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Q05695

- L1CAM_RAT

UniProt

Q05695 - L1CAM_RAT

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Protein

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

GO - Molecular functioni

  1. PDZ domain binding Source: RGD

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. cellular response to ethanol Source: RGD
  4. cellular response to transforming growth factor beta stimulus Source: RGD
  5. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule L1
Short name:
N-CAM-L1
Short name:
NCAM-L1
Alternative name(s):
Nerve-growth factor-inducible large external glycoprotein
Short name:
NILE
CD_antigen: CD171
Gene namesi
Name:L1cam
Synonyms:Caml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619777. L1cam.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: RGD
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 12591240Neural cell adhesion molecule L1PRO_0000015024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 113PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi157 ↔ 208PROSITE-ProRule annotation
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi263 ↔ 311PROSITE-ProRule annotation
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi353 ↔ 403PROSITE-ProRule annotation
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi447 ↔ 496PROSITE-ProRule annotation
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi538 ↔ 590PROSITE-ProRule annotation
Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi824 – 8241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi875 – 8751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1021 – 10211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1029 – 10291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1072 – 10721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1106 – 11061N-linked (GlcNAc...)Sequence Analysis
Modified residuei1165 – 11651PhosphoserineBy similarity
Modified residuei1183 – 11831Phosphoserine; by CaMK2By similarity
Modified residuei1196 – 11961PhosphoserineBy similarity
Modified residuei1250 – 12501PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05695.
PRIDEiQ05695.

PTM databases

PhosphoSiteiQ05695.

Expressioni

Tissue specificityi

Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.

Gene expression databases

GenevestigatoriQ05695.

Interactioni

Protein-protein interaction databases

BioGridi248425. 1 interaction.
STRINGi10116.ENSRNOP00000053189.

Structurei

3D structure databases

ProteinModelPortaliQ05695.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11221103ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1146 – 1259114CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1123 – 114523HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12894Ig-like C2-type 1Add
BLAST
Domaini138 – 22588Ig-like C2-type 2Add
BLAST
Domaini239 – 32789Ig-like C2-type 3Add
BLAST
Domaini332 – 41988Ig-like C2-type 4Add
BLAST
Domaini424 – 50683Ig-like C2-type 5Add
BLAST
Domaini517 – 60084Ig-like C2-type 6Add
BLAST
Domaini613 – 71199Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini716 – 80994Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini811 – 916106Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini919 – 101496Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini1016 – 1116101Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi553 – 5553Cell attachment siteSequence Analysis
Motifi562 – 5643Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293951.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiQ05695.
KOiK06550.
PhylomeDBiQ05695.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q05695) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT
60 70 80 90 100
DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN
110 120 130 140 150
NSFAQRFQGI YRCYASNNLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG
160 170 180 190 200
ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ DERVSMGQNG DLYFANVLTS
210 220 230 240 250
DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSH
260 270 280 290 300
LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN
310 320 330 340 350
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR
360 370 380 390 400
LDCQVQGRPQ PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV
410 420 430 440 450
TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF
460 470 480 490 500
GAPVPSVQWL DEEGTTVLQD ERFFPYANGH LGIRDLQAND TGRYFCQAAN
510 520 530 540 550
DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA SFDPSLQASI
560 570 580 590 600
TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE
610 620 630 640 650
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE
660 670 680 690 700
FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS
710 720 730 740 750
PVSETVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR
760 770 780 790 800
VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ
810 820 830 840 850
VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLRGYNVT
860 870 880 890 900
YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR
910 920 930 940 950
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY
960 970 980 990 1000
LLSYHPLDGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP
1010 1020 1030 1040 1050
GEAIVREGGT MALFGKPDFG NISVTAGENY SVVSWVPREG QCNFRFHILF
1060 1070 1080 1090 1100
KALPEGKVSP DHQPQPQYVS YNQSSYTQWD LQPDTKYEIH LMREKVLLHH
1110 1120 1130 1140 1150
LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL ILCFIKRSKG
1160 1170 1180 1190 1200
GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD
1210 1220 1230 1240 1250
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS

PINPAVALE
Length:1,259
Mass (Da):140,935
Last modified:May 2, 2002 - v3
Checksum:i0F12A7C4415F3C08
GO
Isoform 2 (identifier: Q05695-2) [UniParc]FASTAAdd to Basket

Also known as: L1cs

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1182: Missing.

Show »
Length:1,255
Mass (Da):140,449
Checksum:i3A9E2BD90064F5EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1200 – 12001D → G(PubMed:2466966)Curated
Sequence conflicti1236 – 12361E → K(PubMed:2466966)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1179 – 11824Missing in isoform 2. 1 PublicationVSP_002592

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59149 mRNA. Translation: CAA41860.1.
PIRiS36126.
RefSeqiNP_059041.1. NM_017345.1. [Q05695-2]
UniGeneiRn.10378.

Genome annotation databases

GeneIDi50687.
KEGGirno:50687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59149 mRNA. Translation: CAA41860.1 .
PIRi S36126.
RefSeqi NP_059041.1. NM_017345.1. [Q05695-2 ]
UniGenei Rn.10378.

3D structure databases

ProteinModelPortali Q05695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248425. 1 interaction.
STRINGi 10116.ENSRNOP00000053189.

PTM databases

PhosphoSitei Q05695.

Proteomic databases

PaxDbi Q05695.
PRIDEi Q05695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 50687.
KEGGi rno:50687.

Organism-specific databases

CTDi 3897.
RGDi 619777. L1cam.

Phylogenomic databases

eggNOGi NOG293951.
HOGENOMi HOG000231380.
HOVERGENi HBG000144.
InParanoidi Q05695.
KOi K06550.
PhylomeDBi Q05695.

Miscellaneous databases

NextBioi 610540.
PROi Q05695.

Gene expression databases

Genevestigatori Q05695.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view ]
Pfami PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing."
    Miura M., Kobayashi M., Asou H., Uyemura K.
    FEBS Lett. 289:91-95(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain."
    Prince J.T., Milona N., Stallcup W.B.
    J. Neurosci. 9:876-883(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1237.
  3. Erratum
    Prince J.T., Milona N., Stallcup W.B.
    J. Neurosci. 9:1825-1834(1989) [PubMed] [Europe PMC] [Abstract]

Entry informationi

Entry nameiL1CAM_RAT
AccessioniPrimary (citable) accession number: Q05695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 2, 2002
Last modified: October 1, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3