Reviewed, UniProtKB/Swiss-Prot Q05676 (SOM1_YEAST)

Names and origin

Protein names

Recommended name:
    Protein SOM1, mitochondrial
Alternative name(s):
    Mitochondrial inner membrane protease subunit SOM1

Gene names

Name:	SOM1
Ordered Locus Names:	YEL059C-A
ORF Names:	YEL059BC

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Noncatalytical component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates. Ref.1 Ref.5
Subunit structure	Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.
Subcellular location	Mitochondrion inner membrane Potential.
Miscellaneous	Present with 358 molecules/cell in log phase SD medium. Ref.4

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial respiratory chain complex assembly Inferred from mutant phenotype. Source: SGD proteolysis Ref.1 Inferred from genetic interaction. Source: SGD
Cellular component	mitochondrial inner membrane peptidase complex Inferred from physical interaction. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 74		Protein SOM1, mitochondrial		PRO_0000022385

Sequences

	Sequence		Length	Mass (Da)
	Q05676-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B41CBA3547954E97	FASTA	74	8,416
	10 20 30 40 50 60 MAPPTTIRTR DQALAPLATL DSQTNCRLKE LVQWECQFKG AEYVCSPFKR LFEHCIAPDK 70 SATNYEVTDT YTNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOM1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae." Esser K., Pratje E., Michaelis G. Mol. Gen. Genet. 252:437-445(1996) [PubMed: 8879245] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE IMP COMPLEX. Strain: SC167.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria." Liang H., Luo W., Green N., Fang H. J. Biol. Chem. 279:39396-39400(2004) [PubMed: 15254042] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X90459 Genomic DNA. Translation: CAA62083.1. U18795 Genomic DNA. Translation: AAB65036.1. AY558445 Genomic DNA. Translation: AAS56771.1.
PIR	S72624.
RefSeq	NP_058154.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q05676.
Genome annotation databases
Ensembl	YEL059C-A; YEL059C-A; YEL059C-A; Saccharomyces cerevisiae. [Genome view]
GeneID	856650.
KEGG	sce:YEL059C-A.
NMPDR	fig|4932.3.peg.1903.
Organism-specific databases
CYGD	YEL059c-a.
SGD	S000002954. SOM1.
Phylogenomic databases
HOGENOM	Q05676.
OMA	ITERNTN
OrthoDB	EOG9ZW6TD
Gene expression databases
ArrayExpress	Q05676.
Genevestigator	Q05676.
GermOnline	YEL059C-A. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	982628.

Entry information

Entry name

SOM1_YEAST

Accession

Primary (citable) accession number: Q05676

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)