811
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956771 – 838Adenylate cyclaseAdd BLAST838

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1811.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 541CatalyticSequence analysisAdd BLAST541
Regioni547 – 838RegulatorySequence analysisAdd BLAST292

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.Curated

Phylogenomic databases

eggNOGiENOG4107T0K. Bacteria.
COG3072. LUCA.
HOGENOMiHOG000270910.
KOiK05851.
OMAiDYVMSLY.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYDLFSAQK KVEYLDKLRI ERALSGSSGE FQHVFQLLTL LLHINHPNLP
60 70 80 90 100
GYVADAPVGI ADFVISPYQK QYLLTTVPSL EANQSLLPSF SYRSTNAILG
110 120 130 140 150
VYVMGSIASI SQTPKSDLDT WVCHRDDLST KEKEALQRKT HLLKNWAKQF
160 170 180 190 200
NIEINFYLMD QKRFRCFRYA EPLTAENCGS AQYMLLLDEF YRSAIRLAGK
210 220 230 240 250
PLLWLHLLIE QEENYESEVE RLVRTQQICL DDWVDFGGLG QLSANEYFGA
260 270 280 290 300
SLWQLYKGID APYKSVIKIL LLETYSSEYP NTYLIARQFK EELLTGKLNP
310 320 330 340 350
SHHFDPYLAM LQRATRYLTK HNELKRLGFV RRSVYLKATE GMCWQDPNAT
360 370 380 390 400
NNWRLQHLQK LIQEWDWSDA LIEELNQRAN WKIKQVKKAH NSLIKFLMLS
410 420 430 440 450
YRNLVAFARK HKVNSSIMPQ DISVLTRKLY TAFEELPGKI TLLNPQISLN
460 470 480 490 500
LSEKNLLFFE VKGSKTFKDG WYVVNQTPSV AGFVQKRYTE YSESLNKLVA
510 520 530 540 550
WAYFNRILTA NTDLHIISPN VSLTTLRHFV TDLRLSFPVT VSSVTNEDLT
560 570 580 590 600
HACEIRSLIV AVNLTVDPTK KITQVKSRIQ ASDLFSFGPK EESLVGSIDI
610 620 630 640 650
TYRNLWNEIR TLHFEGPNAI LLALKVLSNK IHRGAPSPKL IQVFSYSHRY
660 670 680 690 700
RRTLSNIVTA LINRCISIQI GDALPPQNNL LRVAGKNWQF FFEERGISLQ
710 720 730 740 750
EIHSNEELEA TGFDTALQTE VEEKESALPD TSRTYPPEID HFASEGFLQF
760 770 780 790 800
FFEDNSDGSF NVYILDEANR IEIYRNCDGQ KEKKILEINH IYQSSGLDEN
810 820 830
NNPYKIVQRD FNYPQFYQLL LQENGVKIVP FHSRLAMS
Length:838
Mass (Da):96,799
Last modified:April 27, 2001 - v2
Checksum:i08D64CA7B0A30E62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti469D → A in AAA25532 (PubMed:1917858).Curated1
Sequence conflicti659 – 660TA → PH in AAA25532 (PubMed:1917858).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68901 Genomic DNA. Translation: AAA25532.1.
AE004439 Genomic DNA. Translation: AAK03895.1.
PIRiA38172.
RefSeqiWP_005724808.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03895; AAK03895; PM1811.
GeneIDi1245158.
KEGGipmu:PM1811.
PATRICi22872949. VBIPasMul88067_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68901 Genomic DNA. Translation: AAA25532.1.
AE004439 Genomic DNA. Translation: AAK03895.1.
PIRiA38172.
RefSeqiWP_005724808.1. NC_002663.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM1811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK03895; AAK03895; PM1811.
GeneIDi1245158.
KEGGipmu:PM1811.
PATRICi22872949. VBIPasMul88067_1835.

Phylogenomic databases

eggNOGiENOG4107T0K. Bacteria.
COG3072. LUCA.
HOGENOMiHOG000270910.
KOiK05851.
OMAiDYVMSLY.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYAA_PASMU
AccessioniPrimary (citable) accession number: Q05766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.