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Protein

Protein kinase YpkA

Gene

ypkA

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a virulence determinant.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163ATPPROSITE-ProRule annotation1
Active sitei270Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 150ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase YpkA (EC:2.7.11.1)
Short name:
Protein kinase A
Alternative name(s):
Targeted effector protein kinase
Gene namesi
Name:ypkA
Ordered Locus Names:pYV0001
Encoded oniPlasmid pIB12 Publications
Plasmid pYV1 Publication
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001011 Componenti: Plasmid pYV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000024392? – 732Protein kinase YpkA
Signal peptidei1 – ?Sequence analysis

Interactioni

Protein-protein interaction databases

IntActiQ05608. 1 interactor.
MINTiMINT-7717103.

Structurei

Secondary structure

1732
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi442 – 460Combined sources19
Helixi466 – 485Combined sources20
Helixi491 – 513Combined sources23
Helixi534 – 537Combined sources4
Helixi539 – 547Combined sources9
Helixi548 – 551Combined sources4
Helixi556 – 558Combined sources3
Helixi559 – 580Combined sources22
Beta strandi583 – 585Combined sources3
Helixi588 – 628Combined sources41
Helixi629 – 631Combined sources3
Helixi633 – 646Combined sources14
Helixi656 – 658Combined sources3
Helixi659 – 676Combined sources18
Helixi677 – 679Combined sources3
Helixi680 – 697Combined sources18
Helixi705 – 730Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7OX-ray2.00A434-732[»]
2H7VX-ray2.60C/D434-732[»]
ProteinModelPortaliQ05608.
SMRiQ05608.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05608.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 408Protein kinasePROSITE-ProRule annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000219636.
OMAiMRNFTAD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR019093. Rac1-binding_domain.
IPR008271. Ser/Thr_kinase_AS.
IPR003547. Ser/thr_kinase_yersinia-type.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF09632. Rac1. 1 hit.
[Graphical view]
PRINTSiPR01373. YERSSTKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVKIMGTM PPSISLAKAH ERISQHWQNP VGELNIGGKR YRIIDNQVLR
60 70 80 90 100
LNPHSGFSLF REGVGKIFSG KMFNFSIARN LTDTLHAAQK TTSQELRSDI
110 120 130 140 150
PNALSNLFGA KPQTELPLGW KGEPLSGAPD LEGMRVAETD KFAEGESHIS
160 170 180 190 200
IIETKDKQRL VAKIERSIAE GHLFAELEAY KHIYKTAGKH PNLANVHGMA
210 220 230 240 250
VVPYGNRKEE ALLMDEVDGW RCSDTLRTLA DSWKQGKINS EAYWGTIKFI
260 270 280 290 300
AHRLLDVTNH LAKAGVVHND IKPGNVVFDR ASGEPVVIDL GLHSRSGEQP
310 320 330 340 350
KGFTESFKAP ELGVGNLGAS EKSDVFLVVS TLLHCIEGFE KNPEIKPNQG
360 370 380 390 400
LRFITSEPAH VMDENGYPIH RPGIAGVETA YTRFITDILG VSADSRPDSN
410 420 430 440 450
EARLHEFLSD GTIDEESAKQ ILKDTLTGEM SPLSTDVRRI TPKKLRELSD
460 470 480 490 500
LLRTHLSSAA TKQLDMGGVL SDLDTMLVAL DKAEREGGVD KDQLKSFNSL
510 520 530 540 550
ILKTYRVIED YVKGREGDTK NSSTEVSPYH RSNFMLSIVE PSLQRIQKHL
560 570 580 590 600
DQTHSFSDIG SLVRAHKHLE TLLEVLVTLS QQGQPVSSET YGFLNRLAEA
610 620 630 640 650
KITLSQQLNT LQQQQESAKA QLSILINRSG SWADVARQSL QRFDSTRPVV
660 670 680 690 700
KFGTEQYTAI HRQMMAAHAA ITLQEVSEFT DDMRNFTVDS IPLLIQLGRS
710 720 730
SLMDEHLVEQ REKLRELTTI AERLNRLERE WM
Length:732
Mass (Da):81,731
Last modified:November 23, 2004 - v2
Checksum:iCEF903AAFE2E57BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti566H → N (PubMed:8441468).Curated1
Sequence conflicti566H → N (PubMed:8045884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69439 Genomic DNA. Translation: CAA49215.1.
L33833 Genomic DNA. Translation: AAA68487.1.
BX936399 Genomic DNA. Translation: CAF25344.1.
PIRiS30060.
RefSeqiWP_011191359.1. NZ_CP009711.1.

Genome annotation databases

EnsemblBacteriaiCAF25344; CAF25344; pYV0001.
KEGGiypo:BZ17_4237.
yps:pYV0001.
PATRICi18637748. VBIYerPse22266_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69439 Genomic DNA. Translation: CAA49215.1.
L33833 Genomic DNA. Translation: AAA68487.1.
BX936399 Genomic DNA. Translation: CAF25344.1.
PIRiS30060.
RefSeqiWP_011191359.1. NZ_CP009711.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7OX-ray2.00A434-732[»]
2H7VX-ray2.60C/D434-732[»]
ProteinModelPortaliQ05608.
SMRiQ05608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ05608. 1 interactor.
MINTiMINT-7717103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF25344; CAF25344; pYV0001.
KEGGiypo:BZ17_4237.
yps:pYV0001.
PATRICi18637748. VBIYerPse22266_0001.

Phylogenomic databases

HOGENOMiHOG000219636.
OMAiMRNFTAD.

Miscellaneous databases

EvolutionaryTraceiQ05608.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR019093. Rac1-binding_domain.
IPR008271. Ser/Thr_kinase_AS.
IPR003547. Ser/thr_kinase_yersinia-type.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF09632. Rac1. 1 hit.
[Graphical view]
PRINTSiPR01373. YERSSTKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPKA_YERPS
AccessioniPrimary (citable) accession number: Q05608
Secondary accession number(s): Q663G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.