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Protein

Phosphate butyryltransferase

Gene

ptb

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.

Catalytic activityi

Butanoyl-CoA + phosphate = CoA + butanoylphosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate butyryltransferase activity Source: CACAO

GO - Biological processi

  1. butyrate metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-234-MONOMER.
UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate butyryltransferase (EC:2.3.1.19)
Alternative name(s):
Phosphotransbutyrylase
Gene namesi
Name:ptb
Ordered Locus Names:Cbei_0203
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Phosphate butyryltransferasePRO_0000179153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_0203.

Structurei

3D structure databases

ProteinModelPortaliQ05624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000009438.
KOiK00634.
OMAiNTKKQII.
OrthoDBiEOG60GRZ3.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR014079. Phosphate_butyryltransferase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 2 hits.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR02706. P_butyryltrans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNFDELLS RLKEVPTKKV AVAVAQDEPV LEAIKEATEN NIAQAILVGD
60 70 80 90 100
KQQIHEIAKK INLDLSDYEI MDIKDPKKAT LEAVKLVSSG HADMLMKGLV
110 120 130 140 150
DTATFLRSVL NKEVGLRTGK LMSHVAVFDV EGWDRLLFLT DAAFNTYPEF
160 170 180 190 200
KDKVGMINNA VVVAHACGID VPRVAPICPV EVVNTSMQST VDAALLAKMS
210 220 230 240 250
DRGQIKGCVI DGPFALDNAI SEEAAHHKGV TGSVAGKADI LLLPNIEAAN
260 270 280 290 300
VMYKTLTYFS KSRNGGLLVG TSAPVILTSR ADSFETKVNS IALAALVAAR

NK
Length:302
Mass (Da):32,442
Last modified:February 1, 1995 - v1
Checksum:i52C3A7BFB187C1FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04468 Genomic DNA. Translation: AAA52080.1.
CP000721 Genomic DNA. Translation: ABR32393.1.
RefSeqiYP_001307349.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR32393; ABR32393; Cbei_0203.
GeneIDi5291437.
KEGGicbe:Cbei_0203.
PATRICi19344246. VBICloBei69853_0208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04468 Genomic DNA. Translation: AAA52080.1.
CP000721 Genomic DNA. Translation: ABR32393.1.
RefSeqiYP_001307349.1. NC_009617.1.

3D structure databases

ProteinModelPortaliQ05624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290402.Cbei_0203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR32393; ABR32393; Cbei_0203.
GeneIDi5291437.
KEGGicbe:Cbei_0203.
PATRICi19344246. VBICloBei69853_0208.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000009438.
KOiK00634.
OMAiNTKKQII.
OrthoDBiEOG60GRZ3.

Enzyme and pathway databases

UniPathwayiUPA00863.
BioCyciCBEI290402:GHL5-234-MONOMER.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR014079. Phosphate_butyryltransferase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 2 hits.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR02706. P_butyryltrans. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052."
    Oultram J.D., Burr I.D., Elmore M.J., Minton N.P.
    Gene 131:107-112(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiPTB_CLOB8
AccessioniPrimary (citable) accession number: Q05624
Secondary accession number(s): A6LPW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.