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Q05609

- CTR1_ARATH

UniProt

Q05609 - CTR1_ARATH

Protein

Serine/threonine-protein kinase CTR1

Gene

CTR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator in the ethylene response pathway.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei578 – 5781ATPPROSITE-ProRule annotation
    Active sitei676 – 6761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi557 – 5659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine/tyrosine kinase activity Source: TAIR
    4. protein serine/threonine kinase activity Source: TAIR

    GO - Biological processi

    1. cellular response to iron ion Source: TAIR
    2. ethylene-activated signaling pathway Source: UniProtKB-KW
    3. gibberellin biosynthetic process Source: TAIR
    4. negative regulation of ethylene-activated signaling pathway Source: TAIR
    5. protein autophosphorylation Source: TAIR
    6. regulation of post-embryonic root development Source: TAIR
    7. regulation of stem cell division Source: TAIR
    8. regulation of timing of transition from vegetative to reproductive phase Source: TAIR
    9. response to ethylene Source: TAIR
    10. response to fructose Source: TAIR
    11. response to sucrose Source: TAIR
    12. sugar mediated signaling pathway Source: TAIR

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Ethylene signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G03730-MONOMER.
    ARA:GQT-223-MONOMER.
    BRENDAi2.7.11.1. 399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase CTR1 (EC:2.7.11.1)
    Gene namesi
    Name:CTR1
    Ordered Locus Names:At5g03730
    ORF Names:F17C15_150
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G03730.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: TAIR

    Pathology & Biotechi

    Disruption phenotypei

    Mutants display ethylene-treated phenotypes, resulting in plants with small, unexpanded leaves and whose seed cotyledon growth is impaired.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi596 – 5961E → K in ctr1-4; exhibits ethylene-treated phenotype.
    Mutagenesisi694 – 6941D → E in ctr1-1; exhibits ethylene-treated phenotype.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Serine/threonine-protein kinase CTR1PRO_0000085907Add
    BLAST

    Proteomic databases

    PaxDbiQ05609.
    PRIDEiQ05609.

    Expressioni

    Tissue specificityi

    Expressed in both seedlings and adult plants.1 Publication

    Gene expression databases

    ArrayExpressiQ05609.
    GenevestigatoriQ05609.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERS1Q388462EBI-1606697,EBI-1606754
    ETR1P493336EBI-1606697,EBI-1606682
    ETR2Q0WPQ22EBI-1606697,EBI-1787533

    Protein-protein interaction databases

    BioGridi17024. 6 interactions.
    IntActiQ05609. 4 interactions.
    STRINGi3702.AT5G03730.1-P.

    Structurei

    Secondary structure

    1
    821
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi548 – 5503
    Beta strandi551 – 5599
    Beta strandi561 – 57010
    Beta strandi573 – 5808
    Helixi587 – 60216
    Beta strandi611 – 6155
    Beta strandi617 – 6193
    Beta strandi622 – 6265
    Helixi633 – 6386
    Helixi642 – 6454
    Helixi648 – 66619
    Beta strandi668 – 6703
    Helixi679 – 6813
    Beta strandi682 – 6843
    Beta strandi690 – 6923
    Beta strandi703 – 7053
    Turni715 – 7173
    Helixi720 – 7234
    Helixi732 – 74615
    Turni750 – 7534
    Helixi756 – 76510
    Helixi778 – 78710
    Helixi792 – 7943
    Helixi798 – 80912

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3P86X-ray2.50A/B540-821[»]
    3PPZX-ray2.99A/B540-821[»]
    ProteinModelPortaliQ05609.
    SMRiQ05609. Positions 540-810.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini551 – 809259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi65 – 695Poly-Gly
    Compositional biasi135 – 1417Poly-Gly

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000239752.
    InParanoidiQ05609.
    KOiK14510.
    OMAiPSFATIM.
    PhylomeDBiQ05609.

    Family and domain databases

    InterProiIPR028324. CTR1.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR23257:SF384. PTHR23257:SF384. 1 hit.
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05609-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMPGRRSNY TLLSQFSDDQ VSVSVTGAPP PHYDSLSSEN RSNHNSGNTG    50
    KAKAERGGFD WDPSGGGGGD HRLNNQPNRV GNNMYASSLG LQRQSSGSSF 100
    GESSLSGDYY MPTLSAAANE IESVGFPQDD GFRLGFGGGG GDLRIQMAAD 150
    SAGGSSSGKS WAQQTEESYQ LQLALALRLS SEATCADDPN FLDPVPDESA 200
    LRTSPSSAET VSHRFWVNGC LSYYDKVPDG FYMMNGLDPY IWTLCIDLHE 250
    SGRIPSIESL RAVDSGVDSS LEAIIVDRRS DPAFKELHNR VHDISCSCIT 300
    TKEVVDQLAK LICNRMGGPV IMGEDELVPM WKECIDGLKE IFKVVVPIGS 350
    LSVGLCRHRA LLFKVLADII DLPCRIAKGC KYCNRDDAAS CLVRFGLDRE 400
    YLVDLVGKPG HLWEPDSLLN GPSSISISSP LRFPRPKPVE PAVDFRLLAK 450
    QYFSDSQSLN LVFDPASDDM GFSMFHRQYD NPGGENDALA ENGGGSLPPS 500
    ANMPPQNMMR ASNQIEAAPM NAPPISQPVP NRANRELGLD GDDMDIPWCD 550
    LNIKEKIGAG SFGTVHRAEW HGSDVAVKIL MEQDFHAERV NEFLREVAIM 600
    KRLRHPNIVL FMGAVTQPPN LSIVTEYLSR GSLYRLLHKS GAREQLDERR 650
    RLSMAYDVAK GMNYLHNRNP PIVHRDLKSP NLLVDKKYTV KVCDFGLSRL 700
    KASTFLSSKS AAGTPEWMAP EVLRDEPSNE KSDVYSFGVI LWELATLQQP 750
    WGNLNPAQVV AAVGFKCKRL EIPRNLNPQV AAIIEGCWTN EPWKRPSFAT 800
    IMDLLRPLIK SAVPPPNRSD L 821
    Length:821
    Mass (Da):90,306
    Last modified:November 1, 1995 - v1
    Checksum:i2922D3DCD0CC15BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08789 mRNA. Translation: AAA32779.1.
    L08790 Genomic DNA. Translation: AAA32780.1.
    AL162506 Genomic DNA. Translation: CAB82938.1.
    CP002688 Genomic DNA. Translation: AED90647.1.
    CP002688 Genomic DNA. Translation: AED90648.1.
    PIRiT48400.
    RefSeqiNP_195993.1. NM_120454.3.
    NP_850760.1. NM_180429.3.
    UniGeneiAt.300.

    Genome annotation databases

    EnsemblPlantsiAT5G03730.1; AT5G03730.1; AT5G03730.
    AT5G03730.2; AT5G03730.2; AT5G03730.
    GeneIDi831748.
    KEGGiath:AT5G03730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08789 mRNA. Translation: AAA32779.1 .
    L08790 Genomic DNA. Translation: AAA32780.1 .
    AL162506 Genomic DNA. Translation: CAB82938.1 .
    CP002688 Genomic DNA. Translation: AED90647.1 .
    CP002688 Genomic DNA. Translation: AED90648.1 .
    PIRi T48400.
    RefSeqi NP_195993.1. NM_120454.3.
    NP_850760.1. NM_180429.3.
    UniGenei At.300.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3P86 X-ray 2.50 A/B 540-821 [» ]
    3PPZ X-ray 2.99 A/B 540-821 [» ]
    ProteinModelPortali Q05609.
    SMRi Q05609. Positions 540-810.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 17024. 6 interactions.
    IntActi Q05609. 4 interactions.
    STRINGi 3702.AT5G03730.1-P.

    Proteomic databases

    PaxDbi Q05609.
    PRIDEi Q05609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G03730.1 ; AT5G03730.1 ; AT5G03730 .
    AT5G03730.2 ; AT5G03730.2 ; AT5G03730 .
    GeneIDi 831748.
    KEGGi ath:AT5G03730.

    Organism-specific databases

    GeneFarmi 884.
    TAIRi AT5G03730.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000239752.
    InParanoidi Q05609.
    KOi K14510.
    OMAi PSFATIM.
    PhylomeDBi Q05609.

    Enzyme and pathway databases

    BioCyci ARA:AT5G03730-MONOMER.
    ARA:GQT-223-MONOMER.
    BRENDAi 2.7.11.1. 399.

    Gene expression databases

    ArrayExpressi Q05609.
    Genevestigatori Q05609.

    Family and domain databases

    InterProi IPR028324. CTR1.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR23257:SF384. PTHR23257:SF384. 1 hit.
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases."
      Kieber J.J., Rothenberg M., Roman G., Feldmann K.A., Ecker J.R.
      Cell 72:427-441(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
      Strain: cv. Columbia.
      Tissue: Seedling.
    2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiCTR1_ARATH
    AccessioniPrimary (citable) accession number: Q05609
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3