Q05701 (BPIB3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family B member 3

Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3

Gene names

Name:	Bpifb3
Synonyms:	Lplunc3, Rya3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.
Subcellular location	Secreted By similarity.
Tissue specificity	Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro odorant binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 473	453	BPI fold-containing family B member 3		PRO_0000017172
Regions
	Compositional bias	21 – 234	214	Gly/Leu-rich
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q05701 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BB6957AFD62A26B9	FASTA	473	49,949
	10 20 30 40 50 60 MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV 70 80 90 100 110 120 NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP TVSIKLLPGV GVQLSLHTKV 130 140 150 160 170 180 SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILILKR CNTLLGHISL TSGLLPTPIF 190 200 210 220 230 240 GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI 250 260 270 280 290 300 ELDINPIVKS IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD 310 320 330 340 350 360 ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN KKVTVSIPVT 370 380 390 400 410 420 IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS LERLTVQLAS SFSQPFDASR 430 440 450 460 470 LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI LNVNFANSVV DVIENAVVLT VAP

References

[1]	"Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa." Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H. EMBO J. 10:2813-2819(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Fischer. Tissue: Olfactory epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X60658 mRNA. Translation: CAA43065.1.
IPI	IPI00359288.
UniGene	Rn.218676.
3D structure databases
ProteinModelPortal	Q05701.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000052216.
Proteomic databases
PaxDb	Q05701.
PRIDE	Q05701.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000055349; ENSRNOP00000052216; ENSRNOG00000013398.
UCSC	RGD:1565613. rat.
Organism-specific databases
RGD	1565613. Bpifb3.
Phylogenomic databases
eggNOG	NOG317196.
GeneTree	ENSGT00620000087589.
HOGENOM	HOG000231741.
HOVERGEN	HBG050718.
InParanoid	Q05701.
OMA	PLISNQY.
OrthoDB	EOG4C5CJM.
Gene expression databases
Genevestigator	Q05701.
GermOnline	ENSRNOG00000013398. Rattus norvegicus.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
PROSITE	PS00400. LBP_BPI_CETP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BPIB3_RAT

Accession

Primary (citable) accession number: Q05701

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program