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Q05701

- BPIB3_RAT

UniProt

Q05701 - BPIB3_RAT

Protein

BPI fold-containing family B member 3

Gene

Bpifb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.

    GO - Molecular functioni

    1. lipid binding Source: InterPro
    2. odorant binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BPI fold-containing family B member 3
    Alternative name(s):
    Ligand-binding protein RYA3
    Long palate, lung and nasal epithelium carcinoma-associated protein 3
    Gene namesi
    Name:Bpifb3
    Synonyms:Lplunc3, Rya3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1565613. Bpifb3.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 473453BPI fold-containing family B member 3PRO_0000017172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 196By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ05701.
    PRIDEiQ05701.

    Expressioni

    Tissue specificityi

    Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.

    Gene expression databases

    GenevestigatoriQ05701.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 234214Gly/Leu-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG317196.
    GeneTreeiENSGT00730000110772.
    HOGENOMiHOG000231741.
    HOVERGENiHBG050718.
    InParanoidiQ05701.
    OMAiPLISNQY.
    OrthoDBiEOG715Q45.
    PhylomeDBiQ05701.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05701-1 [UniParc]FASTAAdd to Basket

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    MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL    50
    QNVLGTVTSV NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP 100
    TVSIKLLPGV GVQLSLHTKV SLHGSGPLVG LLQLAAEVNV SSKVALGMSP 150
    RGTPILILKR CNTLLGHISL TSGLLPTPIF GLVEQTLCKV LPGLLCPVVD 200
    SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI ELDINPIVKS 250
    IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD 300
    ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN 350
    KKVTVSIPVT IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS 400
    LERLTVQLAS SFSQPFDASR LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI 450
    LNVNFANSVV DVIENAVVLT VAP 473
    Length:473
    Mass (Da):49,949
    Last modified:November 1, 1996 - v1
    Checksum:iBB6957AFD62A26B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60658 mRNA. Translation: CAA43065.1.
    RefSeqiXP_006235414.1. XM_006235352.1.
    UniGeneiRn.218676.

    Genome annotation databases

    EnsembliENSRNOT00000055349; ENSRNOP00000052216; ENSRNOG00000013398.
    GeneIDi499924.
    KEGGirno:499924.
    UCSCiRGD:1565613. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60658 mRNA. Translation: CAA43065.1 .
    RefSeqi XP_006235414.1. XM_006235352.1.
    UniGenei Rn.218676.

    3D structure databases

    ProteinModelPortali Q05701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052216.

    Proteomic databases

    PaxDbi Q05701.
    PRIDEi Q05701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055349 ; ENSRNOP00000052216 ; ENSRNOG00000013398 .
    GeneIDi 499924.
    KEGGi rno:499924.
    UCSCi RGD:1565613. rat.

    Organism-specific databases

    CTDi 359710.
    RGDi 1565613. Bpifb3.

    Phylogenomic databases

    eggNOGi NOG317196.
    GeneTreei ENSGT00730000110772.
    HOGENOMi HOG000231741.
    HOVERGENi HBG050718.
    InParanoidi Q05701.
    OMAi PLISNQY.
    OrthoDBi EOG715Q45.
    PhylomeDBi Q05701.
    TreeFami TF315617.

    Miscellaneous databases

    PROi Q05701.

    Gene expression databases

    Genevestigatori Q05701.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa."
      Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.
      EMBO J. 10:2813-2819(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer.
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiBPIB3_RAT
    AccessioniPrimary (citable) accession number: Q05701
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3