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Q05670

- FUS2_YEAST

UniProt

Q05670 - FUS2_YEAST

Protein

Nuclear fusion protein FUS2

Gene

FUS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Promotes cell fusion during zygote formation.

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. conjugation with cellular fusion Source: SGD
    2. cytogamy Source: SGD
    3. karyogamy involved in conjugation with cellular fusion Source: SGD
    4. regulation of termination of mating projection growth Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32913-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear fusion protein FUS2
    Gene namesi
    Name:FUS2
    Ordered Locus Names:YMR232W
    ORF Names:YM9959.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR232w.
    SGDiS000004845. FUS2.

    Subcellular locationi

    Cell tip
    Note: Localizes at the mating projection tip (shmoo).

    GO - Cellular componenti

    1. cell tip Source: UniProtKB-SubCell
    2. cytoplasm Source: SGD
    3. mating projection tip Source: SGD
    4. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Nuclear fusion protein FUS2PRO_0000080954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Phosphothreonine1 Publication
    Modified residuei67 – 671Phosphoserine1 Publication
    Modified residuei72 – 721Phosphoserine1 Publication
    Modified residuei84 – 841Phosphoserine1 Publication
    Modified residuei88 – 881Phosphothreonine1 Publication
    Modified residuei100 – 1001Phosphoserine1 Publication
    Modified residuei106 – 1061Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ05670.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05670.

    Interactioni

    Protein-protein interaction databases

    BioGridi35410. 45 interactions.
    DIPiDIP-2711N.
    IntActiQ05670. 12 interactions.
    MINTiMINT-472882.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 326215DHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43014.
    HOGENOMiHOG000112669.
    OMAiLTPIRDY.
    OrthoDBiEOG7BP8CX.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    InterProiIPR000219. DH-domain.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05670-1 [UniParc]FASTAAdd to Basket

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    MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK    50
    HENKLNDKKF TNKRPASLDL HSIVESLSNK KIYSPINTEI FQNVVRLNLS 100
    PQIPNSPHEG CKFYKIVQEF YLSEVEYYNN LLTANNVYRK ALNSDPRFKN 150
    KLVKLDSSDE LLLFGNIDTI ASISKILVTA IKDLLLAKQR GKMLDANEWQ 200
    KIFTKNEVQQ QLYSTFDISE AFEQHLLRIK STYTSYFVSH QKQMELFTTL 250
    RMNKNHFFNK WYEYCLKESG CIKLEDILKS PMKRLTQWID TLETLESCYE 300
    DILSPELGLK LSPTRRKYSL FSNKLETEVS EYKSNSMYNF SLTPSEIIQS 350
    YDEDQFTHLL KPPDKQNKNI CNASRQESNL DNSRVPSLLS GSSSYYSDVS 400
    GLEIVTNTST ASAEMINLKM DEETEFFTLA DHISKFKKVM KGLLELKKNL 450
    LKNDLSGIID ISLRRINAWK KVIECERPSG AFFAHDNLIS TMCSSYIDKL 500
    HEQKNQVTIL KLTELETDVM NPLERIIAHC TTVKSKLKDL QALKKDYMLF 550
    LQEKKANVRD IKRDLLGMHF QNLQNQMKRE LPVFITLIHD TIECILLNYI 600
    KVFLKYLEII AGGKKYLQKD LENMSLNDSI ATGQIKNLDI LQCYSKSRYM 650
    TKRMVRKDWP FPGDPSGSRV VRKLFEL 677
    Length:677
    Mass (Da):79,037
    Last modified:November 1, 1997 - v1
    Checksum:iD7C89ED0738EA31F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851L → R in CAA62275. (PubMed:7559752)Curated
    Sequence conflicti203 – 2031F → L in CAA62275. (PubMed:7559752)Curated
    Sequence conflicti543 – 5464Missing in CAA62275. (PubMed:7559752)Curated
    Sequence conflicti589 – 67789HDTIE…KLFEL → PRYYRMYLVELYQSLLKIFG NHCWWKKIPAKRS in CAA62275. (PubMed:7559752)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90752 Genomic DNA. Translation: CAA62275.1.
    Z49939 Genomic DNA. Translation: CAA90203.1.
    BK006946 Genomic DNA. Translation: DAA10132.1.
    PIRiS57599.
    RefSeqiNP_013959.1. NM_001182739.1.

    Genome annotation databases

    EnsemblFungiiYMR232W; YMR232W; YMR232W.
    GeneIDi855272.
    KEGGisce:YMR232W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90752 Genomic DNA. Translation: CAA62275.1 .
    Z49939 Genomic DNA. Translation: CAA90203.1 .
    BK006946 Genomic DNA. Translation: DAA10132.1 .
    PIRi S57599.
    RefSeqi NP_013959.1. NM_001182739.1.

    3D structure databases

    ProteinModelPortali Q05670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35410. 45 interactions.
    DIPi DIP-2711N.
    IntActi Q05670. 12 interactions.
    MINTi MINT-472882.

    Proteomic databases

    PaxDbi Q05670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR232W ; YMR232W ; YMR232W .
    GeneIDi 855272.
    KEGGi sce:YMR232W.

    Organism-specific databases

    CYGDi YMR232w.
    SGDi S000004845. FUS2.

    Phylogenomic databases

    eggNOGi NOG43014.
    HOGENOMi HOG000112669.
    OMAi LTPIRDY.
    OrthoDBi EOG7BP8CX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32913-MONOMER.

    Miscellaneous databases

    NextBioi 978888.

    Gene expression databases

    Genevestigatori Q05670.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    InterProi IPR000219. DH-domain.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation."
      Elion E.A., Trueheart J., Fink G.R.
      J. Cell Biol. 130:1283-1296(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-67; SER-72; SER-84; THR-88; SER-100 AND SER-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.

    Entry informationi

    Entry nameiFUS2_YEAST
    AccessioniPrimary (citable) accession number: Q05670
    Secondary accession number(s): D6W058, Q05023
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3