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Protein

Myosin-binding protein H

Gene

MYBPH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
86 kDa protein
H-protein
Gene namesi
Name:MYBPH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • A band Source: AgBase
  • cell Source: AgBase
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Myosin-binding protein HPRO_0000072701Add
BLAST

Proteomic databases

PRIDEiQ05623.

Expressioni

Tissue specificityi

Skeletal muscle. Seems to be also expressed in the slow tonic ald muscle. Not detected in gizzard or heart.

Gene expression databases

ExpressionAtlasiQ05623. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ05623.
SMRiQ05623. Positions 214-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 23296Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini236 – 32489Ig-like C2-type 1Add
BLAST
Domaini333 – 42896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini444 – 52885Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG056788.
InParanoidiQ05623.
PhylomeDBiQ05623.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKTAPAAA KKAPAAKKAP APASKKAPEP APKEKPAPTP KEGHAPTPKE
60 70 80 90 100
EHAPPPKEEH APPPKEEHAP APAAETPPAP EHPPDAEQPA APAAEHAPTP
110 120 130 140 150
THEAAPAHEE GPPPAAPAEA PAPEPEPEKP KEEPPSVPLS LAVEEVTENS
160 170 180 190 200
VTLTWKAPEH TGKSSLDGYV VEICKDGSTD WTAVNKEPFL STRYKIHDLA
210 220 230 240 250
SGEKVHVRVK AISASGTSDP ATLEQPVLIR EITDLPRIRL PRQLRQVYVR
260 270 280 290 300
HVGEAVNLLI PFQGKPQPQV TWTKDNQPLD TSRVNIRNTD KDTIFFIRTA
310 320 330 340 350
QRSDSGKYQL SVRINGAEDK AILDIRVIER PGPPQNLKLV DVWGFNVALE
360 370 380 390 400
WSPPADNGNS EIKGYTVQKS DKKSGKWFTV LERCTRTSCT ISDLIIGNTY
410 420 430 440 450
SFRVFSENAC GMSETAAVAA GVAHIKKTVY QPQKIPERDM MEPPKFTQPL
460 470 480 490 500
TDRATTRGYS THLFCSVRGF PQPKIIWMKN KMEIREDPKY IAMIEQGVCS
510 520 530
LEIRKPSPFD AGVYTCKAVN PLGEASVDCK LDVKMPK
Length:537
Mass (Da):58,679
Last modified:November 1, 1996 - v1
Checksum:i06C4CF0EFE1DD233
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → G AA sequence (PubMed:7679114).Curated
Sequence conflicti9 – 91A → P AA sequence (PubMed:7679114).Curated
Sequence conflicti15 – 151A → K AA sequence (PubMed:7679114).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05605 mRNA. Translation: AAA21418.1.
PIRiA46611.
RefSeqiNP_001026199.1. NM_001031028.2.
UniGeneiGga.882.

Genome annotation databases

GeneIDi421154.
KEGGigga:421154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05605 mRNA. Translation: AAA21418.1.
PIRiA46611.
RefSeqiNP_001026199.1. NM_001031028.2.
UniGeneiGga.882.

3D structure databases

ProteinModelPortaliQ05623.
SMRiQ05623. Positions 214-427.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ05623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi421154.
KEGGigga:421154.

Organism-specific databases

CTDi4608.

Phylogenomic databases

HOVERGENiHBG056788.
InParanoidiQ05623.
PhylomeDBiQ05623.

Miscellaneous databases

NextBioi20823970.
PROiQ05623.

Gene expression databases

ExpressionAtlasiQ05623. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of chicken myosin-binding protein (MyBP) H (86-kDa protein) reveals extensive homology with MyBP-C (C-protein) with conserved immunoglobulin C2 and fibronectin type III motifs."
    Vaughan K.T., Weber F.E., Einheber S., Fischman D.A.
    J. Biol. Chem. 268:3670-3676(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-37.
    Tissue: Pectoralis muscle.

Entry informationi

Entry nameiMYBPH_CHICK
AccessioniPrimary (citable) accession number: Q05623
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.