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Protein

Collagen alpha-1(XIV) chain

Gene

COL14A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).By similarity1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • extracellular matrix structural constituent Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein binding, bridging Source: UniProtKB

GO - Biological processi

  • collagen fibril organization Source: UniProtKB
  • extracellular matrix organization Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:G66-33416-MONOMER.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XIV) chain
Alternative name(s):
Undulin
Gene namesi
Name:COL14A1Imported
Synonyms:UND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2191. COL14A1.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB
  • collagen type XIV trimer Source: UniProtKB
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7373.
MalaCardsiCOL14A1.
OpenTargetsiENSG00000187955.
Orphaneti79501. Punctate palmoplantar keratoderma type 1.
PharmGKBiPA26707.

Polymorphism and mutation databases

DMDMi125987815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000578529 – 1796Collagen alpha-1(XIV) chainAdd BLAST1768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)1 Publication1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi372N-linked (GlcNAc...)1 Publication1
Glycosylationi1384N-linked (GlcNAc...)1 Publication1
Glycosylationi1388N-linked (GlcNAc...)1 Publication1
Modified residuei14674-hydroxyproline1 Publication1
Modified residuei14704-hydroxyproline; partial1 Publication1
Modified residuei14765-hydroxylysine; alternate1 Publication1
Glycosylationi1476O-linked (Gal...); alternate1 Publication1
Modified residuei14824-hydroxyproline1 Publication1
Modified residuei14855-hydroxylysine; partial1 Publication1
Glycosylationi1485O-linked (Gal...); partial1 Publication1
Modified residuei14974-hydroxyproline1 Publication1
Modified residuei15034-hydroxyproline1 Publication1
Modified residuei15174-hydroxyproline1 Publication1
Modified residuei15204-hydroxyproline1 Publication1
Modified residuei15235-hydroxylysine; partial1 Publication1
Glycosylationi1523O-linked (Gal...); partial1 Publication1
Modified residuei15265-hydroxylysine; partial1 Publication1
Glycosylationi1526O-linked (Gal...); partial1 Publication1
Modified residuei15324-hydroxyproline1 Publication1
Modified residuei15384-hydroxyproline1 Publication1
Modified residuei15444-hydroxyproline1 Publication1
Modified residuei15504-hydroxyproline1 Publication1
Modified residuei15564-hydroxyproline1 Publication1
Modified residuei15654-hydroxyproline1 Publication1
Modified residuei15684-hydroxyproline1 Publication1
Modified residuei15744-hydroxyproline1 Publication1
Modified residuei15774-hydroxyproline1 Publication1
Modified residuei15804-hydroxyproline1 Publication1
Modified residuei15954-hydroxyproline1 Publication1
Modified residuei15984-hydroxyproline1 Publication1
Modified residuei16015-hydroxylysine; alternate1 Publication1
Glycosylationi1601O-linked (Gal...); alternate1 Publication1
Modified residuei16434-hydroxyproline; partial1 Publication1
Modified residuei16564-hydroxyproline1 Publication1
Modified residuei16594-hydroxyproline1 Publication1
Modified residuei16624-hydroxyproline1 Publication1
Modified residuei16654-hydroxyproline1 Publication1
Modified residuei16684-hydroxyproline1 Publication1
Modified residuei16744-hydroxyproline1 Publication1
Modified residuei16774-hydroxyproline1 Publication1
Modified residuei16804-hydroxyproline1 Publication1
Modified residuei16864-hydroxyproline1 Publication1
Modified residuei16894-hydroxyproline1 Publication1
Modified residuei16985-hydroxylysine; alternate1 Publication1
Glycosylationi1698O-linked (Gal...); alternate1 Publication1
Modified residuei17015-hydroxylysine; alternate1 Publication1
Glycosylationi1701O-linked (Gal...); alternate1 Publication1
Modified residuei17044-hydroxyproline1 Publication1
Modified residuei17154-hydroxyproline1 Publication1
Modified residuei17264-hydroxyproline; partial1 Publication1
Modified residuei17294-hydroxyproline1 Publication1
Modified residuei17324-hydroxyproline1 Publication1
Modified residuei17354-hydroxyproline1 Publication1
Modified residuei17414-hydroxyproline1 Publication1
Modified residuei17474-hydroxyproline1 Publication1
Modified residuei17564-hydroxyproline1 Publication1

Post-translational modificationi

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity
May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ05707.
PaxDbiQ05707.
PeptideAtlasiQ05707.
PRIDEiQ05707.

PTM databases

iPTMnetiQ05707.
PhosphoSitePlusiQ05707.

Expressioni

Gene expression databases

BgeeiENSG00000187955.
CleanExiHS_COL14A1.
ExpressionAtlasiQ05707. baseline and differential.
GenevisibleiQ05707. HS.

Organism-specific databases

HPAiHPA023781.

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • protein binding, bridging Source: UniProtKB

Protein-protein interaction databases

BioGridi113219. 30 interactors.
IntActiQ05707. 4 interactors.
STRINGi9606.ENSP00000297848.

Structurei

3D structure databases

ProteinModelPortaliQ05707.
SMRiQ05707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini158 – 330VWFA 1PROSITE-ProRule annotationAdd BLAST173
Domaini355 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini445 – 536Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini537 – 626Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini627 – 715Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST89
Domaini737 – 829Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST93
Domaini831 – 921Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini922 – 1010Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST89
Domaini1032 – 1205VWFA 2PROSITE-ProRule annotationAdd BLAST174
Domaini1229 – 1424Laminin G-likeAdd BLAST196
Domaini1462 – 1510Collagen-like 1Add BLAST49
Domaini1514 – 1570Collagen-like 2Add BLAST57
Domaini1571 – 1609Collagen-like 3Add BLAST39
Domaini1653 – 1705Collagen-like 4Add BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1217 – 1458Nonhelical region (NC4)Add BLAST242
Regioni1459 – 1610Triple-helical region 1 (COL2)Add BLAST152
Regioni1654 – 1779Triple-helical region 2 (COL1)Add BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1607 – 1609Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 4 collagen-like domains.Curated
Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG3544. Eukaryota.
ENOG410Y01G. LUCA.
GeneTreeiENSGT00760000119000.
HOVERGENiHBG051060.
InParanoidiQ05707.
KOiK08133.
OMAiWYNRLRI.
OrthoDBiEOG091G002N.
PhylomeDBiQ05707.
TreeFamiTF329914.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 8 hits.
3.40.50.410. 2 hits.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00041. fn3. 8 hits.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 8 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q05707-1) [UniParc]FASTAAdd to basket
Also known as: Undulin 11 Publication, Un11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW
60 70 80 90 100
KAPRGKFGGY KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII
110 120 130 140 150
AYNKDKESKP AQGQFRIKDL EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV
160 170 180 190 200
CQTPAIADIV ILVDGSWSIG RFNFRLVRHF LENLVTAFDV GSEKTRIGLA
210 220 230 240 250
QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA LNYIFENSFK
260 270 280 290 300
PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN
310 320 330 340 350
ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH
360 370 380 390 400
AITGPPTELI TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV
410 420 430 440 450
DGTVSSTVLK NLMSLTEYQI AVFAIYAHTA SEGLRGTETT LALPMASDLL
460 470 480 490 500
LYDVTENSMR VKWDAVPGAS GYLILYAPLT EGLAGDEKEM KIGETHTDIE
510 520 530 540 550
LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN LRISNVGSNS
560 570 580 590 600
ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT
610 620 630 640 650
IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD
660 670 680 690 700
EGLHKLMWIP VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG
710 720 730 740 750
SESEVVTAVG TTLDSFWTEP ATTIVPTTSV TSVFQTGIRN LVVGDETTSS
760 770 780 790 800
LRVKWDISDS DVQQFRVTYM TAQGDPEEEV IGTVMVPGSQ NNLLLKPLLP
810 820 830 840 850
DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE WYNRLRITWD
860 870 880 890 900
PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF
910 920 930 940 950
ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV
960 970 980 990 1000
VIESLQDRQK QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS
1010 1020 1030 1040 1050
IMEKTQSLPT RPPTFPPTIP PAKEVCKAAK ADLVFMVDGS WSIGDENFNK
1060 1070 1080 1090 1100
IISFLYSTVG ALNKIGTDGT QVAMVQFTDD PRTEFKLNAY KTKETLLDAI
1110 1120 1130 1140 1150
KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV ITDGRSQDDV
1160 1170 1180 1190 1200
NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK
1210 1220 1230 1240 1250
IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS
1260 1270 1280 1290 1300
MEPGTFNVFP CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ
1310 1320 1330 1340 1350
EPFALWEILN KNSDPLVGVI LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR
1360 1370 1380 1390 1400
KIFYGSFHKL HIVVSETLVK VVIDCKQVGE KAMNASANIT SDGVEVLGKM
1410 1420 1430 1440 1450
VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD DESCPDLPHS
1460 1470 1480 1490 1500
CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ
1510 1520 1530 1540 1550
GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP
1560 1570 1580 1590 1600
GQRGLPGKDG SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA
1610 1620 1630 1640 1650
KGERGERGDL QSQAMVRSVA RQVCEQLIQS HMARYTAILN QIPSHSSSIR
1660 1670 1680 1690 1700
TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP GNAGVPGTPG ERGLTGIKGE
1710 1720 1730 1740 1750
KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP PGHLGVPGPQ
1760 1770 1780 1790
GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV
Length:1,796
Mass (Da):193,515
Last modified:February 6, 2007 - v3
Checksum:i30A72F6E2CC07F70
GO
Isoform 21 Publication (identifier: Q05707-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1771-1796: APHPDQPEFTPVQDELEAMELWGPGV → DLIPYNDYQH

Show »
Length:1,780
Mass (Da):191,903
Checksum:iD0818CA6359B66D4
GO
Isoform 31 Publication (identifier: Q05707-3) [UniParc]FASTAAdd to basket
Also known as: Undulin 21 Publication, Un21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     197-291: Missing.

Show »
Length:1,701
Mass (Da):183,154
Checksum:i351A5F24379FEDF0
GO

Sequence cautioni

The sequence AAA36795 differs from that shown.Curated
The sequence AAH14640 differs from that shown. Reason: Frameshift at position 1047.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti616T → I in AAA36794 (PubMed:15489334).Curated1
Sequence conflicti1025V → G in AAA36794 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048772563N → H.Corresponds to variant rs4870723dbSNPEnsembl.1
Natural variantiVAR_061113636T → A.Corresponds to variant rs56815167dbSNPEnsembl.1
Natural variantiVAR_048773855P → L.Corresponds to variant rs2305606dbSNPEnsembl.1
Natural variantiVAR_048774922V → I.Corresponds to variant rs11774228dbSNPEnsembl.1
Natural variantiVAR_0487751342V → L.1 PublicationCorresponds to variant rs17833992dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051653197 – 291Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0516541771 – 1796APHPD…WGPGV → DLIPYNDYQH in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020603 Genomic DNA. No translation available.
AC090735 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
BC014640 mRNA. Translation: AAH14640.1. Frameshift.
BC083495 mRNA. Translation: AAH83495.1.
BC140893 mRNA. Translation: AAI40894.1.
Y11709 mRNA. Translation: CAA72401.1.
Y11710 mRNA. Translation: CAA72402.1.
Y11711 mRNA. Translation: CAA72403.1.
M64108 mRNA. Translation: AAA36794.1.
M64109 mRNA. Translation: AAA36795.1. Sequence problems.
CCDSiCCDS34938.1. [Q05707-1]
PIRiA40970.
B40970.
S37749.
S46657.
RefSeqiNP_066933.1. NM_021110.3. [Q05707-1]
XP_005251116.1. XM_005251059.3. [Q05707-2]
XP_006716714.1. XM_006716651.3. [Q05707-1]
XP_016869298.1. XM_017013809.1. [Q05707-1]
UniGeneiHs.409662.
Hs.657621.

Genome annotation databases

EnsembliENST00000297848; ENSP00000297848; ENSG00000187955. [Q05707-1]
ENST00000309791; ENSP00000311809; ENSG00000187955. [Q05707-2]
GeneIDi7373.
KEGGihsa:7373.
UCSCiuc003yox.5. human. [Q05707-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020603 Genomic DNA. No translation available.
AC090735 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
BC014640 mRNA. Translation: AAH14640.1. Frameshift.
BC083495 mRNA. Translation: AAH83495.1.
BC140893 mRNA. Translation: AAI40894.1.
Y11709 mRNA. Translation: CAA72401.1.
Y11710 mRNA. Translation: CAA72402.1.
Y11711 mRNA. Translation: CAA72403.1.
M64108 mRNA. Translation: AAA36794.1.
M64109 mRNA. Translation: AAA36795.1. Sequence problems.
CCDSiCCDS34938.1. [Q05707-1]
PIRiA40970.
B40970.
S37749.
S46657.
RefSeqiNP_066933.1. NM_021110.3. [Q05707-1]
XP_005251116.1. XM_005251059.3. [Q05707-2]
XP_006716714.1. XM_006716651.3. [Q05707-1]
XP_016869298.1. XM_017013809.1. [Q05707-1]
UniGeneiHs.409662.
Hs.657621.

3D structure databases

ProteinModelPortaliQ05707.
SMRiQ05707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113219. 30 interactors.
IntActiQ05707. 4 interactors.
STRINGi9606.ENSP00000297848.

PTM databases

iPTMnetiQ05707.
PhosphoSitePlusiQ05707.

Polymorphism and mutation databases

DMDMi125987815.

Proteomic databases

MaxQBiQ05707.
PaxDbiQ05707.
PeptideAtlasiQ05707.
PRIDEiQ05707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297848; ENSP00000297848; ENSG00000187955. [Q05707-1]
ENST00000309791; ENSP00000311809; ENSG00000187955. [Q05707-2]
GeneIDi7373.
KEGGihsa:7373.
UCSCiuc003yox.5. human. [Q05707-1]

Organism-specific databases

CTDi7373.
DisGeNETi7373.
GeneCardsiCOL14A1.
H-InvDBHIX0007753.
HGNCiHGNC:2191. COL14A1.
HPAiHPA023781.
MalaCardsiCOL14A1.
MIMi120324. gene.
neXtProtiNX_Q05707.
OpenTargetsiENSG00000187955.
Orphaneti79501. Punctate palmoplantar keratoderma type 1.
PharmGKBiPA26707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG3544. Eukaryota.
ENOG410Y01G. LUCA.
GeneTreeiENSGT00760000119000.
HOVERGENiHBG051060.
InParanoidiQ05707.
KOiK08133.
OMAiWYNRLRI.
OrthoDBiEOG091G002N.
PhylomeDBiQ05707.
TreeFamiTF329914.

Enzyme and pathway databases

BioCyciZFISH:G66-33416-MONOMER.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

ChiTaRSiCOL14A1. human.
GeneWikiiCollagen,_type_XIV,_alpha_1.
GenomeRNAii7373.
PROiQ05707.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187955.
CleanExiHS_COL14A1.
ExpressionAtlasiQ05707. baseline and differential.
GenevisibleiQ05707. HS.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 8 hits.
3.40.50.410. 2 hits.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00041. fn3. 8 hits.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 8 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOEA1_HUMAN
AccessioniPrimary (citable) accession number: Q05707
Secondary accession number(s): B2RU07
, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67, Q9UDF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.