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Protein

Glutamine synthetase

Gene

glnA

Organism
Butyrivibrio fibrisolvens
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
OrganismiButyrivibrio fibrisolvens
Taxonomic identifieri831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Glutamine synthetasePRO_0000153278Add
BLAST

Interactioni

Subunit structurei

Homohexamer.

Structurei

3D structure databases

ProteinModelPortaliQ05650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.590.10. 2 hits.
InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view]
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05650-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEASKLTTE FGSLVFNDKI MKERLPKDIY KAVHKTIEKE PHLEPGCSYS
60 70 80 90 100
CSSNHEGVGN REQCYHFTPP GSSPMTGLTA EKHDSFISPT EDGRSSWSSQ
110 120 130 140 150
EKSWLRANLM HQASQWWSSC HNSSMRGYQH GILHHHAFIK DGSLLLPTAF
160 170 180 190 200
CSYGGEALDR DSLLRSMEAL SNEAVKMMRL LGYEDVNRVN TTIGSEQEYF
210 220 230 240 250
LIDKDFYKKR KDLLLTGRTL IGAPASKGQE MEDHYFGVIK PKVSAYMHDL
260 270 280 290 300
DEELWKLGIP AKTKHNEVAP SQHELAPVFE TANIAVDHNQ LTMEVMKKVA
310 320 330 340 350
DKHNYACLLH EKPFEGVNGS GKHNNWSICT DTGINLLDPG KNPGENIPFL
360 370 380 390 400
VFLMSVIAAV DEYAPILRLS VASAGNDHRL GGNEAPPAII SIFVGDELAE
410 420 430 440 450
VLKAVEAGEA YKAAGKSQMT WEQQYFTFTK DNTDRNRTSP FAFTGNKFES
460 470 480 490 500
DGGHSSVANG KYGPQHMQLQ KEVATLNAKL SAYSGDELKE KVKEVLKETL
510 520 530 540 550
LAHKRVLFNG NGYTDEWVEE AAKRGLPNLK ALPDCMPYWI SDESIDLFTR
560 570 580 590 600
HGIFTKEEIY SRYEILLENY SKSIHIESLT MQEMIRKDLT EGLVAYEKDL
610 620 630 640 650
SKEIVQKKSL LDGDCCALEL GVLKSLDKSS AEMGKALSKL FEDTKKAEGM
660 670 680 690 700
TEALETASYY ESTVLADMDE LRKYADEAEA LIPEKYLSYP TYGEMLFSLR
Length:700
Mass (Da):78,541
Last modified:February 1, 1995 - v1
Checksum:i32DDD0FA10B542E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08256 Unassigned DNA. Translation: AAA71923.1.
PIRiI40596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08256 Unassigned DNA. Translation: AAA71923.1.
PIRiI40596.

3D structure databases

ProteinModelPortaliQ05650.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.590.10. 2 hits.
InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view]
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and nucleotide sequence of the Butyrivibrio fibrisolvens gene encoding a type III glutamine synthetase."
    Goodman H.J., Woods D.R.
    J. Gen. Microbiol. 139:1487-1493(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGLNA_BUTFI
AccessioniPrimary (citable) accession number: Q05650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.