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Q05701

- BPIB3_RAT

UniProt

Q05701 - BPIB3_RAT

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Protein
BPI fold-containing family B member 3
Gene
Bpifb3, Lplunc3, Rya3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.

GO - Molecular functioni

  1. lipid binding Source: InterPro
  2. odorant binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1565613. Bpifb3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 473453BPI fold-containing family B member 3
PRO_0000017172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 196 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05701.
PRIDEiQ05701.

Expressioni

Tissue specificityi

Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.

Gene expression databases

GenevestigatoriQ05701.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052216.

Structurei

3D structure databases

ProteinModelPortaliQ05701.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 234214Gly/Leu-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiQ05701.
OMAiPLISNQY.
OrthoDBiEOG715Q45.
PhylomeDBiQ05701.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05701-1 [UniParc]FASTAAdd to Basket

« Hide

MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL    50
QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP 100
TVSIKLLPGV GVQLSLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP 150
RGTPILILKR CNTLLGHISL TSGLLPTPIF GLVEQTLCKV LPGLLCPVVD 200
SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS 250
IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD 300
ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN 350
KKVTVSIPVT IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS 400
LERLTVQLAS SFSQPFDASR LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI 450
LNVNFANSVV DVIENAVVLT VAP 473
Length:473
Mass (Da):49,949
Last modified:November 1, 1996 - v1
Checksum:iBB6957AFD62A26B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60658 mRNA. Translation: CAA43065.1.
RefSeqiXP_006235414.1. XM_006235352.1.
UniGeneiRn.218676.

Genome annotation databases

EnsembliENSRNOT00000055349; ENSRNOP00000052216; ENSRNOG00000013398.
GeneIDi499924.
KEGGirno:499924.
UCSCiRGD:1565613. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60658 mRNA. Translation: CAA43065.1 .
RefSeqi XP_006235414.1. XM_006235352.1.
UniGenei Rn.218676.

3D structure databases

ProteinModelPortali Q05701.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000052216.

Proteomic databases

PaxDbi Q05701.
PRIDEi Q05701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055349 ; ENSRNOP00000052216 ; ENSRNOG00000013398 .
GeneIDi 499924.
KEGGi rno:499924.
UCSCi RGD:1565613. rat.

Organism-specific databases

CTDi 359710.
RGDi 1565613. Bpifb3.

Phylogenomic databases

eggNOGi NOG317196.
GeneTreei ENSGT00730000110772.
HOGENOMi HOG000231741.
HOVERGENi HBG050718.
InParanoidi Q05701.
OMAi PLISNQY.
OrthoDBi EOG715Q45.
PhylomeDBi Q05701.
TreeFami TF315617.

Miscellaneous databases

PROi Q05701.

Gene expression databases

Genevestigatori Q05701.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa."
    Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.
    EMBO J. 10:2813-2819(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiBPIB3_RAT
AccessioniPrimary (citable) accession number: Q05701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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