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Q05701 (BPIB3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene names
Name:Bpifb3
Synonyms:Lplunc3, Rya3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received.

Subcellular location

Secreted By similarity.

Tissue specificity

Highly expressed in olfactory mucosa but undetectable in thymus, kidney, lung, brain, spleen and liver.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

odorant binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 473453BPI fold-containing family B member 3
PRO_0000017172

Regions

Compositional bias21 – 234214Gly/Leu-rich

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Disulfide bond161 ↔ 196 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05701 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BB6957AFD62A26B9

FASTA47349,949
        10         20         30         40         50         60 
MMPGVYALLL LWGLATPCLG LLETVGTLAR IDKDELGKAI QNSLVGGPIL QNVLGTVTSV 

        70         80         90        100        110        120 
NQGLLGAGGL LGGGGLLSYG GLFSLVEELS GLKIEELTLP TVSIKLLPGV GVQLSLHTKV 

       130        140        150        160        170        180 
SLHGSGPLVG LLQLAAEVNV SSKVALGMSP RGTPILILKR CNTLLGHISL TSGLLPTPIF 

       190        200        210        220        230        240 
GLVEQTLCKV LPGLLCPVVD SVLSVVNELL GATLSLVPLG PLGSVEFTLA TLPLISNQYI 

       250        260        270        280        290        300 
ELDINPIVKS IAGDVIDFPK PRLPVKMPPK EDHTSQVTVP LYLFNTVFGL LQTNGALDLD 

       310        320        330        340        350        360 
ITPEMVPRNI PLTTTDLAAL APEALGKLPP GQHLLLSLRV MKSPMILLQN KKVTVSIPVT 

       370        380        390        400        410        420 
IHVLSSVPQG TPVALFQMNG VMTLNAHLVP STTKLHISLS LERLTVQLAS SFSQPFDASR 

       430        440        450        460        470 
LEEWLSDVVR AAYMQKLNEH LEVGIPLPKI LNVNFANSVV DVIENAVVLT VAP 

« Hide

References

[1]"Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa."
Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.
EMBO J. 10:2813-2819(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer.
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60658 mRNA. Translation: CAA43065.1.
RefSeqXP_006235414.1. XM_006235352.1.
UniGeneRn.218676.

3D structure databases

ProteinModelPortalQ05701.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000052216.

Proteomic databases

PaxDbQ05701.
PRIDEQ05701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055349; ENSRNOP00000052216; ENSRNOG00000013398.
GeneID499924.
UCSCRGD:1565613. rat.

Organism-specific databases

RGD1565613. Bpifb3.

Phylogenomic databases

eggNOGNOG317196.
GeneTreeENSGT00730000110772.
HOGENOMHOG000231741.
HOVERGENHBG050718.
InParanoidQ05701.
OMAPLISNQY.
OrthoDBEOG715Q45.
TreeFamTF315617.

Gene expression databases

GenevestigatorQ05701.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
ProtoNetSearch...

Other

PROQ05701.

Entry information

Entry nameBPIB3_RAT
AccessionPrimary (citable) accession number: Q05701
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families