ID   BPIB3_RAT               Reviewed;         473 AA.
AC   Q05701;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 120.
DE   RecName: Full=BPI fold-containing family B member 3 {ECO:0000305};
DE   AltName: Full=Ligand-binding protein RYA3;
DE   AltName: Full=Long palate, lung and nasal epithelium carcinoma-associated protein 3;
DE   Flags: Precursor;
GN   Name=Bpifb3 {ECO:0000312|RGD:1565613}; Synonyms=Lplunc3, Rya3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fischer; TISSUE=Olfactory epithelium;
RX   PubMed=1915264; DOI=10.1002/j.1460-2075.1991.tb07830.x;
RA   Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.;
RT   "Novel genes for potential ligand-binding proteins in subregions of the
RT   olfactory mucosa.";
RL   EMBO J. 10:2813-2819(1991).
CC   -!- FUNCTION: May have the capacity to recognize and bind specific classes
CC       of odorants. May act as a carrier molecule, transporting odorants
CC       across the mucus layer to access receptor sites. May serve as a primary
CC       defense mechanism by recognizing and removing potentially harmful
CC       odorants or pathogenic microorganisms from the mucosa or clearing
CC       excess odorant from mucus to enable new odorant stimuli to be received.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in olfactory mucosa but
CC       undetectable in thymus, kidney, lung, brain, spleen and liver.
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC       {ECO:0000305}.
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DR   EMBL; X60658; CAA43065.1; -; mRNA.
DR   RefSeq; XP_006235414.1; XM_006235352.3.
DR   AlphaFoldDB; Q05701; -.
DR   SMR; Q05701; -.
DR   STRING; 10116.ENSRNOP00000052216; -.
DR   GlyCosmos; Q05701; 1 site, No reported glycans.
DR   GlyGen; Q05701; 1 site.
DR   PhosphoSitePlus; Q05701; -.
DR   PaxDb; 10116-ENSRNOP00000052216; -.
DR   Ensembl; ENSRNOT00055044563; ENSRNOP00055036469; ENSRNOG00055025838.
DR   Ensembl; ENSRNOT00060040224; ENSRNOP00060033197; ENSRNOG00060023262.
DR   Ensembl; ENSRNOT00065042814; ENSRNOP00065035050; ENSRNOG00065024910.
DR   GeneID; 499924; -.
DR   UCSC; RGD:1565613; rat.
DR   AGR; RGD:1565613; -.
DR   CTD; 359710; -.
DR   RGD; 1565613; Bpifb3.
DR   eggNOG; KOG4160; Eukaryota.
DR   HOGENOM; CLU_031635_1_0_1; -.
DR   InParanoid; Q05701; -.
DR   OrthoDB; 5263773at2759; -.
DR   PhylomeDB; Q05701; -.
DR   TreeFam; TF315617; -.
DR   PRO; PR:Q05701; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0005549; F:odorant binding; NAS:UniProtKB.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR46019:SF5; BPI FOLD-CONTAINING FAMILY B MEMBER 3; 1.
DR   PANTHER; PTHR46019; BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00328; BPI1; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..473
FT                   /note="BPI fold-containing family B member 3"
FT                   /id="PRO_0000017172"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        161..196
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   473 AA;  49949 MW;  BB6957AFD62A26B9 CRC64;
     MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV
     NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP TVSIKLLPGV GVQLSLHTKV
     SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILILKR CNTLLGHISL TSGLLPTPIF
     GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI
     ELDINPIVKS IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD
     ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN KKVTVSIPVT
     IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS LERLTVQLAS SFSQPFDASR
     LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI LNVNFANSVV DVIENAVVLT VAP
//