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Protein

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-BTA-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:IGFBP5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000015277520 – 271Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Modified residuei115PhosphoserineBy similarity1
Disulfide bondi191 ↔ 218PROSITE-ProRule annotation
Disulfide bondi229 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ05717.
PRIDEiQ05717.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007062.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009285.

Structurei

3D structure databases

ProteinModelPortaliQ05717.
SMRiQ05717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiQ05717.
OMAiLPIDKHE.
OrthoDBiEOG091G0EIN.
TreeFamiTF331211.

Family and domain databases

CDDicd00191. TY. 1 hit.
Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_cys_sf.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
IPR036857. Thyroglobulin_1_sf.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLTAVLLLL AACAGSAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYREQAK IERDSREHEE PTTSEMAEET YSPKIFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVISAP EMRQKSEQGP CRRHMEASLQ
210 220 230 240 250
ELKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHTFDSSNV E
Length:271
Mass (Da):30,314
Last modified:July 24, 2007 - v2
Checksum:iA4CD8756DD64133D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN511652 mRNA. No translation available.
BC149394 mRNA. Translation: AAI49395.1.
S52657 mRNA. Translation: AAB24874.1.
PIRiB45403.
RefSeqiNP_001098797.1. NM_001105327.2.
UniGeneiBt.55913.

Genome annotation databases

EnsembliENSBTAT00000009285; ENSBTAP00000009285; ENSBTAG00000007062.
GeneIDi404185.
KEGGibta:404185.

Similar proteinsi

Entry informationi

Entry nameiIBP5_BOVIN
AccessioniPrimary (citable) accession number: Q05717
Secondary accession number(s): A6QPM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 24, 2007
Last modified: December 20, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome