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Protein

BPI fold-containing family B member 3

Gene

Bpifb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.

GO - Molecular functioni

  • lipid binding Source: InterPro
  • odorant binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1565613. Bpifb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 473453BPI fold-containing family B member 3PRO_0000017172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 196By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05701.
PRIDEiQ05701.

Expressioni

Tissue specificityi

Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052216.

Structurei

3D structure databases

ProteinModelPortaliQ05701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 234214Gly/Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiQ05701.
OMAiEWLSHVV.
OrthoDBiEOG715Q45.
PhylomeDBiQ05701.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL
60 70 80 90 100
QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP
110 120 130 140 150
TVSIKLLPGV GVQLSLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP
160 170 180 190 200
RGTPILILKR CNTLLGHISL TSGLLPTPIF GLVEQTLCKV LPGLLCPVVD
210 220 230 240 250
SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS
260 270 280 290 300
IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD
310 320 330 340 350
ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN
360 370 380 390 400
KKVTVSIPVT IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS
410 420 430 440 450
LERLTVQLAS SFSQPFDASR LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI
460 470
LNVNFANSVV DVIENAVVLT VAP
Length:473
Mass (Da):49,949
Last modified:November 1, 1996 - v1
Checksum:iBB6957AFD62A26B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60658 mRNA. Translation: CAA43065.1.
RefSeqiXP_006235414.1. XM_006235352.2.
UniGeneiRn.218676.

Genome annotation databases

GeneIDi499924.
UCSCiRGD:1565613. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60658 mRNA. Translation: CAA43065.1.
RefSeqiXP_006235414.1. XM_006235352.2.
UniGeneiRn.218676.

3D structure databases

ProteinModelPortaliQ05701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052216.

Proteomic databases

PaxDbiQ05701.
PRIDEiQ05701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi499924.
UCSCiRGD:1565613. rat.

Organism-specific databases

CTDi359710.
RGDi1565613. Bpifb3.

Phylogenomic databases

eggNOGiNOG317196.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiQ05701.
OMAiEWLSHVV.
OrthoDBiEOG715Q45.
PhylomeDBiQ05701.
TreeFamiTF315617.

Miscellaneous databases

PROiQ05701.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa."
    Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.
    EMBO J. 10:2813-2819(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiBPIB3_RAT
AccessioniPrimary (citable) accession number: Q05701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.