ID PIT1_MELGA Reviewed; 370 AA. AC Q05749; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 27-MAR-2024, entry version 130. DE RecName: Full=Pituitary-specific positive transcription factor 1; DE Short=PIT-1; DE AltName: Full=Growth hormone factor 1; DE Short=GHF-1; GN Name=POU1F1; Synonyms=PIT1; OS Meleagris gallopavo (Wild turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Meleagridinae; Meleagris. OX NCBI_TaxID=9103; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pituitary; RX PubMed=1418622; DOI=10.1089/dna.1992.11.651; RA Wong E.A., Silsby J.L., el Halawani M.E.; RT "Complementary DNA cloning and expression of Pit-1/GHF-1 from the domestic RT turkey."; RL DNA Cell Biol. 11:651-660(1992). RN [2] RP SEQUENCE REVISION, AND ALTERNATIVE SPLICING. RA Wong E.A., Sharova L., Kurima K., Weatherly K.L.; RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Transcription factor that activates growth hormone and CC prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- CC 3'. {ECO:0000250|UniProtKB:P28069}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28069}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=PIT-1beta*; CC IsoId=Q05749-1; Sequence=Displayed; CC Name=PIT-1; CC IsoId=Q05749-2; Sequence=VSP_002318; CC Name=PIT-1*; CC IsoId=Q05749-3; Sequence=VSP_002319; CC -!- TISSUE SPECIFICITY: Pituitary gland. CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large CC number of yeast and animal transcription factors. CC {ECO:0000250|UniProtKB:P28069}. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-1 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U18928; AAB04690.1; -; Genomic_DNA. DR EMBL; U62732; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18923; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18924; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18925; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18926; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18927; AAB04690.1; JOINED; Genomic_DNA. DR EMBL; U18928; AAB04691.1; -; Genomic_DNA. DR EMBL; U62732; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18923; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18924; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18925; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18926; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18927; AAB04691.1; JOINED; Genomic_DNA. DR EMBL; U18928; AAB04692.1; -; Genomic_DNA. DR EMBL; U18923; AAB04692.1; JOINED; Genomic_DNA. DR EMBL; U18924; AAB04692.1; JOINED; Genomic_DNA. DR EMBL; U18925; AAB04692.1; JOINED; Genomic_DNA. DR EMBL; U18926; AAB04692.1; JOINED; Genomic_DNA. DR EMBL; U18927; AAB04692.1; JOINED; Genomic_DNA. DR EMBL; X69471; CAA49229.1; ALT_SEQ; mRNA. DR PIR; S26693; S26693. DR RefSeq; NP_001290151.1; NM_001303222.1. DR AlphaFoldDB; Q05749; -. DR SMR; Q05749; -. DR GeneID; 100151749; -. DR KEGG; mgp:100151749; -. DR CTD; 5449; -. DR InParanoid; Q05749; -. DR OrthoDB; 4250502at2759; -. DR Proteomes; UP000001645; Unplaced. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR PANTHER; PTHR11636:SF84; PITUITARY-SPECIFIC POSITIVE TRANSCRIPTION FACTOR 1; 1. DR PANTHER; PTHR11636; POU DOMAIN; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00157; Pou; 1. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. PE 2: Evidence at transcript level; KW Activator; Alternative splicing; DNA-binding; Homeobox; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..370 FT /note="Pituitary-specific positive transcription factor 1" FT /id="PRO_0000100704" FT DOMAIN 202..276 FT /note="POU-specific" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" FT DNA_BIND 292..351 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT MOTIF 5..13 FT /note="9aaTAD" FT /evidence="ECO:0000250|UniProtKB:P28069" FT VAR_SEQ 1..47 FT /note="MTCQAFASSDNFVPLNSDSSPSLPLIMHHSAAECLPVSNHATSVVST -> M FT YLESSCVFLP (in isoform PIT-1)" FT /evidence="ECO:0000305" FT /id="VSP_002318" FT VAR_SEQ 48..75 FT /note="Missing (in isoform PIT-1*)" FT /evidence="ECO:0000305" FT /id="VSP_002319" SQ SEQUENCE 370 AA; 41191 MW; AB2ABFCBE257C171 CRC64; MTCQAFASSD NFVPLNSDSS PSLPLIMHHS AAECLPVSNH ATSVVSTVPS VLSLIQTPKC SHLHFAMMTS GNVSAGLHYS VPSCHYGNQT STYGVMTGIK PATPEMLSAS LSQSRILQTC SMPHPNVVNG VSTLQSKSFS FSCSLTPCLY KFPEHALSAS SCALGHSFTP MHQTLLSDDP TAADFKQEFR RKSKSVEEPV DMDSPEIREL EKFANEFKLR RIKLGYTQTN VGEALAAVHG SEFSQTTICR FENSQLSFKN ACKLKSILSK WLEEAEQVGA LYNEKVGVNE RKRKRRTTIS IAAKEALERH FGEQSKPSSQ EIMRMAEGLN LEKEVVRVWF CNRRQREKRV KTSLHQNAFS SIIKEHHECR //