ID   PTB_CLOB8               Reviewed;         302 AA.
AC   Q05624; A6LPW3;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Phosphate butyryltransferase;
DE            EC=2.3.1.19;
DE   AltName: Full=Phosphotransbutyrylase;
GN   Name=ptb; OrderedLocusNames=Cbei_0203;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8396545; DOI=10.1016/0378-1119(93)90677-u;
RA   Oultram J.D., Burr I.D., Elmore M.J., Minton N.P.;
RT   "Cloning and sequence analysis of the genes encoding phosphotransbutyrylase
RT   and butyrate kinase from Clostridium acetobutylicum NCIMB 8052.";
RL   Gene 131:107-112(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of butyryl-CoA through butyryl
CC       phosphate to butyrate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=butanoyl-CoA + phosphate = butanoyl phosphate + CoA;
CC         Xref=Rhea:RHEA:20892, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57371, ChEBI:CHEBI:58079; EC=2.3.1.19;
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC   -!- SIMILARITY: Belongs to the phosphate acetyltransferase and
CC       butyryltransferase family. {ECO:0000305}.
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DR   EMBL; L04468; AAA52080.1; -; Genomic_DNA.
DR   EMBL; CP000721; ABR32393.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q05624; -.
DR   SMR; Q05624; -.
DR   KEGG; cbe:Cbei_0203; -.
DR   eggNOG; COG0280; Bacteria.
DR   HOGENOM; CLU_056531_0_0_9; -.
DR   UniPathway; UPA00863; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0050182; F:phosphate butyryltransferase activity; IDA:CACAO.
DR   GO; GO:0019605; P:butyrate metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR012147; P_Ac_Bu_trans.
DR   InterPro; IPR014079; Phosphate_butyryltransferase.
DR   InterPro; IPR002505; PTA_PTB.
DR   NCBIfam; TIGR02706; P_butyryltrans; 1.
DR   PANTHER; PTHR43356; PHOSPHATE ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR43356:SF2; PHOSPHATE ACETYLTRANSFERASE; 1.
DR   Pfam; PF01515; PTA_PTB; 2.
DR   PIRSF; PIRSF000428; P_Ac_trans; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..302
FT                   /note="Phosphate butyryltransferase"
FT                   /id="PRO_0000179153"
SQ   SEQUENCE   302 AA;  32442 MW;  52C3A7BFB187C1FF CRC64;
     MSKNFDELLS RLKEVPTKKV AVAVAQDEPV LEAIKEATEN NIAQAILVGD KQQIHEIAKK
     INLDLSDYEI MDIKDPKKAT LEAVKLVSSG HADMLMKGLV DTATFLRSVL NKEVGLRTGK
     LMSHVAVFDV EGWDRLLFLT DAAFNTYPEF KDKVGMINNA VVVAHACGID VPRVAPICPV
     EVVNTSMQST VDAALLAKMS DRGQIKGCVI DGPFALDNAI SEEAAHHKGV TGSVAGKADI
     LLLPNIEAAN VMYKTLTYFS KSRNGGLLVG TSAPVILTSR ADSFETKVNS IALAALVAAR
     NK
//