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Q05676 (SOM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SOM1, mitochondrial
Alternative name(s):
Mitochondrial inner membrane protease subunit SOM1
Gene names
Name:SOM1
Ordered Locus Names:YEL059C-A
ORF Names:YEL059BC
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length74 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Non-catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates. Ref.1 Ref.6

Subunit structure

Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1. Ref.1

Subcellular location

Mitochondrion inner membrane Potential.

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 74Protein SOM1, mitochondrialPRO_0000022385

Sequences

Sequence LengthMass (Da)Tools
Q05676 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B41CBA3547954E97

FASTA748,416
        10         20         30         40         50         60 
MAPPTTIRTR DQALAPLATL DSQTNCRLKE LVQWECQFKG AEYVCSPFKR LFEHCIAPDK 

        70 
SATNYEVTDT YTNS 

« Hide

References

« Hide 'large scale' references
[1]"SOM1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae."
Esser K., Pratje E., Michaelis G.
Mol. Gen. Genet. 252:437-445(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE IMP COMPLEX.
Strain: SC167.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria."
Liang H., Luo W., Green N., Fang H.
J. Biol. Chem. 279:39396-39400(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90459 Genomic DNA. Translation: CAA62083.1.
U18795 Genomic DNA. Translation: AAB65036.1.
AY558445 Genomic DNA. Translation: AAS56771.1.
BK006939 Genomic DNA. Translation: DAA07595.1.
PIRS72624.
RefSeqNP_058154.3. NM_001180854.3.

3D structure databases

ProteinModelPortalQ05676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36670. 5 interactions.
IntActQ05676. 1 interaction.
MINTMINT-4483551.
STRING4932.YEL059C-A.

Proteomic databases

PaxDbQ05676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL059C-A; YEL059C-A; YEL059C-A.
GeneID856650.
KEGGsce:YEL059C-A.

Organism-specific databases

CYGDYEL059c-a.
SGDS000002954. SOM1.

Phylogenomic databases

eggNOGNOG76771.
HOGENOMHOG000000835.
KOK17802.
OMANECAFNG.
OrthoDBEOG79W9JJ.

Enzyme and pathway databases

BioCycYEAST:G3O-30351-MONOMER.

Gene expression databases

GenevestigatorQ05676.

Family and domain databases

InterProIPR024645. Mitochondr_Som1.
[Graphical view]
PfamPF11093. Mitochondr_Som1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982628.

Entry information

Entry nameSOM1_YEAST
AccessionPrimary (citable) accession number: Q05676
Secondary accession number(s): D3DLJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD