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Q05695

- L1CAM_RAT

UniProt

Q05695 - L1CAM_RAT

Protein

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (02 May 2002)
      Previous versions | rss
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    Functioni

    Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

    GO - Molecular functioni

    1. PDZ domain binding Source: RGD

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. cellular response to ethanol Source: RGD
    4. cellular response to transforming growth factor beta stimulus Source: RGD
    5. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion, Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neural cell adhesion molecule L1
    Short name:
    N-CAM-L1
    Short name:
    NCAM-L1
    Alternative name(s):
    Nerve-growth factor-inducible large external glycoprotein
    Short name:
    NILE
    CD_antigen: CD171
    Gene namesi
    Name:L1cam
    Synonyms:Caml1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619777. L1cam.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: RGD
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 12591240Neural cell adhesion molecule L1PRO_0000015024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 113PROSITE-ProRule annotation
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 208PROSITE-ProRule annotation
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi263 ↔ 311PROSITE-ProRule annotation
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi353 ↔ 403PROSITE-ProRule annotation
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi447 ↔ 496PROSITE-ProRule annotation
    Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi538 ↔ 590PROSITE-ProRule annotation
    Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi824 – 8241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi875 – 8751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1021 – 10211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1029 – 10291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1072 – 10721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1106 – 11061N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1165 – 11651PhosphoserineBy similarity
    Modified residuei1183 – 11831Phosphoserine; by CaMK2By similarity
    Modified residuei1196 – 11961PhosphoserineBy similarity
    Modified residuei1250 – 12501PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ05695.
    PRIDEiQ05695.

    PTM databases

    PhosphoSiteiQ05695.

    Expressioni

    Tissue specificityi

    Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.

    Gene expression databases

    GenevestigatoriQ05695.

    Interactioni

    Protein-protein interaction databases

    BioGridi248425. 1 interaction.
    STRINGi10116.ENSRNOP00000053189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05695.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 11221103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1146 – 1259114CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1123 – 114523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 12894Ig-like C2-type 1Add
    BLAST
    Domaini138 – 22588Ig-like C2-type 2Add
    BLAST
    Domaini239 – 32789Ig-like C2-type 3Add
    BLAST
    Domaini332 – 41988Ig-like C2-type 4Add
    BLAST
    Domaini424 – 50683Ig-like C2-type 5Add
    BLAST
    Domaini517 – 60084Ig-like C2-type 6Add
    BLAST
    Domaini613 – 71199Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini716 – 80994Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini811 – 916106Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini919 – 101496Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1016 – 1116101Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi553 – 5553Cell attachment siteSequence Analysis
    Motifi562 – 5643Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293951.
    HOGENOMiHOG000231380.
    HOVERGENiHBG000144.
    InParanoidiQ05695.
    KOiK06550.
    PhylomeDBiQ05695.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view]
    PfamiPF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 5 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q05695-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT     50
    DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN 100
    NSFAQRFQGI YRCYASNNLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG 150
    ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ DERVSMGQNG DLYFANVLTS 200
    DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSH 250
    LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN 300
    VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR 350
    LDCQVQGRPQ PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV 400
    TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF 450
    GAPVPSVQWL DEEGTTVLQD ERFFPYANGH LGIRDLQAND TGRYFCQAAN 500
    DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA SFDPSLQASI 550
    TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE 600
    SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE 650
    FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS 700
    PVSETVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR 750
    VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ 800
    VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLRGYNVT 850
    YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR 900
    GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY 950
    LLSYHPLDGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP 1000
    GEAIVREGGT MALFGKPDFG NISVTAGENY SVVSWVPREG QCNFRFHILF 1050
    KALPEGKVSP DHQPQPQYVS YNQSSYTQWD LQPDTKYEIH LMREKVLLHH 1100
    LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL ILCFIKRSKG 1150
    GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD 1200
    IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS 1250
    PINPAVALE 1259
    Length:1,259
    Mass (Da):140,935
    Last modified:May 2, 2002 - v3
    Checksum:i0F12A7C4415F3C08
    GO
    Isoform 2 (identifier: Q05695-2) [UniParc]FASTAAdd to Basket

    Also known as: L1cs

    The sequence of this isoform differs from the canonical sequence as follows:
         1179-1182: Missing.

    Show »
    Length:1,255
    Mass (Da):140,449
    Checksum:i3A9E2BD90064F5EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1200 – 12001D → G(PubMed:2466966)Curated
    Sequence conflicti1236 – 12361E → K(PubMed:2466966)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1179 – 11824Missing in isoform 2. 1 PublicationVSP_002592

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59149 mRNA. Translation: CAA41860.1.
    PIRiS36126.
    RefSeqiNP_059041.1. NM_017345.1. [Q05695-2]
    UniGeneiRn.10378.

    Genome annotation databases

    GeneIDi50687.
    KEGGirno:50687.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59149 mRNA. Translation: CAA41860.1 .
    PIRi S36126.
    RefSeqi NP_059041.1. NM_017345.1. [Q05695-2 ]
    UniGenei Rn.10378.

    3D structure databases

    ProteinModelPortali Q05695.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248425. 1 interaction.
    STRINGi 10116.ENSRNOP00000053189.

    PTM databases

    PhosphoSitei Q05695.

    Proteomic databases

    PaxDbi Q05695.
    PRIDEi Q05695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 50687.
    KEGGi rno:50687.

    Organism-specific databases

    CTDi 3897.
    RGDi 619777. L1cam.

    Phylogenomic databases

    eggNOGi NOG293951.
    HOGENOMi HOG000231380.
    HOVERGENi HBG000144.
    InParanoidi Q05695.
    KOi K06550.
    PhylomeDBi Q05695.

    Miscellaneous databases

    NextBioi 610540.
    PROi Q05695.

    Gene expression databases

    Genevestigatori Q05695.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view ]
    Pfami PF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 4 hits.
    PF07679. I-set. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing."
      Miura M., Kobayashi M., Asou H., Uyemura K.
      FEBS Lett. 289:91-95(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Characterization of a partial cDNA clone for the NILE glycoprotein and identification of the encoded polypeptide domain."
      Prince J.T., Milona N., Stallcup W.B.
      J. Neurosci. 9:876-883(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1159-1237.
    3. Erratum
      Prince J.T., Milona N., Stallcup W.B.
      J. Neurosci. 9:1825-1834(1989) [PubMed] [Europe PMC] [Abstract]

    Entry informationi

    Entry nameiL1CAM_RAT
    AccessioniPrimary (citable) accession number: Q05695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3