Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q05744 (CATD_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin D

EC=3.4.23.5

Cleaved into the following 2 chains:

  1. Cathepsin D light chain
  2. Cathepsin D heavy chain
Gene names
Name:CTSD
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.

Catalytic activity

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Subunit structure

Consists of a light chain and a heavy chain.

Subcellular location

Lysosome.

Tissue specificity

Oocytic yolk, preovulatory follicles, liver.

Sequence similarities

Belongs to the peptidase A1 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionAspartyl protease
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 6343Activation peptide Potential
PRO_0000025966
Chain64 – 398335Cathepsin D
PRO_0000025967
Chain64 – 15794Cathepsin D light chain Probable
PRO_0000025968
Chain158 – 398241Cathepsin D heavy chain Probable
PRO_0000025969

Sites

Active site961 By similarity
Active site2831 By similarity

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 116 By similarity
Disulfide bond274 ↔ 278 By similarity
Disulfide bond317 ↔ 354 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05744 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 584C99E2755AA2B1

FASTA39843,298
        10         20         30         40         50         60 
MAPRGLLVLL LLALVGPCAA LIRIPLTKFT STRRMLTEVG SEIPDMNAIT QFLKFKLGFA 

        70         80         90        100        110        120 
DLAEPTPEIL KNYMDAQYYG EIGIGTPPQK FTVVFDTGSS NLWVPSVHCH LLDIACLLHH 

       130        140        150        160        170        180 
KYDASKSSTY VENGTEFAIH YGTGSLSGFL SQDTVTLGNL KIKNQIFGEA VKQPGITFIA 

       190        200        210        220        230        240 
AKFDGILGMA FPRISVDKVT PFFDNVMQQK LIEKNIFSFY LNRDPTAQPG GELLLGGTDP 

       250        260        270        280        290        300 
KYYSGDFSWV NVTRKAYWQV HMDSVDVANG LTLCKGGCEA IVDTGTSLIT GPTKEVKELQ 

       310        320        330        340        350        360 
TAIGAKPLIK GQYVISCDKI SSLPVVTLML GGKPYQLTGE QYVFKVSAQG ETICLSGFSG 

       370        380        390 
LDVPPPGGPL WILGDVFIGP YYTVFDRDND SVGFAKCV 

« Hide

References

[1]"Molecular cloning and functional characterization of chicken cathepsin D, a key enzyme for yolk formation."
Retzek H., Steyrer E., Sanders E.J., Nimpf J., Schneider W.J.
DNA Cell Biol. 11:661-672(1992) [PubMed: 1418623] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 64-97.
Tissue: Follicular cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S49650 mRNA. Translation: AAB24157.1.
IPIIPI00600003.
PIRI51185.
RefSeqNP_990508.1. NM_205177.1.
UniGeneGga.1094.

3D structure databases

ProteinModelPortalQ05744.
SMRQ05744. Positions 65-396.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ05744.

Protein family/group databases

MEROPSA01.009.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000010676; ENSGALP00000010662; ENSGALG00000006613.
GeneID396090.
KEGGgga:396090.

Organism-specific databases

CTD1509.

Phylogenomic databases

eggNOGveNOG11338.
GeneTreeENSGT00600000084042.
HOGENOMHBG590923.
HOVERGENHBG000482.
InParanoidQ05744.
OMASGFMGID.
OrthoDBEOG40GCR5.
PhylomeDBQ05744.

Family and domain databases

InterProIPR001461. Peptidase_A1.
IPR021109. Peptidase_aspartic.
IPR001969. Peptidase_aspartic_AS.
IPR009007. Peptidase_aspartic_catalytic.
IPR012848. Propep_A1.
[Graphical view]
Gene3DG3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits.
KOK01379.
PANTHERPTHR13683. Peptidase_A1. 1 hit.
PfamPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSPR00792. PEPSIN.
SUPFAMSSF50630. Pept_Aspartic. 1 hit.
PROSITEPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATD_CHICK
AccessionPrimary (citable) accession number: Q05744
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 16, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families