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Protein

Neural cell adhesion molecule L1

Gene

L1cam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

GO - Molecular functioni

  • PDZ domain binding Source: RGD

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cellular response to ethanol Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • positive regulation of axon extension Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-437239. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule L1
Short name:
N-CAM-L1
Short name:
NCAM-L1
Alternative name(s):
Nerve-growth factor-inducible large external glycoprotein
Short name:
NILE
CD_antigen: CD171
Gene namesi
Name:L1cam
Synonyms:Caml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619777. L1cam.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1122ExtracellularSequence analysisAdd BLAST1103
Transmembranei1123 – 1145HelicalSequence analysisAdd BLAST23
Topological domaini1146 – 1259CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

  • axon Source: RGD
  • axonal growth cone Source: UniProtKB
  • cell surface Source: RGD
  • dendrite Source: RGD
  • endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • neuronal cell body Source: RGD
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001502420 – 1259Neural cell adhesion molecule L1Add BLAST1240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 113PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi157 ↔ 208PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 311PROSITE-ProRule annotation
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi353 ↔ 403PROSITE-ProRule annotation
Glycosylationi432N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi447 ↔ 496PROSITE-ProRule annotation
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi538 ↔ 590PROSITE-ProRule annotation
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Glycosylationi725N-linked (GlcNAc...)Sequence analysis1
Glycosylationi776N-linked (GlcNAc...)Sequence analysis1
Glycosylationi824N-linked (GlcNAc...)Sequence analysis1
Glycosylationi848N-linked (GlcNAc...)Sequence analysis1
Glycosylationi875N-linked (GlcNAc...)Sequence analysis1
Glycosylationi968N-linked (GlcNAc...)Sequence analysis1
Glycosylationi978N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1021N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1029N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1072N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1106N-linked (GlcNAc...)Sequence analysis1
Modified residuei1165PhosphoserineBy similarity1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1183PhosphoserineCombined sources1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1245PhosphoserineCombined sources1
Modified residuei1246PhosphoserineCombined sources1
Modified residuei1250PhosphoserineBy similarity1
Isoform 2 (identifier: Q05695-2)
Modified residuei1179PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05695.
PRIDEiQ05695.

PTM databases

iPTMnetiQ05695.
PhosphoSitePlusiQ05695.
SwissPalmiQ05695.
UniCarbKBiQ05695.

Expressioni

Tissue specificityi

Isoform 2 is predominantly found in the brain, while isoform 1 is found in the peripheral nervous system.

Interactioni

Subunit structurei

Interacts with SHTN1; the interaction occurs in axonal growth cones (PubMed:18519736).1 Publication

GO - Molecular functioni

  • PDZ domain binding Source: RGD

Protein-protein interaction databases

BioGridi248425. 1 interactor.
STRINGi10116.ENSRNOP00000053191.

Structurei

3D structure databases

ProteinModelPortaliQ05695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 128Ig-like C2-type 1Add BLAST94
Domaini138 – 225Ig-like C2-type 2Add BLAST88
Domaini239 – 327Ig-like C2-type 3Add BLAST89
Domaini332 – 419Ig-like C2-type 4Add BLAST88
Domaini424 – 506Ig-like C2-type 5Add BLAST83
Domaini517 – 600Ig-like C2-type 6Add BLAST84
Domaini613 – 711Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini716 – 809Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini811 – 916Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST106
Domaini919 – 1014Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1016 – 1116Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi553 – 555Cell attachment siteSequence analysis3
Motifi562 – 564Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiQ05695.
KOiK06550.
PhylomeDBiQ05695.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05695-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMMLWYVLP LLLCSPCLLI QIPDEYKGHH VLEPPVITEQ SPRRLVVFPT
60 70 80 90 100
DDISLKCEAR GRPQVEFRWT KDGIHFKPKE ELGVVVHEAP YSGSFTIEGN
110 120 130 140 150
NSFAQRFQGI YRCYASNNLG TAMSHEIQLV AEGAPKWPKE TVKPVEVEEG
160 170 180 190 200
ESVVLPCNPP PSAAPLRIYW MNSKILHIKQ DERVSMGQNG DLYFANVLTS
210 220 230 240 250
DNHSDYICNA HFPGTRTIIQ KEPIDLRVKP TNSMIDRKPR LLFPTNSSSH
260 270 280 290 300
LVALQGQSLI LECIAEGFPT PTIKWLHPSD PMPTDRVIYQ NHNKTLQLLN
310 320 330 340 350
VGEEDDGEYT CLAENSLGSA RHAYYVTVEA APYWLQKPQS HLYGPGETAR
360 370 380 390 400
LDCQVQGRPQ PEVTWRINGM SIEKVNKDQK YRIEQGSLIL SNVQPSDTMV
410 420 430 440 450
TQCEARNQHG LLLANAYIYV VQLPARILTK DNQTYMAVEG STAYLLCKAF
460 470 480 490 500
GAPVPSVQWL DEEGTTVLQD ERFFPYANGH LGIRDLQAND TGRYFCQAAN
510 520 530 540 550
DQNNVTILAN LQVKEATQIT QGPRSTIEKK GARVTFTCQA SFDPSLQASI
560 570 580 590 600
TWRGDGRDLQ ERGDSDKYFI EDGQLVIKSL DYSDQGDYSC VASTELDEVE
610 620 630 640 650
SRAQLLVVGS PGPVPHLELS DRHLLKQSQV HLSWSPAEDH NSPIEKYDIE
660 670 680 690 700
FEDKEMAPEK WFSLGKVPGN QTSTTLKLSP YVHYTFRVTA INKYGPGEPS
710 720 730 740 750
PVSETVVTPE AAPEKNPVDV RGEGNETNNM VITWKPLRWM DWNAPQIQYR
760 770 780 790 800
VQWRPLGKQE TWKEQTVSDP FLVVSNTSTF VPYEIKVQAV NNQGKGPEPQ
810 820 830 840 850
VTIGYSGEDY PQVSPELEDI TIFNSSTVLV RWRPVDLAQV KGHLRGYNVT
860 870 880 890 900
YWWKGSQRKH SKRHVHKSHM VVPANTTSAI LSGLRPYSSY HVEVQAFNGR
910 920 930 940 950
GLGPASEWTF STPEGVPGHP EALHLECQSD TSLLLHWQPP LSHNGVLTGY
960 970 980 990 1000
LLSYHPLDGE SKEQLFFNLS DPELRTHNLT NLNPDLQYRF QLQATTHQGP
1010 1020 1030 1040 1050
GEAIVREGGT MALFGKPDFG NISVTAGENY SVVSWVPREG QCNFRFHILF
1060 1070 1080 1090 1100
KALPEGKVSP DHQPQPQYVS YNQSSYTQWD LQPDTKYEIH LMREKVLLHH
1110 1120 1130 1140 1150
LAVKTNGTGP VRVSTTGSFA SEGWFIAFVS AIILLLLILL ILCFIKRSKG
1160 1170 1180 1190 1200
GKYSVKDKED TQVDSEARPM KDETFGEYRS LESDNEEKAF GSSQPSLNGD
1210 1220 1230 1240 1250
IKPLGSDDSL ADYGGSVDVQ FNEDGSFIGQ YSGKKEKEAA GGNDSSGATS

PINPAVALE
Length:1,259
Mass (Da):140,935
Last modified:May 2, 2002 - v3
Checksum:i0F12A7C4415F3C08
GO
Isoform 2 (identifier: Q05695-2) [UniParc]FASTAAdd to basket
Also known as: L1cs

The sequence of this isoform differs from the canonical sequence as follows:
     1179-1182: Missing.

Show »
Length:1,255
Mass (Da):140,449
Checksum:i3A9E2BD90064F5EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1200D → G (PubMed:2466966).Curated1
Sequence conflicti1236E → K (PubMed:2466966).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0025921179 – 1182Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59149 mRNA. Translation: CAA41860.1.
PIRiS36126.
RefSeqiNP_059041.1. NM_017345.1. [Q05695-2]
UniGeneiRn.10378.

Genome annotation databases

GeneIDi50687.
KEGGirno:50687.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59149 mRNA. Translation: CAA41860.1.
PIRiS36126.
RefSeqiNP_059041.1. NM_017345.1. [Q05695-2]
UniGeneiRn.10378.

3D structure databases

ProteinModelPortaliQ05695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248425. 1 interactor.
STRINGi10116.ENSRNOP00000053191.

PTM databases

iPTMnetiQ05695.
PhosphoSitePlusiQ05695.
SwissPalmiQ05695.
UniCarbKBiQ05695.

Proteomic databases

PaxDbiQ05695.
PRIDEiQ05695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50687.
KEGGirno:50687.

Organism-specific databases

CTDi3897.
RGDi619777. L1cam.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiQ05695.
KOiK06550.
PhylomeDBiQ05695.

Enzyme and pathway databases

ReactomeiR-RNO-437239. Recycling pathway of L1.

Miscellaneous databases

PROiQ05695.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL1CAM_RAT
AccessioniPrimary (citable) accession number: Q05695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 2, 2002
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.