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Protein

Serine/threonine-protein kinase CTR1

Gene

CTR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator in the ethylene response pathway (PubMed:8431946). Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene (PubMed:23132950).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei578ATPPROSITE-ProRule annotation1
Active sitei676Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi557 – 565ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine/tyrosine kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • cellular response to iron ion Source: TAIR
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • gibberellin biosynthetic process Source: TAIR
  • negative regulation of ethylene-activated signaling pathway Source: TAIR
  • protein autophosphorylation Source: TAIR
  • regulation of post-embryonic root development Source: TAIR
  • regulation of stem cell division Source: TAIR
  • regulation of timing of transition from vegetative to reproductive phase Source: TAIR
  • response to ethylene Source: TAIR
  • response to fructose Source: TAIR
  • response to hypoxia Source: TAIR
  • response to sucrose Source: TAIR
  • sugar mediated signaling pathway Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Ethylene signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase CTR11 Publication (EC:2.7.11.1Curated)
Alternative name(s):
Protein CONSTITUTIVE TRIPLE RESPONSE11 Publication
Gene namesi
Name:CTR11 Publication
Ordered Locus Names:At5g03730Imported
ORF Names:F17C15_150Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G03730.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: TAIR
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Mutants display ethylene-treated phenotypes, resulting in plants with small, unexpanded leaves and whose seed cotyledon growth is impaired.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi596E → K in ctr1-4; exhibits ethylene-treated phenotype. 1 Publication1
Mutagenesisi694D → E in ctr1-1; exhibits ethylene-treated phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859071 – 821Serine/threonine-protein kinase CTR1Add BLAST821

Proteomic databases

PaxDbiQ05609.

PTM databases

iPTMnetiQ05609.

Expressioni

Tissue specificityi

Expressed in both seedlings and adult plants.1 Publication

Gene expression databases

ExpressionAtlasiQ05609. baseline and differential.
GenevisibleiQ05609. AT.

Interactioni

Subunit structurei

Interacts with EIN2 (via C-terminus).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ERS1Q388462EBI-1606697,EBI-1606754
ETR1P493336EBI-1606697,EBI-1606682
ETR2Q0WPQ22EBI-1606697,EBI-1787533

Protein-protein interaction databases

BioGridi17024. 6 interactors.
IntActiQ05609. 4 interactors.
STRINGi3702.AT5G03730.1.

Structurei

Secondary structure

1821
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi548 – 550Combined sources3
Beta strandi551 – 559Combined sources9
Beta strandi561 – 570Combined sources10
Beta strandi573 – 580Combined sources8
Helixi587 – 602Combined sources16
Beta strandi611 – 615Combined sources5
Beta strandi617 – 619Combined sources3
Beta strandi622 – 626Combined sources5
Helixi633 – 638Combined sources6
Helixi642 – 645Combined sources4
Helixi648 – 666Combined sources19
Beta strandi668 – 670Combined sources3
Helixi679 – 681Combined sources3
Beta strandi682 – 684Combined sources3
Beta strandi690 – 692Combined sources3
Beta strandi703 – 705Combined sources3
Turni715 – 717Combined sources3
Helixi720 – 723Combined sources4
Helixi732 – 746Combined sources15
Turni750 – 753Combined sources4
Helixi756 – 765Combined sources10
Helixi778 – 787Combined sources10
Helixi792 – 794Combined sources3
Helixi798 – 809Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P86X-ray2.50A/B540-821[»]
3PPZX-ray2.99A/B540-821[»]
ProteinModelPortaliQ05609.
SMRiQ05609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini551 – 809Protein kinasePROSITE-ProRule annotationAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 69Poly-Gly5
Compositional biasi135 – 141Poly-Gly7

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000239752.
InParanoidiQ05609.
KOiK14510.
OMAiDACWANE.
OrthoDBiEOG09360753.
PhylomeDBiQ05609.

Family and domain databases

InterProiIPR028324. CTR1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF384. PTHR23257:SF384. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMPGRRSNY TLLSQFSDDQ VSVSVTGAPP PHYDSLSSEN RSNHNSGNTG
60 70 80 90 100
KAKAERGGFD WDPSGGGGGD HRLNNQPNRV GNNMYASSLG LQRQSSGSSF
110 120 130 140 150
GESSLSGDYY MPTLSAAANE IESVGFPQDD GFRLGFGGGG GDLRIQMAAD
160 170 180 190 200
SAGGSSSGKS WAQQTEESYQ LQLALALRLS SEATCADDPN FLDPVPDESA
210 220 230 240 250
LRTSPSSAET VSHRFWVNGC LSYYDKVPDG FYMMNGLDPY IWTLCIDLHE
260 270 280 290 300
SGRIPSIESL RAVDSGVDSS LEAIIVDRRS DPAFKELHNR VHDISCSCIT
310 320 330 340 350
TKEVVDQLAK LICNRMGGPV IMGEDELVPM WKECIDGLKE IFKVVVPIGS
360 370 380 390 400
LSVGLCRHRA LLFKVLADII DLPCRIAKGC KYCNRDDAAS CLVRFGLDRE
410 420 430 440 450
YLVDLVGKPG HLWEPDSLLN GPSSISISSP LRFPRPKPVE PAVDFRLLAK
460 470 480 490 500
QYFSDSQSLN LVFDPASDDM GFSMFHRQYD NPGGENDALA ENGGGSLPPS
510 520 530 540 550
ANMPPQNMMR ASNQIEAAPM NAPPISQPVP NRANRELGLD GDDMDIPWCD
560 570 580 590 600
LNIKEKIGAG SFGTVHRAEW HGSDVAVKIL MEQDFHAERV NEFLREVAIM
610 620 630 640 650
KRLRHPNIVL FMGAVTQPPN LSIVTEYLSR GSLYRLLHKS GAREQLDERR
660 670 680 690 700
RLSMAYDVAK GMNYLHNRNP PIVHRDLKSP NLLVDKKYTV KVCDFGLSRL
710 720 730 740 750
KASTFLSSKS AAGTPEWMAP EVLRDEPSNE KSDVYSFGVI LWELATLQQP
760 770 780 790 800
WGNLNPAQVV AAVGFKCKRL EIPRNLNPQV AAIIEGCWTN EPWKRPSFAT
810 820
IMDLLRPLIK SAVPPPNRSD L
Length:821
Mass (Da):90,306
Last modified:November 1, 1995 - v1
Checksum:i2922D3DCD0CC15BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08789 mRNA. Translation: AAA32779.1.
L08790 Genomic DNA. Translation: AAA32780.1.
AL162506 Genomic DNA. Translation: CAB82938.1.
CP002688 Genomic DNA. Translation: AED90647.1.
CP002688 Genomic DNA. Translation: AED90648.1.
PIRiT48400.
RefSeqiNP_195993.1. NM_120454.4.
NP_850760.1. NM_180429.4.
UniGeneiAt.300.

Genome annotation databases

EnsemblPlantsiAT5G03730.1; AT5G03730.1; AT5G03730.
AT5G03730.2; AT5G03730.2; AT5G03730.
GeneIDi831748.
GrameneiAT5G03730.1; AT5G03730.1; AT5G03730.
AT5G03730.2; AT5G03730.2; AT5G03730.
KEGGiath:AT5G03730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08789 mRNA. Translation: AAA32779.1.
L08790 Genomic DNA. Translation: AAA32780.1.
AL162506 Genomic DNA. Translation: CAB82938.1.
CP002688 Genomic DNA. Translation: AED90647.1.
CP002688 Genomic DNA. Translation: AED90648.1.
PIRiT48400.
RefSeqiNP_195993.1. NM_120454.4.
NP_850760.1. NM_180429.4.
UniGeneiAt.300.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P86X-ray2.50A/B540-821[»]
3PPZX-ray2.99A/B540-821[»]
ProteinModelPortaliQ05609.
SMRiQ05609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17024. 6 interactors.
IntActiQ05609. 4 interactors.
STRINGi3702.AT5G03730.1.

PTM databases

iPTMnetiQ05609.

Proteomic databases

PaxDbiQ05609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G03730.1; AT5G03730.1; AT5G03730.
AT5G03730.2; AT5G03730.2; AT5G03730.
GeneIDi831748.
GrameneiAT5G03730.1; AT5G03730.1; AT5G03730.
AT5G03730.2; AT5G03730.2; AT5G03730.
KEGGiath:AT5G03730.

Organism-specific databases

TAIRiAT5G03730.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000239752.
InParanoidiQ05609.
KOiK14510.
OMAiDACWANE.
OrthoDBiEOG09360753.
PhylomeDBiQ05609.

Enzyme and pathway databases

BRENDAi2.7.11.1. 399.

Miscellaneous databases

PROiQ05609.

Gene expression databases

ExpressionAtlasiQ05609. baseline and differential.
GenevisibleiQ05609. AT.

Family and domain databases

InterProiIPR028324. CTR1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF384. PTHR23257:SF384. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTR1_ARATH
AccessioniPrimary (citable) accession number: Q05609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.