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Protein

Insulin-like growth factor-binding protein 6

Gene

IGFBP6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:IGFBP6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000015277626 – 237Insulin-like growth factor-binding protein 6Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 30PROSITE-ProRule annotation
Disulfide bondi38 ↔ 42PROSITE-ProRule annotation
Disulfide bondi55 ↔ 61PROSITE-ProRule annotation
Disulfide bondi69 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 102PROSITE-ProRule annotation
Disulfide bondi159 ↔ 186PROSITE-ProRule annotation
Disulfide bondi197 ↔ 208PROSITE-ProRule annotation
Disulfide bondi210 ↔ 231PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05718.
PRIDEiQ05718.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028615.

Structurei

3D structure databases

ProteinModelPortaliQ05718.
SMRiQ05718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 105IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST80
Domaini156 – 231Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3. Eukaryota.
ENOG410YQXU. LUCA.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiQ05718.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR000716. Thyroglobulin_1.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiView protein in Pfam
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHRLLPPL LLTLLLAARP GGALARCPGC GQGVSAGCPG GCAEEEDGGP
60 70 80 90 100
AAEGCAEAGG CLRREGQQCG VYTPNCAPGL QCQPPEKEDL PLRALLQGRG
110 120 130 140 150
RCGRARTPSG ENPKESKPQA GTARSQDVNR RDQQRNSGTS TTPSRSNSGG
160 170 180 190 200
VQDTEMGPCR KHLDSVLQQL QTEVFRGAHT LYVPNCDHRG FYRKRQCRSS
210 220 230
QGQRRGPCWC VERMGQPLPG SSEGGDGSSL CPTGSSG
Length:237
Mass (Da):24,967
Last modified:May 30, 2006 - v2
Checksum:i3502EBDC21DE89AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188H → Q in AAI10142 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110141 mRNA. Translation: AAI10142.1.
S52774 mRNA. Translation: AAB24875.2.
AY197339 Genomic DNA. Translation: AAO45612.1.
PIRiC45403.
T01404.
RefSeqiNP_001035585.1. NM_001040495.2.
UniGeneiBt.9958.

Genome annotation databases

GeneIDi404186.
KEGGibta:404186.

Similar proteinsi

Entry informationi

Entry nameiIBP6_BOVIN
AccessioniPrimary (citable) accession number: Q05718
Secondary accession number(s): Q2YDN5, Q865L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2006
Last modified: June 7, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome