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Q05695

- L1CAM_RAT

UniProt

Q05695 - L1CAM_RAT

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Protein
Neural cell adhesion molecule L1
Gene
L1cam, Caml1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

GO - Molecular functioni

  1. PDZ domain binding Source: RGD

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. cellular response to ethanol Source: RGD
  4. cellular response to transforming growth factor beta stimulus Source: RGD
  5. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule L1
Short name:
N-CAM-L1
Short name:
NCAM-L1
Alternative name(s):
Nerve-growth factor-inducible large external glycoprotein
Short name:
NILE
CD_antigen: CD171
Gene namesi
Name:L1cam
Synonyms:Caml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619777. L1cam.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11221103Extracellular Reviewed prediction
Add
BLAST
Transmembranei1123 – 114523Helical; Reviewed prediction
Add
BLAST
Topological domaini1146 – 1259114Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: RGD
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 12591240Neural cell adhesion molecule L1
PRO_0000015024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 113 By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi157 ↔ 208 By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi263 ↔ 311 By similarity
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi353 ↔ 403 By similarity
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi447 ↔ 496 By similarity
Glycosylationi489 – 4891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi504 – 5041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi538 ↔ 590 By similarity
Glycosylationi670 – 6701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi725 – 7251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi776 – 7761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi824 – 8241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi848 – 8481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi875 – 8751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi968 – 9681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi978 – 9781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1021 – 10211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1029 – 10291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1072 – 10721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1106 – 11061N-linked (GlcNAc...) Reviewed prediction
Modified residuei1165 – 11651Phosphoserine By similarity
Modified residuei1183 – 11831Phosphoserine; by CaMK2 By similarity
Modified residuei1196 – 11961Phosphoserine By similarity
Modified residuei1250 – 12501Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05695.
PRIDEiQ05695.

PTM databases

PhosphoSiteiQ05695.

Expressioni

Tissue specificityi

Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.

Gene expression databases

GenevestigatoriQ05695.

Interactioni

Protein-protein interaction databases

BioGridi248425. 1 interaction.
STRINGi10116.ENSRNOP00000053189.

Structurei

3D structure databases

ProteinModelPortaliQ05695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12894Ig-like C2-type 1
Add
BLAST
Domaini138 – 22588Ig-like C2-type 2
Add
BLAST
Domaini239 – 32789Ig-like C2-type 3
Add
BLAST
Domaini332 – 41988Ig-like C2-type 4
Add
BLAST
Domaini424 – 50683Ig-like C2-type 5
Add
BLAST
Domaini517 – 60084Ig-like C2-type 6
Add
BLAST
Domaini613 – 71199Fibronectin type-III 1
Add
BLAST
Domaini716 – 80994Fibronectin type-III 2
Add
BLAST
Domaini811 – 916106Fibronectin type-III 3
Add
BLAST
Domaini919 – 101496Fibronectin type-III 4
Add
BLAST
Domaini1016 – 1116101Fibronectin type-III 5
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi553 – 5553Cell attachment site Reviewed prediction
Motifi562 – 5643Cell attachment site Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293951.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiQ05695.
KOiK06550.
PhylomeDBiQ05695.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q05695-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT     50
DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN 100
NSFAQRFQGI YRCYASNNLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG 150
ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ DERVSMGQNG DLYFANVLTS 200
DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSH 250
LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN 300
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR 350
LDCQVQGRPQ PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV 400
TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF 450
GAPVPSVQWL DEEGTTVLQD ERFFPYANGH LGIRDLQAND TGRYFCQAAN 500
DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA SFDPSLQASI 550
TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE 600
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE 650
FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS 700
PVSETVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR 750
VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ 800
VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLRGYNVT 850
YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR 900
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY 950
LLSYHPLDGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP 1000
GEAIVREGGT MALFGKPDFG NISVTAGENY SVVSWVPREG QCNFRFHILF 1050
KALPEGKVSP DHQPQPQYVS YNQSSYTQWD LQPDTKYEIH LMREKVLLHH 1100
LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL ILCFIKRSKG 1150
GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD 1200
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS 1250
PINPAVALE 1259
Length:1,259
Mass (Da):140,935
Last modified:May 2, 2002 - v3
Checksum:i0F12A7C4415F3C08
GO
Isoform 2 (identifier: Q05695-2) [UniParc]FASTAAdd to Basket

Also known as: L1cs

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1182: Missing.

Show »
Length:1,255
Mass (Da):140,449
Checksum:i3A9E2BD90064F5EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1179 – 11824Missing in isoform 2.
VSP_002592

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1200 – 12001D → G1 Publication
Sequence conflicti1236 – 12361E → K1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59149 mRNA. Translation: CAA41860.1.
PIRiS36126.
RefSeqiNP_059041.1. NM_017345.1. [Q05695-2]
UniGeneiRn.10378.

Genome annotation databases

GeneIDi50687.
KEGGirno:50687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59149 mRNA. Translation: CAA41860.1 .
PIRi S36126.
RefSeqi NP_059041.1. NM_017345.1. [Q05695-2 ]
UniGenei Rn.10378.

3D structure databases

ProteinModelPortali Q05695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248425. 1 interaction.
STRINGi 10116.ENSRNOP00000053189.

PTM databases

PhosphoSitei Q05695.

Proteomic databases

PaxDbi Q05695.
PRIDEi Q05695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 50687.
KEGGi rno:50687.

Organism-specific databases

CTDi 3897.
RGDi 619777. L1cam.

Phylogenomic databases

eggNOGi NOG293951.
HOGENOMi HOG000231380.
HOVERGENi HBG000144.
InParanoidi Q05695.
KOi K06550.
PhylomeDBi Q05695.

Miscellaneous databases

NextBioi 610540.
PROi Q05695.

Gene expression databases

Genevestigatori Q05695.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view ]
Pfami PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing."
    Miura M., Kobayashi M., Asou H., Uyemura K.
    FEBS Lett. 289:91-95(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain."
    Prince J.T., Milona N., Stallcup W.B.
    J. Neurosci. 9:876-883(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1237.
  3. Erratum
    Prince J.T., Milona N., Stallcup W.B.
    J. Neurosci. 9:1825-1834(1989) [PubMed] [Europe PMC] [Abstract]

Entry informationi

Entry nameiL1CAM_RAT
AccessioniPrimary (citable) accession number: Q05695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 2, 2002
Last modified: September 3, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi