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Q05621

- DHPS_CLOB8

UniProt

Q05621 - DHPS_CLOB8

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Protein

Dihydropteroate synthase

Gene
Cbei_0206
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Magnesium By similarity
Binding sitei29 – 291Substrate By similarity
Binding sitei95 – 951Substrate By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei178 – 1781Substrate By similarity
Binding sitei214 – 2141Substrate By similarity
Binding sitei249 – 2491Substrate By similarity
Binding sitei251 – 2511Substrate By similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-237-MONOMER.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Ordered Locus Names:Cbei_0206
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Dihydropteroate synthasePRO_0000168206Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_0206.

Structurei

3D structure databases

ProteinModelPortaliQ05621.
SMRiQ05621. Positions 1-267.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 261248Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 622Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHPS family.

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217509.
KOiK00796.
OMAiDMFYVAA.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05621-1 [UniParc]FASTAAdd to Basket

« Hide

MKIGSKEFNI GERTYIMGIL NFTPDSFSDG GKFNDIDVAV KHVKEMIDNG    50
ADIIDVGGES TRPGYEIVSE EEEISRVVPI IKAIKEDFDI PVSIDTYKAK 100
VAEQAIEAGA NLINDIWGFK KDKDMAKVAA KYNVPCCLMH NRDNTEYKNL 150
MEDILNDLKE CINIAKDAGV KDENIILDPG IGFGKTYEQN LEAMNNLERI 200
KELGYPILLG TSRKSMIGLA LNLPVEERIE GTVATTVIGI MKDACDFVRV 250
HDVLENSRAA KMTDIIVRR 269
Length:269
Mass (Da):29,948
Last modified:February 26, 2008 - v2
Checksum:iB66922317A603123
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR32396.1.
L04468 Genomic DNA. Translation: AAA52083.1.
RefSeqiYP_001307352.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR32396; ABR32396; Cbei_0206.
GeneIDi5291440.
KEGGicbe:Cbei_0206.
PATRICi19344252. VBICloBei69853_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR32396.1 .
L04468 Genomic DNA. Translation: AAA52083.1 .
RefSeqi YP_001307352.1. NC_009617.1.

3D structure databases

ProteinModelPortali Q05621.
SMRi Q05621. Positions 1-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290402.Cbei_0206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR32396 ; ABR32396 ; Cbei_0206 .
GeneIDi 5291440.
KEGGi cbe:Cbei_0206.
PATRICi 19344252. VBICloBei69853_0211.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217509.
KOi K00796.
OMAi DMFYVAA.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .
BioCyci CBEI290402:GHL5-237-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.
  2. "Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052."
    Oultram J.D., Burr I.D., Elmore M.J., Minton N.P.
    Gene 131:107-112(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205.

Entry informationi

Entry nameiDHPS_CLOB8
AccessioniPrimary (citable) accession number: Q05621
Secondary accession number(s): A6LPW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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