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Q05670 (FUS2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear fusion protein FUS2
Gene names
Name:FUS2
Ordered Locus Names:YMR232W
ORF Names:YM9959.14
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length677 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes cell fusion during zygote formation.

Subcellular location

Cell tip. Note: Localizes at the mating projection tip (shmoo).

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 677677Nuclear fusion protein FUS2
PRO_0000080954

Regions

Domain112 – 326215DH

Amino acid modifications

Modified residue201Phosphothreonine Ref.4
Modified residue671Phosphoserine Ref.4
Modified residue721Phosphoserine Ref.4
Modified residue841Phosphoserine Ref.4
Modified residue881Phosphothreonine Ref.4
Modified residue1001Phosphoserine Ref.4
Modified residue1061Phosphoserine Ref.4

Experimental info

Sequence conflict1851L → R in CAA62275. Ref.1
Sequence conflict2031F → L in CAA62275. Ref.1
Sequence conflict543 – 5464Missing in CAA62275. Ref.1
Sequence conflict589 – 67789HDTIE…KLFEL → PRYYRMYLVELYQSLLKIFG NHCWWKKIPAKRS in CAA62275. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q05670 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: D7C89ED0738EA31F

FASTA67779,037
        10         20         30         40         50         60 
MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK HENKLNDKKF 

        70         80         90        100        110        120 
TNKRPASLDL HSIVESLSNK KIYSPINTEI FQNVVRLNLS PQIPNSPHEG CKFYKIVQEF 

       130        140        150        160        170        180 
YLSEVEYYNN LLTANNVYRK ALNSDPRFKN KLVKLDSSDE LLLFGNIDTI ASISKILVTA 

       190        200        210        220        230        240 
IKDLLLAKQR GKMLDANEWQ KIFTKNEVQQ QLYSTFDISE AFEQHLLRIK STYTSYFVSH 

       250        260        270        280        290        300 
QKQMELFTTL RMNKNHFFNK WYEYCLKESG CIKLEDILKS PMKRLTQWID TLETLESCYE 

       310        320        330        340        350        360 
DILSPELGLK LSPTRRKYSL FSNKLETEVS EYKSNSMYNF SLTPSEIIQS YDEDQFTHLL 

       370        380        390        400        410        420 
KPPDKQNKNI CNASRQESNL DNSRVPSLLS GSSSYYSDVS GLEIVTNTST ASAEMINLKM 

       430        440        450        460        470        480 
DEETEFFTLA DHISKFKKVM KGLLELKKNL LKNDLSGIID ISLRRINAWK KVIECERPSG 

       490        500        510        520        530        540 
AFFAHDNLIS TMCSSYIDKL HEQKNQVTIL KLTELETDVM NPLERIIAHC TTVKSKLKDL 

       550        560        570        580        590        600 
QALKKDYMLF LQEKKANVRD IKRDLLGMHF QNLQNQMKRE LPVFITLIHD TIECILLNYI 

       610        620        630        640        650        660 
KVFLKYLEII AGGKKYLQKD LENMSLNDSI ATGQIKNLDI LQCYSKSRYM TKRMVRKDWP 

       670 
FPGDPSGSRV VRKLFEL 

« Hide

References

« Hide 'large scale' references
[1]"Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation."
Elion E.A., Trueheart J., Fink G.R.
J. Cell Biol. 130:1283-1296(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-67; SER-72; SER-84; THR-88; SER-100 AND SER-106, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90752 Genomic DNA. Translation: CAA62275.1.
Z49939 Genomic DNA. Translation: CAA90203.1.
BK006946 Genomic DNA. Translation: DAA10132.1.
PIRS57599.
RefSeqNP_013959.1. NM_001182739.1.

3D structure databases

ProteinModelPortalQ05670.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35410. 45 interactions.
DIPDIP-2711N.
IntActQ05670. 12 interactions.
MINTMINT-472882.

Proteomic databases

PaxDbQ05670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR232W; YMR232W; YMR232W.
GeneID855272.
KEGGsce:YMR232W.

Organism-specific databases

CYGDYMR232w.
SGDS000004845. FUS2.

Phylogenomic databases

eggNOGNOG43014.
HOGENOMHOG000112669.
OMALTPIRDY.
OrthoDBEOG7BP8CX.

Enzyme and pathway databases

BioCycYEAST:G3O-32913-MONOMER.

Gene expression databases

GenevestigatorQ05670.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
InterProIPR000219. DH-domain.
[Graphical view]
SMARTSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
PROSITEPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978888.

Entry information

Entry nameFUS2_YEAST
AccessionPrimary (citable) accession number: Q05670
Secondary accession number(s): D6W058, Q05023
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families