Q05707 (COEA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XIV) chain

Alternative name(s):
Undulin

Gene names

Name:	COL14A1
Synonyms:	UND

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1796 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors By similarity. Ref.6
Subunit structure	Homotrimer By similarity. UniProtKB P32018
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Post-translational modification	Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates By similarity. UniProtKB P32018 Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity. UniProtKB P32018 May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding By similarity. UniProtKB P32018
Sequence similarities	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. Contains 4 collagen-like domains. Contains 8 fibronectin type-III domains. Contains 1 laminin G-like domain. Contains 2 VWFA domains.
Sequence caution	The sequence AAA36795.1 differs from that shown. Reason: The sequence AAH14640.1 differs from that shown. Reason: Frameshift at position 1047.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Collagen Repeat Signal
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Non-traceable author statement Ref.3. Source: UniProtKB collagen fibril organization Non-traceable author statement Ref.6. Source: UniProtKB
Cellular_component	collagen type XIV Non-traceable author statement Ref.3. Source: UniProtKB endoplasmic reticulum lumen Traceable author statement. Source: Reactome extracellular space Inferred from direct assay PubMed 20551380. Source: BHF-UCL
Molecular_function	collagen binding Non-traceable author statement Ref.6. Source: UniProtKB extracellular matrix structural constituent Non-traceable author statement Ref.6Ref.3. Source: UniProtKB protein binding, bridging Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.3 (identifier: Q05707-1)

Also known as: Undulin 1; Un1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.3 (identifier: Q05707-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1771-1796: APHPDQPEFTPVQDELEAMELWGPGV → DLIPYNDYQH

Isoform 3 Ref.4 (identifier: Q05707-3)

Also known as: Undulin 2; Un2;

The sequence of this isoform differs from the canonical sequence as follows:
     197-291: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1796	1768	Collagen alpha-1(XIV) chain		PRO_0000005785
Regions
	Domain	29 – 117	89	Fibronectin type-III 1
	Domain	158 – 330	173	VWFA 1
	Domain	352 – 440	89	Fibronectin type-III 2
	Domain	442 – 532	91	Fibronectin type-III 3
	Domain	534 – 621	88	Fibronectin type-III 4
	Domain	623 – 712	90	Fibronectin type-III 5
	Domain	735 – 826	92	Fibronectin type-III 6
	Domain	828 – 917	90	Fibronectin type-III 7
	Domain	921 – 1005	85	Fibronectin type-III 8
	Domain	1032 – 1205	174	VWFA 2
	Domain	1229 – 1424	196	Laminin G-like
	Domain	1462 – 1510	49	Collagen-like 1
	Domain	1514 – 1570	57	Collagen-like 2
	Domain	1571 – 1609	39	Collagen-like 3
	Domain	1653 – 1705	53	Collagen-like 4
	Region	1217 – 1458	242	Nonhelical region (NC4)
	Region	1459 – 1610	152	Triple-helical region 1 (COL2)
	Region	1654 – 1779	126	Triple-helical region 2 (COL1)
	Motif	1607 – 1609	3	Cell attachment site Potential
Amino acid modifications
	Modified residue	1467	1	4-hydroxyproline Ref.5
	Modified residue	1470	1	4-hydroxyproline; partial Ref.5
	Modified residue	1476	1	5-hydroxylysine Ref.5
	Modified residue	1482	1	4-hydroxyproline Ref.5
	Modified residue	1485	1	5-hydroxylysine; partial Ref.5
	Modified residue	1497	1	4-hydroxyproline Ref.5
	Modified residue	1503	1	4-hydroxyproline Ref.5
	Modified residue	1517	1	4-hydroxyproline Ref.5
	Modified residue	1520	1	4-hydroxyproline Ref.5
	Modified residue	1523	1	5-hydroxylysine; partial Ref.5
	Modified residue	1526	1	5-hydroxylysine; partial Ref.5
	Modified residue	1532	1	4-hydroxyproline Ref.5
	Modified residue	1538	1	4-hydroxyproline Ref.5
	Modified residue	1544	1	4-hydroxyproline Ref.5
	Modified residue	1550	1	4-hydroxyproline Ref.5
	Modified residue	1556	1	4-hydroxyproline Ref.5
	Modified residue	1565	1	4-hydroxyproline Ref.5
	Modified residue	1568	1	4-hydroxyproline Ref.5
	Modified residue	1574	1	4-hydroxyproline Ref.5
	Modified residue	1577	1	4-hydroxyproline Ref.5
	Modified residue	1580	1	4-hydroxyproline Ref.5
	Modified residue	1595	1	4-hydroxyproline Ref.5
	Modified residue	1598	1	4-hydroxyproline Ref.5
	Modified residue	1601	1	5-hydroxylysine Ref.5
	Modified residue	1643	1	4-hydroxyproline; partial Ref.5
	Modified residue	1656	1	4-hydroxyproline Ref.5
	Modified residue	1659	1	4-hydroxyproline Ref.5
	Modified residue	1662	1	4-hydroxyproline Ref.5
	Modified residue	1665	1	4-hydroxyproline Ref.5
	Modified residue	1668	1	4-hydroxyproline Ref.5
	Modified residue	1674	1	4-hydroxyproline Ref.5
	Modified residue	1677	1	4-hydroxyproline Ref.5
	Modified residue	1680	1	4-hydroxyproline Ref.5
	Modified residue	1686	1	4-hydroxyproline Ref.5
	Modified residue	1689	1	4-hydroxyproline Ref.5
	Modified residue	1698	1	5-hydroxylysine Ref.5
	Modified residue	1701	1	5-hydroxylysine Ref.5
	Modified residue	1704	1	4-hydroxyproline Ref.5
	Modified residue	1715	1	4-hydroxyproline Ref.5
	Modified residue	1726	1	4-hydroxyproline; partial Ref.5
	Modified residue	1729	1	4-hydroxyproline Ref.5
	Modified residue	1732	1	4-hydroxyproline Ref.5
	Modified residue	1735	1	4-hydroxyproline Ref.5
	Modified residue	1741	1	4-hydroxyproline Ref.5
	Modified residue	1747	1	4-hydroxyproline Ref.5
	Modified residue	1756	1	4-hydroxyproline Ref.5
	Glycosylation	94	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Glycosylation	372	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	1384	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	1388	1	N-linked (GlcNAc...) Ref.7
	Glycosylation	1476	1	O-linked (Gal...) Ref.5
	Glycosylation	1485	1	O-linked (Gal...); partial Ref.5
	Glycosylation	1523	1	O-linked (Gal...); partial Ref.5
	Glycosylation	1526	1	O-linked (Gal...); partial Ref.5
	Glycosylation	1601	1	O-linked (Gal...) Ref.5
	Glycosylation	1698	1	O-linked (Gal...) Ref.5
	Glycosylation	1701	1	O-linked (Gal...); partial Ref.5
Natural variations
	Alternative sequence	197 – 291	95	Missing in isoform 3. Ref.4		VSP_051653
	Alternative sequence	1771 – 1796	26	APHPD…WGPGV → DLIPYNDYQH in isoform 2. Ref.3		VSP_051654
	Natural variant	563	1	N → H. Corresponds to variant rs4870723 [ dbSNP | Ensembl ].		VAR_048772
	Natural variant	636	1	T → A. Corresponds to variant rs56815167 [ dbSNP | Ensembl ].		VAR_061113
	Natural variant	855	1	P → L. Corresponds to variant rs2305606 [ dbSNP | Ensembl ].		VAR_048773
	Natural variant	922	1	V → I. Corresponds to variant rs11774228 [ dbSNP | Ensembl ].		VAR_048774
	Natural variant	1342	1	V → L. Ref.2 Corresponds to variant rs17833992 [ dbSNP | Ensembl ].		VAR_048775
Experimental info
	Sequence conflict	616	1	T → I in AAA36794. Ref.2
	Sequence conflict	1025	1	V → G in AAA36794. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Undulin 1) (Un1) [UniParc]. Last modified February 6, 2007. Version 3. Checksum: 30A72F6E2CC07F70	FASTA	1,796	193,515
	10 20 30 40 50 60 MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW KAPRGKFGGY 70 80 90 100 110 120 KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII AYNKDKESKP AQGQFRIKDL 130 140 150 160 170 180 EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV CQTPAIADIV ILVDGSWSIG RFNFRLVRHF 190 200 210 220 230 240 LENLVTAFDV GSEKTRIGLA QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA 250 260 270 280 290 300 LNYIFENSFK PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN 310 320 330 340 350 360 ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH AITGPPTELI 370 380 390 400 410 420 TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV DGTVSSTVLK NLMSLTEYQI 430 440 450 460 470 480 AVFAIYAHTA SEGLRGTETT LALPMASDLL LYDVTENSMR VKWDAVPGAS GYLILYAPLT 490 500 510 520 530 540 EGLAGDEKEM KIGETHTDIE LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN 550 560 570 580 590 600 LRISNVGSNS ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT 610 620 630 640 650 660 IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD EGLHKLMWIP 670 680 690 700 710 720 VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG SESEVVTAVG TTLDSFWTEP 730 740 750 760 770 780 ATTIVPTTSV TSVFQTGIRN LVVGDETTSS LRVKWDISDS DVQQFRVTYM TAQGDPEEEV 790 800 810 820 830 840 IGTVMVPGSQ NNLLLKPLLP DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE 850 860 870 880 890 900 WYNRLRITWD PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF 910 920 930 940 950 960 ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV VIESLQDRQK 970 980 990 1000 1010 1020 QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS IMEKTQSLPT RPPTFPPTIP 1030 1040 1050 1060 1070 1080 PAKEVCKAAK ADLVFMVDGS WSIGDENFNK IISFLYSTVG ALNKIGTDGT QVAMVQFTDD 1090 1100 1110 1120 1130 1140 PRTEFKLNAY KTKETLLDAI KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV 1150 1160 1170 1180 1190 1200 ITDGRSQDDV NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK 1210 1220 1230 1240 1250 1260 IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS MEPGTFNVFP 1270 1280 1290 1300 1310 1320 CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ EPFALWEILN KNSDPLVGVI 1330 1340 1350 1360 1370 1380 LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR KIFYGSFHKL HIVVSETLVK VVIDCKQVGE 1390 1400 1410 1420 1430 1440 KAMNASANIT SDGVEVLGKM VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD 1450 1460 1470 1480 1490 1500 DESCPDLPHS CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ 1510 1520 1530 1540 1550 1560 GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP GQRGLPGKDG 1570 1580 1590 1600 1610 1620 SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA KGERGERGDL QSQAMVRSVA 1630 1640 1650 1660 1670 1680 RQVCEQLIQS HMARYTAILN QIPSHSSSIR TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP 1690 1700 1710 1720 1730 1740 GNAGVPGTPG ERGLTGIKGE KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP 1750 1760 1770 1780 1790 PGHLGVPGPQ GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV
	Isoform 2 [UniParc]. Checksum: D0818CA6359B66D4	FASTA	1,780	191,903
	10 20 30 40 50 60 MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW KAPRGKFGGY 70 80 90 100 110 120 KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII AYNKDKESKP AQGQFRIKDL 130 140 150 160 170 180 EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV CQTPAIADIV ILVDGSWSIG RFNFRLVRHF 190 200 210 220 230 240 LENLVTAFDV GSEKTRIGLA QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA 250 260 270 280 290 300 LNYIFENSFK PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN 310 320 330 340 350 360 ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH AITGPPTELI 370 380 390 400 410 420 TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV DGTVSSTVLK NLMSLTEYQI 430 440 450 460 470 480 AVFAIYAHTA SEGLRGTETT LALPMASDLL LYDVTENSMR VKWDAVPGAS GYLILYAPLT 490 500 510 520 530 540 EGLAGDEKEM KIGETHTDIE LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN 550 560 570 580 590 600 LRISNVGSNS ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT 610 620 630 640 650 660 IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD EGLHKLMWIP 670 680 690 700 710 720 VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG SESEVVTAVG TTLDSFWTEP 730 740 750 760 770 780 ATTIVPTTSV TSVFQTGIRN LVVGDETTSS LRVKWDISDS DVQQFRVTYM TAQGDPEEEV 790 800 810 820 830 840 IGTVMVPGSQ NNLLLKPLLP DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE 850 860 870 880 890 900 WYNRLRITWD PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF 910 920 930 940 950 960 ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV VIESLQDRQK 970 980 990 1000 1010 1020 QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS IMEKTQSLPT RPPTFPPTIP 1030 1040 1050 1060 1070 1080 PAKEVCKAAK ADLVFMVDGS WSIGDENFNK IISFLYSTVG ALNKIGTDGT QVAMVQFTDD 1090 1100 1110 1120 1130 1140 PRTEFKLNAY KTKETLLDAI KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV 1150 1160 1170 1180 1190 1200 ITDGRSQDDV NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK 1210 1220 1230 1240 1250 1260 IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS MEPGTFNVFP 1270 1280 1290 1300 1310 1320 CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ EPFALWEILN KNSDPLVGVI 1330 1340 1350 1360 1370 1380 LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR KIFYGSFHKL HIVVSETLVK VVIDCKQVGE 1390 1400 1410 1420 1430 1440 KAMNASANIT SDGVEVLGKM VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD 1450 1460 1470 1480 1490 1500 DESCPDLPHS CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ 1510 1520 1530 1540 1550 1560 GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP GQRGLPGKDG 1570 1580 1590 1600 1610 1620 SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA KGERGERGDL QSQAMVRSVA 1630 1640 1650 1660 1670 1680 RQVCEQLIQS HMARYTAILN QIPSHSSSIR TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP 1690 1700 1710 1720 1730 1740 GNAGVPGTPG ERGLTGIKGE KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP 1750 1760 1770 1780 PGHLGVPGPQ GPSGQPGYCD PSSCSAYGVR DLIPYNDYQH
	Isoform 3 (Undulin 2) (Un2) [UniParc]. Checksum: 351A5F24379FEDF0	FASTA	1,701	183,154
	10 20 30 40 50 60 MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW KAPRGKFGGY 70 80 90 100 110 120 KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII AYNKDKESKP AQGQFRIKDL 130 140 150 160 170 180 EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV CQTPAIADIV ILVDGSWSIG RFNFRLVRHF 190 200 210 220 230 240 LENLVTAFDV GSEKTRIGVK NADVNELQEI ASEPDSTHVY NVAEFDLMHT VVESLTRTLC 250 260 270 280 290 300 SRVEEQDREI KASAHAITGP PTELITSEVT ARSFMVNWTH APGNVEKYRV VYYPTRGGKP 310 320 330 340 350 360 DEVVVDGTVS STVLKNLMSL TEYQIAVFAI YAHTASEGLR GTETTLALPM ASDLLLYDVT 370 380 390 400 410 420 ENSMRVKWDA VPGASGYLIL YAPLTEGLAG DEKEMKIGET HTDIELSGLL PNTEYTVTVY 430 440 450 460 470 480 AMFGEEASDP VTGQETTLAL SPPRNLRISN VGSNSARLTW DPTSRQINGY RIVYNNADGT 490 500 510 520 530 540 EINEVEVDPI TTFPLKGLTP LTEYTIAIFS IYDEGQSEPL TGVFTTEEVP AQQYLEIDEV 550 560 570 580 590 600 TTDSFRVTWH PLSADEGLHK LMWIPVYGGK TEEVVLKEEQ DSHVIEGLEP GTEYEVSLLA 610 620 630 640 650 660 VLDDGSESEV VTAVGTTLDS FWTEPATTIV PTTSVTSVFQ TGIRNLVVGD ETTSSLRVKW 670 680 690 700 710 720 DISDSDVQQF RVTYMTAQGD PEEEVIGTVM VPGSQNNLLL KPLLPDTEYK VTVTPIYTDG 730 740 750 760 770 780 EGVSVSAPGK TLPSSGPQNL RVSEEWYNRL RITWDPPSSP VKGYRIVYKP VSVPGPTLET 790 800 810 820 830 840 FVGADINTIL ITNLLSGMDY NVKIFASQAS GFSDALTGMV KTLFLGVTNL QAKHVEMTSL 850 860 870 880 890 900 CAHWQVHRHA TAYRVVIESL QDRQKQESTV GGGTTRHCFY GLQPDSEYKI SVYTKLQEIE 910 920 930 940 950 960 GPSVSIMEKT QSLPTRPPTF PPTIPPAKEV CKAAKADLVF MVDGSWSIGD ENFNKIISFL 970 980 990 1000 1010 1020 YSTVGALNKI GTDGTQVAMV QFTDDPRTEF KLNAYKTKET LLDAIKHISY KGGNTKTGKA 1030 1040 1050 1060 1070 1080 IKYVRDTLFT AESGTRRGIP KVIVVITDGR SQDDVNKISR EMQLDGYSIF AIGVADADYS 1090 1100 1110 1120 1130 1140 ELVSIGSKPS ARHVFFVDDF DAFKKIEDEL ITFVCETASA TCPVVHKDGI DLAGFKMMEM 1150 1160 1170 1180 1190 1200 FGLVEKDFSS VEGVSMEPGT FNVFPCYQLH KDALVSQPTR YLHPEGLPSD YTISFLFRIL 1210 1220 1230 1240 1250 1260 PDTPQEPFAL WEILNKNSDP LVGVILDNGG KTLTYFNYDQ SGDFQTVTFE GPEIRKIFYG 1270 1280 1290 1300 1310 1320 SFHKLHIVVS ETLVKVVIDC KQVGEKAMNA SANITSDGVE VLGKMVRSRG PGGNSAPFQL 1330 1340 1350 1360 1370 1380 QMFDIVCSTS WANTDKCCEL PGLRDDESCP DLPHSCSCSE TNEVALGPAG PPGGPGLRGP 1390 1400 1410 1420 1430 1440 KGQQGEPGPK GPDGPRGEIG LPGPQGPPGP QGPSGLSIQG MPGMPGEKGE KGDTGLPGPQ 1450 1460 1470 1480 1490 1500 GIPGGVGSPG RDGSPGQRGL PGKDGSSGPP GPPGPIGIPG TPGVPGITGS MGPQGALGPP 1510 1520 1530 1540 1550 1560 GVPGAKGERG ERGDLQSQAM VRSVARQVCE QLIQSHMARY TAILNQIPSH SSSIRTVQGP 1570 1580 1590 1600 1610 1620 PGEPGRPGSP GAPGEQGPPG TPGFPGNAGV PGTPGERGLT GIKGEKGNPG VGTQGPRGPP 1630 1640 1650 1660 1670 1680 GPAGPSGESR PGSPGPPGSP GPRGPPGHLG VPGPQGPSGQ PGYCDPSSCS AYGVRAPHPD 1690 1700 QPEFTPVQDE LEAMELWGPG V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-1342. Tissue: Brain, Muscle and PNS.
[3]	"Complete primary structure of human collagen type XIV (undulin)." Bauer M., Dieterich W., Ehnis T., Schuppan D. Biochim. Biophys. Acta 1354:183-188(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-165, NUCLEOTIDE SEQUENCE [MRNA] OF 1026-1796 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1760-1796 (ISOFORM 2).
[4]	"Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins." Just M., Herbst H., Hummel M., Duerkop H., Tripier D., Stein H., Schuppan D. J. Biol. Chem. 266:17326-17332(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 149-582 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 188-1030 (ISOFORM 1).
[5]	"Structure and stability of the triple-helical domains of human collagen XIV." Brown J.C., Golbik R., Mann K., Timpl R. Matrix Biol. 14:287-295(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1459-1635 AND 1640-1767, HYDROXYLATION AT PRO-1467; PRO-1470; LYS-1476; PRO-1482; LYS-1485; PRO-1497; PRO-1503; PRO-1517; PRO-1520; LYS-1523; LYS-1526; PRO-1532; PRO-1538; PRO-1544; PRO-1550; PRO-1556; PRO-1565; PRO-1568; PRO-1574; PRO-1577; PRO-1580; PRO-1595; PRO-1598; LYS-1601; PRO-1643; PRO-1656; PRO-1659; PRO-1662; PRO-1665; PRO-1668; PRO-1674; PRO-1677; PRO-1680; PRO-1686; PRO-1689; LYS-1698; LYS-1701; PRO-1704; PRO-1715; PRO-1726; PRO-1729; PRO-1732; PRO-1735; PRO-1741; PRO-1747 AND PRO-1756, GLYCOSYLATION AT LYS-1476; LYS-1485; LYS-1523; LYS-1526; LYS-1601; LYS-1698 AND LYS-1701. Tissue: Placenta.
[6]	"Undulin, an extracellular matrix glycoprotein associated with collagen fibrils." Schuppan D., Cantaluppi M., Becker J., Veit A., Bunte T., Troyer D., Schuppan F., Schmid M., Ackermann R., Hahn E. J. Biol. Chem. 265:8823-8832(1990) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94; ASN-372; ASN-1384 AND ASN-1388, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020603 Genomic DNA. No translation available. AC090735 Genomic DNA. No translation available. AC107877 Genomic DNA. No translation available. BC014640 mRNA. Translation: AAH14640.1. Frameshift. BC083495 mRNA. Translation: AAH83495.1. BC140893 mRNA. Translation: AAI40894.1. Y11709 mRNA. Translation: CAA72401.1. Y11710 mRNA. Translation: CAA72402.1. Y11711 mRNA. Translation: CAA72403.1. M64108 mRNA. Translation: AAA36794.1. M64109 mRNA. Translation: AAA36795.1. Sequence problems.
IPI	IPI00176193. IPI00402215. IPI00550918.
PIR	A40970. B40970. S37749. S46657.
RefSeq	NP_066933.1. NM_021110.2.
UniGene	Hs.409662.
3D structure databases
ProteinModelPortal	Q05707.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q05707. 2 interactions.
PTM databases
PhosphoSite	Q05707.
Polymorphism databases
DMDM	125987815.
Proteomic databases
PaxDb	Q05707.
PRIDE	Q05707.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247781; ENSP00000247781; ENSG00000187955. ENST00000297848; ENSP00000297848; ENSG00000187955. ENST00000309791; ENSP00000311809; ENSG00000187955.
GeneID	7373.
KEGG	hsa:7373.
UCSC	uc003yox.3. human.
Organism-specific databases
CTD	7373.
GeneCards	GC08P121093.
H-InvDB	HIX0007753.
HGNC	HGNC:2191. COL14A1.
HPA	HPA023781.
MIM	120324. gene.
neXtProt	NX_Q05707.
PharmGKB	PA26707.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307460.
HOVERGEN	HBG051060.
InParanoid	Q05707.
KO	K08133.
OMA	VYNVAEF.
OrthoDB	EOG4PC9R7.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	Q05707.
Bgee	Q05707.
CleanEx	HS_COL14A1.
Genevestigator	Q05707.
GermOnline	ENSG00000187955. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 8 hits.
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR001791. Laminin_G. IPR002035. VWF_A. [Graphical view]
Pfam	PF01391. Collagen. 4 hits. PF00041. fn3. 8 hits. PF00092. VWA. 2 hits. [Graphical view]
SMART	SM00060. FN3. 8 hits. SM00210. TSPN. 1 hit. SM00327. VWA. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 8 hits.
PROSITE	PS50853. FN3. 8 hits. PS50025. LAM_G_DOMAIN. False negative. PS50234. VWFA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	COL14A1. human.
GenomeRNAi	7373.
NextBio	28870.
SOURCE	Search...

Entry information

Entry name

COEA1_HUMAN

Accession

Primary (citable) accession number: Q05707
Secondary accession number(s): B2RU07 , O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67, Q9UDF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.