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Protein

Myosin-binding protein H

Gene

MYBPH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
86 kDa protein
H-protein
Gene namesi
Name:MYBPH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

  • A band Source: AgBase
  • cell Source: AgBase
  • M band Source: GO_Central
  • muscle myosin complex Source: GO_Central
  • myosin filament Source: UniProtKB-KW
  • Z disc Source: GO_Central

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727011 – 537Myosin-binding protein HAdd BLAST537

Proteomic databases

PRIDEiQ05623.

Expressioni

Tissue specificityi

Skeletal muscle. Seems to be also expressed in the slow tonic ald muscle. Not detected in gizzard or heart.

Gene expression databases

BgeeiENSGALG00000000164.
ExpressionAtlasiQ05623. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ05623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 232Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini236 – 324Ig-like C2-type 1Add BLAST89
Domaini333 – 428Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini444 – 528Ig-like C2-type 2Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00860000133685.
HOVERGENiHBG056788.
InParanoidiQ05623.
OrthoDBiEOG091G07IP.
PhylomeDBiQ05623.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
SMARTiView protein in SMART
SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Q05623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKTAPAAA KKAPAAKKAP APASKKAPEP APKEKPAPTP KEGHAPTPKE
60 70 80 90 100
EHAPPPKEEH APPPKEEHAP APAAETPPAP EHPPDAEQPA APAAEHAPTP
110 120 130 140 150
THEAAPAHEE GPPPAAPAEA PAPEPEPEKP KEEPPSVPLS LAVEEVTENS
160 170 180 190 200
VTLTWKAPEH TGKSSLDGYV VEICKDGSTD WTAVNKEPFL STRYKIHDLA
210 220 230 240 250
SGEKVHVRVK AISASGTSDP ATLEQPVLIR EITDLPRIRL PRQLRQVYVR
260 270 280 290 300
HVGEAVNLLI PFQGKPQPQV TWTKDNQPLD TSRVNIRNTD KDTIFFIRTA
310 320 330 340 350
QRSDSGKYQL SVRINGAEDK AILDIRVIER PGPPQNLKLV DVWGFNVALE
360 370 380 390 400
WSPPADNGNS EIKGYTVQKS DKKSGKWFTV LERCTRTSCT ISDLIIGNTY
410 420 430 440 450
SFRVFSENAC GMSETAAVAA GVAHIKKTVY QPQKIPERDM MEPPKFTQPL
460 470 480 490 500
TDRATTRGYS THLFCSVRGF PQPKIIWMKN KMEIREDPKY IAMIEQGVCS
510 520 530
LEIRKPSPFD AGVYTCKAVN PLGEASVDCK LDVKMPK
Length:537
Mass (Da):58,679
Last modified:November 1, 1996 - v1
Checksum:i06C4CF0EFE1DD233
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → G AA sequence (PubMed:7679114).Curated1
Sequence conflicti9A → P AA sequence (PubMed:7679114).Curated1
Sequence conflicti15A → K AA sequence (PubMed:7679114).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05605 mRNA. Translation: AAA21418.1.
PIRiA46611.
RefSeqiNP_001026199.1. NM_001031028.2.
UniGeneiGga.882.

Genome annotation databases

EnsembliENSGALT00000040700; ENSGALP00000039903; ENSGALG00000000164.
GeneIDi421154.
KEGGigga:421154.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYBPH_CHICK
AccessioniPrimary (citable) accession number: Q05623
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families