Q05624 (PTB_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate butyryltransferase
EC=2.3.1.19

Alternative name(s):
Phosphotransbutyrylase

Gene names

Name:	ptb
Ordered Locus Names:	Cbei_0203

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]

Taxonomic identifier

290402 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium beijerinckii

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.
Catalytic activity	Butanoyl-CoA + phosphate = CoA + butanoylphosphate.
Pathway	Lipid metabolism; butanoate metabolism.
Sequence similarities	Belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	butyrate metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphate butyryltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Phosphate butyryltransferase		PRO_0000179153

Sequences

	Sequence		Length	Mass (Da)
	Q05624 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 52C3A7BFB187C1FF	FASTA	302	32,442
	10 20 30 40 50 60 MSKNFDELLS RLKEVPTKKV AVAVAQDEPV LEAIKEATEN NIAQAILVGD KQQIHEIAKK 70 80 90 100 110 120 INLDLSDYEI MDIKDPKKAT LEAVKLVSSG HADMLMKGLV DTATFLRSVL NKEVGLRTGK 130 140 150 160 170 180 LMSHVAVFDV EGWDRLLFLT DAAFNTYPEF KDKVGMINNA VVVAHACGID VPRVAPICPV 190 200 210 220 230 240 EVVNTSMQST VDAALLAKMS DRGQIKGCVI DGPFALDNAI SEEAAHHKGV TGSVAGKADI 250 260 270 280 290 300 LLLPNIEAAN VMYKTLTYFS KSRNGGLLVG TSAPVILTSR ADSFETKVNS IALAALVAAR NK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052." Oultram J.D., Burr I.D., Elmore M.J., Minton N.P. Gene 131:107-112(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Clostridium beijerinckii NCIMB 8052." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51743 / NCIMB 8052.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04468 Genomic DNA. Translation: AAA52080.1. CP000721 Genomic DNA. Translation: ABR32393.1.
RefSeq	YP_001307349.1. NC_009617.1.
3D structure databases
ProteinModelPortal	Q05624.
ModBase	Search...
Protein-protein interaction databases
STRING	290402.Cbei_0203.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR32393; ABR32393; Cbei_0203.
GeneID	5291437.
KEGG	cbe:Cbei_0203.
PATRIC	19344246. VBICloBei69853_0208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0280.
HOGENOM	HOG000009438.
KO	K00634.
OMA	FEVPNYD.
ProtClustDB	PRK05805.
Enzyme and pathway databases
BioCyc	CBEI290402:GHL5-344-MONOMER.
UniPathway	UPA00863.
Family and domain databases
InterPro	IPR012147. P_Ac_Bu_trans. IPR014079. Phosphate_butyryltransferase. IPR002505. PTA_PTB. [Graphical view]
Pfam	PF01515. PTA_PTB. 2 hits. [Graphical view]
PIRSF	PIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMs	TIGR02706. P_butyryltrans. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTB_CLOB8

Accession

Primary (citable) accession number: Q05624
Secondary accession number(s): A6LPW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program