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Q05622 (GUNE_RUMFL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoglucanase E

Short name=EGE
EC=3.2.1.4
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase E
Gene names
Name:celE
OrganismRuminococcus flavefaciens
Taxonomic identifier1265 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

Hydrolyzes both carboxymethylcellulose and xylan. Probably has a role in hydrolyzing oligosaccharides derived from cellulose, which are transported across the cell wall.

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Subcellular location

Secreted.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
Xylan degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

xylan catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 320291Endoglucanase E
PRO_0000012253

Sites

Active site1501Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05622 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: DD5C549423405AFD

FASTA32035,938
        10         20         30         40         50         60 
MRKRITSMIT VISLTLCGTI GTYPHNANAS AKEAFEDISK RSECTKVFDN DNGTYTAYSN 

        70         80         90        100        110        120 
TAPIHYLNND EWKEIDNTLI EDSDDYYRNK DNSFNIYIPK EYSLGKNIKN PVIMNYDTFS 

       130        140        150        160        170        180 
LSTSITDIKM PDRPEEETFS EGVYADINNE VYTTIDNSAI AEGMKAALKK SASMATYHSI 

       190        200        210        220        230        240 
VEDIDLDIAV HNASVSESII INKLESLPET ITYSISVEDA IIKKTEDNRL QLIKDNEAVL 

       250        260        270        280        290        300 
ILSPFTISDS SENVNVMQVE YDLTESEEGY EVTLYPAETV NRMSSPVMPL SLGSEYSYDR 

       310        320 
PFSTVYNSQA SLHPSIIIIT 

« Hide

References

[1]"Transcriptional regulation of an endoglucanase and a cellodextrinase gene in Ruminococcus flavefaciens FD-1."
Wang W., Reid S.J., Thomson J.A.
J. Gen. Microbiol. 139:1219-1226(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FD-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L03800 Genomic DNA. Translation: AAA26468.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameGUNE_RUMFL
AccessionPrimary (citable) accession number: Q05622
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries