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Protein

Histidine decarboxylase

Gene

Hdc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required in photoreceptor transmitter synthesis.

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Substrate; via amide nitrogenBy similarity1
Binding sitei193SubstrateBy similarity1

GO - Molecular functioni

  • histidine decarboxylase activity Source: FlyBase
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • catecholamine biosynthetic process Source: UniProtKB-KW
  • cellular amino acid metabolic process Source: InterPro
  • phototransduction Source: FlyBase
  • thermotaxis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.22. 1994.
ReactomeiR-DME-70921. Histidine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:Hdc
ORF Names:CG3454
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005619. Hdc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469531 – 847Histidine decarboxylaseAdd BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ05733.
PRIDEiQ05733.

Expressioni

Gene expression databases

BgeeiFBgn0005619.
ExpressionAtlasiQ05733. baseline.
GenevisibleiQ05733. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi61897. 2 interactors.
IntActiQ05733. 2 interactors.
MINTiMINT-952075.
STRINGi7227.FBpp0304256.

Structurei

3D structure databases

ProteinModelPortaliQ05733.
SMRiQ05733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
InParanoidiQ05733.
KOiK01590.
OMAiMRYIEAD.
OrthoDBiEOG091G03KI.
PhylomeDBiQ05733.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKEYRQRG KEMVDYIADY LENIRERRVF PDVSPGYMRQ LLPESAPIEG
60 70 80 90 100
EPWPKIFSDV ERIVMPGITH WQSPHMHAYF PALNSMPSLL GDMLADAINC
110 120 130 140 150
LGFTWASSPA CTELEIIVMN WLGKMIGLPD AFLHLSSQSQ GGGVLQTTAS
160 170 180 190 200
EATLVCLLAG RTRAIQRFHE RHPGYQDAEI NARLVAYCSD QAHSSVEKAA
210 220 230 240 250
LIGLVRMRYI EADDDLAMRG KLLREAIEDD IKQGLVPFWV CATLGTTGSC
260 270 280 290 300
SFDNLEEIGI VCAEHHLWLH VDAAYAGSAF ICPEFRTWLR GIERADSIAF
310 320 330 340 350
NPSKWLMVHF DATALWVRDS TAVHRTFNVE PLYLQHENSG VAVDFMHWQI
360 370 380 390 400
PLSRRFRALK VWFVLRSYGI KGLQRHIREG VRLAQKFEAL VLADHRFELP
410 420 430 440 450
AKRHLGLVVF RIRGDNEITE KLLKRLNHRG NLHCIPSSLK GQYVIRFTIT
460 470 480 490 500
STHTTLDDIV KDWMEIRQVA STVLEEMNIT ISNRVYLKET KEKNEAFGSS
510 520 530 540 550
LLLSNSPLSP KVVNGSFAAI FDADEFLAKT YAGVRIAHQE SPSMRRRVRG
560 570 580 590 600
ILMSGKQFSL DSHMDVVVQT TLDAGNGATR TSTTNSYGHT TSAAQANSER
610 620 630 640 650
QASIQEDNEE SPEETELLSL CRTSNVPSPE HAHSLSTPSR SCSSSSHSLI
660 670 680 690 700
HSLTQSSPRS SPVNQFRPIT LCAVPSQSQL SMPLAMPLPN RNVTVSVDSL
710 720 730 740 750
LNPVTTCNVY HGKRFLEPLE NLAQTSASFS SSIFRLPTPI ATPTRESPED
760 770 780 790 800
PDWPAKTFSQ LLLERYSSQS QSLGNNSSTE SSSLSGGATP TPTPMSSLDE
810 820 830 840
LVTPLLLSFA SPSQPMLSAH GIGEGQREQG SDSDATVCST TSSMESL
Length:847
Mass (Da):94,036
Last modified:June 21, 2005 - v2
Checksum:iC04F32F01C176951
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214D → E in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti650I → T in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti658P → A in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti668P → H in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti679Q → H in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti740I → M in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti829Q → R in CAA49989 (PubMed:8096176).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70644 mRNA. Translation: CAA49989.1.
AE013599 Genomic DNA. Translation: AAF58823.1.
PIRiS36337.
RefSeqiNP_001260855.1. NM_001273926.1.
NP_001286274.1. NM_001299345.1.
NP_523679.2. NM_078955.3.
UniGeneiDm.2585.

Genome annotation databases

EnsemblMetazoaiFBtr0088333; FBpp0087422; FBgn0005619.
FBtr0331923; FBpp0304256; FBgn0005619.
FBtr0345474; FBpp0311591; FBgn0005619.
GeneIDi36076.
KEGGidme:Dmel_CG3454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70644 mRNA. Translation: CAA49989.1.
AE013599 Genomic DNA. Translation: AAF58823.1.
PIRiS36337.
RefSeqiNP_001260855.1. NM_001273926.1.
NP_001286274.1. NM_001299345.1.
NP_523679.2. NM_078955.3.
UniGeneiDm.2585.

3D structure databases

ProteinModelPortaliQ05733.
SMRiQ05733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61897. 2 interactors.
IntActiQ05733. 2 interactors.
MINTiMINT-952075.
STRINGi7227.FBpp0304256.

Proteomic databases

PaxDbiQ05733.
PRIDEiQ05733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088333; FBpp0087422; FBgn0005619.
FBtr0331923; FBpp0304256; FBgn0005619.
FBtr0345474; FBpp0311591; FBgn0005619.
GeneIDi36076.
KEGGidme:Dmel_CG3454.

Organism-specific databases

CTDi3067.
FlyBaseiFBgn0005619. Hdc.

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
InParanoidiQ05733.
KOiK01590.
OMAiMRYIEAD.
OrthoDBiEOG091G03KI.
PhylomeDBiQ05733.

Enzyme and pathway databases

BRENDAi4.1.1.22. 1994.
ReactomeiR-DME-70921. Histidine catabolism.

Miscellaneous databases

ChiTaRSiHdc. fly.
GenomeRNAii36076.
PROiQ05733.

Gene expression databases

BgeeiFBgn0005619.
ExpressionAtlasiQ05733. baseline.
GenevisibleiQ05733. DM.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCHS_DROME
AccessioniPrimary (citable) accession number: Q05733
Secondary accession number(s): Q9V5I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.