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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

cna-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi128IronBy similarity1
Metal bindingi130IronBy similarity1
Metal bindingi156IronBy similarity1
Metal bindingi156ZincBy similarity1
Metal bindingi188ZincBy similarity1
Active sitei189Proton donorBy similarity1
Metal bindingi237ZincBy similarity1
Metal bindingi319ZincBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase, Protein phosphatase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Calmodulin-dependent calcineurin A subunit
Gene namesi
Name:cna-1
ORF Names:99H12.070, NCU03804
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU03804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588331 – 558Serine/threonine-protein phosphatase 2B catalytic subunitAdd BLAST558

Proteomic databases

PRIDEiQ05681

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ05681
SMRiQ05681
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172699
InParanoidiQ05681
KOiK04348
OrthoDBiEOG092C1CSB

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q05681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNNGTGAP GAFHTQQVDN AIRAIQHKRP LPEIDFTIHT MEDGSQVSTM
60 70 80 90 100
ERVCKDVQAP AMFKPSDEQF FEDETHTKPD IQFLKQHFYR EGRLTEEQAL
110 120 130 140 150
WIIREGTKLL RAEPNLLEMD APITVCGDVH GQYYDLMKLF EVGGDPAETR
160 170 180 190 200
YLFLGDYVDR GYFSIECVLY LWALKIHYPK TLWLLRGNHE CRHLTDYFTF
210 220 230 240 250
KLECKHKYSE AIYEACMESF CCLPLAAVMN KQFLCIHGGL SPELHTLDDI
260 270 280 290 300
RNIDRFREPP TQGLMCDILW ADPLEDFGQE KTTDFFVHNH VRGCSYFFSY
310 320 330 340 350
SAACHFLEKN NLLSIIRAHE AQDAGYRMYR KTRTTGFPSV MTIFSAPNYL
360 370 380 390 400
DVYNNKAAVL KYENNVMNIR QFNCTPHPYW LPNFMDVFTW SLPFVGEKIT
410 420 430 440 450
DMLIAILSTC SEEELREDSA TTSPGSASPA LPSAANQDPD SIEFKRRAIK
460 470 480 490 500
NKILAIGRLS RVFQVLREES ERVTELKTVS GGRLPAGTLM LGAEGIKNAI
510 520 530 540 550
SSFEDARKVD LQNERLPPSH DEVVKMQDEE RAQALERATR EADNDKKLQT

LSRRLSTS
Length:558
Mass (Da):63,914
Last modified:December 4, 2007 - v2
Checksum:iFDE74D72A000A55E
GO

Sequence cautioni

The sequence AAA33565 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC18243 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73032 mRNA Translation: AAA33565.1 Different initiation.
AL451018 Genomic DNA Translation: CAC18243.1 Sequence problems.
CM002240 Genomic DNA Translation: ESA42471.1
PIRiA40942
RefSeqiXP_011394597.1, XM_011396295.1

Genome annotation databases

EnsemblFungiiESA42471; ESA42471; NCU03804
GeneIDi3877353
KEGGincr:NCU03804

Similar proteinsi

Entry informationi

Entry nameiPP2B_NEUCR
AccessioniPrimary (citable) accession number: Q05681
Secondary accession number(s): Q1K7G7, Q9HEE2, V5INZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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