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Protein

Cathepsin D

Gene

CTSD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.

Catalytic activityi

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961PROSITE-ProRule annotation
Active sitei283 – 2831PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-GGA-1442490. Collagen degradation.
R-GGA-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin D (EC:3.4.23.5)
Cleaved into the following 2 chains:
Gene namesi
Name:CTSD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 6343Activation peptideSequence analysisPRO_0000025966Add
BLAST
Chaini64 – 398335Cathepsin DPRO_0000025967Add
BLAST
Chaini64 – 15794Cathepsin D light chainCuratedPRO_0000025968Add
BLAST
Chaini158 – 398241Cathepsin D heavy chainCuratedPRO_0000025969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi109 ↔ 116By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi274 ↔ 278By similarity
Disulfide bondi317 ↔ 354By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ05744.
PRIDEiQ05744.

Expressioni

Tissue specificityi

Oocytic yolk, preovulatory follicles, liver.

Gene expression databases

BgeeiENSGALG00000006613.
ExpressionAtlasiQ05744. baseline and differential.

Interactioni

Subunit structurei

Consists of a light chain and a heavy chain.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010662.

Structurei

3D structure databases

ProteinModelPortaliQ05744.
SMRiQ05744. Positions 65-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 395318Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ05744.
KOiK01379.
OMAiWVNVTRK.
OrthoDBiEOG091G0JP7.
PhylomeDBiQ05744.
TreeFamiTF314990.

Family and domain databases

CDDicd05490. Cathepsin_D2. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033736. Cathepsin_chordata.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRGLLVLL LLALVGPCAA LIRIPLTKFT STRRMLTEVG SEIPDMNAIT
60 70 80 90 100
QFLKFKLGFA DLAEPTPEIL KNYMDAQYYG EIGIGTPPQK FTVVFDTGSS
110 120 130 140 150
NLWVPSVHCH LLDIACLLHH KYDASKSSTY VENGTEFAIH YGTGSLSGFL
160 170 180 190 200
SQDTVTLGNL KIKNQIFGEA VKQPGITFIA AKFDGILGMA FPRISVDKVT
210 220 230 240 250
PFFDNVMQQK LIEKNIFSFY LNRDPTAQPG GELLLGGTDP KYYSGDFSWV
260 270 280 290 300
NVTRKAYWQV HMDSVDVANG LTLCKGGCEA IVDTGTSLIT GPTKEVKELQ
310 320 330 340 350
TAIGAKPLIK GQYVISCDKI SSLPVVTLML GGKPYQLTGE QYVFKVSAQG
360 370 380 390
ETICLSGFSG LDVPPPGGPL WILGDVFIGP YYTVFDRDND SVGFAKCV
Length:398
Mass (Da):43,298
Last modified:February 1, 1994 - v1
Checksum:i584C99E2755AA2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49650 mRNA. Translation: AAB24157.1.
PIRiI51185.
RefSeqiNP_990508.1. NM_205177.1.
UniGeneiGga.1094.

Genome annotation databases

EnsembliENSGALT00000010676; ENSGALP00000010662; ENSGALG00000006613.
GeneIDi396090.
KEGGigga:396090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49650 mRNA. Translation: AAB24157.1.
PIRiI51185.
RefSeqiNP_990508.1. NM_205177.1.
UniGeneiGga.1094.

3D structure databases

ProteinModelPortaliQ05744.
SMRiQ05744. Positions 65-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010662.

Protein family/group databases

MEROPSiA01.009.

Proteomic databases

PaxDbiQ05744.
PRIDEiQ05744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000010676; ENSGALP00000010662; ENSGALG00000006613.
GeneIDi396090.
KEGGigga:396090.

Organism-specific databases

CTDi396090.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ05744.
KOiK01379.
OMAiWVNVTRK.
OrthoDBiEOG091G0JP7.
PhylomeDBiQ05744.
TreeFamiTF314990.

Enzyme and pathway databases

ReactomeiR-GGA-1442490. Collagen degradation.
R-GGA-2132295. MHC class II antigen presentation.

Miscellaneous databases

PROiQ05744.

Gene expression databases

BgeeiENSGALG00000006613.
ExpressionAtlasiQ05744. baseline and differential.

Family and domain databases

CDDicd05490. Cathepsin_D2. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033736. Cathepsin_chordata.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATD_CHICK
AccessioniPrimary (citable) accession number: Q05744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.