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Q05676

- SOM1_YEAST

UniProt

Q05676 - SOM1_YEAST

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Protein

Protein SOM1, mitochondrial

Gene

SOM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Non-catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. SOM1 facilitates cleavage of a subset of IMP substrates.2 Publications

GO - Biological processi

  1. mitochondrial respiratory chain complex assembly Source: SGD
  2. proteolysis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOM1, mitochondrial
Alternative name(s):
Mitochondrial inner membrane protease subunit SOM1
Gene namesi
Name:SOM1
Ordered Locus Names:YEL059C-A
ORF Names:YEL059BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL059c-a.
SGDiS000002954. SOM1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: SGD
  2. mitochondrial inner membrane peptidase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 74Protein SOM1, mitochondrialPRO_0000022385
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ05676.
PaxDbiQ05676.

Expressioni

Gene expression databases

GenevestigatoriQ05676.

Interactioni

Subunit structurei

Component of the mitochondrial inner membrane peptidase (IMP) complex which at least consists of IMP1, IMP2 and SOM1.1 Publication

Protein-protein interaction databases

BioGridi36670. 5 interactions.
IntActiQ05676. 1 interaction.
MINTiMINT-4483551.
STRINGi4932.YEL059C-A.

Structurei

3D structure databases

ProteinModelPortaliQ05676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG76771.
HOGENOMiHOG000000835.
InParanoidiQ05676.
KOiK17802.
OMAiGKSARCH.
OrthoDBiEOG79W9JJ.

Family and domain databases

InterProiIPR024645. Mitochondr_Som1.
[Graphical view]
PfamiPF11093. Mitochondr_Som1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05676-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPTTIRTR DQALAPLATL DSQTNCRLKE LVQWECQFKG AEYVCSPFKR
60 70
LFEHCIAPDK SATNYEVTDT YTNS
Length:74
Mass (Da):8,416
Last modified:November 1, 1996 - v1
Checksum:iB41CBA3547954E97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90459 Genomic DNA. Translation: CAA62083.1.
U18795 Genomic DNA. Translation: AAB65036.1.
AY558445 Genomic DNA. Translation: AAS56771.1.
BK006939 Genomic DNA. Translation: DAA07595.1.
PIRiS72624.
RefSeqiNP_058154.3. NM_001180854.3.

Genome annotation databases

EnsemblFungiiYEL059C-A; YEL059C-A; YEL059C-A.
GeneIDi856650.
KEGGisce:YEL059C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90459 Genomic DNA. Translation: CAA62083.1 .
U18795 Genomic DNA. Translation: AAB65036.1 .
AY558445 Genomic DNA. Translation: AAS56771.1 .
BK006939 Genomic DNA. Translation: DAA07595.1 .
PIRi S72624.
RefSeqi NP_058154.3. NM_001180854.3.

3D structure databases

ProteinModelPortali Q05676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36670. 5 interactions.
IntActi Q05676. 1 interaction.
MINTi MINT-4483551.
STRINGi 4932.YEL059C-A.

Proteomic databases

MaxQBi Q05676.
PaxDbi Q05676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL059C-A ; YEL059C-A ; YEL059C-A .
GeneIDi 856650.
KEGGi sce:YEL059C-A.

Organism-specific databases

CYGDi YEL059c-a.
SGDi S000002954. SOM1.

Phylogenomic databases

eggNOGi NOG76771.
HOGENOMi HOG000000835.
InParanoidi Q05676.
KOi K17802.
OMAi GKSARCH.
OrthoDBi EOG79W9JJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30351-MONOMER.

Miscellaneous databases

NextBioi 982628.

Gene expression databases

Genevestigatori Q05676.

Family and domain databases

InterProi IPR024645. Mitochondr_Som1.
[Graphical view ]
Pfami PF11093. Mitochondr_Som1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SOM1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae."
    Esser K., Pratje E., Michaelis G.
    Mol. Gen. Genet. 252:437-445(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE IMP COMPLEX.
    Strain: SC167.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria."
    Liang H., Luo W., Green N., Fang H.
    J. Biol. Chem. 279:39396-39400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSOM1_YEAST
AccessioniPrimary (citable) accession number: Q05676
Secondary accession number(s): D3DLJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3