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Q05676

- SOM1_YEAST

UniProt

Q05676 - SOM1_YEAST

Protein

Protein SOM1, mitochondrial

Gene

SOM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Non-catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates.2 Publications

    GO - Biological processi

    1. mitochondrial respiratory chain complex assembly Source: SGD
    2. proteolysis Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30351-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SOM1, mitochondrial
    Alternative name(s):
    Mitochondrial inner membrane protease subunit SOM1
    Gene namesi
    Name:SOM1
    Ordered Locus Names:YEL059C-A
    ORF Names:YEL059BC
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL059c-a.
    SGDiS000002954. SOM1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: SGD
    2. mitochondrial inner membrane peptidase complex Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 74Protein SOM1, mitochondrialPRO_0000022385
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ05676.
    PaxDbiQ05676.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05676.

    Interactioni

    Subunit structurei

    Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.1 Publication

    Protein-protein interaction databases

    BioGridi36670. 5 interactions.
    IntActiQ05676. 1 interaction.
    MINTiMINT-4483551.
    STRINGi4932.YEL059C-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05676.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG76771.
    HOGENOMiHOG000000835.
    KOiK17802.
    OMAiGKSARCH.
    OrthoDBiEOG79W9JJ.

    Family and domain databases

    InterProiIPR024645. Mitochondr_Som1.
    [Graphical view]
    PfamiPF11093. Mitochondr_Som1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPTTIRTR DQALAPLATL DSQTNCRLKE LVQWECQFKG AEYVCSPFKR   50
    LFEHCIAPDK SATNYEVTDT YTNS 74
    Length:74
    Mass (Da):8,416
    Last modified:November 1, 1996 - v1
    Checksum:iB41CBA3547954E97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90459 Genomic DNA. Translation: CAA62083.1.
    U18795 Genomic DNA. Translation: AAB65036.1.
    AY558445 Genomic DNA. Translation: AAS56771.1.
    BK006939 Genomic DNA. Translation: DAA07595.1.
    PIRiS72624.
    RefSeqiNP_058154.3. NM_001180854.3.

    Genome annotation databases

    EnsemblFungiiYEL059C-A; YEL059C-A; YEL059C-A.
    GeneIDi856650.
    KEGGisce:YEL059C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90459 Genomic DNA. Translation: CAA62083.1 .
    U18795 Genomic DNA. Translation: AAB65036.1 .
    AY558445 Genomic DNA. Translation: AAS56771.1 .
    BK006939 Genomic DNA. Translation: DAA07595.1 .
    PIRi S72624.
    RefSeqi NP_058154.3. NM_001180854.3.

    3D structure databases

    ProteinModelPortali Q05676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36670. 5 interactions.
    IntActi Q05676. 1 interaction.
    MINTi MINT-4483551.
    STRINGi 4932.YEL059C-A.

    Proteomic databases

    MaxQBi Q05676.
    PaxDbi Q05676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL059C-A ; YEL059C-A ; YEL059C-A .
    GeneIDi 856650.
    KEGGi sce:YEL059C-A.

    Organism-specific databases

    CYGDi YEL059c-a.
    SGDi S000002954. SOM1.

    Phylogenomic databases

    eggNOGi NOG76771.
    HOGENOMi HOG000000835.
    KOi K17802.
    OMAi GKSARCH.
    OrthoDBi EOG79W9JJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30351-MONOMER.

    Miscellaneous databases

    NextBioi 982628.

    Gene expression databases

    Genevestigatori Q05676.

    Family and domain databases

    InterProi IPR024645. Mitochondr_Som1.
    [Graphical view ]
    Pfami PF11093. Mitochondr_Som1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOM1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae."
      Esser K., Pratje E., Michaelis G.
      Mol. Gen. Genet. 252:437-445(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE IMP COMPLEX.
      Strain: SC167.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria."
      Liang H., Luo W., Green N., Fang H.
      J. Biol. Chem. 279:39396-39400(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSOM1_YEAST
    AccessioniPrimary (citable) accession number: Q05676
    Secondary accession number(s): D3DLJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 358 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3