Q05639 (EF1A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 140.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Elongation factor 1-alpha 2 Short name=EF-1-alpha-2 Alternative name(s): Eukaryotic elongation factor 1 A-2 Short name=eEF1A-2 Statin-S1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 463 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Brain, heart, and skeletal muscle. |
| Sequence similarities | Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 463 | 463 | Elongation factor 1-alpha 2 | PRO_0000090891 | |||||
Regions | |||||||||
| Nucleotide binding | 14 – 21 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 91 – 95 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 153 – 156 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 29 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 55 | 1 | N6,N6,N6-trimethyllysine By similarity | ||||||
| Modified residue | 141 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 165 | 1 | N6,N6,N6-trimethyllysine By similarity | ||||||
| Modified residue | 179 | 1 | N6-acetyllysine Ref.8 | ||||||
| Modified residue | 301 | 1 | 5-glutamyl glycerylphosphorylethanolamine By similarity | ||||||
| Modified residue | 374 | 1 | 5-glutamyl glycerylphosphorylethanolamine By similarity | ||||||
| Modified residue | 439 | 1 | N6-acetyllysine Ref.8 | ||||||
Experimental info | |||||||||
| Sequence conflict | 427 | 1 | R → P in AAA91835. Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha." Knudsen S.M., Frydenberg J., Clark B.F.C., Leffers H. Eur. J. Biochem. 215:549-554(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity." Bischoff C., Kahns S., Lund A., Joergensen H.F., Praestegaard M., Clark B.F.C., Leffers H. Genomics 68:63-70(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. Nomura N.Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum and Lung. |
| [7] | "Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway." Lee S., Ann D.K., Wang E. Biochem. Biophys. Res. Commun. 203:1371-1377(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-463. Tissue: Hippocampus. |
| [8] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-179 AND LYS-439, MASS SPECTROMETRY. |
| [9] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [10] | "The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles." Dai S., Crawford F., Marrack P., Kappler J.W. Proc. Natl. Acad. Sci. U.S.A. 105:11893-11897(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 343-355 IN COMPLEX WITH HLA-DRA/HLA-DRB3 HETERODIMER. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X70940 mRNA. Translation: CAA50280.1. AF163763 Genomic DNA. Translation: AAF80488.1. AB451389 mRNA. Translation: BAG70203.1. AL121829 Genomic DNA. Translation: CAC15522.1. CH471077 Genomic DNA. Translation: EAW75260.1. BC000432 mRNA. Translation: AAH00432.1. BC110409 mRNA. Translation: AAI10410.1. L10340 mRNA. Translation: AAA91835.1. | ||||||||||||
| IPI | IPI00014424. | ||||||||||||
| PIR | EFHUA2. S35033. | ||||||||||||
| RefSeq | NP_001949.1. NM_001958.3. | ||||||||||||
| UniGene | Hs.433839. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q05639. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q05639. 20 interactions. | ||||||||||||
| MINT | MINT-1141378. | ||||||||||||
| STRING | 9606.ENSP00000217182. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q05639. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 544231. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | Q05639. | ||||||||||||
| PeptideAtlas | Q05639. | ||||||||||||
| PRIDE | Q05639. | ||||||||||||
Protocols and materials databases | |||||||||||||
| DNASU | 1917. | ||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000217182; ENSP00000217182; ENSG00000101210. ENST00000298049; ENSP00000298049; ENSG00000101210. | ||||||||||||
| GeneID | 1917. | ||||||||||||
| KEGG | hsa:1917. | ||||||||||||
| UCSC | uc002yfe.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 1917. | ||||||||||||
| GeneCards | GC20M062119. | ||||||||||||
| HGNC | HGNC:3192. EEF1A2. | ||||||||||||
| HPA | CAB034019. | ||||||||||||
| MIM | 602959. gene. | ||||||||||||
| neXtProt | NX_Q05639. | ||||||||||||
| PharmGKB | PA36219. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG5256. | ||||||||||||
| HOGENOM | HOG000229291. | ||||||||||||
| HOVERGEN | HBG000179. | ||||||||||||
| InParanoid | Q05639. | ||||||||||||
| KO | K03231. | ||||||||||||
| OMA | PVFHCHT. | ||||||||||||
| OrthoDB | EOG40K7ZP. | ||||||||||||
| PhylomeDB | Q05639. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | Q05639. | ||||||||||||
| CleanEx | HS_EEF1A2. | ||||||||||||
| Genevestigator | Q05639. | ||||||||||||
| GermOnline | ENSG00000101210. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR000795. EF_GTP-bd_dom. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004539. Transl_elong_EF1A_euk/arc. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004160. Transl_elong_EFTu/EF1A_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view] | ||||||||||||
| Pfam | PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00315. ELONGATNFCT. | ||||||||||||
| SUPFAM | SSF50465. Elong_init_C. 1 hit. SSF50447. Translat_factor. 1 hit. | ||||||||||||
| TIGRFAMs | TIGR00483. EF-1_alpha. 1 hit. | ||||||||||||
| PROSITE | PS00301. EFACTOR_GTP. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| BindingDB | Q05639. | ||||||||||||
| ChEMBL | CHEMBL1795122. | ||||||||||||
| EvolutionaryTrace | Q05639. | ||||||||||||
| GenomeRNAi | 1917. | ||||||||||||
| NextBio | 7803. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | EF1A2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q05639 Secondary accession number(s): B5BUF3 Q0VGC7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
