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Q05670

- FUS2_YEAST

UniProt

Q05670 - FUS2_YEAST

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Protein
Nuclear fusion protein FUS2
Gene
FUS2, YMR232W, YM9959.14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes cell fusion during zygote formation.

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. conjugation with cellular fusion Source: SGD
  2. cytogamy Source: SGD
  3. karyogamy involved in conjugation with cellular fusion Source: SGD
  4. regulation of termination of mating projection growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32913-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fusion protein FUS2
Gene namesi
Name:FUS2
Ordered Locus Names:YMR232W
ORF Names:YM9959.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR232w.
SGDiS000004845. FUS2.

Subcellular locationi

Cell tip
Note: Localizes at the mating projection tip (shmoo).

GO - Cellular componenti

  1. cell tip Source: UniProtKB-SubCell
  2. cytoplasm Source: SGD
  3. mating projection tip Source: SGD
  4. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Nuclear fusion protein FUS2
PRO_0000080954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphothreonine1 Publication
Modified residuei67 – 671Phosphoserine1 Publication
Modified residuei72 – 721Phosphoserine1 Publication
Modified residuei84 – 841Phosphoserine1 Publication
Modified residuei88 – 881Phosphothreonine1 Publication
Modified residuei100 – 1001Phosphoserine1 Publication
Modified residuei106 – 1061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05670.

Expressioni

Gene expression databases

GenevestigatoriQ05670.

Interactioni

Protein-protein interaction databases

BioGridi35410. 45 interactions.
DIPiDIP-2711N.
IntActiQ05670. 12 interactions.
MINTiMINT-472882.

Structurei

3D structure databases

ProteinModelPortaliQ05670.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 326215DH
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG43014.
HOGENOMiHOG000112669.
OMAiLTPIRDY.
OrthoDBiEOG7BP8CX.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05670-1 [UniParc]FASTAAdd to Basket

« Hide

MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK    50
HENKLNDKKF TNKRPASLDL HSIVESLSNK KIYSPINTEI FQNVVRLNLS 100
PQIPNSPHEG CKFYKIVQEF YLSEVEYYNN LLTANNVYRK ALNSDPRFKN 150
KLVKLDSSDE LLLFGNIDTI ASISKILVTA IKDLLLAKQR GKMLDANEWQ 200
KIFTKNEVQQ QLYSTFDISE AFEQHLLRIK STYTSYFVSH QKQMELFTTL 250
RMNKNHFFNK WYEYCLKESG CIKLEDILKS PMKRLTQWID TLETLESCYE 300
DILSPELGLK LSPTRRKYSL FSNKLETEVS EYKSNSMYNF SLTPSEIIQS 350
YDEDQFTHLL KPPDKQNKNI CNASRQESNL DNSRVPSLLS GSSSYYSDVS 400
GLEIVTNTST ASAEMINLKM DEETEFFTLA DHISKFKKVM KGLLELKKNL 450
LKNDLSGIID ISLRRINAWK KVIECERPSG AFFAHDNLIS TMCSSYIDKL 500
HEQKNQVTIL KLTELETDVM NPLERIIAHC TTVKSKLKDL QALKKDYMLF 550
LQEKKANVRD IKRDLLGMHF QNLQNQMKRE LPVFITLIHD TIECILLNYI 600
KVFLKYLEII AGGKKYLQKD LENMSLNDSI ATGQIKNLDI LQCYSKSRYM 650
TKRMVRKDWP FPGDPSGSRV VRKLFEL 677
Length:677
Mass (Da):79,037
Last modified:November 1, 1997 - v1
Checksum:iD7C89ED0738EA31F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851L → R in CAA62275. 1 Publication
Sequence conflicti203 – 2031F → L in CAA62275. 1 Publication
Sequence conflicti543 – 5464Missing in CAA62275. 1 Publication
Sequence conflicti589 – 67789HDTIE…KLFEL → PRYYRMYLVELYQSLLKIFG NHCWWKKIPAKRS in CAA62275. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90752 Genomic DNA. Translation: CAA62275.1.
Z49939 Genomic DNA. Translation: CAA90203.1.
BK006946 Genomic DNA. Translation: DAA10132.1.
PIRiS57599.
RefSeqiNP_013959.1. NM_001182739.1.

Genome annotation databases

EnsemblFungiiYMR232W; YMR232W; YMR232W.
GeneIDi855272.
KEGGisce:YMR232W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90752 Genomic DNA. Translation: CAA62275.1 .
Z49939 Genomic DNA. Translation: CAA90203.1 .
BK006946 Genomic DNA. Translation: DAA10132.1 .
PIRi S57599.
RefSeqi NP_013959.1. NM_001182739.1.

3D structure databases

ProteinModelPortali Q05670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35410. 45 interactions.
DIPi DIP-2711N.
IntActi Q05670. 12 interactions.
MINTi MINT-472882.

Proteomic databases

PaxDbi Q05670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR232W ; YMR232W ; YMR232W .
GeneIDi 855272.
KEGGi sce:YMR232W.

Organism-specific databases

CYGDi YMR232w.
SGDi S000004845. FUS2.

Phylogenomic databases

eggNOGi NOG43014.
HOGENOMi HOG000112669.
OMAi LTPIRDY.
OrthoDBi EOG7BP8CX.

Enzyme and pathway databases

BioCyci YEAST:G3O-32913-MONOMER.

Miscellaneous databases

NextBioi 978888.

Gene expression databases

Genevestigatori Q05670.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
InterProi IPR000219. DH-domain.
[Graphical view ]
SMARTi SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation."
    Elion E.A., Trueheart J., Fink G.R.
    J. Cell Biol. 130:1283-1296(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-67; SER-72; SER-84; THR-88; SER-100 AND SER-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.

Entry informationi

Entry nameiFUS2_YEAST
AccessioniPrimary (citable) accession number: Q05670
Secondary accession number(s): D6W058, Q05023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi