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Protein

Histidine decarboxylase

Gene

Hdc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required in photoreceptor transmitter synthesis.

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Substrate; via amide nitrogenBy similarity1
Binding sitei193SubstrateBy similarity1

GO - Molecular functioni

  • histidine decarboxylase activity Source: FlyBase
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • catecholamine biosynthetic process Source: UniProtKB-KW
  • cellular amino acid metabolic process Source: InterPro
  • thermotaxis Source: FlyBase

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.22 1994
ReactomeiR-DME-70921 Histidine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:Hdc
ORF Names:CG3454
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005619 Hdc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469531 – 847Histidine decarboxylaseAdd BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ05733
PRIDEiQ05733

Expressioni

Gene expression databases

BgeeiFBgn0005619
ExpressionAtlasiQ05733 baseline and differential
GenevisibleiQ05733 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi61897, 2 interactors
IntActiQ05733, 2 interactors
STRINGi7227.FBpp0304256

Structurei

3D structure databases

ProteinModelPortaliQ05733
SMRiQ05733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
InParanoidiQ05733
KOiK01590
OrthoDBiEOG091G03KI
PhylomeDBiQ05733

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

Q05733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKEYRQRG KEMVDYIADY LENIRERRVF PDVSPGYMRQ LLPESAPIEG
60 70 80 90 100
EPWPKIFSDV ERIVMPGITH WQSPHMHAYF PALNSMPSLL GDMLADAINC
110 120 130 140 150
LGFTWASSPA CTELEIIVMN WLGKMIGLPD AFLHLSSQSQ GGGVLQTTAS
160 170 180 190 200
EATLVCLLAG RTRAIQRFHE RHPGYQDAEI NARLVAYCSD QAHSSVEKAA
210 220 230 240 250
LIGLVRMRYI EADDDLAMRG KLLREAIEDD IKQGLVPFWV CATLGTTGSC
260 270 280 290 300
SFDNLEEIGI VCAEHHLWLH VDAAYAGSAF ICPEFRTWLR GIERADSIAF
310 320 330 340 350
NPSKWLMVHF DATALWVRDS TAVHRTFNVE PLYLQHENSG VAVDFMHWQI
360 370 380 390 400
PLSRRFRALK VWFVLRSYGI KGLQRHIREG VRLAQKFEAL VLADHRFELP
410 420 430 440 450
AKRHLGLVVF RIRGDNEITE KLLKRLNHRG NLHCIPSSLK GQYVIRFTIT
460 470 480 490 500
STHTTLDDIV KDWMEIRQVA STVLEEMNIT ISNRVYLKET KEKNEAFGSS
510 520 530 540 550
LLLSNSPLSP KVVNGSFAAI FDADEFLAKT YAGVRIAHQE SPSMRRRVRG
560 570 580 590 600
ILMSGKQFSL DSHMDVVVQT TLDAGNGATR TSTTNSYGHT TSAAQANSER
610 620 630 640 650
QASIQEDNEE SPEETELLSL CRTSNVPSPE HAHSLSTPSR SCSSSSHSLI
660 670 680 690 700
HSLTQSSPRS SPVNQFRPIT LCAVPSQSQL SMPLAMPLPN RNVTVSVDSL
710 720 730 740 750
LNPVTTCNVY HGKRFLEPLE NLAQTSASFS SSIFRLPTPI ATPTRESPED
760 770 780 790 800
PDWPAKTFSQ LLLERYSSQS QSLGNNSSTE SSSLSGGATP TPTPMSSLDE
810 820 830 840
LVTPLLLSFA SPSQPMLSAH GIGEGQREQG SDSDATVCST TSSMESL
Length:847
Mass (Da):94,036
Last modified:June 21, 2005 - v2
Checksum:iC04F32F01C176951
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214D → E in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti650I → T in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti658P → A in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti668P → H in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti679Q → H in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti740I → M in CAA49989 (PubMed:8096176).Curated1
Sequence conflicti829Q → R in CAA49989 (PubMed:8096176).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70644 mRNA Translation: CAA49989.1
AE013599 Genomic DNA Translation: AAF58823.1
PIRiS36337
RefSeqiNP_001260855.1, NM_001273926.1
NP_001286274.1, NM_001299345.1
NP_523679.2, NM_078955.3
UniGeneiDm.2585

Genome annotation databases

EnsemblMetazoaiFBtr0088333; FBpp0087422; FBgn0005619
FBtr0331923; FBpp0304256; FBgn0005619
FBtr0345474; FBpp0311591; FBgn0005619
GeneIDi36076
KEGGidme:Dmel_CG3454

Similar proteinsi

Entry informationi

Entry nameiDCHS_DROME
AccessioniPrimary (citable) accession number: Q05733
Secondary accession number(s): Q9V5I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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