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Q05695 (L1CAM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neural cell adhesion molecule L1

Short name=N-CAM-L1
Short name=NCAM-L1
Alternative name(s):
Nerve-growth factor-inducible large external glycoprotein
Short name=NILE
CD_antigen=CD171
Gene names
Name:L1cam
Synonyms:Caml1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.

Sequence similarities

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Contains 5 fibronectin type-III domains.

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q05695-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q05695-2)

Also known as: L1cs;

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1182: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 12591240Neural cell adhesion molecule L1
PRO_0000015024

Regions

Topological domain20 – 11221103Extracellular Potential
Transmembrane1123 – 114523Helical; Potential
Topological domain1146 – 1259114Cytoplasmic Potential
Domain35 – 12894Ig-like C2-type 1
Domain138 – 22588Ig-like C2-type 2
Domain239 – 32789Ig-like C2-type 3
Domain332 – 41988Ig-like C2-type 4
Domain424 – 50683Ig-like C2-type 5
Domain517 – 60084Ig-like C2-type 6
Domain613 – 71199Fibronectin type-III 1
Domain716 – 80994Fibronectin type-III 2
Domain811 – 916106Fibronectin type-III 3
Domain919 – 101496Fibronectin type-III 4
Domain1016 – 1116101Fibronectin type-III 5
Motif553 – 5553Cell attachment site Potential
Motif562 – 5643Cell attachment site Potential

Amino acid modifications

Modified residue11651Phosphoserine By similarity
Modified residue11831Phosphoserine; by CaMK2 By similarity
Modified residue11961Phosphoserine By similarity
Modified residue12501Phosphoserine By similarity
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4891N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Glycosylation6701N-linked (GlcNAc...) Potential
Glycosylation7251N-linked (GlcNAc...) Potential
Glycosylation7761N-linked (GlcNAc...) Potential
Glycosylation8241N-linked (GlcNAc...) Potential
Glycosylation8481N-linked (GlcNAc...) Potential
Glycosylation8751N-linked (GlcNAc...) Potential
Glycosylation9681N-linked (GlcNAc...) Potential
Glycosylation9781N-linked (GlcNAc...) Potential
Glycosylation10211N-linked (GlcNAc...) Potential
Glycosylation10291N-linked (GlcNAc...) Potential
Glycosylation10721N-linked (GlcNAc...) Potential
Glycosylation11061N-linked (GlcNAc...) Potential
Disulfide bond57 ↔ 113 By similarity
Disulfide bond157 ↔ 208 By similarity
Disulfide bond263 ↔ 311 By similarity
Disulfide bond353 ↔ 403 By similarity
Disulfide bond447 ↔ 496 By similarity
Disulfide bond538 ↔ 590 By similarity

Natural variations

Alternative sequence1179 – 11824Missing in isoform 2.
VSP_002592

Experimental info

Sequence conflict12001D → G Ref.2
Sequence conflict12361E → K Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 2, 2002. Version 3.
Checksum: 0F12A7C4415F3C08

FASTA1,259140,935
        10         20         30         40         50         60 
MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT DDISLKCEAR 

        70         80         90        100        110        120 
GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN NSFAQRFQGI YRCYASNNLG 

       130        140        150        160        170        180 
TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ 

       190        200        210        220        230        240 
DERVSMGQNG DLYFANVLTS DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR 

       250        260        270        280        290        300 
LLFPTNSSSH LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN 

       310        320        330        340        350        360 
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR LDCQVQGRPQ 

       370        380        390        400        410        420 
PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV TQCEARNQHG LLLANAYIYV 

       430        440        450        460        470        480 
VQLPARILTK DNQTYMAVEG STAYLLCKAF GAPVPSVQWL DEEGTTVLQD ERFFPYANGH 

       490        500        510        520        530        540 
LGIRDLQAND TGRYFCQAAN DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA 

       550        560        570        580        590        600 
SFDPSLQASI TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE 

       610        620        630        640        650        660 
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE FEDKEMAPEK 

       670        680        690        700        710        720 
WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS PVSETVVTPE AAPEKNPVDV 

       730        740        750        760        770        780 
RGEGNETNNM VITWKPLRWM DWNAPQIQYR VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF 

       790        800        810        820        830        840 
VPYEIKVQAV NNQGKGPEPQ VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV 

       850        860        870        880        890        900 
KGHLRGYNVT YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR 

       910        920        930        940        950        960 
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY LLSYHPLDGE 

       970        980        990       1000       1010       1020 
SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP GEAIVREGGT MALFGKPDFG 

      1030       1040       1050       1060       1070       1080 
NISVTAGENY SVVSWVPREG QCNFRFHILF KALPEGKVSP DHQPQPQYVS YNQSSYTQWD 

      1090       1100       1110       1120       1130       1140 
LQPDTKYEIH LMREKVLLHH LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL 

      1150       1160       1170       1180       1190       1200 
ILCFIKRSKG GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD 

      1210       1220       1230       1240       1250 
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS PINPAVALE 

« Hide

Isoform 2 (L1cs) [UniParc].

Checksum: 3A9E2BD90064F5EC
Show »

FASTA1,255140,449

References

[1]"Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing."
Miura M., Kobayashi M., Asou H., Uyemura K.
FEBS Lett. 289:91-95(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain."
Prince J.T., Milona N., Stallcup W.B.
J. Neurosci. 9:876-883(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1237.
[3]Erratum
Prince J.T., Milona N., Stallcup W.B.
J. Neurosci. 9:1825-1834(1989) [PubMed] [Europe PMC] [Abstract]
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59149 mRNA. Translation: CAA41860.1.
PIRS36126.
RefSeqNP_059041.1. NM_017345.1.
UniGeneRn.10378.

3D structure databases

ProteinModelPortalQ05695.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248425. 1 interaction.
STRING10116.ENSRNOP00000053189.

PTM databases

PhosphoSiteQ05695.

Proteomic databases

PaxDbQ05695.
PRIDEQ05695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID50687.
KEGGrno:50687.

Organism-specific databases

CTD3897.
RGD619777. L1cam.

Phylogenomic databases

eggNOGNOG293951.
HOGENOMHOG000231380.
HOVERGENHBG000144.
InParanoidQ05695.
KOK06550.
PhylomeDBQ05695.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.
REACT_195021. Developmental Biology.

Gene expression databases

GenevestigatorQ05695.

Family and domain databases

Gene3D2.60.40.10. 11 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 3 hits.
PROSITEPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio610540.
PROQ05695.

Entry information

Entry nameL1CAM_RAT
AccessionPrimary (citable) accession number: Q05695
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 2, 2002
Last modified: April 16, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families